Download or read book Biostatistical Methods for HIV Monitoring and Prevention written by Brett S. Hanscom and published by . This book was released on 2014 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pooled-testing methods can greatly reduce the number of tests needed to identify failures in a collection of samples. Existing methodology has focused primarily on binary tests, but there is a clear need for improved efficiency when using expensive quantitative tests, such as tests for HIV viral load in resource-limited settings. We propose a matrix-pooling method which uses the EM algorithm to identify individual samples most likely to be failures. Simulation studies show that the proposed method can improve testing efficiency by a modest amount, and dramatically reduce the total number of testing rounds needed to identify all failures. In settings where the turn-around time for testing services is significant, the EM method can substantial time savings. The EM method does not perform as well when the measurements of interest are highly skewed, as is often the case with viral load concentrations. We therefore propose a second method that accommodates situations where target quantities do not follow a normal distribution. This approach uses Markov Chain Monte Carlo (MCMC) sampling to identify the failure status of individual samples, and is highly flexible in terms of assumptions regarding the distributions of both target quantities and measurement error. This method is further extended to include covariate information. Simulation studies show that the proposed method can substantially reduce turn-around time as compared to existing group-testing methods, particularly when covariate data is available that are highly predictive of failure. The proposed method did not perform as well when applied to a series of real datasets taken from actual pooled specimens. This may be due to measurement error variances for viral load testing that are much higher than anticipated. Discordant partner studies are commonly used to quantify per-act infectivity rates for HIV. Statistical models used to estimate these rates depend on self-reported sexual activity, which is notoriously unreliable. The degree to which misreported sexual activity can affect infectivity estimates has not previously been reported. By using a basic transmission model in the context of measurement error, we show that infectivity estimates can be severely biased, and that the size and direction of bias depends on the underlying infectivity rate and on the mean number of sex acts occurring in the observation window. We show that by modifying the size of this window, in certain circumstances it is possible to avoid measurement-error bias without having to use a more sophisticated statistical model. We also show that, when misreporting is ignored, covariate parameter estimates can be biased, particularly when subgroup differences are large or when sexual frequency is heterogeneous. Recent discordant partner studies have begun collecting sexual history data from both partners. We propose a latent-variable transmission model which incorporates data from both partners, and accounts for the mis-reporting of sex acts as well as non-overlapping recall periods. Bayes-MCMC methods are used to generate parameter estimates. Simulation studies demonstrate that the proposed method can dramatically reduce measurement-error bias for per-act infectivity estimation. We then apply this method to the Partners PrEP study dataset and show that HIV infectivity may be 25% higher than would be estimated with a naive model.

Download or read book HIV Transmission written by D. M. Basavarajaiah and published by Springer Nature. This book was released on 2019-11-29 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents models describing HIV transmission rates at population level, discussing the main statistical methods and analytical interventions. It also assesses the practical applicability of the various modelling techniques, offering readers insights into what methods are available and, more importantly, when they should be used to address HIV transmission at global level. The book includes realistic simulation models fitted to clarify the rate of HIV mother-to-child transmission (HIV MTCT), and substantiates the conclusions that can be drawn as well as the appropriate time for making global-level clinical decisions concerning people living with HIV/AIDS (PLHIVs). Intended for students, academics and researchers, the book offers more than just an introduction to the topic – it also features in-depth, yet easy-to-understand, descriptions of a new mathematical/statistical HIV mother-to-child transmission model, making it a useful resource for clinicians, public health workers and policymakers involved in implementing HIV-prevention programmes at national /global level.

Download or read book Monitoring HIV Care in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2013-01-19 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September 2010, the White House Office of National AIDS Policy commissioned an Institute of Medicine (IOM) committee to respond to a two-part statement of task concerning how to monitor care for people with HIV. The IOM convened a committee of 17 members with expertise in HIV clinical care and supportive services, epidemiology, biostatistics, health policy, and other areas to respond to this task. The committee's first report, Monitoring HIV Care in the United States: Indicators and Data Systems, was released in March 2012. The report identified 14 core indicators of clinical HIV care and mental health, substance abuse, and supportive services for use by the Department of Health and Human Services (HHS) to monitor the impact of the National HIV/AIDS Strategy (NHAS) and the Patient Protection and Affordable Care Act (ACA) on improvements in HIV care and identified sources of data to estimate the indicators. The report also addressed a series of questions related to the collection, analysis, and dissemination of data necessary to estimate the indicators. In this second report, Monitoring HIV Care in the United States: A Strategy for Generating National Estimates of HIV Care and Coverage, the committee addresses how to obtain national estimates that characterize the health care of people with HIV within the context of the ACA, both before 2014 and after 2014, when key provisions of the ACA will be implemented. This report focuses on how to monitor the anticipated changes in health care coverage, service utilization, and quality of care for people with HIV within the context of the ACA.

