Download or read book Bradykinin Kallidin and Kallikrein written by and published by Springer. This book was released on 2014-12-04 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.
Download or read book Hypotensive Peptides written by E. G. Erdös and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers collected in this volume were presented at the International Symposium on Hypotensive Peptides held in Flor ence, Italy, on October 25-29, 1965. The purpose of the meeting was to bring together scientists of fourteen countries ranging from the chemist to the surgeon, who usually do not speak a common language and for whom it would be quite difficult to follow the latest developments in fields allied to, but still some what removed from their basic interest. Their reports sum marized their recent progress and current achievements, and gave indication of the trend that future research on hypotensive peptides may take. Various aspects of the structure and function of brady kinin, kallidin, kallikrein, gastrin, eledoiSin, physalaemin, sub stance P, and related substances were discussed during the nine sessions. The first session was devoted to the chemistry of peptides. This was followed in loose order by reports dealing with the structure of some newer peptides, with kininogen, and with enzymes that release or inactivate peptides. Subsequently, reports on the physiological, pharmacological, pathological, and clinical importance of kinins, kallikrein, and eledoisin were presented. One entire session was devoted to substance P. At the closing session two motion pictures demonstrated the effect of the peptides on the circulation. The appendix of this volume contains the report of the international Committee on Nomenclature.
Download or read book Bradykinin Kallidin and Kallikrein written by and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.
Download or read book Bradykinin Kallidin and Kallikrein written by Ervin G. Erdös and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bradykinin is frequently referred to as an elusive substance; the editor of a comprehensive volume dealing with kinins thus has a difficult task. The com plexity of the issues calls for a large number of contributors who approach the topics from the various angles that are dictated by the sometimes divergent views of the individuals. The editor saw no reason to prescribe the mode of presentation, which was left to the authors and accounts for the variety of approaches. Contributors from nine countries were asked to participate in the volume. The chapters were organized to present, first, the history of the discoveries and methods of approach to kinin research. Then follows a discussion of the enzymes that release kinins, their substrates, and other enzymes that inactivate the peptides. If the release of kinin is important, then the inhibition of the releasing enzymes is of obvious interest and is described. Since the measurement of kinin ogen levels in blood has been frequently used as an indicator of kinin liberation, in addition to a separate chapter, kininogens are also mentioned where the functions of kinins are discussed. The conclusions drawn from establishing structure-action relationships for many analogs and the actions of kinins are indicated and summarized.
Download or read book Bradykinin and Related Kinins written by F. Sicuteri and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Mediators of the Acute Inflammatory Reaction written by Maurício Rocha e Silva and published by Pergamon. This book was released on 1972 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Mediators of the Acute Inflammatory Reaction ...
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Download or read book The Kinin System written by Stephen G. Farmer and published by Academic Press. This book was released on 1997-04-09 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews: "A delicious masterpiece." --Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins. * Provides a distinctly immunopharmacological approach to the kinin system. * Reviews of the role of kinins in disease and inlcudes data from human studies. * Includes information that is fully up-to-date and comprehensive.
Download or read book Bradykinin Antagonists written by Ronald M. Burch and published by Marcel Dekker. This book was released on 1991 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1985, when John Stewart and Ray Vavrek reported the first bradykinin analogs with antagonist activity at the B2 bradykinin receptor, several of the antagonists have been extensively used in studies of bradykinin receptor subtypes and of the role of bradykinin in blood pressure regulation, infl
Download or read book Molecular Biology and Pharmacology of Bradykinin Receptors written by Ronald M. Burch and published by R. G. Landes. This book was released on 1993 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nunn s Applied Respiratory Physiology written by John F. Nunn and published by Butterworth-Heinemann. This book was released on 1993-10-04 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nunn's Applied Respiratory Physiology.
Download or read book Kinin Hormones with Special Reference to Bradykinin and Related Kinins written by Maurício Rocha e Silva and published by . This book was released on 1970 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Download or read book Bradykinin Kallidin and Kallikrein written by Ervin G. Erdös and published by Springer. This book was released on 2012-03-19 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bradykinin is frequently referred to as an elusive substance; the editor of a comprehensive volume dealing with kinins thus has a difficult task. The com plexity of the issues calls for a large number of contributors who approach the topics from the various angles that are dictated by the sometimes divergent views of the individuals. The editor saw no reason to prescribe the mode of presentation, which was left to the authors and accounts for the variety of approaches. Contributors from nine countries were asked to participate in the volume. The chapters were organized to present, first, the history of the discoveries and methods of approach to kinin research. Then follows a discussion of the enzymes that release kinins, their substrates, and other enzymes that inactivate the peptides. If the release of kinin is important, then the inhibition of the releasing enzymes is of obvious interest and is described. Since the measurement of kinin ogen levels in blood has been frequently used as an indicator of kinin liberation, in addition to a separate chapter, kininogens are also mentioned where the functions of kinins are discussed. The conclusions drawn from establishing structure-action relationships for many analogs and the actions of kinins are indicated and summarized.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Download or read book ACE Inhibitors written by Pedro D'Orléans-Juste and published by Birkhäuser. This book was released on 2012-12-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiotensin converting enzyme inhibitors (ACEI) represent the first class of antihypertensive agents that was designed and developed on the basis of a well-defined physiopathological axis of arterial hypertension, a vascular dis order that is now becoming one of the major causes of morbidity/mortality, not only in developed societies but also in the highly populated developing coun tries [1]. CAPTOPRIL, the prototype of the "PRIL" family, which now comprises more than 40 molecule-species, was quite hazardous and the clinical develop ment almost failed when serious side-effects were reported in an alarmist fash ion in reputable scientific journals, such as the New England Journal of Medicine and Lancet. Squibb & Sons came very close to withdrawing CAPTOPRIL from clinical investigation [2]. However, after re-examination of the data obtained from different categories of patients and appropriate dose-adjustments, the clinical use of CAPTOPRIL turned out to be revolutionary. The prototype, as well as other members of the "PRIL" family became the starting point for numerous basic and clinical research programs, focusing on the interactions of ACEI with the kinin, endothelin, and nitric oxide systems, and the contribution of the receptors for AT I, AT 2, bradykinin Bland B , ETA and ET B to the pharmacological actions 2 of the respective peptides. This research activity led to the development of new pharmacological agents, such as the angiotensin receptor antagonists and, more recently, the neutral endopeptidase inhibitors. In the near future, bradykinin receptor antagonists also will be available to modulate ACEI phar macological actions.
Download or read book ABC of Hypertension written by D. Gareth Beevers and published by John Wiley & Sons. This book was released on 2010-07-15 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension is a condition which affects millions of peopleworldwide and its treatment greatly reduces the risk of strokes andheart attacks. This fully revised and updated edition of the ABCof Hypertension is an established guide providing all thenon-specialist needs to know about the measurement of bloodpressure and the investigation and management of hypertensivepatients. This new edition provides comprehensively updated andrevised information on how and whom to treat. The ABC of Hypertension will prove invaluable to generalpractitioners who may be screening large numbers of patients forhypertension, as well as nurse practitioners, midwives and otherhealthcare professionals.
