Download or read book Breast Cancer Biological and Clinical Progress written by L. Dogliotti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fight against breast cancer is expected to be effectively stimulated by interdisciplinary approaches and cross-fertilization between laboratory and clinical research findings. Of major importance are therefore meetings promoting fast transfer to clinical applications of findings by basic scientists. The present volume, reporting the proceedings of the 1991 Biennial Conference of the International Association for Breast Cancer Research, hopes to achieve this goal by presenting the most recent observations in the laboratory and their possible applications for diagnostic evaluations and clinical treatments. The sections of the book focus first on the oncogenes more likely involved in mammary tumorigenesis and on the polypeptide factors and steroid hormones affecting proliferation and possibly inducing carcinogenesis in breast epithelium. A section is devoted to the epidemiological studies and to the identification of risk factors, a way to select populations at higher risk and, possibly, to help in preventing the disease. Special emphasis is given to the establishment of diagnostic criteria and to the selection of prognostic factors, which must support an effective therapeutic planning. It is our hope that this volume, a timely update of the most recent advances in specific fields presented by basic scientists, pathologists and clinicians will stimulate new insights and progresses leading ultimately to the control of breast cancer.
Download or read book Breast Cancer Biological and Clinical Progress written by L. Dogliotti and published by Springer. This book was released on 1992-05-31 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fight against breast cancer is expected to be effectively stimulated by interdisciplinary approaches and cross-fertilization between laboratory and clinical research findings. Of major importance are therefore meetings promoting fast transfer to clinical applications of findings by basic scientists. The present volume, reporting the proceedings of the 1991 Biennial Conference of the International Association for Breast Cancer Research, hopes to achieve this goal by presenting the most recent observations in the laboratory and their possible applications for diagnostic evaluations and clinical treatments. The sections of the book focus first on the oncogenes more likely involved in mammary tumorigenesis and on the polypeptide factors and steroid hormones affecting proliferation and possibly inducing carcinogenesis in breast epithelium. A section is devoted to the epidemiological studies and to the identification of risk factors, a way to select populations at higher risk and, possibly, to help in preventing the disease. Special emphasis is given to the establishment of diagnostic criteria and to the selection of prognostic factors, which must support an effective therapeutic planning. It is our hope that this volume, a timely update of the most recent advances in specific fields presented by basic scientists, pathologists and clinicians will stimulate new insights and progresses leading ultimately to the control of breast cancer.
Download or read book Biological and Clinical Progress in Breast Cancer written by Ava Santiago and published by Foster Academics. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a type of cancer that starts from the breast cells. Some of its common symptoms are formation of lump in the breast, dimpling of breast skin, and changes in the size and appearance of the breast. There are many different types of breast cancer such as ductal carcinoma in situ, invasive lobular carcinoma, angiosarcoma, Paget's disease of the breast and inflammatory breast cancer. Factors such as obesity, lack of physical exercise, alcoholism, hormone replacement therapy during menopause, and ionizing radiation may result in the development of breast cancer. It can be diagnosed with the help of biopsy. The treatment of breast cancer involves performing surgery, prescribing medications, and therapies such as chemotherapy or radiation therapy. A number of latest researches have been included in this book to keep the readers updated with the latest concepts related to the biological and clinical progress in breast cancer. It is an excellent resource guide for oncologists as well as students.
Download or read book Breast Cancer Scientific and Clinical Progress written by Marvin A. Rich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.
Download or read book Charting the Course written by National Cancer Institute (U.S.). Breast Cancer Progress Review Group and published by . This book was released on 1998 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Circulating Tumor Cells in Breast Cancer Metastatic Disease written by Roberto Piñeiro and published by Springer Nature. This book was released on 2020-04-17 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.
Download or read book Breast Cancer written by Israel) International Association for Breast Cancer Research Conference (1989 : Tel Aviv and published by . This book was released on 1989 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Breast Cancer Research Protocols written by Susan A. Brooks and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of both well-established and cutting-edge methods for investigating breast cancer biology not only in the laboratory, but also in clinical settings. These readily reproducible techniques solve a variety of problems, ranging from how to collect, store, and prepare human breast tumor samples for analysis, to analyzing cells in vivo and in vitro. Additional chapters address the technology of handling biopsies, new methods for analyzing genes and gene expression, markers of clinical outcome and progress, analysis of tumor-derived proteins and antigens, validating targets, and investigating the biology of newly discovered genes.
