Download or read book The Breakthrough written by Charles Graeber and published by Twelve. This book was released on 2018-11-13 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment," a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.
Download or read book Immunotherapy A Novel Facet of Modern Therapeutics written by Sujata P. Sawarkar and published by Springer Nature. This book was released on 2020-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.
Download or read book Breakthrough in Immunotherapy written by Baptiste Durand and published by BoD – Books on Demand. This book was released on 2024-08-22 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book AHCC written by Fred Pescatore, M.D. and published by Turner Publishing Company. This book was released on 2010-04-01 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lowly mushroom, grown quietly, in the dark, has suddenly sprung onto the health scene as a miracle cure. Once castigated as a mere fungus, the mushroom has acquired a signature cachet in the form of active hexose-correlated compound (AHCC), a nutritional product made from healing mushrooms fermented in rice bran. AHCC is used in over 700 clinics and hospitals in Japan, mainly in cancer treatment. Now AHCC: The Medical Breakthrough in Natural Immunotherapy reveals what the Japanese have known for decades: AHCC is as well-researched as any conventional prescription drug. The quality control of AHCC is so stringent that it would easily qualify as a licensed pharmaceutical, but the manufacturers believe that this would limit its availability to the many people in Japan—healthy people, who use it as a preventive as well as for a variety of other purposes. Because it is actually a mushroom-based food, even though it is often made available in capsule form, it is extremely safe for anyone to take, including children, pets, frail elderly people, and patients who have undergone surgery. AHCC: The Medical Breakthrough in Natural Immunotherapy explores AHCC in depth, explaining: How it is manufactured How it is used in clinics in Japan and other parts of the world Its safety and efficacy The scientific evidence supporting its striking versatility and profound effectiveness for a wide variety of conditions AHCC: The Medical Breakthrough in Natural Immunotherapy will introduce you to AHCC and expand your knowledge of one of the most important food supplements available on the market today.
Download or read book The Basics of Cancer Immunotherapy written by Haidong Dong and published by Springer Nature. This book was released on with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
Download or read book The Immunotherapy Revolution written by Jason R. Williams and published by . This book was released on 2019-10-15 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Future Of Treating Cancer Has Finally Arrived.Cancer treatments can be torture! Surgery, chemotherapy, and radiation are not only extreme but can be just as painful and dangerous as the cancer itself. When doctors treat cancer aggressively it leaves the body in a weakened, susceptible state open to contracting other diseases or relapses. Most of the medical field refuses to acknowledge the major problems with the way they treat cancer. So is there really a better way to heal from cancer against all odds? YES!In this eye-opening book, Dr. Williams shares his most groundbreaking, shocking conclusions from his decades of in-depth research on cancer. He provides life-changing advice in the most critical and overlooked areas in cancer treatment and recovery. He has personally developed a revolutionary medical treatment that will change the way we treat cancer - forever.Dr. Jason R. Williams is a board-certified radiologist, image-guided oncologist, researcher, and professor. He is the Founder and Director of Interventional Oncology for the Williams CancerInstitute and adjunct professor at Case Western Reserve University. He has pioneered a brand new less invasive, less toxic solution to treating cancer.Committed to further advance research in intra-tumoral immunotherapy and help those who are struggling financially to cover medical costs, Dr. Williams is donating all proceeds from this book for this cause. Grab your copy now, and discover the promising solution to cancer!
Download or read book Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-12-10 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.
Download or read book The Beautiful Cure written by Daniel M. Davis and published by University of Chicago Press. This book was released on 2021-03-19 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Visceral.”—Wall Street Journal “Illuminating.”—Publishers Weekly “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy.
Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Download or read book Ending Medical Reversal written by Vinayak K. Prasad and published by JHU Press. This book was released on 2015-11 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medications such as Vioxx and procedures such as vertebroplasty for back pain are among the medical "advances" that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base—and then stop using it when it is found not to help, or even to harm, patients. In Ending Medical Reversal, Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors' offices and hospitals is truly effective. "Every doctor should read this book."—JAMA Internal Medicine "[A]n excellent and realistic discussion of some of the horror stories that occur in medical practice . . . Highly recommended."—Choice "Ending Medical Reversal goes far in teaching medical students and practicing physicians alike how to learn on our own."—The Lancet "This has to be on the reading list for medical and nursing students."—Nursing Times "Ending Medical Reversal presents persuasive evidence that many current standard-of-care treatments are probably ineffective or harmful, thoroughly explains how such treatments came to be accepted, and proposes a number of ways to address the general problem (only some of which involve avaricious companies and mercenary physicians) and minimize its impact on a specific patient."—Journal of Clinical Research Best Practices "Dr. Prasad and Dr. Cifu offer a five-step plan, including pointers for determining if a given treatment is really able to do what you want it to do, and advice on finding a like-minded doctor who won't object to a certain amount of back-seat driving."—The New York Times "When I describe Ending Medical Reversal as revolutionary, I don't use the term lightly. Go out and read it—right now."—Common Sense Family Doctor "Should be considered for undergraduate reading lists. Keep a copy in the pharmacy or your briefcase as a great icebreaker or discussion point with other local healthcare professionals."—The Pharmaceutical Journal
Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance
Download or read book Cancer Treatment Breakthrough written by Serge Jurasunas and published by . This book was released on 2021-05-25 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Treatment Breakthrough explains in detail the mechanisms of the immune system and offers a complete approach using alternative diagnostic methods as well as molecular markers testing, a comprehensive approach to diet and supplements and reports of patient treatment histories.
Download or read book Ahcc written by Fred Pescatore and published by . This book was released on 2010-09-27 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lowly mushroom, grown quietly, in the dark, has suddenly sprung onto the health scene as a miracle cure. Once castigated as a mere fungus, the mushroom has acquired a signature cachet in the form of active hexose-correlated compound (AHCC), a nutritional product made from healing mushrooms fermented in rice bran. AHCC is used in over 700 clinics and hospitals in Japan, mainly in cancer treatment. Now Japan's secret has crossed the Pacific, and this new book reveals what the Japanese have known for decades; AHCC is as well researched as any conventional prescription drug. The quality control of AHCC is so stringent that it would easily qualify as a licensed pharmaceutical, but the manufacturers believe that this would limit its availability to the many people in Japan - healthy people, who use it as a preventive as well as for a variety of other purposes. Because it is actually a mushroom-based food, even though it is often made available in capsule form, it is extremely safe for anyone to take, including children, pets, frail elderly, and patients who have undergone surgery. Dr. Fred Pescatore explores AHCC in depth, explaining; How it is manufactured How it is used in clinics in Japan and other parts of the world Its safety and efficacy The scientific evidence supporting its striking versatility and profound effectiveness for a wide variety of conditions This book will introduce readers to AHCC and expand their knowledge of one of the most important food supplements available on the market today.
Download or read book Toll Like Receptors TLRs and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2022-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of immuno-oncology continues to rapidly evolve as new insights to fight and treat cancer emerge. The fourth edition of Immunotherapy provides the most current overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. While immunotherapy has revolutionized the treatment landscape of several solid malignancies, several challenges still exist. Only a subset of patients derive clinical benefits; some do not respond at all, and others respond initially, only for their disease to progress later. Because these drugs can activate a broad range of immune cells, patients suffer from a unique set of side effects known as immune-related adverse events. As more immunotherapeutic agents are used in the clinic, it is important to provide updates about current and ongoing developments in the field to further research efforts and inform treatment decisions. The fourth edition will have a new focus on strategies to overcome the challenges associated with immunotherapy. Chapters will discuss topics such as biomarkers of response, resistance mechanisms, role of imaging in predicting immune-related adverse events, and management of immune-related adverse events. Written by leading experts conducting cutting-edge research, readers will gain up-to-date knowledge on the current state and future of immunotherapy.