Download or read book Quantitative Methods for HIV AIDS Research written by Cliburn Chan and published by CRC Press. This book was released on 2017-08-07 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory data used for immune monitoring, biomarker discovery and vaccine development; the final section focuses on statistical issues in the mathematical modeling of HIV/AIDS pathogenesis, treatment and epidemiology. This book brings together a broad perspective of new quantitative methods in HIV/AIDS research, contributed by statisticians and mathematicians immersed in HIV research, many of whom are current or previous leaders of CFAR quantitative cores. It is the editors’ hope that the work will inspire more statisticians, mathematicians and computer scientists to collaborate and contribute to the interdisciplinary challenges of understanding and addressing the AIDS pandemic.

Download or read book AIDS Epidemiology written by Ron Brookmeyer and published by Oxford University Press, USA. This book was released on 1994 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to a comprehensive discussion of methods for gauging the extent of the epidemic and forecasting AIDS incidence, this book presents methods and results concerning the risks of HIV transmission, the incubation period of HIV infection, markers of disease progression, prevention strategies, including strategies to protect the blood supply, and the evaluation of treatments and vaccines. These topics are presented quantitatively, with an emphasis on the strengths and weaknesses of available data. The book highlights how a naive statistical approach to the design or analysis of such studies can lead to seriously misleading results. The various methods of monitoring and forecasting HIV disease and AIDS incidence are given thorough treatment.

Download or read book Evaluating AIDS Prevention Programs written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: With insightful discussion of program evaluation and the efforts of the Centers for Disease Control, this book presents a set of clear-cut recommendations to help ensure that the substantial resources devoted to the fight against AIDS will be used most effectively. This expanded edition of Evaluating AIDS Prevention Programs covers evaluation strategies and outcome measurements, including a realistic review of the factors that make evaluation of AIDS programs particularly difficult. Randomized field experiments are examined, focusing on the use of alternative treatments rather than placebo controls. The book also reviews nonexperimental techniques, including a critical examination of evaluation methods that are observational rather than experimentalâ€"a necessity when randomized experiments are infeasible.

Download or read book Community Collaborative Partnerships written by Mary M. McKay and published by Routledge. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Find out how best to develop HIV prevention programs that work Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts is a must read for anyone interested in developing prevention programs within high-risk urban environments. Illustrative case studies, quality research, revealing personal stories, and helpful tables and figures provide valuable insights on innovative ways to partner in the prevention of the spread of HIV in youths. Leading experts in the field offer practical strategies to dissolve the distrust individuals in a community hold for researchers not a part of that community, fostering an effective collaboration to deal with problems. The book also describes ways to go beyond the United States’ model to reveal how to replicate the same dynamic relationships in international communities. Active participation with the community and families has been found to be vital for the success of HIV/AIDS prevention efforts. Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts solves the common problem of forcing ineffective program models onto an unreceptive community. Program developers get the necessary tools to develop relationships and cultivate substantive input from those in the community to help ensure better program results. The research here is up-to-date, and the suggestions invaluable. Topics in Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts include: the role of parenting in mental health and HIV risk research findings about frequency of sexual intercourse among adolescents racial socialization and family role in HIV knowledge family influences on exposure to situations of sexual possibility preadolescent risk behavior influence on parental monitoring strategies for collaboration between community and academic HIV prevention researchers involving urban parents as collaborators in HIV prevention research motivatorsand barriersto participation of minority families in a prevention program transferring a university-led HIV prevention program to the community Trinidad and Tobago HIV/AIDS prevention using a family-based program and much more! Community Collaborative Partnerships: The Foundation for HIV Prevention Research Efforts is valuable reading for researchers, program developers, community-based organizations, public policy/advocacy organizations, community organizers, educators, and students in the fields of social work, public health, public administration, and community medicine.

Download or read book Monitoring the Health of Populations written by Ron Brookmeyer and published by Oxford University Press. This book was released on 2003-10-23 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health faces critical challenges ranging from outbreaks of new and old pathogens to the threat of bioterrorism and the impact of lifestyle and environmental changes on health. Modern tools of health surveillance and sound statistical practices are essential for meeting these challenges and providing accurate warnings about real public health threats without wasting resources on false alarms. Advances in statistical techniques, computing power and the Internet have led to many new approaches to monitoring population health, analyzing the data, and rapidly sharing it. This text explores the critical issues in the statistical analysis and interpretation of public health surveillance data. It covers statistical methods for detecting disease outbreaks and clusters, the use of survey methods, interpreting time trends and geographic patterns, exploratory statistical analysis of surveillance data, and web-based health reporting systems for the rapid detection of public health problems, among other topics. The methodological approaches are illustrated in discussions of several current public health issues, including the HIV/AIDS epidemic, anthrax, health effects of particulate air pollution, and trends in prostate cancer. The methods are broadly applicable to surveillance systems and registries for numerous health conditions, e.g. infectious diseases, chronic diseases, adverse drug reactions. The book provides numerous illustrations, worked examples, and practical information for actually implementing the methods. It will serve as a reference for public health practitioners and as a textbook for courses on disease surveillance taken by students of statistics biostatistics, epidemiology or public health.

