Download or read book Calcium Phosphate Coatings for Bone Regeneration written by Lan Yang and published by . This book was released on 2010 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Calcium Phosphate Nanocoatings for Bone Regeneration written by Andy H. Choi and published by Springer Nature. This book was released on 2023-09-11 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth assessment on the latest clinical advances in multifunctional calcium phosphate nanocoatings and its influence on bone regeneration and early healing following implantation. A greater emphasis will be placed on the use of nanocomposite coatings to deliver biological materials such as mesenchymal stem cells, growth factors, bone morphogenetic and extracellular matrix proteins, and pharmaceutics such as simvastatin to improve and promote bone growth as well as reducing the timeframe needed for implant integration in both healthy and osteoporotic patients. The content of the book caters to clinical practitioners and researchers working in the field of biomaterials for bone regeneration.
Download or read book Advances in Calcium Phosphate Biomaterials written by Besim Ben-Nissan and published by Springer Science & Business. This book was released on 2014-04-17 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Download or read book Effect of Calcium Phosphate Coating and RhBMP 2 on Bone Regeneration in Rabbit Calvaria Using Poly propylene Fumarate Scaffolds written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Calcium Phosphate based Resorbable Biomaterials for Bone Regeneration written by Daniel O. Costa and published by . This book was released on 2012 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone defects are a prevalent problem in orthopedics and dentistry. Calcium phosphate-based coatings and nanocomposites offer unique solutions towards producing scaffolds with suitable physical, mechanical and biological properties for bone regeneration. We developed a novel method to synthesize hydroxyapatite (HA) particles with high aspect ratio using sol-gel chemistry and hydrothermal treatment. We obtained tunable pure-phase carbonated-HA in the form of micro/nanorods and nanowires (diameters 25-800 nm). To mimic the structure of bone, HA nanowires were homogenously mixed within poly( -caprolactone) (PCL) to produce nanocomposites with improved mechanical properties as determined by uniaxial tensile testing. Surface chemistry and topography of biomaterials play prominent roles in regulating cell adhesion and differentiation. Bone-like apatite coatings, produced by incubating materials in a simulated body fluid (SBF), improve the osteoconductivity of scaffold materials. However, few studies have controlled the surface topography of biomimetic HA. We assessed the effect of SBF ion concentration and soaking time on the surface properties of apatite coatings. Calcium phosphates such as carbonated-HA with similar chemical composition and stiffness were deposited onto PCL films. Characterization of these coatings revealed an increase in topographical complexity and surface roughness with increasing ion concentration of SBF and soaking time. To investigate their potential application in bone regeneration, we studied the influence of topography of biomimetic HA coatings on the behavior of osteoblasts and osteoclasts in vitro. Osteoblast attachment and differentiation were significantly greater iv when cultured on rougher HA surfaces (Ra 2̃ m) than on smoother topographies (Ra 1̃ m). In contrast, activity of tartrate-resistant acid phosphatase (an osteoclast marker) was greater on smoother than on rougher HA surfaces. Furthermore, osteoclastic resorption lacunae were found exclusively on smoother HA coatings. Inhibition of resorption on rougher HA surfaces was associated with disruption of filamentous actin sealing zones. In conclusion, HA coatings can be prepared with different topographies, which regulate responses of osteoblasts and osteoclasts. Thus, it may be possible to design HA-polymer composites and HA-coated polymers with physical, mechanical and biological properties suitable for tissue engineering. By modulating topography, rates of bone formation and biodegradation could be tailored for specific applications in orthopedics and dentistry.
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Download or read book A Bioinspired Gelatin Amorphous Calcium Phosphate Coating on Titanium Implant for Bone Regeneration written by Yanhuizhi Feng and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developments and Applications of Calcium Phosphate Bone Cements written by Changsheng Liu and published by Springer. This book was released on 2017-10-20 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Download or read book Advanced Synthesis and Medical Applications of Calcium Phosphates written by S.S. Nanda and published by CRC Press. This book was released on 2024-05-15 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium phosphate materials are used in many medical and dental applications. Advanced Synthesis and Medical Applications of Calcium Phosphates covers the structure, chemistry, synthesis, and properties of both natural and synthetic calcium-based biomaterials and details a variety of medical applications. Depicts the latest advances in using calcium phosphates in bone regeneration and tissue engineering Includes the latest generation of regenerative biomaterials with an integrated perspective combining both research and clinical issues Provides an understanding of the clinical targets and requirements for regenerative medicine Detailing fundamentals through applications, this book helps biomaterials researchers to better understand the clinical targets and requirements for use of these materials for optimal synthesis and development.
