Download or read book Carbohydrate Modifications in Antisense Research written by Yogesh S. Sanghvi and published by . This book was released on 1994 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent developments and progress in the carbohydrate-related chemistry of novel nucleic acid mimics and their applications in antisense therapeutics. Discusses the use of new chemical classes to rationally design and synthesize oligonucleotides. Explores several carbohydrate modifications of the oligonucleotide to stabilize against nuclease degradation and to enhance the binding affinity for a given target. Suggests future directions of carbohydrate-related modifications for antisense molecules.
Download or read book Antisense Research and Application written by Stanley T. Crooke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Download or read book Progress in drug research 48 1997 written by Ernst Jucker and published by Springer Science & Business Media. This book was released on 1997 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by Eric J. Lien and published by Birkhäuser. This book was released on 2012-12-06 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antisense Technology Part A General Methods Methods of Delivery and RNA Studies written by and published by Elsevier. This book was released on 1999-11-01 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Download or read book Antisense Drug Technology written by Stanley T. Crooke and published by CRC Press. This book was released on 2007-07-25 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati
Download or read book Carbohydrate Chemistry written by R. J. Ferrier and published by Royal Society of Chemistry. This book was released on 1997 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Springer Science & Business Media. This book was released on 2003-09-08 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Download or read book Biotechnology And Safety Assessment written by J A Thomas and published by CRC Press. This book was released on 1998-11-17 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated text explains how advances in mammalian and plant genetics contribute to better therapeutics agents and more wholesome foods. It addresses such topics as new pharmaceutical agents, agribiotechnology, safety evaluation of biotechnology-derived drugs, food safety, nutritional science, and regulatory and environmental aspects of genetically-modified organisms. New to this edition are chapters on biotherapeutics and herbicide-resistant crops. It should be of interest to biotechnology, toxicologists, pharmaceutical scientists, environmental scientists and agriculturists.
Download or read book Electrostatic and Stereoelectronic Effects in Carbohydrate Chemistry written by Momcilo Miljkovic and published by Springer Science & Business Media. This book was released on 2014-01-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with polar effects in carbohydrates and how these effects control the stereochemistry of carbohydrate reactions. This is important for understanding the mechanisms of certain carbohydrate reactions, including enzymatic reactions such as glycosidases, a very important group of enzymes in living matter. It is also very useful for synthetic carbohydrate chemists who would like to synthesize stereoselectively certain classes of carbohydrates. This book will be a very important source of information for practicing synthetic carbohydrate chemists. The book will also be helpful for organic chemists, or for those studying glycobiology.
Download or read book Advances in Drug Discovery Techniques written by Alan L. Harvey and published by CRC Press. This book was released on 1998-08-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.
Download or read book Manual of Antisense Methodology written by Gunther Hartmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.
Download or read book Gene Therapy written by and published by Academic Press. This book was released on 1997-08-12 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more. Key Features* It provides an excellent overview on a series of topics on gene therapy for the serious investigator
Download or read book Annual Reports in Medicinal Chemistry written by David Robertson and published by Academic Press. This book was released on 1998-10-21 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.
Download or read book Frontiers in Clinical Drug Research Anti Infectives written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2014-06-30 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research – Anti Infectives is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti Infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The first volume of this series features reviews that cover a variety of topics including: -Bacteriophage research against gram positive bacteria -Edible vaccines -Novel antibiotics against gram negative bacteria -Antimicrobial resistance among enteric pathogens
Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Download or read book Natural Products in Medicinal Chemistry written by Stephen Hanessian and published by John Wiley & Sons. This book was released on 2013-12-18 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
