Download or read book Bone Morphogenetic Proteins Systems Biology Regulators written by Slobodan Vukicevic and published by Springer. This book was released on 2017-03-14 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
Download or read book Bone Morphogenetic Proteins From Local to Systemic Therapeutics written by Slobodan Vukicevic and published by Springer Science & Business Media. This book was released on 2008-08-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.
Download or read book Bone Morphogenetic Proteins written by Slobodan Vukicevic and published by Springer. This book was released on 2012-11-28 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.
Download or read book Bone Morphogenetic Proteins Regeneration of Bone and Beyond written by Slobodan Vukicevic and published by Springer. This book was released on 2012-11-28 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica cy of BMPs in almost all crucial developmental events as well as during regenera tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Physiology and Pharmacology of Bone written by Gregory R. Mundy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors, all accomplished and world-renowned experts in their topic areas, have provided controversial and up-to-date accounts of the current status of research in calcium and bone metabolism by reviewing major areas of basic science which have an impact on the understanding of bone diseases and related disorders.
Download or read book The Cytokine Factsbook and Webfacts written by Katherine A. Fitzgerald and published by Elsevier. This book was released on 2001-09-03 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.
Download or read book Feedback Control in Systems Biology written by Carlo Cosentino and published by CRC Press. This book was released on 2011-10-17 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like engineering systems, biological systems must also operate effectively in the presence of internal and external uncertainty—such as genetic mutations or temperature changes, for example. It is not surprising, then, that evolution has resulted in the widespread use of feedback, and research in systems biology over the past decade has shown that feedback control systems are widely found in biology. As an increasing number of researchers in the life sciences become interested in control-theoretic ideas such as feedback, stability, noise and disturbance attenuation, and robustness, there is a need for a text that explains feedback control as it applies to biological systems. Written by established researchers in both control engineering and systems biology, Feedback Control in Systems Biology explains how feedback control concepts can be applied to systems biology. Filling the need for a text on control theory for systems biologists, it provides an overview of relevant ideas and methods from control engineering and illustrates their application to the analysis of biological systems with case studies in cellular and molecular biology. Control Theory for Systems Biologists The book focuses on the fundamental concepts used to analyze the effects of feedback in biological control systems, rather than the control system design methods that form the core of most control textbooks. In addition, the authors do not assume that readers are familiar with control theory. They focus on "control applications" such as metabolic and gene-regulatory networks rather than aircraft, robots, or engines, and on mathematical models derived from classical reaction kinetics rather than classical mechanics. Another significant feature of the book is that it discusses nonlinear systems, an understanding of which is crucial for systems biologists because of the highly nonlinear nature of biological systems. The authors cover tools and techniques for the analysis of linear and nonlinear systems; negative and positive feedback; robustness analysis methods; techniques for the reverse-engineering of biological interaction networks; and the analysis of stochastic biological control systems. They also identify new research directions for control theory inspired by the dynamic characteristics of biological systems. A valuable reference for researchers, this text offers a sound starting point for scientists entering this fascinating and rapidly developing field.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
Download or read book Bone Morphogenetic Proteins written by Melissa B. Rogers and published by Humana. This book was released on 2018-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods to study bone morphogenetic proteins (BMPs) and BMP modulators in cell culture, in both invertebrate and vertebrate animal models, and for therapeutic applications. Chapters guide the reader in the use of primary and immortalized cell lines, methodologies that exploit transcription and receptor mechanisms, newly developed animal models using nematodes, flies, amphioxus, frogs, zebrafish, and genetically engineered mice, and pre-clinical approaches to understanding BMP function in bone regeneration, heterotopic ossification, and cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bone Morphogenetic Proteins: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Download or read book Principles of Developmental Genetics written by Sally A. Moody and published by Academic Press. This book was released on 2014-09-02 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content. All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciences Chapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic application Clinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes
Download or read book Invertebrate Cytokines and the Phylogeny of Immunity written by Alain Beschin and published by Springer Science & Business Media. This book was released on 2003-10-10 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.
Download or read book Factors Affecting Neurodevelopment written by Colin R Martin and published by Academic Press. This book was released on 2021-05-29 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems. Provides the most comprehensive coverage of a broad range of topics relating to the neuroscience of development Features sections on the genetics of developmental conditions and accompanying behavior Contains an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding in each chapter Focuses on neurodevelopmental disorders and environmental factors that influence neural development Includes more than 500 illustrations and tables
Download or read book Plastic Surger 6 Volume Set E Book written by Peter C. Neligan and published by Elsevier Health Sciences. This book was released on 2023-09-25 with total page 6280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and fully up to date, Dr. Peter Neligan’s six-volume masterwork, Plastic Surgery, 5th Edition, remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, it features new, full-color clinical photos, procedural videos, and lectures across all six volumes. Bonus material online includes additional text, images, and over 200 procedural videos that help you improve your mastery of the latest techniques. Easily find the answers you need with an organization that features separate volumes covering Principles • Aesthetic • Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery • Lower Extremity, Trunk and Burns • Breast • and Hand and Upper Extremity. Each easily readable, individual volume is a standalone comprehensive text full of salient and applicable anatomy and techniques. Key procedures include gender affirmation management and surgery, microsurgery and surgery for lymphedema, aesthetic facial surgery, aesthetic body surgery, and the education, training and practice of plastic surgery. New digital video preface by Dr. Neligan addresses the changes across all six volumes. New treatment and decision-making algorithms added to chapters where applicable. New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. Four new international experts join the editorial team, and lead editor Peter C. Neligan creates a cohesive tone throughout the chapters and content across all six volumes. Evidence-based advice from a diverse collection of experts allows you to apply the very latest advances in every area of plastic surgery and ensure optimal outcomes. Purchase only the volumes you need or own the entire set, with the ability to search across all six volumes online!
Download or read book Plastic Surgery written by Geoffrey C Gurtner and published by Elsevier Health Sciences. This book was released on 2023-08-31 with total page 2937 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and fully up to date, the six-volume Plastic Surgery remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, Principles, Volume 1 of Plastic Surgery, 5th Edition, features new, full-color clinical photos, procedural videos, lectures, and authoritative coverage of hot topics in the field. Editor-narrated video presentations offer a step-by-step audio-visual walkthrough of techniques and procedures. New chapters cover value-based healthcare, health services research in plastic surgery, education and teaching in plastic surgery, and gender-affirming surgery; coverage throughout includes new, pioneering translational work shaping the future of plastic surgery. New digital video preface by Dr. Peter C. Neligan addresses the changes across all six volumes. New treatment and decision-making algorithms added to chapters where applicable. New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. Evidence-based advice from an expanded roster of international experts allows you to apply the very latest advances in plastic surgery and ensure optimal outcomes. Purchase this volume individually or own the entire set, with the ability to search across all six volumes online!
