Download or read book Bone Remodeling and Mechanomics written by Madge Martin and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our skeleton, an essential structure for the human body, has multiple functions, among which are the regulation of metabolism and the protection of organs. We focus here on bone remodeling, a process by which the structure and chemical composition of bone evolve over time. The biochemical and structural changes of bone tissue are orchestrated by bone cells, able to synthesize bone matrix (osteoblasts), resorb mineralized bone (osteoclasts), and to regulate biochemical signaling pathways according to their mechanical environment (osteocytes). In this context, we are particularly interested in mechanomics, which is the description of the action of mechanics on biological tissues.We first study the mechanics of bone remodeling at the cellular level, where signaling pathways are essential. We therefore introduce a fine mathematical representation of bone remodeling by a system of differential equations describing the interactions between bone cells of osteoclastic and osteoblastic lineages, as well as the regulation of the biochemical environment by osteocytes. This model reproduces the bone loss in the contexts of micro-gravity during space flight and postmenopausal osteoporosis (PMO). The development of a pharmacokinetic-pharmacodynamic model coupled with biochemical dynamics makes it possible to link the dosage of an anabolic treatment of PMO (romosozumab) and the gain of bone mass, which would be beneficial for the design of a treatment specific to the patient.We also propose a macroscopic description of bone remodeling based on a generalized continuum mechanics model. First, this representation is introduced in the context of rotary remodeling of the bone microstructure. Indeed, bone is a material with a micro-architecture, composed of a mineralized collagen matrix and a fluid phase which hosts active bone cells. First, we propose an analytical identification of stable equilibrium states of rotary remodeling. This theory is then used in a 2D finite element study applied to the human femoral head. Finally, we enrich this theoretical framework by linking macroscopic mechanics to mechanobiology: the kinematics of bone remodeling is described through the evolution of macroscopic deformation, microstructural rotation, mineral fraction, porous fraction and cells concentrations. This description encompassing chemistry, biology and mechanics provides a structure for the study of interactions between these three fields in the context of remodeling. The promising results of our preliminary simulations enable an interpretation of remodeling on a small scale that can be compared with clinical data.Finally, we present in this thesis a first clinical application of our multi-scale theory with the study of bone remodeling in patients with idiopathic scoliosis of the adolescent (AIS), pathology of unknown origin characterized by a three-dimensional deviation of the spine. The analysis of the first vertebral body samples from AIS patients taken intraoperatively suggests a dependence of the properties of the material on the abnormal loading conditions due to the pathology. These observations motivate the prospect of a comparison of these results with simulations based on our mechanistic theory.In summary, we present in this thesis several bone remodeling modeling approaches, resulting in the development of a novel unifying theory whose purpose is to better understand and address the mechanisms of bone pathologies, which ultimately aim at the development of patient-specific therapeutic solutions.
Download or read book Bone Remodeling Process written by Rabeb Ben Kahla and published by Academic Press. This book was released on 2021-08-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Remodeling Process: Mechanics, Biology, and Numerical Modeling provides a literature review. The first part of the book discusses bones in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and the second discusses pathological conditions, highlighting the attack vectors of each bone disease. The third part is devoted to the mathematical descriptions of bone remodeling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics.This book creates an overall image of the complex communication network established between the diverse remodeling actors, based on overwhelming control evidence revealed over recent years, as well as visualizes the remodeling defects and possible treatments in each case. It also regroups the models allowing readers to analyze and assess bone mechanical and biological properties. This book details the cellular mechanisms allowing the bone to adapt its microarchitecture to the requirements of the human body, which is the main issue in bone biology and presents the evolution of mathematical modeling used in a bone computer simulation. Each chapter covers a core topic in bone biomechanics Provides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulation Draws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodeling process
Download or read book Mechanics of Cellular Bone Remodeling written by Qing-Hua Qin and published by CRC Press. This book was released on 2013-01-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on bone remodeling has resulted in much new information and has led to improvements in design and biomedical practices. Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects presents a unified exploration of recent advances, giving readers a sound understanding of bone remodeling and its mathematical representation. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads. Topics include: Fundamental concepts and basic formulations for bone remodeling Applications of formulations to multifield internal bone remodeling of inhomogeneous long cylindrical bone Theory and solution of multifield surface bone remodeling A hypothetical regulation mechanism on growth factors for bone modeling and remodeling under multifield loading The RANK–RANKL–OPG pathway and formulation for analyzing the bone remodeling process A model of bone cell population dynamics for cortical bone remodeling under mechanical and pulsed electromagnetic stimulus Recent developments in experiments with bone materials Readers will benefit from the thorough coverage of general principles for each topic, followed by detailed mathematical derivations and worked examples, as well as tables and figures where appropriate. The book not only serves as a reliable reference but is also destined to attract interested readers and researchers to a field that offers fascinating and technologically important challenges.
