Download or read book Biomarkers for Stroke Recovery written by Pradeep Kumar and published by Frontiers Media SA. This book was released on 2023-04-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Broken Movement written by John W. Krakauer and published by MIT Press. This book was released on 2022-06-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: An account of the neurobiology of motor recovery in the arm and hand after stroke by two experts in the field. Stroke is a leading cause of disability in adults and recovery is often difficult, with existing rehabilitation therapies largely ineffective. In Broken Movement, John Krakauer and S. Thomas Carmichael, both experts in the field, provide an account of the neurobiology of motor recovery in the arm and hand after stroke. They cover topics that range from behavior to physiology to cellular and molecular biology. Broken Movement is the only accessible single-volume work that covers motor control and motor learning as they apply to stroke recovery and combines them with motor cortical physiology and molecular biology. The authors cast a critical eye at current frameworks and practices, offer new recommendations for promoting recovery, and propose new research directions for the study of brain repair. Krakauer and Carmichael discuss such subjects as the behavioral phenotype of hand and arm paresis in human and non-human primates; the physiology and anatomy of the motor system after stroke; mechanisms of spontaneous recovery; the time course of early recovery; the challenges of chronic stroke; and pharmacological and stem cell therapies. They argue for a new approach in which patients are subjected to higher doses and intensities of rehabilitation in a more dynamic and enriching environment early after stroke. Finally they review the potential of four areas to improve motor recovery: video gaming and virtual reality, invasive brain stimulation, re-opening the sensitive period after stroke, and the application of precision medicine.
Download or read book Stroke Recovery and Rehabilitation written by Richard L. Harvey, MD and published by Demos Medical Publishing. This book was released on 2008-11-20 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title 2012 Stroke Recovery and Rehabilitation is the new gold standard comprehensive guide to the management of stroke patients. Beginning with detailed information on risk factors, epidemiology, prevention, and neurophysiology, the book details the acute and long-term treatment of all stroke-related impairments and complications. Additional sections discuss psychological issues, outcomes, community reintegration, and new research. Written by dozens of acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, Stroke Recovery and Rehabilitation features: The first full-length discussion of the most commonly-encountered component of neurorehabilitation Multi-specialty coverage of issues in rehabilitation, neurology, PT, OT, speech therapy, and nursing Focus on therapeutic management of stroke related impairments and complications An international perspective from dozens of foremost authorities on stroke Cutting edge, practical information on new developments and research trends Stroke Recovery and Rehabilitation is a valuable reference for clinicians and academics in rehabilitation and neurology, and professionals in all disciplines who serve the needs of stroke survivors.
Download or read book Precision Medicine in Stroke written by Ana Catarina Fonseca and published by Springer. This book was released on 2022-05-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.
Download or read book Biomarkers of Perioperative Stroke in Older Patients written by Li Li and published by Frontiers Media SA. This book was released on 2023-05-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Blood Based Biomarkers in Acute Ischemic Stroke and Hemorrhagic Stroke written by Robert G. Kowalski and published by Frontiers Media SA. This book was released on 2022-03-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor, Prof. Heinrich Audebert, received funding from institutional funding by Roche Diagnostics International Ltd. and the Berlin Future Funds. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Download or read book FUNCTIONAL IMAGING BIOMARKERS PREDICTING UPPER LIMB RECOVERY FROM SEVERE MOTOR IMPAIRMENT AFTER STROKE written by Yun-Hee Kim and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: IntroductionUnderstanding recovery mechanism and predicting recovery outcome after stroke are important to implicate individually-tailored rehabilitation strategy. In case of recovery of upper extremity (UE) motor function, most biomarkers demonstrate low predictive power in severe stroke. This study focused on investigation of functional imaging biomarkers optimally predicting recovery of UE motor function in severe stroke patients.MethodsForty-two subacute ischemic stroke patients (24 males, mean age 57.2u00b112.4 years) with severe motor impairment participated. They underwent T1-weighted, diffusion tensor imaging, resting-state functional MRI at 2 weeks after stroke. Motor function was assessed using the Fugl-Meyer Assessment scale at 2 weeks and 3 months after stroke. Participants were divided into the Fitter and Non-fitter groups according to whether the UE motor recovery achieves 70% of initial impairment based on proportional recovery. Important neuroimaging measures were investigated; fractional anisotropy (FA) values of the corticospinal tract (CST), corpus callosum (CC), superior cerebellar peduncle (SCP), lesion load of the CST, and interhemispheric connectivity were extracted. ResultsFA value of the SCP was considered as a significant predictive biomarker for UE motor recovery in the Fitter group. FA value of the CC and strength of functional connectivity between visual and auditory areas were predictive biomarkers in the Non-fitter group.ConclusionsDomains of predictive biomarkers were different according to the recovery pattern in severe stroke. Especially, non-motor domains were considered as predictive biomarkers for UE recovery in Non-fitter group. This study implies the need to develop different strategy for UE motor recovery in severe stroke patients with highly unpredictable individuals. AcknowledgementThis study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP; NRF-2017R1A2A1A05000730, NRF-2017R1D1A1B03034109, NRF-2017M3A9G5083690) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI17C1501).
