Download or read book Calcium Phosphate based Resorbable Biomaterials for Bone Regeneration written by Daniel O. Costa and published by . This book was released on 2012 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone defects are a prevalent problem in orthopedics and dentistry. Calcium phosphate-based coatings and nanocomposites offer unique solutions towards producing scaffolds with suitable physical, mechanical and biological properties for bone regeneration. We developed a novel method to synthesize hydroxyapatite (HA) particles with high aspect ratio using sol-gel chemistry and hydrothermal treatment. We obtained tunable pure-phase carbonated-HA in the form of micro/nanorods and nanowires (diameters 25-800 nm). To mimic the structure of bone, HA nanowires were homogenously mixed within poly( -caprolactone) (PCL) to produce nanocomposites with improved mechanical properties as determined by uniaxial tensile testing. Surface chemistry and topography of biomaterials play prominent roles in regulating cell adhesion and differentiation. Bone-like apatite coatings, produced by incubating materials in a simulated body fluid (SBF), improve the osteoconductivity of scaffold materials. However, few studies have controlled the surface topography of biomimetic HA. We assessed the effect of SBF ion concentration and soaking time on the surface properties of apatite coatings. Calcium phosphates such as carbonated-HA with similar chemical composition and stiffness were deposited onto PCL films. Characterization of these coatings revealed an increase in topographical complexity and surface roughness with increasing ion concentration of SBF and soaking time. To investigate their potential application in bone regeneration, we studied the influence of topography of biomimetic HA coatings on the behavior of osteoblasts and osteoclasts in vitro. Osteoblast attachment and differentiation were significantly greater iv when cultured on rougher HA surfaces (Ra 2̃ m) than on smoother topographies (Ra 1̃ m). In contrast, activity of tartrate-resistant acid phosphatase (an osteoclast marker) was greater on smoother than on rougher HA surfaces. Furthermore, osteoclastic resorption lacunae were found exclusively on smoother HA coatings. Inhibition of resorption on rougher HA surfaces was associated with disruption of filamentous actin sealing zones. In conclusion, HA coatings can be prepared with different topographies, which regulate responses of osteoblasts and osteoclasts. Thus, it may be possible to design HA-polymer composites and HA-coated polymers with physical, mechanical and biological properties suitable for tissue engineering. By modulating topography, rates of bone formation and biodegradation could be tailored for specific applications in orthopedics and dentistry.
Download or read book Advances in Calcium Phosphate Biomaterials written by Besim Ben-Nissan and published by Springer Science & Business. This book was released on 2014-04-17 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Download or read book Calcium Phosphate Nanocoatings for Bone Regeneration written by Andy H. Choi and published by Springer Nature. This book was released on 2023-09-11 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth assessment on the latest clinical advances in multifunctional calcium phosphate nanocoatings and its influence on bone regeneration and early healing following implantation. A greater emphasis will be placed on the use of nanocomposite coatings to deliver biological materials such as mesenchymal stem cells, growth factors, bone morphogenetic and extracellular matrix proteins, and pharmaceutics such as simvastatin to improve and promote bone growth as well as reducing the timeframe needed for implant integration in both healthy and osteoporotic patients. The content of the book caters to clinical practitioners and researchers working in the field of biomaterials for bone regeneration.
Download or read book Bone graft substitutes written by Cato T. Laurencin and published by ASTM International. This book was released on 2003 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developments and Applications of Calcium Phosphate Bone Cements written by Changsheng Liu and published by Springer. This book was released on 2017-10-20 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Download or read book Bioactive Materials for Bone Regeneration written by Jiang Chang and published by Academic Press. This book was released on 2020-02-28 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments
Download or read book Advanced Synthesis and Medical Applications of Calcium Phosphates written by S.S. Nanda and published by CRC Press. This book was released on 2024-05-15 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium phosphate materials are used in many medical and dental applications. Advanced Synthesis and Medical Applications of Calcium Phosphates covers the structure, chemistry, synthesis, and properties of both natural and synthetic calcium-based biomaterials and details a variety of medical applications. Depicts the latest advances in using calcium phosphates in bone regeneration and tissue engineering Includes the latest generation of regenerative biomaterials with an integrated perspective combining both research and clinical issues Provides an understanding of the clinical targets and requirements for regenerative medicine Detailing fundamentals through applications, this book helps biomaterials researchers to better understand the clinical targets and requirements for use of these materials for optimal synthesis and development.
Download or read book Bone Grafting Biomaterials written by Yoshiki Oshida and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-05-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone augmentation is a procedure to replace and repair fractured bone in extreme circumstances. The materials used in such grafting techniques must be biocompatible and might come from natural bone sources or synthetic materials. This book defines bone augmentation and describes different bone grafting materials, techniques, and applications. Recently developed materials are also explored.
