Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Download or read book Store Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Download or read book Calcium and Calmodulin Function in the Cell Nucleus written by Oriol Bachs and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.

Download or read book Neurotransmitter Release written by Hugo J. Bellen and published by Oxford University Press, USA. This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.

Download or read book Principles of Molecular Regulation written by P. Michael Conn and published by Springer Science & Business Media. This book was released on 2000-07-28 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the dramatic growth in our knowledge of hormone action and the mechanisms of cell regulation, the need for an up-to-date broad-ranging survey of these processes has become pressing. In Principles of Molecular Regulation, P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear receptor-initiated gene regulation. Chosen for the excellence of their research as well as their demonstrated writing skills, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. They also discuss the molecular regulation of cell proliferation and death, as well as the impact of new technologies on rational drug discovery. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.

Download or read book Calcium Ions in Nerve Cell Function written by Platon Grigorʹevich Kosti͡uk and published by . This book was released on 1992 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work reviews the progress that has been made in recent years in understanding the mechanisms by which calcium ions regulate nerve cell function. It covers all aspects of the topic in detail, from the interaction of calcium ions with the external surface of the plasma membrane, to the function of transient changes in cytoplasmic calcium concentration. Much of the book is devoted to a discussion of the different types of receptor- and voltage-operated calcium channels, and the basis of their selectivity, gating, inactivation, and pharmacological modulation. The development of calcium conductance during ontogenesis is described and the fate of calcium ions in the cell is discussed. This volume clearly assesses the contribution made by the release of calcium from internal stores to cytoplasmic calcium transients, and analyses mechanisms by which this release may be controlled. The first book in the Oxford Neuroscience Series, Calcium Ions in Nerve Cell Function meets the need for a comprehensive account that draws together the enormous body of research on this important topic. It will be an indispensable to specialists in the field, and will also provide an accessible review for non-specialists.

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Download or read book Calcium Movement in Excitable Cells written by P. F. Baker and published by Elsevier. This book was released on 2018-02-08 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Movement in Excitable Cells, which is a second in a series, is a collection of articles taken from articles published in Progress in Biophysics and Molecular Biology, just like the first. The monograph is divided into two chapters. Chapter 1, Transport and Metabolism of Calcium Ions in Nerve, tackles the mechanisms responsible for maintaining the electrochemical gradient for calcium and effecting changes for the permeability of the cell membrane to calcium ions. Chapter 2, Divalent Cations as Charge Carriers in Excitable Membranes, tries to find out if divalent cations such as calcium, barium, and strontium can permeate excitable membranes. With two in-depth studies about movement of calcium as well as other cations and the factors behind it, the text is recommended to medical doctors, biologists, and biochemists who wish to learn more about this phenomenon.

Download or read book Calcium Signaling written by Geert Bultynck and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. This new volume explores the channels and pumps that transport calcium, calcium buffers and sensors, and how these produce distinct spatiotemporal signals in different circumstances. It covers calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis"--

Download or read book The Basal Ganglia IV written by Gerard Percheron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''Emphasis on new issues and emerging concepts insures that the information presented is still timely...A compelling source of information on recent research in the field.'' ---Journal of Chemical Neuroanatomy, May 1997

Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by CRC Press. This book was released on 1984-04-03 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is wholly devoted to Ca2+ metal ion, as it is so important in regulating a wide variety of biological activities. It deals with calcium and brain proteins, the role of ca2+ in exocytosis, blood coagulation, and the regulation of the skeletal muscle contraction-relaxation cycle.

Download or read book Calcium in Living Cells written by and published by Academic Press. This book was released on 2010-11-26 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every cell of the body is dependent on calcium to function. Calcium is found in teeth and bones, and calcium signalling is necessary for the movement of muscles and for the action of the heart and the intestines as well as blood coagulation. Calcium in Living Cells will update classic techniques in detecting microscopic levels of calcium ions (Ca2+) in living cells, as well as address new techniques in the field of calcium detection and calcium signaling. Such detection and measurement of intracellular calcium is important to researchers studying the heart, musculoskeletal, gastrointestinal, and immune systems, whose findings will aid in the advancement of drug and genomic therapies to treat heart, gastrointestinal, autoimmune, and infectious diseases. Gives researchers much needed information on how to study calcium in live cells, which is becoming increasingly important in heart, musculoskeletal, and immune system research Provides an overview of the latest methods--fluorescence resonance energy transfer (FRET), for example-- that are new to the field Allows understanding of how calcium plays a role in intracellular function at the cellular level, which has proved important in Alzheimer's research, heart disease, and areas of musculoskeletal research Updated chapters reflect advancements in the classic techniques used'preparing calcium buffers, vibrating the Ca2+ Electrode and confocal imaging

Download or read book Vascular Ion Channels in Physiology and Disease written by Irena Levitan, PhD and published by Springer. This book was released on 2016-07-06 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Calcium and Comparable Cations in Animal Behaviour written by Patricia Wilkins and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium and comparable cations are fast being recognised for their role as vital components of animal physiology. When trying to answer questions such as why salmon can adjust to life in fresh water as well as seawater, or why chilli peppers taste hot to humans but evoke little response from chickens, we often find the answers lie in patterns of movement of these ions and their roles in sensing, transmitting and collecting messages. Bringing together scattered literature on calcium, sodium, potassium and magnesium in biology, this book examines important biological contributions of these ions including enzyme activation, effects in all types of muscle and biomineralization. Attention is focused on: channel construction and ion movement; calcium as a second messenger and in the construction of solids and ion channelopathies, with the help of personalities such as Agatha Christie, van Gogh and Captain Cook. The Role of Calcium and Comparable Cations in Animal Behaviour will be valued by a wide-range of readers including students of bioinorganic chemistry and animal behavioural studies, teachers and other professionals in academia.

Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.

Download or read book Calcium regulating Hormones written by Hirotoshi Morii and published by . This book was released on 1991 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: