Download or read book Biomarkers in Bone Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Download or read book Marcus and Feldman s Osteoporosis written by David W. Dempster and published by Academic Press. This book was released on 2020-10-08 with total page 1950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders
Download or read book Osteoporotic Fracture and Systemic Skeletal Disorders written by Hideaki E. Takahashi and published by Springer Nature. This book was released on 2021-11-30 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly. Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of “Remodeling” and “Modeling” is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are included Treatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.
Download or read book Osteoporosis in Men written by Eric S. Orwoll and published by Academic Press. This book was released on 2009-11-30 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book
Download or read book Osteoporosis written by Benjamin Z. Leder and published by Springer Nature. This book was released on 2020-01-31 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.
Download or read book Bone Health and Osteoporosis written by United States Public Health Service and published by . This book was released on 2004-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
Download or read book Principles of Bone and Joint Research written by Peter Pietschmann and published by Springer. This book was released on 2017-08-24 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook discusses the basics and clinical aspects of bone research in an accessible way. It aims at enhancing students’ understanding of the structure, pathophysiology and regeneration of bone and associated connective tissues. The book covers a diverse aspects of this interdisciplinary field, including immunology, molecular biology and regenerative medicine, as well as tissue engineering and strategies that combine biomaterials, cells and growth-stimulating factors to trigger tissue development and regeneration. As such, the book offers an essential guide for advanced master’s students and PhD students in biomedicine, orthopedics and rheumatology.
Download or read book Bone Markers written by Matthias Baumann and published by CRC Press. This book was released on 2001-03-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph brings together the proceedings of a workshop held in Geneva, Switzerland in March 2000 under the joint sponsorship of the University of Sheffield and F Hoffmann La Roche Ltd. Chapters by leading scientists present the latest research on biochemical markers of bone remodelling as well as their clinical applications in the management of osteoporosis. The text focuses on four major areas of interest: 1) potential candidates for markers of bone remodelling, 2) sources of biological bone marker variability, 3) use of biochemical markers in monitoring treatment of osteoporosis, and 4) use of biochemical markers in the prediction of bone loss and fractures. The book also includes transcripts of the lively panel discussions from the Geneva workshop.
Download or read book Glucocorticoid induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
Download or read book Clinical Impact of Bone and Connective Tissue Markers written by Bozzano G Luisa and published by Academic Press. This book was released on 2012-12-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.
Download or read book Bone Metastases from Prostate Cancer written by Francesco Bertoldo and published by Springer. This book was released on 2016-11-07 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.
Download or read book Bone Markers written by Richard Eastell and published by CRC PressI Llc. This book was released on 2001-01-01 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dynamics of Bone and Cartilage Metabolism written by Markus J. Seibel and published by Elsevier. This book was released on 2006-07-24 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Pocket Reference to Osteoporosis written by Serge Livio Ferrari and published by Springer. This book was released on 2018-12-28 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book responds to the daily needs of all clinicians treating patients with osteoporosis and provides a key reference guide for any challenges that arise in clinical practice. This book also covers the genetics of the disease, clinical presentation, diagnosis, and current and upcoming treatment recommendations in accordance with the latest international guidelines. Osteoporosis is a disease in which the density and quality of bone are greatly reduced, and as bones become more porous and fragile the risk of fracture increases greatly. It is one of the most common metabolic bone diseases globally with one in three women and one in five men at risk of an osteoporotic fracture, and can result in devastating physical, psychosocial, and economic consequences. However, in spite of this osteoporosis can often be overlooked and undertreated, thus there is a real need to raise awareness of this disease.
Download or read book Pediatric Bone written by Francis H. Glorieux and published by Academic Press. This book was released on 2011-09-28 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric osteology, a medical specialty that has come of age, has contributed to the understanding of adult bone diseases as well. This second edition reference updates the 2003 edition with more emphasis on management as well as new and revised contributions. Thirty chapters present basic information regarding bone development, tools and techniques for evaluation (including a new chapter on radiographic imaging), and the specifics of various diseases. The three editors are affiliated as follows: Francis H. Glorieux (McGill U., Canada), John M. Pettifor (Chir Hani Baragwanath Hospital, South Africa), and Harald Juppner (Harvard Medical School, US). Academic Press is an imprint of Elsevier. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
