Download or read book Biomimetic Remineralisation of Hydroxyapatite on Human Enamel and Dentine written by 曹穎 and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomimetic Remineralisation of Hydroxyapatite on Human Enamel and Dentine written by Ying Cao and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Biomimetic Remineralisation of Hydroxyapatite on Human Enamel and Dentine" by Ying, Cao, 曹穎, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Dental enamel is the highly mineralised tissue made up of approximately 95% hydroxyapatite. As the outermost layer of teeth, enamel is susceptible to caries due to the products of bacteria metabolism; or can be lost by trauma or by non-carious tooth loss resulting from dental erosion, attrition, abrasion or acidic foods. As the enamel lesions progress into dentine, tooth hypersensitivity often develops when the exposed dentine is subjected to stimuli. Traditional treatments include replacing the defected tooth structure with dental restorative materials such as amalgam, composite resin, and ceramics. However, marginal leakage, hypersensitivity and secondary caries often happens at the interface. Therefore, there is a need for scientists to design an alternative strategy to repair the tooth lesions. Biomineralisation process is an organic matrix-mediated non-classical crystallization pathway. Biomimetic mineralisation is concepts from biomineralisation trying to transfer biomineralisation principles to the regeneration of new biomaterials. This study systematically reviewed the laboratory methods on biomimetic mineralisation of demineralised human enamel and dentine, respectively. Many studies reported success in biomimetic mineralisation of enamel and dentine. However, there still exist some problems in the biomimetic mineralisation of enamel and dentine, such as remineralisation conducted under non-physiological conditions, potential contamination in natural protein-guided mineralisation, and the difficulties in reproducing the structural hierarchy of apatite deposition within the collagen matrix. Thus, we aimed to remineralise the demineralised enamel and dentine using biomimetic mineralisation methods. Firstly, we constructed an agarose hydrogel biomimetic mineralisation model to mimic the gel-like microenvironment of initial enamel formation. The tissue generated in this model had enamel prism-like layers containing well-defined hexagonal hydroxyapatite crystals. The modulus of elasticity and the nanohardness of the regenerated enamel prism-like tissue were similar to those of natural enamel. Based on this study, a follow-up study was designed by adding enamel matrix derivative in this agarose hydrogel biomimetic mineralisation model to mimic the organic matrix protein in guiding the formation of enamel prism-like tissue. Enamel matrix derivative promoted in vitro biomimetic mineralisation and facilitated enamel prism-like tissue formation on demineralised human enamel. The regeneration of enamel using this model is a promising approach for the management of enamel loss. Secondly, casein phosphopeptide-amorphous calcium phosphate was applied to the phosphorylated dentine surface to induce the biomimetic mineralisation of dentine collagen fibrils. Casein phosphopeptide-amorphous calcium phosphate could induce intrafibrillar and interfibrillar apatite crystals nucleation and growth along the phosphorylated dentine collagen fibres. We also successfully designed and fabricated a novel oligopeptide to mimic the functions of non-collagenous proteins in the biomineralisation process of dentine. Crystals were observed covering the oligopeptide-coated dentine surface, within the demineralised dentine collagen matrix and occluding dentinal tubules. This oligopeptide can induce biomimetic mineralisation of dentine. Therefore, we concluded that biomimetic mineralisation of enamel and dentine is a potential
Download or read book The Teeth and Their Environment written by Ralph M. Duckworth and published by Karger Medical and Scientific Publishers. This book was released on 2006 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a current overview of how physical, chemical and biochemical aspects of the oral environment influence tooth condition, this publication covers caries, calculus, tooth wear and erosion, and the roles of pellicle, saliva and plaque in inducing and/or moderating these conditions. It highlights topics such as new intra-oral and laboratory methods to assess tooth wear, the latest ideas on de- and re-mineralisation processes involving enamel and dentine, new insights into the tooth structure-function relationship and the site specificity of anticaries treatments. Reviews of pellicle function and of the inverse relationship between caries and calculus complete the volume. This book is recommended to all oral care scientists, laboratory and clinical researchers alike, and to lecturers in dental medicine.
Download or read book Dentine Hypersensitivity written by David G. Gillam and published by Springer. This book was released on 2015-03-05 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides wide-ranging information on the progress achieved in the diagnosis, treatment and management of dentine hypersensitivity during the past few years. Recent advances in research, including innovations in the development of desensitizing agents, are fully described and detailed attention is paid to novel clinical approaches and potential future strategies in product development. Introductory chapters cover important aspects of physiology, prevalence and aetiology and advances in diagnosis and in vitro testing techniques for dentine hypersensitivity are discussed. Dentine hypersensitivity is a troublesome clinical condition that continues to perplex the clinician despite the vast array of available treatments that have been formulated to resolve the problem. There continues to be under-reporting of the condition by clinicians and uncertainty over aetiology, diagnosis and effective management. This book will hopefully contribute in combating these deficiencies and assist the clinician in delivering optimal patient care.