Download or read book Methodological Challenges in Biomedical HIV Prevention Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2008-05-13 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of people infected with HIV or living with AIDS is increasing at unprecedented rates as various scientists, organizations, and institutions search for innovative solutions to combating and preventing the disease. At the request of the Bill & Melinda Gates Foundation, Methodological Challenges in Biomedical HIV Prevention Trials addresses methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials. This book recommends a number of ways to improve the design, monitoring, and analysis of late-stage clinical trials that evaluate nonvaccine biomedical interventions. The objectives include identifying a beneficial method of intervention, enhancing quantification of the impact, properly assessing the effects of using such an intervention, and reducing biases that can lead to false positive trial results. According to Methodological Challenges in Biomedical HIV Prevention Trials, the need to identify a range of effective, practical, and affordable preventive strategies is critical. Although a large number of promising new HIV prevention strategies and products are currently being tested in late-stage clinical trials, these trials face a myriad of methodological challenges that slow the pace of research and limit the ability to identify and fully evaluate effective biomedical interventions.

Download or read book Preventing and Mitigating AIDS in Sub Saharan Africa written by National Research Council (U.S.). Panel on Data and Research Priorities for Arresting AIDS in Sub-Saharan Africa and published by National Academies. This book was released on 1996-01-01 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AIDS epidemic in Sub-Saharan Africa continues to affect all facets of life throughout the subcontinent. Deaths related to AIDS have driven down the life expectancy rate of residents in Zambia, Kenya, and Uganda with far-reaching implications. This book details the current state of the AIDS epidemic in Africa and what is known about the behaviors that contribute to the transmission of the HIV infection. It lays out what research is needed and what is necessary to design more effective prevention programs.

Download or read book Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence written by World Health Organization. Department of Mental Health and Substance Abuse and published by World Health Organization. This book was released on 2009 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: "These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv

Download or read book Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection written by World Health Organization and published by . This book was released on 2016 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care. This edition updates the 2013 consolidated guidelines on the use of antiretroviral drugs following an extensive review of evidence and consultations in mid-2015, shared at the end of 2015, and now published in full in 2016. It is being published in a changing global context for HIV and for health more broadly.

Download or read book Setting Up Community Health and Development Programmes in Low and Middle Income Settings written by Ted Lankester and published by Oxford University Press. This book was released on 2019 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over half the world's rural population, and many in urban slums, have minimal access to health services. This book describes how to set up new, and develop existing, community-based health care for, by and with, the community.

Download or read book Global AIDS Monitoring 2019 written by United Nations Publications and published by UN. This book was released on 2019-04-17 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this document is to provide guidance to national AIDS programmes and partners on the use of indicators to measure and report on the country response. The 2016 United Nations Political Declaration on Ending AIDS, adopted at the United Nations General Assembly High-Level Meeting on AIDS in June 2016, mandated UNAIDS to support countries in reporting on the commitments in the Political Declaration. The Political Declaration on Ending AIDS built on three previous political declarations: the 2001 Declaration of Commitment on HIV/AIDS, the 2006 Political Declaration on HIV/AIDS and the 2011 Political Declaration on HIV and AIDS.

Download or read book AIDS Sexual Behavior and Intravenous Drug Use written by National Research Council and published by National Academies Press. This book was released on 1989-02-01 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AIDS virus is spread by human behaviors enacted in a variety of social situations. In order to prevent further infection, we need to know more about these behaviors. This volume explores what is known about the number of people infected, risk-associated behaviors, facilitation of behavioral change, and barriers to more effective prevention efforts.

Download or read book Fundamentals of Biostatistics written by Bernard Rosner and published by Cengage Learning. This book was released on 2015-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bernard Rosner's FUNDAMENTALS OF BIOSTATISTICS is a practical introduction to the methods, techniques, and computation of statistics with human subjects. It prepares students for their future courses and careers by introducing the statistical methods most often used in medical literature. Rosner minimizes the amount of mathematical formulation (algebra-based) while still giving complete explanations of all the important concepts. As in previous editions, a major strength of this book is that every new concept is developed systematically through completely worked out examples from current medical research problems. Most methods are illustrated with specific instructions as to implementation using software either from SAS, Stata, R, Excel or Minitab. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Download or read book Monitoring the Declaration of Commitment on HIV AIDS written by Joint United Nations Programme on HIV/AIDS. and published by World Health Organization. This book was released on 2005 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: On cover and title page: United Nations General Assembly Special Session on HIV/AIDS