Download or read book Mechanism of Action of Antimicrobial and Antitumor Agents written by J. F. Snell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
Download or read book Bleomycin Chemical Biochemical and Biological Aspects written by Sidney M. Hecht and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book records the proceedings of a joint U.S.-Japan symposium on the chem istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ................... , 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.
Download or read book Bleomycin Chemotherapy written by Branimir Ivan Sikic and published by Elsevier. This book was released on 2013-10-22 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bleomycin Chemotherapy focuses on the clinical uses of bleomycin. Bleomycin, a group of glycopeptides isolated from Streptomyces verticillus, has a unique structure and mechanism of action among anticancer drugs. The drug’s remarkable lack of bone marrow toxicity prompted its addition to myelosuppressive regimens and enabled treatment of patients with compromised hematopoietic function. Bleomycin is an integral component of one of the great triumphs of medical oncology—the curative treatment of metastatic testicular carcinomas. Similar curative potential has been demonstrated for bleomycin in combination with cisplatin and vinblastine in germ-cell cancers of the ovary. Bleomycin is included in several important treatment regimens for Hodgkin's disease and non-Hodgkin's lymphomas. The drug also has clinical activity against squamous carcinomas of various sites. These uses and other aspects, including the development of new bleomycin analogs, are discussed in the following chapters, which were first presented at a symposium jointly sponsored by the Northern California Cancer Program and Bristol Laboratories in San Francisco, California, 14-15 September 1984.
Download or read book Principles and Practice of Gynecologic Oncology written by William J. Hoskins and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 1466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated Fourth Edition provides comprehensive coverage of the biology of gynecologic cancer, the therapeutic modalities available, and the diagnosis and treatment of site-specific malignancies. Because of the importance of multimodality treatment, the site-specific chapters are co-authored by a surgical oncologist, a medical oncologist, a radiation oncologist, and a pathologist. A significant portion of this edition focuses on monoclonal antibodies, vaccines, and gene directed therapies and how they can greatly improve treatment outcomes. A new chapter on end-of-life care is also included. Three distinguished new editors—Richard R. Barakat, MD, Maurie Markman, MD, and Marcus E. Randall, MD—now join the editorial team.
Download or read book Transforming Growth Factor Beta in Cancer Therapy Volume I written by Sonia B. Jakowlew and published by Springer Science & Business Media. This book was released on 2010-01-01 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.
Download or read book Fundamental and Clinical Studies of Bleomycin written by Stephen K. Carter and published by . This book was released on 1976 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consists of the proceedings of international conference and symposia.
Download or read book Pharmacology and Therapeutics for Dentistry E Book written by John A. Yagiela and published by Elsevier Health Sciences. This book was released on 2010-03-19 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use your knowledge of pharmacology to enhance oral care! Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic fundamentals of pharmacology, special topics such as pain control, fear and anxiety, and oral complications of cancer therapy, and most importantly, the actions of specific drug groups on the human body. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. An emphasis on the dental applications of pharmacology relates drugs to dental considerations in clinical practice. Dental aspects of many drug classes are expanded to include antibiotics, analgesics, and anesthetics. The Alternative Medicine in Dentistry chapter discusses chemicals used as alternative medicines and assesses their potential benefits and risks. The Nonopioid Analgesics chapter groups together non-opioid analgesics, nonsterioidal anti-inflammatory drugs, and antirheumatic and antigout drugs, making these easier to locate and study. Coverage of the endocrine system includes four separate chapters for the most comprehensive coverage. Drug Interactions in Clinical Dentistry appendix lists potential interactions between drugs a patient is taking for nondental conditions and drugs that may be used or prescribed during dental treatment, including effects and recommendations. Glossary of Abbreviations appendix includes the most common abbreviations used for drugs or conditions. New Pharmacogenetics and Pharmacogenomics chapter covers the effects of genetic traits of patients on their responses to drugs. A NEW introductory section offers tips for the study of dental pharmacology and relates pharmacology to dental considerations. An updated discussion of drug-drug interactions covers the harmful effects of mixing medications. Coverage of adverse effects and mechanisms of COX-2 inhibitors, antibiotic prophylaxis, and antiplaque agents explains the dental risks relating to common drug treatments.
Download or read book Some Antiviral and Antineoplastic Drugs and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.
Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature
Download or read book Encyclopedia of Cancer written by and published by . This book was released on 2002 with total page 2800 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Basis of Clinical Effect of Bleomycin written by Antonio Caputo and published by S. Karger AG (Switzerland). This book was released on 1976 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Production and Function of Macrophage Inflammatory Protein 1 in Bleomycin Induced Lung Injury written by Robert Erne Smith and published by . This book was released on 1997 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Mechanism of Bleomycin written by Corin Deann Slown and published by ProQuest. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bleomycins are a class of glycopeptide antitumor antibiotics isolated by Umezawa and coworkers in 1966. Bleomycin A2 is the major component (70%) of the clinical anticancer drug Blenoxane, employed in the treatment of several forms of cancer. Through DNA binding and degradation, a process that is both metal ion and oxygen dependent, bleomycin A2 cleaves double stranded DNA selectively at 5'-GC or 5'-GT sites by minor groove C4'-H atom abstraction and subsequent fragmentation of the deoxyribose backbone. Many key questions concerning the mechanism and functional roles of the structural units still remain unanswered, including the nature of the metal-binding ligands and their arrangement in the metal complexes. Efforts to address these questions include the synthesis of 15N-labeled analogues of the pyrimidoblamic acid as well as the carbamoyl portion of the disaccharide, their incorporation into bleomycin A2 and subsequent Electron Nuclear Double Resonance (ENDOR) spectroscopy studies.
Download or read book Handbook of Imaging in Pulmonary Disease written by Subha Ghosh and published by Springer Nature. This book was released on 2021-04-20 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and easy-to-read guide to pulmonary imaging. Medical Imaging is one of the cornerstones of modern medicine, and nowhere is this more apparent than pulmonary disease. We have come a long way from the days of chest radiography, though the chest radiograph still remains the single most common imaging test ordered worldwide. Pulmonary disease is now routinely evaluated with ultra-modern computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) scanners, while ultrasonography plays a limited role in critical care and pleural/chest wall diseases. Rapid advancements in the sub-specialty of chest imaging and an exponential increase in the knowledge of pulmonary disease have led to an increasing demand for a comprehensive yet easily digestible handbook of pulmonary imaging, which prepackages knowledge in a form that can be easily understood and readily visualized with high-quality representative images. This book answers that need by providing the most important, relevant medical knowledge needed to handle pulmonary cases. It is divided into two sections, neoplastic disease and non-neoplastic disease. Chapters detail essential information about each disease, including presentation and the different modalities used to accurately diagnose and/or plan treatment. Major topics that are covered include bronchogenic carcinoma and other lung tumors, COPD, ILD, developmental lung disorders, pulmonary hypertension, and pulmonary infections. Each chapter includes extensive radiographic images to give a complete perspective on how these diseases present. Readers can easily see what the radiology of a particular disease entity looks like, what would be the differential diagnoses for a particular imaging abnormality, and compare the bullet review points associated with an image to their particular case. This is an ideal guide for general and thoracic radiologists, pulmonary, sleep medicine, and critical care specialists, thoracic surgeons, as well as residents and all clinicians who treat patients with pulmonary disease.
Download or read book Therapeutic Locus and Mechanism of Bleomycin Action written by Anil Thomas Abraham and published by . This book was released on 2000 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigation of Sugar Biosynthesis Pathways of Antitumor Antibiotics C 1027 and Bleomycin written by Jeffrey Michael Murrell and published by . This book was released on 2003 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt:
