Download or read book Brain Energetics and Neuronal Activity written by Robert G. Shulman and published by John Wiley & Sons. This book was released on 2005-08-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states It provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders. Novel and potentially controversial Will inspire future research directions
Download or read book The link between brain energy homeostasis and neuronal activity written by Yuri Zilberter and published by Frontiers E-books. This book was released on with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is an extremely energy consuming part of the body, which makes it dangerously vulnerable to metabolic stress. It’s no wonder then that abnormalities of brain energy metabolism are becoming the usual suspects and a hallmark of many neurodegenerative diseases. The socioeconomic burden of these alone begs for urgent measures to be taken for better understanding both fundamental and applied problems of neuroenergetics and neuroprotection. For instance, brain imaging reveals that the diseased brains of Alzheimer’s patients cannot efficiently utilize the vital brain fuel, glucose. The resulting energy deficit causes neuronal hyperactivity, seizures and cognitive impairments. Administration of native energy substrates complementary to glucose is a logical (and attractive in its simplicity) approach in fighting the energy crisis in the brain*. The two closely related aspects of brain activity -- neuronal and metabolic – are currently considered to be of utmost importance in both fundamental and applied neuroscience. Although recently the studies of both brain activity and metabolism in normal conditions, under metabolic stress, and in neurodegenerative diseases have experienced significant progress, their overlapping areas deserve further clarification by joint efforts from experts in such fields as (1) energy demands, supplies, and efficiency at the cellular level: in neurons, glial elements, micro-vessels and in the process of their coordinated interactions; (2) specific roles of energy substrates in fine-tuning of the demand-supply mechanism in the condition of metabolic stress; and (3) the macro-level of energy homeostasis and dietary manipulations possible beneficial for neurodegenerative diseases. The result of combining into a coherent whole the recent findings in these fields will hopefully bring forward a broader view and better understanding of the knowledge continuum, which is under the threat of further fragmentation due to the unavoidable process of specialization in neuroscience. Current issue covers the three major groups of topics: 1. The Pros and Cons of studies of neuronal activity using brain slice preparations 2. The role of particular energy substrates in metabolic support of neuronal activity 3. The macro-level of energy homeostasis and the dietary manipulations that seem promising in prevention and correction of the diseases of brain energy metabolism.
Download or read book Brain Energy Metabolism written by Johannes Hirrlinger and published by Humana Press. This book was released on 2014-09-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
Download or read book Neural Metabolism In Vivo written by In-Young Choi and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter
Download or read book Mechanisms of Coupling Energy Metabolism and Neuronal Activity at the Molecular Level written by Anusha Priya and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Gary E. Gibson and published by Springer Science & Business Media. This book was released on 2007-03-13 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytochrome Oxidase in Neuronal Metabolism and Alzheimer s Disease written by Francisco Gonzalez-Lima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.
Download or read book Handbook of Neurochemistry written by Abel Lajtha and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutrients Neurotransmitters and Brain Energetics written by Adriana Ximenes-da-Silva and published by Frontiers Media SA. This book was released on 2021-09-28 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Energy Metabolism written by Johannes Hirrlinger and published by Humana. This book was released on 2016-09-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
Download or read book Persistent Activity in the Brain Functions and Origin written by Shintaro Funahashi and published by Frontiers Media SA. This book was released on 2022-03-07 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neuronal Environment written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2001-12-26 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.
Download or read book Metabolism of the Nervous System written by Derek Richter and published by Elsevier. This book was released on 2013-10-22 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of the Nervous System contains the proceedings of the 2nd International Neurochemical Symposium, held at Aarhus, Denmark, in July 1956. The book discusses the molecular structure and morphology of the adult nervous tissue; the chemical composition and cytochemical localization of adult nervous tissue; and the permeability and blood-brain barrier. The text also describes topics on electrolytes and nervous conduction; the metabolism of isolated nerve and ganglion; and the metabolism of the brain in vivo. The metabolism of brain tissue preparations in vitro; energy metabolism and coenzymes in relation to the nervous system; and lipid and fatty acid metabolism are also considered. The book further tackles nucleic acid metabolism; protein and amino acid metabolism; and cholinergic and non-cholinergic transmission. The text also discusses other pharmacologically active compounds related to the adult nervous tissue.
Download or read book Brain Energy Metabolism written by Bo K. Siesjö and published by John Wiley & Sons. This book was released on 1978 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Energetics and Human Information Processing written by G.M. Hockey and published by Springer Science & Business Media. This book was released on 1986-09-30 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme of this book is the role of energetical factors in the regulation of human information processing activity. This is a restatement of one of the classic problems of psychology - that of acc ounting for motivational or intensive aspects of behaviour, as opposed to structural or directional aspects. The term "energetics" was first used in the 1930's by Freeman, Duffy and others, following Cannon's energy mobilization view of emotion and motivation. The original concept had a limited life, probably because of its unnecessary focus on relativ ely peripheral processes, but it provided the foundations for the con cepts of "arousal" and "activation" which became the popular motivational constructs of the 1950's and 1960's. Now, these too are found wanting. The original assumptions of a unitary, non-specific process based on activation of the brain stem reticular formation have been shown to be misleading. Current work in neurobiology has demonstrated evidence of discrete neurotransmitter systems having quite specific information processing functions, and central roles in the regulation of behaviour. Even the venerable curvilinear relationship between motivation and per formance (the Yerkes-Dodson law) has been shown to be, at best, an unhelpful oversimplification. On a different front psychophysiologists have found complex patterns in the response of different bodily systems to external stressors and to task demands.
Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Download or read book The Glutamate GABA Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.