Download or read book The Computational Mechanics of Bone Tissue written by Jorge Belinha and published by Springer Nature. This book was released on 2020-02-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.
Download or read book Bone Adaptation written by Yoshitaka Kameo and published by Springer. This book was released on 2018-01-10 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
Download or read book Multiscale Mechanobiology of Bone Remodeling and Adaptation written by Peter Pivonka and published by Springer. This book was released on 2017-06-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
Download or read book The Computational Mechanics of Bone Tissue written by and published by . This book was released on 2020 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field. --
Download or read book Finite Element Analysis of Bone Remodeling Implementation of a Remodeling Algorithm in MATLAB and ANSYS written by Martin Groß and published by GRIN Verlag. This book was released on 2008-08-18 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master's Thesis from the year 2006 in the subject Medicine - Biomedical Engineering, grade: 1.0, Technical University of Munich (LS Statik), course: Master of Science of Computational Mechanics, language: English, abstract: The process of adaptive bone remodeling can be described mathematically and simulated in a computer model, integrated with the finite element method. The main focus of this thesis is the implementation of a bone remodeling algorithm in MATLAB and ANSYS on the basis of FEM. The strain energy density is used as mechanical stimulus. The cortical and trabecular bone are described as continuous materials with variable density. This thesis can be divided into four main parts. The first part is due to the material properties of cortical and trabecular bone. The second part is about the remodeling theory and gives an historical review of the developed numerical approaches up to now. The implementation of the remodeling algorithm in ANSYS and MATLAB as well as its validation is topic of part three. In last main part, the algorithm is applied to a 2D FE-model of a human proximal femur.
Download or read book Bone Regeneration and Repair written by Jay R. Lieberman and published by Springer Science & Business Media. This book was released on 2005-02-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.
Download or read book Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling written by Chao Liang and published by Frontiers Media SA. This book was released on 2022-01-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bone Remodeling and Osseointegration of Implants written by Andy H. Choi and published by Springer Nature. This book was released on 2023-05-10 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an insight into the latest advances in bone fracture healing and remodeling algorithm and their incorporation into patient-specific finite element models and the use of machine learning and artificial intelligence to predict the bone regeneration and osseointegration process with a certain degree of accuracy. It also examines the applications of numerical models to simulate the fracture healing process, which may prove to be advantageous in determining the optimal mechanical-based treatment or reconstruction after an accident or illness. This book is aimed at medical and dental professionals who are involved in implantology and tissue engineering such as dentists, oral and maxillofacial surgeons, orthopedic surgeons, students, and researchers.
Download or read book Principles of Bone Regeneration written by Jona J. Sela and published by Springer Science & Business Media. This book was released on 2012-03-13 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
Download or read book Bone Remodeling and Its Disorders written by Gregory R. Mundy and published by . This book was released on 1995 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Law of Bone Remodelling written by Julius Wolff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translated from the German by Maquet, P.; Furlong, R.
Download or read book Skeletal Development and Remodeling in Health Disease and Aging Volume 1068 written by Mone Zaidi and published by Wiley-Blackwell. This book was released on 2006-06-23 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade. Using advanced molecular technologies including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have not only helped us understand the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but also, in some instances, clarified the source of pathophysiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. This volume presents the significant headway that scientists have made in this undertaking and the book is organized around four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Also included are papers that focus on current and emerging therapies for osteoporosis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Download or read book Multi scale Modeling of Bone Remodeling written by Tobias Ebinger and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Bone Remodeling written by Donald H. Enlow and published by . This book was released on 1963 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