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Download or read book Biomimetic Restorative Dentistry written by Pascal Magne and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Applies the biomimetic principle to bonded restorations using composite resins and ceramics, describing the broad spectrum of indications and detailing the treatment planning, diagnostic approach, step-by-step treatment, and maintenance for each"--
Download or read book Carbonated Hydroxyapatite written by Michael E. Fleet and published by CRC Press. This book was released on 2014-12-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces recent advances in understanding the crystal structure of carbonate hydroxylapatite (also known as bone mineral), which forms the hard tissue of bones and teeth. Bone mineral is the reservoir for carbon dioxide in the body and maintains the concentration of mineral ions in body fluids at homeostasis. The detailed structure of b
Download or read book Erosive Tooth Wear written by A. Lussi and published by Karger Medical and Scientific Publishers. This book was released on 2014-06-24 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erosive tooth wear is a multifactorial condition of growing concern to the clinician and the subject of extensive research. Since the publication of the first edition of the book with the title Dental Erosion, new knowledge for a better understanding of this important subject has been gathered. The new and more detailed insights resulted in this second, extended publication. It presents a broad spectrum of views, from the molecular level to behavioural aspects, as well as trends in society. In particular, the issues concerning chemical and biological factors as well as dental erosion in children are covered more extensively in this second edition. The first chapters include topics such as the definition, diagnosis, interaction, epidemiology and histopathology of tooth wear. Further, the aetiology of dental erosion, including nutritional and patient-related factors, and dental erosion in children are discussed. This book is a valuable and indispensable guide to better oral health and is highly recommended to faculty members, researchers, dental students, practitioners and other dental professionals.
Download or read book Hydroxyapatite and Related Materials written by Paul W. Brown and published by CRC Press. This book was released on 2017-12-14 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Audience Applied biomathematicians, orthopedists, clinical orthopedists.
Download or read book Dental Caries written by Zhou Xuedong and published by Springer. This book was released on 2015-10-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a well-illustrated and comprehensive guide to the etiology, clinical manifestations, diagnosis, clinical management and prevention of dental caries. Current challenging problems in the field are analyzed and the latest research findings, presented. After an introductory chapter on tooth development, the relationships of biofilm and saliva to dental caries and the significance of the balance between demineralization and remineralization for the development of carious lesions are discussed. Subsequent chapters address the state of the art in diagnosis and treatment, the implications of disease burden for prevention and the association between systemic diseases and dental caries. Dental Caries: Principles and Management is intended for dental school students, practicing dentists and researchers in dentistry.
Download or read book Calcium Phosphates in Oral Biology and Medicine written by Racquel Zapanta LeGeros and published by S. Karger AG (Switzerland). This book was released on 1991 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Planning and Care for Children and Adolescents with Dental Enamel Defects written by Bernadette K. Drummond and published by Springer. This book was released on 2014-11-24 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defective development of tooth enamel or dentin is a significant dental problem for children and adolescents in various respects, and dentists and other oral health workers find managing these problems challenging and stressful. While a considerable amount of relevant research is currently being undertaken, much further investigation is needed. This book discusses the known causes of defective dental enamel and explains why it is so difficult to restore. Most importantly, it presents the signs and symptoms that allow accurate diagnosis and documents the best contemporary management. The full range of enamel defects is considered, including defects in primary teeth and permanent teeth, associated syndromes, molar incisor hypomineralization, and genetic defects. The clinical chapters are well illustrated, providing clear guidelines for each procedure. In addition, avenues for future research are identified, with explanation of their rationale.
Download or read book Nanoscience and Nanotechnology for Human Health written by Bert Müller and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unique in combining the expertise of practitioners from university hospitals and that of academic researchers, this timely monograph presents selected topics catering specifically to the needs and interests of natural scientists and engineers as well as physicians who are concerned with developing nanotechnology-based treatments to improve human health. To this end, the book cover the materials aspects of nanomedicine, such as the hierarchical structure of biological materials, the imaging of hard and soft tissues and, in particular, concrete examples of nanotechnology-based approaches in modern medical treatments. The whole is rounded off by a discussion of the opportunities and risks of using nanotechnology and nanomaterials in medicine, backed by case studies taken from real life.
Download or read book Nanobiomaterials in Clinical Dentistry written by Karthikeyan Subramani and published by Elsevier. This book was released on 2019-04-14 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Clinical Dentistry, Second Edition shows how a variety of nanomaterials are being used to solve problems in clinical dentistry. New nanomaterials are leading to a range of emerging dental treatments that utilize more biomimetic materials that more closely duplicate natural tooth structure (or bone, in the case of implants). The book's chapters discuss the advantages and challenges of using nanomaterials and include case studies to illustrate how a variety of materials are best used in research and practice. - Contains information from an interdisciplinary, international group of scientists and practitioners in the fields of nanomaterials, dental implants, medical devices and clinical practice - Presents a comprehensive reference on the subject that covers material fabrication and the use of materials for all major diagnostic and therapeutic dental applications--repair, restoration, regeneration, implants and prevention - Complements the editors' previous book on nanotechnology applications for dentistry
Download or read book Mechanisms of Human Enamel and Dentine De and Remineralisation written by Xue Jun Gao and published by . This book was released on 1992 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Calcium Phosphate Biomaterials written by Besim Ben-Nissan and published by Springer Science & Business. This book was released on 2014-04-17 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Download or read book BiodentineTM written by Imad About and published by Springer Nature. This book was released on 2021-10-20 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to BiodentineTM, an innovative biocompatible and bioactive material based on pure tricalcium silicate that can permanently replace dentin and can also serve as a temporary enamel substitute. Although BiodentineTM has been widely used across the world for the past decade, this is the first book to be devoted to its properties, interactions with the soft and hard tissues, and its multiple clinical applications. The coverage encompasses applications in primary and permanent teeth, in specialties as diverse as restorative dentistry, endodontics, paediatric dentistry, dental traumatology, and prosthetic dentistry. BiodentineTM application both in vital pulp therapy and endodontic procedures is illustrated and clinical step by step protocols are provided. The book provides a detailed update on BiodentineTM use to preserve the pulp vitality in direct/indirect pulp capping, pulpotomy and irreversible pulpitis treatment. It also details BiodentineTM use for non-vital teeth treatment in indications such as root/furcation perforation repair, apexification as well as in regenerative endodontic procedures. BiodentineTM: Properties and Clinical Applications will be a rich source of guidance and information for all dentists as well as dental students and academics.
