Download or read book Cardiac Adaptation to Hemodynamic Overload Training and Stress written by R. Jacob and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac hypertrophy and accompanying phenomena have received increasing attention in recent years - particularly in the basic sciences. The present volume contains the proceedings of the Erwin RIESCH SYMPOSIUM on "CARDIAC ADAPTATION TO HEMODYNAMIC OVERLOAD, TRAINING AND STRESS" held in Tiibingen on Sep tember 19-22, 1982. In addition to the topics of the previous symposia (1976 and 1979) concerned with problems of cardiac hypertrophy, the scope of this sequel meeting has been expanded to include related fields. The intention was to consider numerous related features and problems of chronic reactions of the heart (and vascular system) to abnormal hemodynamic loading, as well as alterations due to maturation, aging, training, neuroendocrine status and stress. Special attention has been paid to cardiac reactions at the level of contractile proteins. The results are considered primarily in light of long-term adaptation of the heart. Of course, research at the forefront of current knowledge need not always lead to congruent conclusions. Neither can the individual contributions always agree with the viewpoint of the editors. However, the broad array of individual approaches employed by biochemists, biolo gists, pathologists, physiologists, pharmacologists and clinical cardio logists will certainly help to provide a more balanced interpretation of the results in individual fields, stimulate reexamination of established con cepts and provide direction for future research.
Download or read book Cardiac Adaptations written by Bohuslav Ostadal and published by Springer Science & Business Media. This book was released on 2012-10-12 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation. Particular attention is paid to the still underestimated adaptive cardiac responses during development, to adaptation to the frequently occurring pressure and volume overload as well as to cardiac changes, induced by enduring exercise and chronic hypoxia. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
Download or read book Muscle 2 Volume Set written by Joseph Hill and published by Academic Press. This book was released on 2012-08 with total page 1469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.
Download or read book Pathophysiology of Heart Disease written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc.
Download or read book Scientific Directory and Annual Bibliography written by National Institutes of Health (U.S.) and published by . This book was released on 1984 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Energetics written by R. Jacob and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book Experimental Hypertension and Therapeutic Progress Vasodilation and Beyond written by Bernward Garthoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the workshop held in Leverkusen on December 1, 1993, Professor Dr. Stanislav Kazda was honored on the occasion of his retirement for his scientific contributions and his involvement in drug development in our company, Bayer AG. In a recent article by Eugene Garfield (Current ContentslLife Sciences 36:3-15, 1993), what most of us participating in this workshop have supposed for years was confirmed: that Kazda is one of the leading scientific authors in academia worldwide. In the said survey of citations of biomedical research articles, Kazda is number 29 in terms of actual impact, individual ~itations, and total number of published manuscripts (and this only covers the time period from 1981 to 1992). In addition, his work has contributed significantly to the number eight ranking of our company in the so-called Corporation List. With the support of colleagues inside and outside the company, Kazda made a new substance class, the 1, 4-dihydropyridines, discovered by Bossert and Vater, well known to the scientific community on a worldwide basis and established its outstanding usefulness in hypertension. He has contributed numerous publi cations on the pharmacology of these calcium antagonists and organized several international conferences on the topic. Although he became famous as a cardiovascular pharmacologist, he started his career as a physician with the subjects obstetrics and gynecology. He studied at the Medical Faculty in Prague and at the Universities of Kasan and Kharkow (1950-1957).
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Function and Metabolism written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Symposium held at the 8th Annual Meeting of the American Section of the International Society for Heart Research, July 8-11, 1986, Winnipeg, Canada
Download or read book The Right Ventricle written by Marvin A. Konstam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is quite natural that literature related to car heart disease, cardiomyopathy, pulmonary and diac structure, function, pathology, and patho pulmonary vascular disease, trauma, acquired valvular disease, congenital disease, and surgi physiology has emphasized the left heart and systemic circulation. The relative lack of im cal considerations. The pathologic and clinical relevance of myocardial infarction of the right portance of the right ventricle was supported by studies performed in the 1940s and 1950s ventricle has only been documented over the which suggested that the right ventricular free last 15 years. The chapter on right ventricular wall could be effectively destroyed in an animal infarction integrates clinical, functional, patho model without detectable untoward hemody physiologic, and pathologic observations to pro namic consequences. The relative inadequacy vide the reader with a thorough review, equally of noninvasive tools to study right ventricular relevant to the clinician and investigator. The contribution on dilated cardiomyopathy pro structure and function obviated detailed and systematic investigation. However, over the vides novel insight into the impact of right ventricular performance on the functional in past 15 years there has been a resurgence of interest in the right ventricle by a variety of capacity accompanying left heart failure. A book dealing with the right ventricle would investigators. The skeptic would argue that this renewed interest resulted from an exhaustion be incomplete without at least cursory reference we have of clinically-related observations that could be to the pulmonary circulation.
