Download or read book Biomarker Studies in Brain Aging written by Maddy Evans and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of aging refer to those biomarkers that can predict functional capacity at a later age more accurately than chronological age. Validated biomarkers of aging can enable interventions which can extend the lifespan, as any changes in the biomarkers can be observed during the life span of the organism. The levels of CD4 and CD8 memory T cells along with naive T cells are found to provide an estimate of lifespan. One of the significant biomarker of aging is the epigenetic clock, which has the capability to forecast human chronological age accurately. Some of the other prominent biomarkers of determining brain aging are proteomic clocks and neuroimaging age predictors. Furthermore, cell counts and blood chemistry can also be used for predicting chronological age accurately. This book is compiled in such a manner, that it will provide in-depth knowledge about the biomarker studies in brain aging. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this area of study have been included herein. This book will provide comprehensive knowledge to the readers.
Download or read book Reviews on Biomarker Studies in Aging and Anti Aging Research written by Paul C. Guest and published by Springer Nature. This book was released on 2019-09-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.
Download or read book Biomarkers to Disentangle the Physiological From Pathological Brain Aging written by F. G. Guerini and published by Frontiers Media SA. This book was released on 2020-06-22 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biosocial Surveys written by National Research Council and published by National Academies Press. This book was released on 2008-01-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosocial Surveys analyzes the latest research on the increasing number of multipurpose household surveys that collect biological data along with the more familiar interviewerâ€"respondent information. This book serves as a follow-up to the 2003 volume, Cells and Surveys: Should Biological Measures Be Included in Social Science Research? and asks these questions: What have the social sciences, especially demography, learned from those efforts and the greater interdisciplinary communication that has resulted from them? Which biological or genetic information has proven most useful to researchers? How can better models be developed to help integrate biological and social science information in ways that can broaden scientific understanding? This volume contains a collection of 17 papers by distinguished experts in demography, biology, economics, epidemiology, and survey methodology. It is an invaluable sourcebook for social and behavioral science researchers who are working with biosocial data.
Download or read book Preclinical Biomarkers and Functional Compensation in Brain Aging written by Panteleimon Giannakopoulos and published by Frontiers Media SA. This book was released on 2020-08-10 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolic and Vascular Imaging Biomarkers for Brain Aging and Alzheimer s Disease written by Ai-Ling Lin and published by Frontiers Media SA. This book was released on 2020-08-10 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.
Download or read book Biomarkers in Brain Disease Volume 1180 written by Simon Lovestone and published by Wiley-Blackwell. This book was released on 2009-12-07 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume presents manuscripts stemming from the conference "Biomarkers in Brain Disease" held in Oxford, United Kingdom on January 26-28, 2009."
Download or read book Biomarkers of Human Aging written by Alexey Moskalev and published by Springer Nature. This book was released on 2019-09-13 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Download or read book Metabolic and Vascular Imaging Biomarkers for Brain Aging and Alzheimer s Disease written by Ai-Ling Lin and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Biomarkers in Neurology written by Mohamed Mosaad Salama and published by Frontiers Media SA. This book was released on 2020-05-12 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Redox Signaling and Biomarkers in Ageing written by Ufuk Çakatay and published by Springer Nature. This book was released on 2021-12-02 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.
Download or read book The Neurobiology of Aging and Alzheimer Disease in Down Syndrome written by Elizabeth Head and published by Academic Press. This book was released on 2021-08-31 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Download or read book Assessments Treatments and Modeling in Aging and Neurological Disease written by Colin R Martin and published by Academic Press. This book was released on 2021-06-01 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer's, stroke and multiple sclerosis. - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging - Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's and stroke - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables
Download or read book Evidence based Dementia Practice written by Nawab Qizilbash and published by John Wiley & Sons. This book was released on 2002-05-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The era of therapeutic nihilism in dementia has ended, with the emergence of agents for symptomatic treatment, those that delay the course of the disease or prevent the onset of dementia, and new methods to manage symptoms. With the expansion of therapies, there is a clear danger of being overwhelmed by the volume of data. This book is designed to collect this information, distil what is relevant and reliable, and present it in a format that is useful to clinicians who manage and treat people with dementia. The book is designed to bring together the latest, best and practical evidence on all aspects of management, from diagnosis and therapy to social and ethical considerations. The editors are all dynamic clinicians involved in the care of patients with dementia and the evaluation of therapies. Two of the editors are the leaders of the Cochrane Collaboration for the examination of therapies for dementia. There are no other books that take such a practical and problem-oriented or approach to the diagnosis and management of dementia. Furthermore none but this can be described as truely evidence-based.
Download or read book Heterogeneity in Brain Aging written by Jasmine Alexandra Nettiksimmons and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is a neurodegenerative disease that appears in the elderly and is characterized by cognitive impairment, specifically in memory. Due to shifting demographics and improving medical technology resulting in longer lifespans, the prevalence of AD and other types of dementia is on the rise. While AD has been recognized for over a century, the scientific understanding of the biological pathways involved is still fragmentary. Definitive diagnosis of AD requires examination of the brain in an autopsy, which complicates studying the disease in living patients. A wide variety of cognitive tests exist, but intra- and inter-person variability in test-taking ability along with overlapping symptomology between different types of dementia makes precise characterization of disease more difficult. In recent years, there has been substantial development in the use of a variety of different types of biomarkers to understand AD. AD biomarkers include regional brain volume measures from MRI, measures of regional metabolism with FDG-PET, protein levels in cerebrospinal fluid (CSF), along with others. The Alzheimer's Disease Neuroimaging Initiative (ADNI) was a large, prospective study of AD biomarkers funded by a public/private partnership. Starting in 2003, ADNI enrolled approximately 800 subjects, 200 with AD, 400 with mild cognitive impairment (MCI), and 200 who were cognitively normal, and followed each group longitudinally over 2-3 years collecting repeated clinical and biological data. Although there are many biomarkers that are associated with AD, none of them is sufficiently sensitive or specific enough to be used as a diagnostic test; for most biomarkers, there is substantial overlap in distribution between the three diagnostic groups. This research focused on examining multivariate structure in AD biomarkers using unsupervised cluster analysis in an effort to understand whether subgroups exist which have clinical implications. The biomarker profiles found in both the cognitively normal controls and MCI subjects were highly informative regarding the degree and type of biological heterogeneity accompanying the relative clinical homogeneity in each diagnostic group. A small subgroup of the ADNI controls had a biomarker profile clearly characteristic of the early stages of AD at baseline, even though they were still cognitively normal. Over time, this group experienced more rapid cognitive decline than the rest of the controls. Another large subgroup of the normal controls demonstrated marked atrophy in multiple brain regions, but lacked the CSF profile characteristic of AD. Vascular damage was examined as a possible explanation, and in fact, this group was consistently associated with a variety of vascular risk factors and also exhibited significantly more cognitive decline than the typical/healthy normal cluster. There was a great deal of biological heterogeneity in the MCI group, with two of the four clusters exhibiting biomarker patterns that are not well described by the prevailing theory of AD. Finally, structurally missing data in ADNI provoked an exploration into the possibilities of using imputation techniques for clustering. Although imputation is very commonly used in regression, there is virtually no literature on its use with other statistical techniques. The simulation performed here indicated that both single and multiple imputation methods have the capacity to perform very well in a clustering context, even when the clusters are not compact and well-separated.
Download or read book Exploring Reliable Markers and Prediction Indexes for the Progression from Subjective Cognitive Decline to Cognitive Impairment written by Ying Han and published by Frontiers Media SA. This book was released on 2021-11-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