Download or read book Breast Cancer Progress in Biology Clinical Management and Prevention written by International Association for Breast Cancer Research. Conference and published by Springer. This book was released on 1989-10-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Association for Breast-Cancer Research Conference, Tel-Aviv, Isreal, March 1989
Download or read book Approaches to Understanding Breast Cancer written by and published by Academic Press. This book was released on 2017-10-19 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approaches to Understanding Breast Cancer, Volume 151, the latest volume in the Progress in Molecular Biology and Translational Science series focuses on breast cancer, with new chapters that include information on Breast Cancer Epidemiology, Prevention, and Screening, DCIS: Current Principles of Management, Pregnancy and Hormonal Prevention of Breast Cancer, Chemokines: Key Players in Pathobiology of Breast Cancer, Mircrobiota and Breast Cancer, Experimental Therapeutic Use of Estrogen Receptor Beta Agonists in Prevention and Treatment of Endocrine Therapy Resistant Breast Cancers: Observations from Pre-Clinical Models, Targeting Breast Cancer Stem Cells: Key for Anti-Metastatic Therapy, and Experimental Therapy of Advanced Breast Cancer: Target NFAT1-MDM2-p53 Pathway. Accessible to students and researchers alike Written by leading authorities in the field
Download or read book Progress in Anti Cancer Chemotherapy written by Gabriel N. Hortobagyi and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third volume of our series Progress in Anti-Cancer Chemo therapy. Following the strategy of the first two volumes, it covers selected aspects of progress in this fast moving field of Oncology, with contribu tions from some of the world's best known leaders in both basic and clin ical research. This year we focused on seven areas: Three prominent Clinical investigators reviewed conceptual advances in cancer research. Dr Buzdar presented a history and overview of the protection of human subjects who participate in clinical research, and the mechanisms developed to assure the ethical conduct of research on human beings. Frei reviewed an exciting and rapidly moving area of che motherapy of solid tumors, including a cogent discussion of the issues related to dose-intensification. Fisher summarized conceptual advances in our therapeutic approach to breast cancer and the paradigm shifts that lead us to our current management strategies. From this summary he pro jected breast cancer research into the future, a daunting task under any circumstance. Fundamental research in cancer biology has been responsible for our improved understanding of the development and progession of malignant disease. Such understanding will lead to improved diagnosis, therapy, and eventually, prevention. Isaacs reviews the area of hereditary breast cancer, a topic undergoing rapid transformation and with mUltiple impli cations in the daily practice of medicine. Fidler, an international expert in metastasis research reviews the potential utility of angiogenesis inhib itors in research and the therapeutic ramifications.
Download or read book Breast Cancer Progress in Biology Clinical Management and Prevention written by Marvin A. Rich and published by Springer. This book was released on 2013-05-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In breast cancer as in other cancers on the front line of modern interdisciplinary research we have crossed the threshhold of new understanding. Fueled by an awareness that breast cancer is a leading cause of morbidity and mortality in women and honed by rapid technological advances in molecular mechanisms, major inroads into the darkness of this scourge have been accomplished during the past several years. Basic laboratory and clinical research findings must influence and in turn be influenced by efforts to detect, to diagnose and to cure the human disease. It is indeed gratifying to note that the efforts of scientists and clinicians from throughout the world reported in this volume are achieving this objective. The first section of the book focuses on the molecular and genetic basis of breast cancer. The role of specific oncogenes in mammary tumorigenesis using transgenic mice and mammary glands correlating molecular events with specific stages in neoplastic development are described and discussed. Such topics as the nature of specific oncogenes, levels of oncogene expression, the alteration of expression of other growth regulatory genes and the state of the cell in which the oncogene is expressed are specifically addressed. This section of the book is rounded out with discussions on the potential of genetic alterations as indicators of prognosis, the characterization of full-length cDNA codes for breast cancer markers and the function of antigens in tuomorigenesis.
Download or read book Breast Cancer Metastasis and Drug Resistance written by Aamir Ahmad and published by Springer Nature. This book was released on 2019-08-27 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
Download or read book Etiology of Breast and Gynecological Cancers written by C. Marcelo Aldaz and published by John Wiley & Sons. This book was released on 1997-03-21 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29–December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including: recent advances in the molecular genetics of hereditary breast and ovarian cancer molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia genotoxicity of environmental agents in human mammary epithelial cells rodent model of reproductive tract leiomyomata estrogens and the genetic control of tumor growth Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.
Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
