Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Download or read book Cachexia and Wasting written by Stefan D. Anker and published by Springer Science & Business Media. This book was released on 2007-10-06 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cachexia may well represent the flip side of the tremendous achievements of modern medicine. The aim of this volume, written by world-renowned scientists, is to provide the best available evidence on the pathogenesis, clinical features and therapeutic approach of cachexia, and to facilitate the understanding of the complex yet unequivocal clinical role of this syndrome, that truly represents a disease, or, more likely, a disease within other different diseases.

Download or read book Cancer Cachexia written by Egidio Del Fabbro and published by Springer. This book was released on 2015-04-02 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Cachexia is a concise, fully illustrated handbook written with the aim of increasing awareness of cancer cachexia and highlighting best practice diagnosis, treatment, and management options for this devastating disorder. This is another title in the ongoing Springer Healthcare Cancer Supportive Care Series.

Download or read book Pharmacotherapy of Cachexia written by Karl G. Hofbauer and published by CRC Press. This book was released on 2005-12-22 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although a wealth of information can be found scattered throughout periodicals and research papers, tracking down the most effective treatment for a heterogeneous syndrome such as cachexia can be problematic. Edited by experts in the field, with contributions from a multidisciplinary panel, Pharmacotherapy of Cachexia is the first book devoted sole

Download or read book The Systemic Effects of Advanced Cancer written by Swarnali Acharyya and published by Springer Nature. This book was released on 2022-09-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.

Download or read book Cancer Cachexia written by Isabella White and published by Independently Published. This book was released on 2024-01-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up to 80% of advanced cancer patients suffer from the debilitating condition of cancer cachexia. This complex, devastating syndrome robs patients of quality of life and longevity at a time when they need their strength most. Why does cachexia remain underdiagnosed and undertreated despite its heavy toll? How can we overcome barriers to providing compassionate, holistic, cachexia-focused care? This comprehensive guide answers these questions and more. This book illuminates cachexia's intricate mechanisms, multifaceted impacts, and emerging management strategies. It equips clinicians to improve detection, empowers patients to seek specialized care, and motivates policymakers to make cachexia-directed therapies accessible. Key features include: Clear illustrations demystify the pathophysiology underlying cachexia's wasting. Practical guidance on diagnostic criteria, body composition analysis, and monitoring. Evidence-based overviews of pharmacological, nutritional, exercise, and behavioral interventions. In-depth discussions of cachexia's influence across the cancer journey, from diagnosis to end-of-life. Real-world insights on challenges in cachexia management and advice to overcome them. While reversing advanced cachexia proves difficult, this book shows stabilization is possible through multimodal care targeting nutrition, anabolism, and quality of life. Nobody needs to face cancer's worst alone. We all have a role in ensuring cachexia patients receive the compassionate, integrated support they deserve. Perfect for oncology providers, trainees, and specialists in nutrition, rehabilitation, or palliative medicine, this definitive reference aims to advance the care of cancer cachexia through awareness, education, research, and advocacy. Do not allow cachexia to continue stealing life and vitality from those with cancer. Take action and get this invaluable book today!

Download or read book The Veterinary ICU Book written by Wayne E. Wingfield and published by CRC Press. This book was released on 2020-06-03 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to the fundamental clinical signs of astute observation, careful differential diagnosis and analytical therapeutic decision-making in emergency veterinary settings. It clearly defines the physiological and clinical principles fundamental to the management of the critically ill small animal patient. With clear guidelines for organizing an emergency/critical care unit, the book also discusses ethical and legal concerns. The 80 expert authors have created a clinically specific resource for the specialist, residents in training, veterinary practitioners, technicians and students.Published by Teton New Media in the USA and distributed by CRC Press outside of North America.

Download or read book Cachexia anorexia in Cancer Patients written by Eduardo Bruera and published by . This book was released on 1996 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Symptoms of weight loss, weakness, and lassitude (ie cachexia) can be found among 50 and 90% of cancer patients. This book provides the most comprehensive text in understanding the causes of these symptoms, how they are recognised and measured, which types of patients are affected, and the possible treatments. The book also examines the psychological impact on the patient and family and ways of managing this. The editors' high international standing has enabled them to assemble an outstanding group of authors to write on the many aspects of cancer cachexia.

