Download or read book Nitroarenes written by Paul C. Howard and published by Springer. This book was released on 2011-09-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Download or read book Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes written by Charles M. King and published by Elsevier Publishing Company. This book was released on 1988 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carcinogenic and Mutagenic N substituted Aryl Compounds written by and published by . This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Mutagenesis Research written by Günter Obe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by aplethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discused by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his Life and Scientific Achievements. - Arylnitrenium Ions and the Genotoxic Potency of Aromatic Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical Structure in Various Series of Related Compounds. - Formation of 8-Hydroxyguanine by Oxidative DNA Damage, its Repair and its Mutagenic Effects. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of Induced Mutagenesis by Ultraviolet Light in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the Identification of SCEs per Cell Cycle: Fundamentals and Applications. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi Analysis. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.
Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Download or read book Toxicology written by Hans Marquardt and published by Academic Press. This book was released on 1999-10-05 with total page 1355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments. Key Features * Comprehensive text, covering all aspects of the field of toxicology * Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects * Identifies the various classes of chemical compounds responsible for the toxic effects * Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention * Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables
Download or read book Nitroarenes written by Paul C. Howard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Download or read book Mechanisms of Environmental Mutagenesis Carcinogenesis written by A. Kappas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 19th annual meeting of the European Environmental Mutagen Society was held in Rhodes, Greece, from October 21st to 26th, 1989. The programme was chosen to explore what is currently known about the mechanisms of mutagenesis and carcinogenesis, induced by environmental agents, and the questions regarding the relationship of these two processes. Recent findings, techniques and methodologies in the area of biomonitoring of humans exposed to environmental mutagens-carcinogens were presented and considerable attention was also paid to the aspects and issues of collaborative environmental policy. Researchers from allover the world contributed to the programme of the meeting with posters and oral presentations, providing a variety of new data and interesting scientific approaches. A number of outstanding scientists were invited to present the results of their work. It is only their presenta tions which are included in this book, covering the following topics: Mutations and carcinogenesis; mechanisms of chemical ly-induced genetic effects on molecular, chromosomal and cell division level; adaptability and repair mechanisms; chemical carcinogenesis and oncogenes; structure and metabolism of mutagens-carcinogens; biomonitoring and epidemiology of humans exposed to environmental mutagens-carcinogens. For the sake of evaluating and controlling the mutagenic and carcinogenic potential of our environment it is indispens able to understand the mechanisms and processes by which chemicals act on the genetic material, causing either heredi tary disease or cancer. The pUblication of these proceedings will hopefully contribute to this task.
Download or read book In vitro Environmental Toxicology Concepts Application and Assessment written by Georg Reifferscheid and published by Springer. This book was released on 2017-05-16 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Download or read book Plants for Environmental Studies written by Wuncheng (Woodrow) Wang and published by CRC Press. This book was released on 2020-02-10 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the problems of using plants in environmental studies is finding current information. Because plants play a key role in environmental studies, from the greenhouse effect to environmental toxicological studies, information is widely scattered over many different fields and in many different sources. Plants for Environmental Studies solves that problem with a single, comprehensive source of information on the many ways plants are used in environmental studies. Written by experts from around the world and edited by a team of prominent environmental specialists, this book is the only source of complete information on environmental impacts, mutation, statistical analyses, relationships between plants and water, algae, plants in ecological risk assessment, compound accumulations, and more. Encompassing algae and vascular plants in both aquatic and terrestrial environments, this book contains a diverse collection of laboratory and in situ studies, methods, and procedures using plants to evaluate air, water, wastewater, sediment, and soil.
Download or read book Mutagens in Food written by Veikko Hayatsu and published by CRC Press. This book was released on 2018-05-04 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes many different kinds of mutagens that are detected in food, and also discusses various ways to suppress their formation and activities. The mutagens discussed include those of natural origin, those caused by human manipulation of food (e.g., cooking and adding preservatives), and those formed after food has been consumed (e.g., nitrosamines). Other topics include mutagenesis and mutagen-formation inhibitors, contemporary mutagen detection methods, the fate of ingested mutagens, and risk assessments for mutagens as human carcinogens. The book emphasizes cooked-food mutagens, especially the heterocyclic amines, because of their potential as human carcinogens. Researchers and students concerned with mutagens in food will consider this book to be valuable additions to their reference libraries.
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Conjugation Reactions In Drug Metabolism written by Gerard J. Mulder and published by CRC Press. This book was released on 1990-02-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes "in vivo". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.
Download or read book Acrylamide and Other Hazardous Compounds in Heat Treated Foods written by K Skog and published by Woodhead Publishing. This book was released on 2006-10-30 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the aim of cooking foods is to make them more appetizing and microbiologically safe, it is now known that cooking and food processing at high temperatures generate various kinds of toxic substances, such as heterocyclic amines and acrylamide, via the Maillard reaction. Summarising the latest research in this field, this important collection discusses both the formation of health-hazardous compounds during heat treatment of foods and practical methods to minimise their formation.Part one analyses the formation of hazardous compounds in heat-treated foods such as meat, potatoes, cereal and coffee. Part two discusses the health risks posed by heat-induced toxicants. It includes chapters on bio-monitoring, exposure assessment and risk assessment, as well as chapters on the risks of specific compounds. The final part of the book is concerned with the key area of minimising the formation of harmful compounds in food products. This can be achieved by controlling processing conditions and modifying ingredients, among other methods.With its distinguished editors and international team of contributors with unrivalled academic and industry experience, Acrylamide and other hazardous compounds in heat-treated foods, is invaluable for all those concerned with this crucial safety issue throughout the food industry. Analyses the formation of health hazardous compounds during heat treatment of foods Discusses practical methods to minimise formation Distinguished editors and international team of contributors
Download or read book The Medicinal Chemist s Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-27 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Download or read book Health Assessment Document for Diesel Emissions written by and published by . This book was released on 1994 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicological Profile for Benzidine written by and published by . This book was released on 1995 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
