Download or read book Brain Neuropeptide Y Mechanisms written by Anders Härfstrand and published by . This book was released on 1987 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropeptides in Neuroprotection and Neuroregeneration written by Fred Nyberg and published by CRC Press. This book was released on 2012-06-19 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides
Download or read book Neuropeptide Y and Related Peptides written by Martin C. Michel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.
Download or read book Metabolism of Brain Peptides written by Gerard O'Cuinn and published by CRC Press. This book was released on 1995-06-09 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research. It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological functions. The book also examines termination mechanisms for the biological activities of neuropeptides in light of recent knowledge of their distribution, their receptors and their possible inactivation enzymes in various functional regions of the brain and at the blood-brain barrier.
Download or read book Neuropeptide Y and Drug Development written by Lars Grundemar and published by Elsevier. This book was released on 1996-11-15 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. - The hypothalamic role of NPY and its relationship with eating disorders and diabetes - The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders - Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology - Development of peptide and non-peptide receptor antagonists
Download or read book The Biology of Neuropeptide Y and Related Peptides written by William F. Colmers and published by Springer Science & Business Media. This book was released on 1993-03-24 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts critically summarize the state of knowledge concerning the molecular, anatomical, physiological, and behavioral aspects of NPY and its congeners. Each article provides a comprehensive and in-depth survey, an overview of the role of NPY in the discipline covered, a discussion of the likely future direction that the field will take, and an up-to-date bibliography. Chapters include a treatment of the evolution of the PP family of genes, the structure of the NPY gene, and the distribution of NPY on the cardiovascular system, actions of NPY on the electrophysiological properties of nerve cells, and the effects of NPY on feeding and behavior. The chapters are written in an accessible style and serve both as an introduction to the field and as an extensive and detailed treatment of the current state of knowledge.
Download or read book Personalized Epigenetics written by Trygve Tollefsbol and published by Elsevier. This book was released on 2024-08 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Download or read book Central and Peripheral Significance of Neuropeptide Y and Its Related Peptides written by and published by . This book was released on 1990 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current meeting sponsored by the New York Academy of Sciences represents the first open meeting on the NPY family of peptides. We attempted to highlight several areas of NPY research, including an in-depth discussion of the structure of the native NPY molecule, which we hope will serve as a guide to aid in the development of analogues to assess the critical feature of the molecule essential for receptor binding and signal transduction. Emphasis was also placed on the molecule mechanisms regulating the expression of the genes encoding the peptides. Since NPY is concentrated in tissues affecting cardiovascular performance, attention was directed to the significance of NPY in regulating cardiac and renal function. Finally, much of our present knowledge of NPY has been derived from studies of NPY in neuronal systems. Presentations on the anatomy and physiology of NPY in higher brain centers are followed by an in- depth-review of the function of NPY in the hypothalamus, concentrating on feeding, reproduction and pituitary function.
Download or read book Neuropeptide Y written by Viktor Mutt and published by . This book was released on 1989 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Download or read book From the Couch to the Lab written by Aikaterini Fotopoulou and published by Oxford University Press. This book was released on 2012-05-17 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can the psychodynamics of the mind be correlated with neurodynamic processes in the brain? The book revisits a question that scientists and psychoanalysts have been asking for more than a century. It brings together experts from Psychology, Psychoanalysis, Neuroscience, Philosophy, Psychiatry and Neurology to consider this question.
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book Schizophrenia and Psychotic Spectrum Disorders written by S. Charles Schulz and published by Oxford University Press. This book was released on 2016-04-01 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. - Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field - The essential resource for anyone involved in the study of bones and bone diseases - Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics - Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Neuropeptide Systems as Targets for Parasite and Pest Control written by Timothy G. Geary and published by Springer Science & Business Media. This book was released on 2011-01-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.
Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Download or read book Effects of Npy Y1 Receptor Activation Or Inhibition on Free Radical Generation During in Vitro Or in Vivo Cerebral Ischemia written by Pui-Shan Chan and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of NPY-Y1 Receptor Activation or Inhibition on Free Radical Generation During in Vitro or in Vivo Cerebral Ischemia" by Pui-shan, Chan, 陳佩珊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Effects of NPY-Y1 receptor activation or inhibition on free radical generation during in vitro or in vivo cerebral ischemia" Submitted by CHAN Pui Shan for the degree of Master of Philosophy at The University of Hong Kong in January 2006 Neuropeptide Y (NPY) is one of the most abundant and widely distributed neuropeptides in the mammalian central and peripheral nervous system. Previous studies in the rat have shown that the infarct volume and the relative brain nitric oxide (NO) concentration increase following middle cerebral artery occlusion (MCAO) plus an intracerebroventricular (ICV) injection of NPY or its Y1 agonist. NPY appears to have a harmful role in ischemic damage via the activation of its Y1 receptors. However, the pathogenic mechanisms of NPY acting via its Y1 receptors during ischemic damage are uncertain. Electron paramagnetic resonance (EPR) spectroscopy was used in the first study to measure the brain NO concentration in order to study how an ICV administration of NPY or its Y1 antagonist, BIBP3226, plus an intraperitoneal administration of a selective or non-selective nNOS inhibitor (selective: 7-Nitroindazole, 7-NI; non-selective: N-Nitro-L-arginine methyl ester hydrochloride, L-NAME) or a NO donor (sodium nitroprusside, SNP) would modulate the brain NO level between the bregma levels +2 and -4 mm during MCAO in the rat. The relative brain NO concentration of the groups treated with NPY plus 7-NI and with BIBP plus SNP was increased, but results of these two groups were not significantly different from that of the vehicle-control group. When compared to vehicle treatment, NPY increased the relative brain NO concentration, but there was no further increase with NPY plus SNP treatment. The present results suggest that, during ischemia, NPY acts via its Y1 receptors to activate nNOS which, in turn, is partly responsible for ischemia-induced NO overproduction. In the in vitro studies, oxygen and glucose deprivation (OGD) was applied to two types of human neuroblastoma cell lines, SK-N-MC and SH-SY5Y cells, which express the NPY Y1 and Y2 receptors, respectively. The NO-sensitive fluorescent dye, DAF-2 DA, the superoxide radical (O ) sensitive dye, hydroethidine (HEt), and the calcium ion sensitive fluorescent dye, fluo 3/AM were used to detect the - 2+ generation of NO, O and the calcium concentration ([Ca ] ), respectively, in the 2 i cells after OGD. These studies were conducted to determine whether NPY and its analogs would modulate the intracellular generation of NO, O and the intracellular calcium concentration following OGD. NPY and LP-NPY, a Y1 agonist, increased -- 2+ the cellular level of NO, O and [Ca ] following OGD in the SK-N-MC cells. In 2 i -- 2+ contrast, BIBP3226 suppressed the level of NO, O and [Ca ]
