Download or read book Biomarkers of Environmentally Associated Disease written by Samuel H. Wilson and published by CRC Press. This book was released on 2002-06-19 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The end of the 20th century brought with it a revolution in molecular biology that culminated in advances such as the completion of the human genome. This has brought optimism to the fields of toxicology and environmental health, and the anticipation that molecular biomarkers might soon come of age and have a major impact on human and environmental health. Biomarker research is an area of current interest to scientists in a number of fields that are concerned with environmental exposure to pollutants and environmentally associated disease. Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives provides comprehensive coverage of the current status and future prospects of a field that will play a key role in emerging areas of public health and medicine. It focuses on the risk to human and environmental health of exposure to persistent organic pollutants, heavy metals, airborne toxics, environmental estrogens, and other environmental pollutants. This material will aid researchers in understanding, treating, and preventing environmentally induced disease. Validated molecular biomarkers have long been recognized as invaluable tools for identifying and preventing human disease. As biomarkers begin to be applied more widely, it is also important to assure that they are implemented ethically, with attention to the social and legal issues associated with their use. Biomarkers of Environmentally Associated Disease is an outstanding resource providing state-of-the-art information for the fields that encompass molecular biomarkers.
Download or read book Biomarkers written by Vishal S. Vaidya and published by John Wiley & Sons. This book was released on 2010-10-28 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.
Download or read book Biomarkers written by David B. Peakall and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program.
Download or read book Biomarkers of Environmentally Associated Disease written by Samuel H. Wilson and published by CRC Press. This book was released on 2002-06-19 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The end of the 20th century brought with it a revolution in molecular biology that culminated in advances such as the completion of the human genome. This has brought optimism to the fields of toxicology and environmental health, and the anticipation that molecular biomarkers might soon come of age and have a major impact on human and environmental
Download or read book Biomarkers in Environmental and Human Health Biomonitoring written by Ritu Mishra and published by Elsevier. This book was released on 2024-05-29 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Environmental and Human Health Biomonitoring: An Integrated Perspective provides a holistic view of the biomonitoring of environmental degradation, accumulated toxicity, and associated human health concerns. The book incorporates theoretical and practical aspects of the biomonitoring of environmental pollution and the health surveillance of ecological communities using samples from living organisms which are analyzed for contaminants and toxin levels. In the first half, the book provides a general overview if the different types of biomarkers, their significance as bioindicators for contaminants and detection of toxicity, as well as how they can be utilized in the restoration of degraded ecosystems. The second half of the book discusses molecular biomarkers and how they are used as diagnostic and prognostic tools for pollution monitoring. It also reviews analytical tools used to validate the biomarkers in the detection and monitoring of pollution and disease. Finally, the book delves into how novel approaches like genetic ecotoxicology; Big Data, and artificial intelligence calculates the potential consequences of environmental pollution on the ecosystems and on human health. - Covers the fundamentals, types, significance, and limitations of biomarkers - Examines various types of plants, animals, and secondary metabolites in identifying and monitoring toxicity in different ecosystems and potential impacts on health - Reviews biomarker-based and bioinformatic tools in the detection and monitoring of environmental pollution and associated human health
Download or read book Biomarkers of Environmental Contamination written by 0 McCarthy and published by CRC Press. This book was released on 2018-01-18 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.
Download or read book Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants written by Curtis C. Travis and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological markers (biomarkers) are useful tools for understanding the nature and extent of human exposure and risk from environmental toxicants. Biomarkers are classified into three basic categories: exposure, effect, or susceptibility. A marker of exposure is the product of the interaction between a target cell or molecule and a foreign substance (NAS, 1989). These markers can be used to determine the biologically effective dose necessary to elicit a particular physiological change in an organism. A marker of effect is a biochemical or physiological change in an organism that can predict the onset of adverse health effects resulting from a given exposure. Lastly, markers of susceptibility act as indicators of an inherent or acquired tendency of an organism to experience an adverse health effect (NAS, 1989). These markers are already used to detect a variety of diseases and show great promise for developing a better understanding of the mechanicisms of disease. Additionally, biomarkers can be used to establish a more rational basis for quantitative risk extrapolation between species, as weIl as to obtain more precise estimates of the time of critical exposure. These markers can also prove helpful in identifying potentially damaging exposures before the onset of adverse health effects. Biomarkers serve as a valuable exposure assessment tool because they take into account exposure from all routes and integrate exposure from all sources. They have the potential to yield better risk estimates than current monitoring and modeling protocols. In lune 1992, Dr. Travis and Dr.
Download or read book Predicting Human Health Effects from Environmental Exposures written by and published by . This book was released on 2020 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of effect are measurable changes in an individual that indicate health impairment or disease. Although biomarkers have long been a crucial part of medical practice - blood pressure is a simple example - researchers have recently identified a variety of new biomarkers that signal the presence of conditions such as nervous system damage, autoimmune disorders, and cancer. Of particular interest is the potential of these new biomarkers to measure adverse health effects that may arise from exposure to environmental pollutants. On August 12-13, 2020, the Standing Committee on the Use of Emerging Science for Environmental Health Decisions of the National Academies of Sciences, Engineering, and Medicine held a 2-day workshop to explore how new biomarker approaches can be applied to understanding the consequences of environmental exposures and improve environmental health decisions. The workshop brought together a multidisciplinary group, including experts in public health, environmental health, clinical medicine, and health disparities to discuss the state of the art in biomarkers and health. This Proceedings of a Workshop-in Brief summarizes the workshop presentations and the discussions that took place among the participants.