Download or read book Clinical Pathways in Stroke Rehabilitation written by Thomas Platz and published by Springer Nature. This book was released on 2021-01-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when and in which settings to provide rehabilitation over the course of recovery post stroke. Each chapter starts with a description of the clinical problem encountered. This is followed by a systematic, but concise review of the evidence (RCTs, systematic reviews and meta-analyses) that is relevant for clinical decision-making, and comments on assessment, therapy (training, technology, medication), and the use of technical aids as appropriate. Based on these summaries, clinical algorithms / pathways are provided and the main clinical-decision situations are portrayed. The book is invaluable for all neurorehabilitation team members, clinicians, nurses, and therapists in neurology, physical medicine and rehabilitation, and related fields. It is a World Federation for NeuroRehabilitation (WFNR) educational initiative, bridging the gap between the rapidly expanding clinical research in stroke rehabilitation and clinical practice across societies and continents. It can be used for both clinical decision-making for individuals and as well as clinical background knowledge for stroke rehabilitation service development initiatives.
Download or read book Stroke Biomarkers written by Philip V. Peplow and published by Humana. This book was released on 2019-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the latest data on recent achievements in new and emerging technologies for stroke biomarkers and innovations in stroke assessment. The topics discussed in this book explore the role of upcoming biomarkers in different types of stroke, and explores techniques that will allow researchers to be more effective when approaching clinical management and patient care. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to ensure successful results in the laboratory. Cutting-edge and comprehensive, Stroke Biomarkers is a valuable resource for both experimental and clinical scientists interested in expanding their knowledge in the field of stroke research.
Download or read book Precision Medicine in Stroke written by Ana Catarina Fonseca and published by Springer Nature. This book was released on 2021-05-04 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive coverage of the state of the art in precision medicine in stroke. It starts by explaining and giving general information about precision medicine. Current applications in different strokes types (ischemic, haemorrhagic) are presented from diagnosis to treatment. In addition, ongoing research in the field (early stroke diagnosis and estimation of prognosis) is extensively discussed. The final part provides an in-depth discussion of how different interdisciplinary areas like artificial intelligence, molecular biology and genetics are contributing to this area. Precision Medicine in Stroke provides a practical approach to each chapter, reinforcing clinical applications and presenting clinical cases. This book is intended for all clinicians that interact with stroke patients (neurologists, internal medicine doctors, general practitioners, neurosurgeons), students and basic researchers.
