Download or read book Biomechanics and Mechanobiology of Aneurysms written by Tim McGloughlin and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

Download or read book Biomechanics of Abdominal Aortic Aneurysms written by Jianhua Tong and published by . This book was released on 2013 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomechanics of Abdominal Aortic Aneurysm written by and published by . This book was released on 2013 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Abdominal Aortic Aneurysm Wall Biomechanics in Endovascular Repair Assessment written by Zinan He and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cardiovascular disease is a leading cause of death around the world. In particular, abdominal aortic aneurysm (AAA) is a top silent killer and even claimed the life of our eminent scientist Albert Einstein. Symptoms often only appear in the late stages, and since AAA involves the main artery carrying blood from the heart to the torso, it may trigger catastrophic events such as rupture and coincides with a mortality up to 90%. The prevalence in western countries is especially high, around 20,000 patients are diagnosed with AAA every year in Canada, and AAA rupture has been ranked the 15th leading cause of death for the past two decades in the United Sates. Endovascular repair (EVAR), a minimally invasive AAA treatment, was introduced in the 90’s and is considered as a promising option compared to the traditional open surgery. Regardless of the significant reduction in surgical risks and recovery time, no difference has been reported for the long-term outcome, mainly due to graft related complications. Therefore, better understanding the biomechanics of AAA, particularly in contact with endovascular devices, will provide an essential path to improve endovascular treatments.Although the biomechanics of AAA has been extensively investigated, efforts have mostly been devoted to the risks of major AAA characteristics associated with vascular rupture, such as stiffened wall, gigantic thrombus and calcification. The roles of those characteristics during the interaction with endovascular devices remain to be elucidated. Moreover, controversial understanding on the role of calcification (Ca) persists, partly due to its complicated nature and morphological variability, often resulting in oversimplification or exclusion from clinical evaluations. The intrinsic property of Ca has always been considered, however the combined effects of Ca shapes and locations have been questioned but not yet addressed. Besides, most studies have focused on major AAA characteristics, but rarely on the surrounding tissues, such as the abdominal fat despite its high prevalence. Hence, further research on the biomechanical response of AAA during EVAR, taking into account both the major AAA characteristics and the surrounding tissues, is sought.Consequently, the main objective of this thesis is to provide insight into the role of AAA wall biomechanics, specifically for the aortic Ca and surrounding tissues, in EVAR assessment. A novel quantitative and qualitative analysis, using 3D models reconstructed from clinical data to describe the extent, shape and location of Ca, has been conducted to investigate the effects of Ca morphological characteristics on EVAR outcomes. In addition, a series of hydrogel-based anthropomorphic mockups simulating the mechanical, anatomical and pathological characteristics of AAA have been developed for the first time, in order to evaluate the biomechanical interaction between endovascular devices and AAA, with and without the presence of surrounding abdominal fat. Results from Ca analysis confirmed that, not only the intrinsic properties but also the morphological characteristics of Ca, can together alter the global behavior of AAA, thus playing an essential role in EVAR assessment. Specifically, including the combined effects from Ca morphological characteristics can lead to very different prediction compared to conventional assessment, where the intrinsic property is merely considered. Furthermore, results from AAA mockup analysis highlighted the indispensable role of surrounding tissues, not only the spine but also the abdominal fat, as to account for realistic interactions with endovascular devices. The discoveries and novel approaches within the scope of this thesis have potential clinical significance which, with future revisions and validation, could improve the current knowledge in AAA biomechanics and EVAR assessment"--

Download or read book Development of an Ex Vivo Tissue Testing System for Three Dimensional Biomechanical Analysis of Abdominal Aortic Aneurysm written by Bradley Ryan Johns and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Abdominal aortic aneurysms (AAA) are localized, progressive dilations of the aortic wall and are the 13th most common cause of death in the United States (~15,000 per year) and surgery is usually recommended when the aneurysm is 5 cm or larger in diameter. Because of this clinical parameter, previous studies of AAA biomechanics have utilized a one-dimensional analysis that focuses solely on changes in wall diameter and have attempted to model geometric changes with mathematical formulas, generally based on the LaPlace equation. This is not sufficient however, as the mechanical behavior of the tissue at sites of aneurysm have been documented as being nonlinear, anisotropic, and non-homogeneous in addition to having a complex geometry. Further, since aneurysms have been found to vary in their progression, the success of such models in predicting geometric changes leading to rupture has been minimal. Therefore, an approach to quantify the 3D changes in the wall geometry of AAA is necessary for adequate estimations of the abnormal wall stresses that occur at the site of aneurysm. The overall aim of this project was to develop an ex vivo tissue testing system that will allow for 3D biomechanical analysis of aorta specimens from small animals. More specifically, we have designed, assembled, and calibrated a computer-controlled experimental setup that allows tissue samples to be pressure loaded and imaged from multiple angles at prescribed pressure increments. We have also developed custom LabVIEW scripts to control the hardware and MATLAB scripts to produce 3D images and geometry data of the specimen at these prescribed pressure levels. Our calibration study with image phantoms revealed that percent error for curvature and diameter calculations ranged between 2-10%. Additionally, aortic wall stresses under varying pressures were calculated and compared in normal tissue samples and an aorta with an artificially induced bulge. The stress levels ranged between 96-219 kPa and 15-76kPa (under 30-150 mmHg pressure) for the artificially bulging sample and normal tissues, respectively. These results demonstrated that the novel ex vivo tissue testing system developed in the present study was capable of quantifying both surface curvature and diameter of small animal aorta specimens under a wide range of pressures, allowing for wall stress estimations and opening up the possibility of more thorough testing of experimental AAA treatments.