Download or read book Functional Aspects of the Normal Hypertrophied and Failing Heart written by Francesco Abel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: These Proceedings are from the Fifth Annual Meeting of the American Section of the International Society for Heart Research held at Hilton Head Island, South Carolina, September 21-24, 1983. The program and abstracts were published in the Journal of Molecular and Cellular Cardiology, Vol. 15, Supplement 4, September 1983, Academic Press. This Symposium Proceedings consists of three sections. Section I deals with the mechanical factors and their i'nfluence on coronary blood flow in the normal and failing heart. Section II is developed around the area of vascular smooth muscle and the factors that may control it which ultimately play such an important role in the regulation of coronary blood flow. Section III is primarily devoted to the mechanical aspects of the function of the heart in both hypertrophy and failure including the molecular changes in the myocyte, alterations in neural control, and in inotropic responsiveness of the hypertrophied and failing heart. The editors hope that these three areas encompass a significant body of new and ongoing information that will be helpful to those who work in these areas as well as those who treat patients with varying degrees of myocardial failure or with compromised coronary circulations. The editors express their appreciation to all the contributors and to Ms. Jeri B. McClain for assisting in the organization and compiling of this volume. Francis L. Abel, M. D. , Ph. D. Walter H. Newman, Ph. D.
Download or read book Nutritional Pathophysiology of Obesity and its Comorbidities written by Susan Ettinger and published by Academic Press. This book was released on 2016-09-01 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutritional Pathophysiology of Obesity and Its Comorbidities: A Case-Study Approach challenges students and practitioners to understand the role of nutrients within the pathophysiology and development of disease, specifically those diseases which develop as a result of obesity. Through a case-based approach, the author presents complex clinical scenarios that require multiple treatment strategies, including targeted diet modification as an adjuvant to medical therapy. The book is divided into 9 modules and 5 appendices each of which covers aspects of obesity and its comorbidities. Within each module, a case is detailed with relevant history, laboratory and physical data, and follow-up information. Each case is followed by a resource section which delineates current understanding of the pathophysiology of the condition, as well as the actions of nutrients and food components shown to modify these processes. A "further readings" section cites current supporting clinical and basic literature as well as published guidelines. - Explores how obesity is a key player in the pathophysiology of many diseases, including diabetes mellitus, chronic renal failure, hypertension, and atherosclerosis - Integrates current understandings of the molecular mechanisms of nutrient action on the processes of disease development and treatment - Presents students and early practitioners with complex clinical scenarios through a practical case-based approach
Download or read book The Developing Heart written by Marianne J. Legato and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart disease, despite recent improvements, continues to be the single most im portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.
Download or read book Pathogenesis of Stress Induced Heart Disease written by R. E. Beamish and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recent comprehensive study of stress and human health by the Institute of Medicine/National Academy of Sciences concludes that individuals who experience any of a wide range of stressful events or situations are at increased risk of developing a physical or mental disorder, including heart disease. Since cardiovascular disease continues to be a leading cause of illness and death, and since the etiology and pathogenesis of several of the commonest forms of heart disease are incompletely known, it is of fundamental impor tance to study the potential role of stress in the genesis of heart disease. Accordingly an International Symposium on Stress and Heart Disease was held in Winnipeg, Canada, June 26-29, 1984 and the proceedings form the basis of this book and its companion volume, "Stress and Heart Disease". The connection between stress (the behavioral sciences) and heart disease (the biomedical sciences) occurs in the mechanisms through which the brain affects or controls the endocrine and the autonomic nervous systems. Initially this linkage appeared to be relatively simple, mainly involving catecholamines and corticosteroids, and communication between nerve cells was thought to be electrical. Now knowledge has increased and concepts have change dramatic ally. Major advances have occurred in biochemical, anatomical, physiological, pharmacological, pathological and behavioral aspects of the neuroendocrine system. The over whelming significance of chemical communication in the nli xviii nervous system has become clear.
Download or read book Regulation of Heart Function written by Heinz Rupp and published by . This book was released on 1986 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