Download or read book Proteomic Analysis of Ischemic Stroke Blood Biomarkers written by April Arnold Daubenspeck and published by . This book was released on 2017 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a global burden that claims 6 million lives and permanently disables another 5 million each year. The risk of morbidity and mortality following stroke decreases when early diagnosis and treatment are achieved. However there is no blood test to diagnose ischemic stroke because biomarkers to date have not shown adequate sensitivity and specificity to be adopted into hospital protocols. The overall objective of this dissertation was to identify novel blood protein biomarkers of ischemic stroke. We achieved this by using a number of proteomic and statistical techniques to investigate the differential abundance of proteins in the blood of stroke and non-stroke groups. We identified four high-abundance serum proteins differentially expressed between the ischemic brain of stroke patients undergoing mechanical thrombectomy and the same patient's circulating arterial blood. Three proteins were significantly higher in the circulating blood, and a fourth protein had a large fold change in abundance in the ischemic blood of a few patients. We then identified an additional fourteen serum proteins with significant differences between the venous blood of stroke patients and that of healthy individuals. To expand these findings in a more clinically relevant patient group, protein concentrations for these eighteen individual proteins were evaluated in stroke patients and patients with stroke-mimicking symptoms. Separate analysis of each protein revealed a low diagnostic accuracy. A new analysis was therefore initiated to compare the concentrations of 1310 serum proteins in stroke patients and stroke-mimicking patients. We identified 27 additional proteins that were significantly different between stroke and stroke-mimicking patient groups, and used machine learning to determine combinations of these proteins that could constitute a stroke biomarker panel. Random Forest Analysis identified three protein panels which differentiated stroke from non-stroke groups. Thus, consistent with previous research, we did not find an individual blood protein that was likely to be clinically useful as a diagnostic biomarker. However, three protein biomarker panels successfully differentiated stroke patients from stroke-mimicking patients which may lead to the development of a validated point-of-care diagnostic test.
Download or read book Biomarkers for Traumatic Brain Injury written by Svetlana Dambinova and published by Royal Society of Chemistry. This book was released on 2012 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.
Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Download or read book MRI Biomarkers of Recovery for Acute Stroke written by Davide Carone and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Download or read book INFLAMMATORY AND HEMOSTASIS BLOOD BIOMARKERS PREDICT THE CLINICAL OUTCOME OF STROKE PATIENTS TREATED BY THROMBOLYSIS THROMBECTOMY written by S andrine Delbosc and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction In ischemic stroke, the lack of blood flow triggers local inflammation and vascular injury, which further promotes tissue remodeling and angiogenesis. The aim of the present study was to investigate whether biomarkers of inflammation, hemostasis, vascular injury, and tissue remodeling measured in the plasma of stroke patients could stratify stroke patients concerning their clinical outcome. MethodsWe included 153 patients consecutively admitted for ischemic stroke treated by thrombolysis with or without thrombectomy. Blood was sampled at admission and 21 biomarkers related to inflammation (MPO, Osteopontin, CCL2/MCP-1, Adiponectin, Resistin, CD40L), hemostasis (uPA/Urokinase, alpha 2-macroglobulin, Serpin C1/Antithrombin-III, Serpin E1/PAI-1, Kallikrein 6/Neurosin, CD40L), endothelium activation (VCAM-1, ICAM-1 , CD31/PECAM-1, CD40L, Neuropilin-1), and tissue remodeling (Osteopontin, MMP-2, MMP-3, MMP-9, MMP-13, Cathepsin S, Cystatin C, Neuropilin-1) were assayed by a quantitative Luminex multiplex technic. ResultsPatients with higher NIHSS at admission presented higher levels of the inflammatory biomarker MPO, the hemostasis biomarker uPA/Urokinase and the endothelial activation biomarker VCAM. Logistic regression analyses correlated levels of uPA/Urokinase to NIHSS at arrival (p=0.0037), suggesting the major role of hemostasis in initial stroke gravitymRS>1 at 3 months was correlated to higher levels of MPO, the endothelial activation biomarkers ICAM-1, VCAM-1 and the tissue remodeling biomarkers Osteopontin, Cathepsine S, and lower levels of MMP-13. Logistic regression analyses correlated mRS 0-1 at three months to levels of Cathepsine S (p=0.0201) and VCAM-1 (p=0.0048). The area under ROC curve of both biomarkers was 0.75. Symptomatic hemorrhagic transformation, defined according to ECASS-3 criteria, was correlated to MMP-9 (p=0.0382)ConclusionsAs expected, initial NIHSS was related to early hemostasis response. Importantly, initial inflammatory response, endothelial activation and tissue remodeling biomarkers significantly impact the three-month outcome and the hemorrhagic transformation.
Download or read book Neurophysiological Biomarkers of Motor Recovery in Severe Chronic Stroke written by Andreas Markus Ray and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