Download or read book Elucidating the Molecular and Cellular Mechanism Underlying Cancer Cachexia written by Wei He and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Cachexia is a debilitating syndrome associated with multiple chronic diseases, including cancer. It is characterized by extreme weight loss primarily due to the depletion of skeletal muscle as well as adipose tissue. In cancer, patients that suffer from cachexia are more susceptible to dose-limiting toxicity in chemotherapy . Cachexia not only diminishes the quality of life of cancer patients, but is also positively related to cancer mortality. Pancreatic and other gastrointestinal cancers exhibit the highest incidence of cancer cachexia, with one third of these patients losing more than 10% of their pre-illness body weight. Efforts to understand the mechanism underlying cancer cachexia might eventually improve the treatment outcome as well as the quality of life of these and other cancer patients. Muscle wasting in cachexia results mainly from aberrant signaling of pathways that usually maintains a balance between protein synthesis and degradation. The increase in catabolism usually associates with a decrease in anabolism including the Akt and mTOR signaling pathways. Although events as such inside the myofibers have been firmly established to take place in cancer cachexia, relatively little is known about events outside the muscle fibers, in the muscle microenvironment, and their potential significance in regulating wasting in cancer cachexia. To understand whether events in the muscle microenvironment are dysregulated in cancer cachexia, we started out this study by examining the ultrathin sections of skeletal muscle using electron microscopy. We observed an abnormal accumulation of cells in the interstitial space of cachectic muscles from tumor bearing mice. We further identified these cells as activated muscle stem cells. Using cellular and genetic approaches in murine cachexia models and muscle biopsies from cachectic patients, we describe in detail cancer cachexia is associated with an impaired regeneration program, and this is due to compromised differentiation from satellite cells, as well as other muscle resident myogenic progenitors. Our results further showed that the self-renewing transcription factor, Pax7, which under the control of classical NF-kB signaling, becomes deregulated and is responsible for the block of myogenic differentiation and promoting muscle wasting. Down regulation of NF-kB or Pax7, or overexpression of Pax7's downstream target, MyoD, successfully rescued muscle weight loss in cancer cachexia. When examining the deregulated events in the muscle microenvironment, we also observed apoptosis activity in cachecitic muscles. Our results showed that a portion of Pax7+ muscle stem cells become TUNEL+ in response to tumor bearing. We further found that this apoptotic activity is induced by microvesicles derived from both cancer cell lines as well as cachectic serum. Mechanistically, tumor secreted microvesicles contain miR-21 that signals through TLR7 receptor on myoblasts to promote cell death. Furthermore, this apoptotic response is dependent on the activation of c-Jun N-terminal kinase (JNK) activity in muscle cells. Together, findings in this study provide new insights into the mechanisms of cachexia, highlighting the importance and relevance of events that take place in the muscle microenvironment in regulating muscle wasting in cancer cachexia.

Download or read book Cancer Management in Small Animal Practice E Book written by Carolyn J. Henry and published by Elsevier Health Sciences. This book was released on 2009-12-03 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Management in Small Animal Practice provides you with all the tools needed to diagnose, stage, and manage the many different disease entities known as "cancer." This manual is designed to provide you with easy-to-access, clinically relevant details for complete care of the small animal cancer patient, while considering the needs, concerns, and capabilities of the client. It provides quick reference sections for information not included in current oncology texts, including drug interactions and resources for participation in clinical trials. All information is well referenced and the reference section on the accompanying website includes links to the original and related articles. The latest information including diagnostic procedures, treatment modalities, and outcome predictions to help clients make the best decisions for their pets. Expert contributors, renowned for clinical, as well as academic and research expertise, offer a wide breadth and depth of expertise. Full-color format provides accurate visual depictions of specific diseases and procedures to enhance your diagnostic capabilities. Key Points highlight critical information, enabling quick, easy access. Systems approach to diagnosis and management offers logical, systematic, head-to-tail procedure for accurate diagnosis, treatment, and prognosis. Extensive discussions of supportive care limit adverse events and increase patient survival and puts emergency information at the practitioner’s fingertips. Suggested readings highlight the latest information for further investigation and research. Comprehensive drug safety guidelines thoroughly discuss all information required to safely handle and administer cancer drugs. Helpful drug formularies offer available formulations, recommended dosages, toxicities, and relative costs. Chapter on how to access clinical trials provides helpful information and hope for patients and their caregivers.