Download or read book Computational Modeling and Simulation Examples in Bioengineering written by Nenad Filipovic and published by John Wiley & Sons. This book was released on 2021-12-14 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A systematic overview of the quickly developing field of bioengineering—with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

Download or read book Biomechanics of the Aorta written by T. Christian Gasser and published by Elsevier. This book was released on 2024-06-18 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures. Represents a comprehensive means for those involved in the aortic research and the related developments in the industry Introduces the most recent imaging technologies to characterize factors, such as aortic geometry, mechanical properties of the aortic tissue, and the local cellular activity in the vessel wall Synthesizes advances in vascular biomechanics, medical imaging and computational finite element fluid and solid models to increase understanding of aorta function

Download or read book Biomedical Technology written by Peter Wriggers and published by Springer. This book was released on 2017-08-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

Download or read book Calcific Aortic Valve Disease written by Elena Aikawa and published by BoD – Books on Demand. This book was released on 2013-06-12 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Download or read book Abdominal Aortic Aneurysm written by Igor Koncar and published by . This book was released on 2019-05-29 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, intended for all physicians who are facing patients with abdominal aortic aneurysms, has been assembled by interested, invited authors and contains important topics from basic research to clinical practice. Experimental studies focus on biomechanical and biochemical factors. In clinical practice, the decision to treat, based on risk-benefit ratio, is very delicate in patients with concomitant malignant diseases. Periprocedural risk is determined by anatomy, while aneurysms causing neck pain are one of the most frequent challenges for both open and endovascular methods. Finally, careful planning is crucial. Postoperative complications are different from post-implantation syndrome, which is still an underestimated problem, toward detection and treatment of endoleaks and eventual conversion.

Download or read book Biomechanical Assessment of Abdominal Aortic Aneurysm Rupture Risk and Growth Using Clinical Data a Probabilistic Approach written by Lukas Bruder and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Patient specific 3D Vascular Reconstruction and Computational Assessment of Biomechanics an Application to Abdominal Aortic Aneurysm written by Samarth Shankar Raut and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aneurysm written by Yasuo Murai and published by IntechOpen. This book was released on 2012-08-29 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book's focus is on diagnosis and treatment of intracranial aneurysm, abdominal and thoracic aortic aneurysms. It addresses neurosurgical, vascular and cardiothoracic surgeons and interventional radiologists, but also anyone engaged in vascular medicine. It presents is an effort to collect an up-to-date account of existing knowledge, involving recent developments in this field. Various experts described details of established knowledge or newly recognized advances associated with diagnosis, treatment, perioperative management and mechanism. This is the first book that deals with the whole body aneurysm, such as cerebral aneurysm, abdominal aneurysm, and splenial aneurysm and to learn the latest developments in other fields is always useful. I hope this book will be used worldwide by vascular surgeons and interventionalists enhancing their knowledge and stimulating the advancement of this field.

Download or read book Changes in Geometric Configuration and Biomechanical Parameters of a Rapidly Growing Abdominal Aortic Aneurysm May Provide Insight in Aneurysms Natural History and Rupture Risk written by Dresden Dresden Press and published by . This book was released on 2016-01-09 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abdominal aortic aneurysms (AAA) are currently being treated based on the maximum diameter criterion which has often been proven insufficient to determine rupture risk in case of every AAA. We analyzed a rare case of an AAA which presented an extremely fast growth focusing on biomechanical determinants that may indicate a high risk profile. The examination of such a case is expected to motivate future research towards patient-specific rupture risk estimations.

Download or read book Patient Specific Three Dimensional Vascular Reconstruction and Computational Assessment of Biomechanics an Application to Abdominal Aortic Aneurysm written by Samarth S. Raut and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomechanic and Hemodynamic Perspectives in Abdominal Aortic Aneurysm Rupture Risk Assessment written by Nikolaos Kontopodis and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abdominal aortic aneurysms (AAAs) pose a significant source of mortality for the elderly, especially if they go on undetected and ultimately rupture. Therefore, elective repair of these lesions is recommended in order to avoid risk of rupture which is associated with high mortality. Currently, the risk of rupture and thus the indication to intervene is evaluated based on the size of the AAA as determined by its maximum diameter. Since AAAs actually present original geometric configurations and unique hemodynamic and biomechanic conditions, it is expected that other variables may affect rupture risk as well. This is the reason why the maximum diameter criterion has often been proven inaccurate. The biomechanical approach considers rupture as a material failure where the stresses exerted on the wall outweigh its strength. Therefore, rupture depends on the pointwise comparison of the stress and strength for every point of the aneurysmal surface. Moreover, AAAs hemodynamics play an essential role in AAAs natural history, progression and rupture. This chapter summarizes advances in AAAs rupture risk estimation beyond the ,Äúone size fits all,Äù maximum diameter criterion.

Download or read book Vascular Biomechanics written by T. Christian Gasser and published by Springer Nature. This book was released on 2022-02-14 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations. Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination; Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system; Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.