Download or read book Use of Biomarkers for Environmental Quality Assessment written by Jean-Claude Amiard and published by CRC Press. This book was released on 2021-05-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is primarily designed for any person or organization in charge of assessment of the quality of natural resources and of pollution prevention.
Download or read book Biomarkers of Radiation in the Environment written by Michael D. Wood and published by Springer Nature. This book was released on 2022-04-04 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation. The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop: · Techniques for biomarker development · Low-dose effect mechanisms · Biomarkers for risk evaluation · Biomarkers in wildlife · Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.
Download or read book Biomarkers and Occupational Health written by Mary Janet Normandy and published by Joseph Henry Press. This book was released on 1995-02-16 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers have emerged as an exciting tool in disease prevention, particularly in the workplace. They may be used to document workers' exposure to toxins, signal the onset of health effects, or identify individuals with susceptibility to certain environmental threats. But the uncertainty is as great as the potential. Are biomarkers suitable for widespread use? How can they be deployed in diverse contexts? How can biological information about workers be handled fairly and ethically? Biomarkers and Occupational Health describes the state of biomarker development, including the implications of the Human Genome program, and presents a range of viewpoints on the future of biomarkers from the leaders in the field. This book explores the three basic types of biomarkers (markers of exposure, markers of health effects, and markers of susceptibility to disease) from a variety of perspectives. It examines what can be learned from well-known exposure sitesâ€"Hiroshima and Nagasaki, Chernobyl, and the Hanford nuclear site in the United States, for exampleâ€"and a wide range of human cases and animal studies. The book also explores the costs and ramifications of developing a large-scale program to monitor potentially exposed workers (e.g., at a cleanup site). A framework is offered for the use of biomarkers based on the mandate to "change the environment before you change the worker." The book explores how to identify ethical issues, how to set development priorities, and how to integrate biomarkers into an occupational health and safety program. The authors present the latest technical findings about markers for chronic beryllium disease as well as markers for exposure to carcinogens, radiation, and chroniumâ€"including prospects for detecting long-past exposures. Biomarkers and Occupational Health offers an update on biomarker development and explores a wide scope of issues. This book will be important to occupational health professionals, biomedical researchers, toxicologists, epidemiologists, and labor and management officials involved in worker health issues. Moritmer L. Mendelsohn, M.D., Ph.D., is Vice-Chairman of the Radiation Effects Research Foundation (RERF) in Japan, which studies the long-term health effects of the atomic blasts in Hiroshima and Nagasaki, and he is former Associate Director of the Lawrence Livermore National Laboratory in California. John P. Peeters, Ph.D., is a geneticist who is currently directing a division of the Office of Occupational Medicine for the United States Department of Energy. Mary Janet Normandy, Ph.D., is a toxicologist who specializes in the metabolism of xenobiotics in mammalian systems. She is currently a member of the Department of Energy's Office of Occupational Medicine.
Download or read book Biomarkers of Environmental Contamination written by 0 McCarthy and published by CRC Press. This book was released on 2018-01-18 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.
Download or read book Biomarkers of Exposure Effect and Susceptibility to Environmental and Occupational Chemicals written by Manosij Ghosh and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomarkers of Environmental Toxicants written by Kun Lu and published by Mdpi AG. This book was released on 2020-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
Download or read book Genomic and Epigenomic Biomarkers of Toxicology and Disease written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2022-05-02 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.
Download or read book Bioindicators and Biomarkers of Environmental Pollution and Risk Assessment written by Jamil Kaiser and published by . This book was released on 2001 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the reader with an overview of the variety of animal and plants that are available for use as environmental monitors. The author emphasizes that the use of a single species of target bioindicator is not appropriate or scientifically sound for the monitoring of several toxic pollutants.
Download or read book Environmental Exposures and Human Health Challenges written by Papadopoulou, Paraskevi and published by IGI Global. This book was released on 2019-03-15 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental health is an area with significant developments and noteworthy challenges that expand into various disciplines: medicine and public health, sociology and communications, technology, policymaking, and legislation. Due to the massive amount of health-related issues, additional literature involving environmental health is required to improve the wellbeing of citizens worldwide. Environmental Exposures and Human Health Challenges provides interdisciplinary insights into concepts and theories related to environmental exposures and human health impacts via the air, water, soil, heavy metal exposure, and other chemical toxins. The book also addresses inequalities and environmental injustices in relation to environmental exposures and health impacts. Covering topics such as health policies, pollution effects, and heavy metal exposure, this publication is designed for public health professionals, preventive medicine specialists, clinicians, data scientists, environmentalists, academicians, practitioners, researchers, and students.