Download or read book Encyclopedia of Bone Biology written by and published by Academic Press. This book was released on 2020-06-26 with total page 2390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles. Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field Includes multimedia features, cross-references and color images/videos

Download or read book Protein and Amino Acid Metabolism in Cancer Cachexia written by Peter W.T. Pisters and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cachexia is a complex syndrome characterized by diminished nutrient intake and progressive tissue depletion manifest clinically as anorexia and weight loss. This review examines the basic research that has addressed the fundamental derangements in host intermediary protein metabolism and evaluates current therapeutic approaches to the management of cancer cachexia. This volume provides a new approach as well as a comprehensive review of current basic and clinical research.

Download or read book Hormones and Nutrition in Obesity and Cachexia written by Manfred J. Müller and published by Springer. This book was released on 1990-03-23 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: International experts are brought together in this book to give basic as well as clinical data on obesity and cachexia, and an integrated picture of the regulation of intermediary metabolism in both situations. The data provide evidence that tissue catabolism and anabolism are regulated by similar mechanisms, which again are the target of different hormonal and metabolic factors. This joint discussion of the similarities evident in both areas will greatly benefit future understanding and research in obesity and cachexia.

Download or read book Treatment of Cancer Cachexia Practical Guide written by Filippo Rossi Fanelli and published by . This book was released on 2015 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Interdisciplinary Nutritional Management and Care for Older Adults written by Ólöf G. Geirsdóttir and published by Springer Nature. This book was released on 2021 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intro -- Foreword -- Acknowledgements -- Contents -- Part I: Nutritional Care in Geriatrics -- 1: Overview of Nutrition Care in Geriatrics and Orthogeriatrics -- 1.1 Defining Malnutrition -- 1.2 Nutrition Care in Older Adults: A Complex and Necessary Challenge -- 1.3 Malnutrition: A Truly Wicked Problem -- 1.4 Building the Rationale for Integrated Nutrition Care -- 1.5 Managing the Wicked Nutrition Problems with a SIMPLE Approach (or Other Tailored Models) -- 1.5.1 Keep It SIMPLE When Appropriate -- 1.5.2 A SIMPLE Case Example -- 1.5.2.1 S-Screen for Malnutrition -- 1.5.2.2 I-Interdisciplinary Assessment -- 1.5.2.3 M-Make the Diagnosis (es) -- 1.5.2.4 P-Plan with the Older Adult -- 1.5.2.5 L-Implement Interventions -- 1.5.2.6 E-Evaluate Ongoing Care Requirements -- 1.6 Bringing It All Together: Integrated Nutrition Care Across the Four Pillars of (Ortho) Geriatric Care -- 1.7 Summary: Finishing Off with a List of New Questions -- References -- Recommended Reading -- 2: Nutritional Requirements in Geriatrics -- 2.1 Nutritional Recommendations for Older Adults, Geriatric and Orthogeriatric Patients -- 2.2 Nutritional Recommendations for Older Adults -- 2.2.1 Energy Requirement and Recommended Intake -- 2.2.2 Protein Requirement and Recommended Intake -- 2.2.3 Micronutrients and Dietary Fibers -- 2.3 Nutritional Risk Factors in Older Adults -- 2.4 Estimating Intake in Older Adults -- 2.5 Nutritional Status of Older Adults, Geriatric and Orthogeriatric Patients -- 2.6 Summary -- References -- Recommended Reading -- 3: Nutritional Assessment, Diagnosis, and Treatment in Geriatrics -- 3.1 The Nutrition Care Process -- 3.2 Nutritional Screening/Risk Detection -- 3.3 Nutritional Assessment and Diagnosis -- 3.3.1 Nutrition Impact Symptoms -- 3.3.2 Nutritional Diagnosis -- 3.3.3 Etiologic Criteria.

Download or read book Hormones and Nutrition in Obesity and Cachexia written by Manfred J. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: International experts are brought together in this book to give basic as well as clinical data on obesity and cachexia, and an integrated picture of the regulation of intermediary metabolism in both situations. The data provide evidence that tissue catabolism and anabolism are regulated by similar mechanisms, which again are the target of different hormonal and metabolic factors. This joint discussion of the similarities evident in both areas will greatly benefit future understanding and research in obesity and cachexia.

Download or read book Frailty and Sarcopenia written by Yannis Dionyssiotis and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.