Download or read book Interface Oral Health Science 2016 written by Keiichi Sasaki and published by . This book was released on 2020-10-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis-Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted "Interface Oral Health Science" several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014.This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Bone Response to Dental Implant Materials written by Adriano Piattelli and published by Woodhead Publishing. This book was released on 2016-10-27 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. Presents a specific focus on the development and use of biomaterials in the oral environment Discusses the basic science of the dental interface and its clinical applications Contains important coverage on the monitoring and analysis of the dental implant interface
Download or read book Calcium Phosphate Coatings for Fixation of Bone Implants written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Octacalcium Phosphate Biomaterials written by Gerard Insley and published by Woodhead Publishing. This book was released on 2019-11-20 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration
Download or read book Hydroxyapatite HAp for Biomedical Applications written by Michael Mucalo and published by Elsevier. This book was released on 2015-03-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydroxyapatite in the form of hydroxycarbonate apatite is the principal mineral component of bone tissue in mammals. In Bioceramics, it is classed as a bioactive material, which means bone tissue grows directly on it when placed in apposition without intervening fibrous tissue. Hydroxyapatite is hence commonly used as bone grafts, fillers and as coatings for metal implants. This important book provides an overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application. Reviews the important properties of hydroxyapatite as a biomaterial Considers a range of specific forms of the material and their advantages Reviews a range of specific medical applications for this important material
Download or read book Bone Regeneration by Tuning the Drug Release from the Calcium Phosphate Scaffolds written by Kanupriya Khurana and published by . This book was released on 2018 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone is among the most transplanted tissues for regeneration of bone defects, caused by trauma, age-related bone loss or bone infections. Due to their similar characteristics to the mineral phase of bone, calcium phosphates (CaPs) have raised a lot of interest. Some properties of CaPs, like biodegradability, biocompatibility, bioactivity and osteoconduction represent a great potential for this application. Among them, calcium phosphate cements (CPCs) have additional advantages like injectability and in situ hardening ability. Moreover, the possibility to tune the porosity of CaPs in general and of CPCs in particular, makes them suitable vehicles for local delivery of drugs. Loading CaPs with drugs allows conferring additional functionalities to the synthetic bone grafts, which is of great interest. The main aim of this thesis is to explore CaP bioceramics as vehicles for local delivery of drugs, covering both low temperature biomimetic ceramics, like calcium deficient hydroxyapatite (CDHA), and high temperature sintered ceramics, like beta tricalcium phosphate (ß-TCP), in the form of microporous and macroporous substrates. The physic-chemical nature of these bioceramics, their porosity and textural properties plays an essential role in their drug delivery properties. In order to be able to tailor the drug release kinetics of the bioceramics beyond their intrinsic properties, plasma polymerization has been investigated. Plasma is a particular state of a gas, electrically neutral, which can be employed in different applications. Although plasma polymerization has been widely studied for biomedical applications, its combination with bioceramics is rather unexplored. To select a suitable drug for bone regeneration, an extensive literature review was done on statins, and more particularly on simvastatin as a potential osteogenic and angiogenic promoter. This drug was evaluated within macroporous scaffolds of either CDHA or ß-TCP as drug delivery vehicles. The drug-loaded materials were plasma-coated with polycaprolactone: poly ethylene glycol (PCL:PEG) co-polymers. The coating covered the micro and nanopores of the CaPs surface and produced complex geometries presenting a nano and micro rough morphology which led to low wettability despite the hydrophilicity of the copolymer. Plasma coating with PCL-co-PEG on scaffolds loaded with simvastatin acid allowed delaying and modulating the drug release from the bone scaffolds depending on the thickness of the layer deposited, which, in turn depended on the initial specific surface area of the CaP. To further investigate the fundamentals of plasma polymerization on bioceramics, PEG-like polymer coatings of different thickness were deposited on microporous ß-TCP loaded with antibiotics. The rough ß-TCP surface was associated to strong hydrophobic surface properties, which nevertheless retained their suitable biological behavior with regard to human osteoblast cells. The microbiological activity of the antibiotics was preserved, and the coatings reduced the total amount of drug released as a function of the increasing plasma treatment time. In another approach, a statin that had never before been employed in combination with CaPs, Pitavastatin (PITA), was investigated as potentially osteogenic and angiogenic promoter through in vitro studies which revealed dose-dependent enhancement of mineralization and vascularization. The incorporation of PITA to the liquid phase of an injectable CDHA foam allowed obtaining injectable local drug delivery scaffolds, without altering their macroporosity or textural properties. The drug release kinetics was affected by the evolving microstructure of the setting of the macroporous cement. Overall the results obtained proved that PITA seems to be a suitable novel candidate to enhance the osteogenic potential of synthetic bone grafts and identified the required doses to obtain the desired biological effects.
Download or read book Bioceramics and Biocomposites written by Iulian Antoniac and published by John Wiley & Sons. This book was released on 2019-04-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of the research into and clinical uses of bioceramics and biocomposites Developments related to bioceramics and biocomposites appear to be one the most dynamic areas in the field of biomaterials, with multiple applications in tissue engineering and medical devices. This book covers the basic science and engineering of bioceramics and biocomposites for applications in dentistry and orthopedics, as well as the state-of-the-art aspects of biofabrication techniques, tissue engineering, remodeling, and regeneration of bone tissue. It also provides insight into the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Featuring contributions from leading experts in the field, Bioceramics and Biocomposites: From Research to Use in Clinical Practice offers complete coverage of everything from extending the concept of hemopoietic and stromal niches, to the evolution of bioceramic-based scaffolds. It looks at perspectives on and trends in bioceramics in endodontics, and discusses the influence of newer biomaterials use on the structuring of the clinician’s attitude in dental practice or in orthopedic surgery. The book also covers such topics as biofabrication techniques for bioceramics and biocomposites; glass ceramics: calcium phosphate coatings; brain drug delivery bone substitutes; and much more. Presents the biggest trends in bioceramics and biocomposites relating to medical devices and tissue engineering products Systematically presents new information about bioceramics and biocomposites, developing diagnostics and improving treatments and their influence on the clinicians' approaches Describes how to use these biomaterials to create new functionalities when interfaced with biological molecules or structures Offers a range of applications in clinical practice, including bone tissue engineering, remodeling, and regeneration Delineates essential requirements for resorbable bioceramics Discusses clinical results obtained in dental and orthopedic applications Bioceramics and Biocomposites: From Research to Use in Clinical Practice is an excellent resource for biomaterials scientists and engineers, bioengineers, materials scientists, and engineers. It will also benefit mechanical engineers and biochemists who work with biomaterials scientists.
