Download or read book Biomarkers and Pathogenesis of Alpha Synuclein in Parkinson s Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Prognostic and Predictive Markers in Cancer Progression written by Susan Costantini Alfredo Budillon and published by MDPI. This book was released on 2021-02-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.
Download or read book Alpha Synuclein as a Biomarker for Parkinson s Disease written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parkinson s Disease written by Stewart A. Factor, DO and published by Demos Medical Publishing. This book was released on 2007-12-15 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.
Download or read book Disorders of Movement written by Davide Martino and published by Springer. This book was released on 2015-12-17 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise but comprehensive book will help interested readers in the health care professions to navigate their way through the jungle of movement disorders, including the potentially complex differential diagnosis and management. The different disorders are discussed in individual sections that explain how to examine the patient and recognize the disorder from its basic phenomenology, how to confirm a diagnosis, how to distinguish a particular disorder from related conditions, and how to treat each disorder effectively. The book makes liberal use of diagrams, algorithms, tables, summary boxes, and illustrations to facilitate solution of clinical problems at the bedside and to solidify previously learned clinical and therapeutic concepts. It will be of interest to a broad audience of health professionals, scientists, and medical students.
Download or read book Etiology and Pathophysiology of Parkinson s Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2011-10-12 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book about Parkinson's disease provides a detailed account of etiology and pathophysiology of Parkinson's disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson's disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson's disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson's disease.
Download or read book Oxidative Stress and Redox Signalling in Parkinson s Disease written by Rodrigo Franco and published by Royal Society of Chemistry. This book was released on 2017-07-25 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.
Download or read book Biomarkers in CNS originating Extracellular Vesicles for Parkinson s Disease and Multiple System Atrophy written by Hash Brown Taha and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synucleinopathies are a group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of [alpha]-synuclein ([alpha]-syn) in Lewy bodies (LBs) in PD and DLB or as glial cytoplasmic inclusions in MSA. Current antemortem differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) is challenging due to the overlap of Parkinsonian symptoms, especially in the early stages. Analysis of biomarkers in CNS-originating extracellular vesicles (EVs) isolated from blood is a promising strategy for these diseases. EVs are released by all cell types and pass through the blood-brain barrier, providing a proxy of the brain's biochemistry. We have shown previously that [alpha]-synuclein ([alpha]-syn) concentration in neuronal- and oligodendroglial-EVs (nEVs and oEVs, respectively) isolated from the serum or plasma of healthy controls (HC), and patients with PD or MSA allowed separating MSA from both HC and PD with high sensitivity and specificity. In healthy brains, only ∼4% of [alpha]-syn is phosphorylated at Ser129 (pS129-[alpha]-syn), whereas >90% pS129-[alpha]-syn may be found in LBs, suggesting that pS129-[alpha]-syn could be a helpful biomarker for synucleinopathies. Further, tau is implicated in patients with PD but not MSA. Here, I describe the development of a novel electrochemiluminescence ELISA for the measurement of pS129-[alpha]-syn in nEVs and oEVs based on the Meso Scale Discovery platform. Using this in-house assay and other commercial assays, we measured [alpha]-syn phosphorylated at Ser 129 (pS129-[alpha]-syn), total tau, and neurofilament light chain (NfL) in subsets of patients with PD, MSA or HCs to test if they improved the diagnostic power.The findings may suggest that a biomarker panel compromising nEVs [alpha]-syn, oEVs:nEVs [alpha]-syn, oEVs pS129-[alpha]-syn and exosome concentration may help distinguish patients with PD from MSA. However, many limitations currently exist with issues related to preanalytical variables, the need for independent validation and replication, differing postmortem diagnosis from the antemortem diagnosis, assay matrix effects, and issues with the L1CAM antibody, among others. Several notable limitations are associated with the current state of research in this area. These limitations encompass various factors such as preanalytical variables, the necessity for independent validation and replication, discrepancies between postmortem and antemortem diagnoses, assay matrix effects, challenges related to the L1CAM antibody, and other related issues.
Download or read book Neurodegenerative Diseases Biomarkers written by Philip V. Peplow and published by . This book was released on 2021 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alpha Synuclein Effects at the ER to Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson s Disease written by Philippe Guillaume Coune and published by . This book was released on 2011 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Experimental Models written by Samar Basu and published by Springer Science & Business Media. This book was released on 2011-04-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.
Download or read book Imaging Acute Neurologic Disease written by Massimo Filippi and published by Cambridge University Press. This book was released on 2014-09-11 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of best practice in using diagnostic imaging in acute neurologic conditions. The symptom-based approach guides the choice of the available imaging tools for efficient, accurate, and cost-effective diagnosis. Effective examination algorithms integrate neurological and imaging concepts with the practical demands and constraints of emergency care.
Download or read book DJ 1 PARK7 Protein written by Hiroyoshi Ariga and published by Springer. This book was released on 2017-11-16 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.
Download or read book Volatile Biomarkers written by Cristina Davis and published by Newnes. This book was released on 2013-03-27 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. - Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis - Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds - Includes case presentations documenting applications in multiple areas of human health and safety
Download or read book Amyloid and synuclein Cerebrospinal Fluid Biomarkers Andcognition in Early Parkinson s Disease written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropsychiatric and Cognitive Changes in Parkinson s Disease and Related Movement Disorders written by Dag Aarsland and published by Cambridge University Press. This book was released on 2013-08-29 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: A broad and in-depth discussion of the important, but still uninformed, field of behavioral disturbances associated with Parkinson's disease.
