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Download or read book Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants written by Curtis C. Travis and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological markers (biomarkers) are useful tools for understanding the nature and extent of human exposure and risk from environmental toxicants. Biomarkers are classified into three basic categories: exposure, effect, or susceptibility. A marker of exposure is the product of the interaction between a target cell or molecule and a foreign substance (NAS, 1989). These markers can be used to determine the biologically effective dose necessary to elicit a particular physiological change in an organism. A marker of effect is a biochemical or physiological change in an organism that can predict the onset of adverse health effects resulting from a given exposure. Lastly, markers of susceptibility act as indicators of an inherent or acquired tendency of an organism to experience an adverse health effect (NAS, 1989). These markers are already used to detect a variety of diseases and show great promise for developing a better understanding of the mechanicisms of disease. Additionally, biomarkers can be used to establish a more rational basis for quantitative risk extrapolation between species, as weIl as to obtain more precise estimates of the time of critical exposure. These markers can also prove helpful in identifying potentially damaging exposures before the onset of adverse health effects. Biomarkers serve as a valuable exposure assessment tool because they take into account exposure from all routes and integrate exposure from all sources. They have the potential to yield better risk estimates than current monitoring and modeling protocols. In lune 1992, Dr. Travis and Dr.

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Download or read book PHEs Environment and Human Health written by Claudio Bini and published by Springer. This book was released on 2014-05-14 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to the occurrence and behaviour of PHEs in the different compartments of the environment, with special reference to soil. Current studies of PHEs in ecosystems have indicated that many industrial areas near urban agglomerates, abandoned or active mines, major road systems and ultimately also agricultural land act as sources and at the same time sinks, of PHEs and large amounts of metals are recycled or dispersed in the environment, posing severe concerns to human health. Thanks to the collaboration of numerous colleagues, the book outlines the state of art in PHEs research in several countries and is enforced with case studies and enriched with new data, not published elsewhere. The book will provide to Stakeholders (both Scientists Professionals and Public Administrators) and also to non-specialists a lot of data on the concentrations of metals in soils and the environment and the critical levels so far established, in the perspective to improve the environmental quality and the human safety.