Download or read book Toxicological Profile for Bis chloromethyl ether written by and published by . This book was released on 1989 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2012-04-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. This volume in the series includes AEGLs for bis-chloromethyl ether, chloromethyl methyl ether, chlorosilanes, nitrogen oxides, and vinyl chloride.
Download or read book A Review of Human Carcinogens written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Combinatorial Index written by Barry A. Bunin and published by Elsevier. This book was released on 1998-04-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. - Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods - Serves as a laboratory manual for bench chemists - Includes a chapter on linkers to assist in choice of linking strategy - Discusses strengths and limitations of the various methods - Contains a structural index showing functional group transformations in solid-phase synthesis
Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
Download or read book Polymer Synthesis written by Stanley R. Sandler and published by Gulf Professional Publishing. This book was released on 1992 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and updated second edition of Polymer Syntheses, Volume I brings together useful preparative methods for polymers and resins by functional group type that are of interest to both academic and industrial researchers. Several new directions for polymerization procedures have been included and are organized by various methodologies. Tables of physical property data and preparations make this book a valuable addition to any research library or research group. Provides detailed directions for the synthesis of various functional groups Includes up-to-date references to the journal literature and patents (foreign and domestic) Reviews the chemistry for each functional group and suggests where additional research is needed
Download or read book Bis chloromethyl Ether and Chloromethyl Methyl Ether written by Canada. Environment Canada and published by . This book was released on 1993 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Priority Substances List identifies substances, including chemicals, groups of chemicals, effluents, and wastes that may be harmful to the environment or constitute a danger to human health. This study looks at bis(chloromethyl) ether and chloromethyl methyl ether in Canada. It provides a summary of critical information, identity, properties, production and uses of these substances, their entry into the environment and exposure-related and effects-related information. Finally, it provides an assessment of toxic under the Canadian Environmental Protection Act with regards to the environment and human life or health.
Download or read book A Review of Human Carcinogens F Chemical Agents and Related Occupations written by International Agency for Research on Cancer and published by International Agency for Research on Cancer. This book was released on 2012-09-24 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 100 compiles information on tumor sites and mechanisms of carcinogenesis. About half of the agents classified in Group 1 were last reviewed more than 20 years ago, before mechanistic studies became prominent in evaluations of carcinogenicity. In addition, more recent epidemiological studies and animal cancer bioassays have demonstrated that many cancer hazards reported in earlier studies were later observed in other organs or through different exposure scenarios. Much can be learned by updating the assessments of agents that are known to cause cancer in humans. Accordingly, IARC has selected A Review of Human Carcinogensto be the topic for Volume 100. It is hoped that this volume, by compiling the knowledge accumulated through several decades of cancer research, will stimulate cancer prevention activities worldwide, and will be a valued resource for future research to identify other agents suspected of causing cancer in humans. Volume 100 was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Metals, particles, and fibres; Radiation; Personal habits and household exposures; Chemical agents and related occupations. Because the scope of Volume 100 is so broad, its Monographs are focused on key information. Each Monograph presents a description of a carcinogenic agent and how people are exposed, critical overviews of the epidemiological studies and animal cancer bioassays, and a concise review of the agent's toxicokinetics, plausible mechanisms of carcinogenesis, and potentially susceptible populations, and life-stages. Details of the design and results of individual epidemiological studies and animal cancer bioassays are summarized in tables. Short tables that highlight key results are printed in Volume 100, and more extensive tables that include all studies appear on the Monographs programe website (http://monographs.iarc.fr/). For a few well-established associations (for example, tobacco smoke and human lung cancer), it was impractical to include all studies, even in the website tables. In those instances, the rationale for inclusion or exclusion of sets of studies is given.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1987 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An Introduction to Interdisciplinary Toxicology written by Carey N. Pope and published by Academic Press. This book was released on 2020-02-21 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.
Download or read book Annual Report on Carcinogens written by and published by . This book was released on 1994 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research and Discovery written by and published by . This book was released on 1998 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NIH Research Advances written by and published by . This book was released on 1977 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DHEW Publication written by and published by . This book was released on 1975 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Advances written by National Institutes of Health (U.S.) and published by . This book was released on 1975 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multimedia Environmental Goals for Environmental Assessment MEG charts and background information summaries Categories 1 12 written by and published by . This book was released on 1977 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nasal Tumors in Animals and Man Vol III 1983 written by Gerd Reznik and published by CRC Press. This book was released on 2017-11-22 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals. and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.