Download or read book Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates written by Michael R. Mucalo and published by MDPI. This book was released on 2020-12-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into the use of calcium phosphates in the development and clinical application of biomedical materials has been a significantly diverse activity conducted by a wide range of scientists, engineers, and medical practitioners, among others. The field of research in this area can, hence, be truly defined as interdisciplinary, and much interesting work leading to imaginative and innovative solutions for the improvement of health outcomes continues to be generated. It has been the intention of this Special Issue to summarise a number of current topical research advances in this area, as well as to review the important area of calcium phosphate-based biomaterials, namely, composites of hydroxyapatite with carbon-based materials. The scientific papers contained in this Special Issue report on advances in the areas of dental-based materials science, bone cements, use of biomaterials created from natural sources, influences of added agents such as adipose stem cells and statins on bioactivity as well as surface influences on electrical potential of biomaterials and uses of glow discharge methods to remove impurities from biomaterial surfaces.
Download or read book Biomaterials for Bone Regenerative Medicine written by Nandyala Sooraj Hussain and published by Trans Tech Publications Ltd. This book was released on 2010-03-01 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume is indexed by Thomson Reuters BCI (WoS). The aim of Biomaterials for Bone Regenerative Medicine is to review extensively the latest developments in Biomaterials and their application to bone regeneration in vivo. Indeed, research on biomaterials and their novel applications is essential because of the health issues related to the aging population. A wide range of worldwide investigations is being undertaken by eminent scholars in order to develop further innovative materials for next-generation applications. In future, it is expected that a tissue engineering approach, associating novel biomaterials with stem cells, will be available for all types of bone defect.
Download or read book Octacalcium Phosphate Biomaterials written by Gerard Insley and published by Woodhead Publishing. This book was released on 2019-11-20 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties Presents the clinical potential of octacalcium phosphate biomaterials Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration
Download or read book Bone Repair Biomaterials written by Kendell Pawelec and published by Woodhead Publishing. This book was released on 2018-11-29 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites
Download or read book Composition Morphology and Crystallinity Biomaterials Based on Calcium Phosphate for Implant Bone Regeneration written by Fernando M Abreu and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The alveolar bone and surrounding soft tissues must present volume and ideal qualities in order to receive implants. When these characteristics are lacking, biomaterials based on Ca and PO4 composition are regularly used to obtain adequate bone volume and height. The inorganic phase of bones and teeth is characterized by a dominant concentration of calcium phosphate. This has led researchers to develop biomaterials with similar chemical composition and characteristics. The present study analyzed the chemical composition, morphological aspect and crystallinity of four biomaterials, Bio-Oss, Cerasorb, BoneCeramic and Osteogen. The analyses applied were instrumental neutron activation (NAA), energy dispersive X-ray (DX), elemental analysis (EA), X-ray diffraction (XRD), thermogravimetric (TGA), scanning electron microscopy (SEM) and energy dispersive spectroscopy (SEM/EDS). The chemical analyses were effective and detected differences in the elemental composition between the studied biomaterials. The most highly concentrated elements in the biomaterials based on calcium phosphate were Ca and P. Other elements (Al, K, V, Mn, Br, La, Sm, Eu, W, Na, Mg, Si, S, Cl, Fe, Zn, Sr) that are not usually found in the inorganic bone structure were also detected. Thermogravimetric curves agree with the data of the elemental analysis of C, H and N, regarding the content of organic groups, however in Cerasorb, no data could be identified due to the lack of organic elements. Osteogen and Boneceramic, perhaps are synthetic elaboration, presented a low carbon content (0.23% and 0.12%). Morphological data assessed using SEM revealed that these four biomaterials are quite different in shape, surface topography and crystalline size. The biomaterial features may determine their biological, biochemical and biomechanical performance during bone formation and, consequently, their successful clinical use.
Download or read book Orthopedic Biomaterials written by Bingyun Li and published by Springer. This book was released on 2018-03-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest advances, applications, and challenges in orthopedic biomaterials. Topics covered include materials for orthopedic applications, including nanomaterials, biomimetic materials, calcium phosphates, polymers, biodegradable metals, bone grafts/implants, and biomaterial-mediated drug delivery. Absorbable orthopedic biomaterials and challenges related to orthopedic biomaterials are covered in detail. This is an ideal book for graduate and undergraduate students, researchers, and professionals working with orthopedic biomaterials and tissue engineering. This book also: Describes biodegradable metals for orthopedic applications, such as Zn-based medical implants Thoroughly covers various materials for orthopedic applications, including absorbable orthopedic biomaterials with a focus on polymers Details the state-of-the-art research on orthopedic nanomaterials and nanotechnology
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Download or read book Calcium Phosphate Based Bioceramics for Bone Tissue Engineering written by Sergey Barinov and published by Trans Tech Publications Ltd. This book was released on 2008-10-02 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is a new biotechnology that combines various aspects of medicine, biology and engineering, in order to produce, repair or replace human tissue. It is therefore easy to grasp the potential of these new therapies in helping to improve the quality-of-life of patients suffering from rare diseases. Typically, bone tissue engineering approaches foresee the use of scaffolding material combined with tissue cells. An advanced scaffolding material for tissue engineering must exhibit high quality, reliability, sustainability and cost-effectiveness throughout the individuals life and provide new advanced levels of medical assistance in therapy and surgery. One particular requirement of bone tissue engineering is that the scaffold should be porous because, in that form, large numbers of cells can be incorporated.
Download or read book Smart Biomaterials written by Mitsuhiro Ebara and published by Springer. This book was released on 2014-05-28 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
