Download or read book Biology and Treatment of High Risk CLL written by John Riches and published by Frontiers Media SA. This book was released on 2023-03-31 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.

Download or read book Chronic Lymphocytic Leukemia written by Guy B. Faguet and published by Springer Science & Business Media. This book was released on 2003-11-30 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Download or read book Utilizing Laboratory and Mouse Models to Explore High risk Genetic Determinants of Chronic Lymphocytic Leukemia written by Janek S. Walker and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the United States, historically characterized by significant genetic and clinical heterogeneity. Most patients are asymptomatic at diagnosis, where slow progression of the indolent CLL tumor burden is manageable to the point where patients can comfortably live with this disease for the full extent of their natural lifespan. Many patients, however, experience rapid tumor progression that requires intensive clinical intervention. Further, up to 10% of patients experience a morphologic CLL evolution to a rapidly progressing large B cell lymphoma, termed Richter’s Transformation, with abysmal survival outcomes frequently less than 12 months from the time of diagnosis. Advances in the understanding of CLL tumor biology have led to development of several targeted therapeutic strategies that have dramatically improved outcomes in patients with more rapid progression, nearly removing the need for systems-based cytotoxic and chemotherapeutic regimens. Despite the tremendous success with these targeted therapies, not all patients respond favorably, and new observations of therapeutic resistance and disease relapse are increasing with long term treatment using these compounds. Thus, CLL remains an incurable disease, requiring further investigation to identify treatment strategies in high-risk patient populations. Advances in genome editing techniques and tools to generate laboratory and mouse models have streamlined our understanding of genetic and epigenetic aberrations in CLL by allowing for their evaluation in the context of mammalian systems resembling the CLL disease environment. However, there remains an incomplete understanding of the physiologic impact for many the putative driving genes and cytogenetic aberrations regarding their contribution to CLL biology, and most of the CLL-specific models do not entirely recapitulate what is observed in CLL patients. Compounding this situation, no unifying genetic event has been identified in all CLL cases, making the presently available CLL tumor models inadequate for studying systems applicable to a majority of CLL patients. Overall, highlighting a need for further development of CLL models to provide a more robust characterization of the genetic complexity in CLL patients. To address this need, in these studies we have generated a suite of novel laboratory and mouse models with the intent of evaluating previously unexplored genetic aberrations with strong associations to cases of advanced CLL. Here, we explore the leukemogenic potential of recurrent E571 XPO1 mutations and discuss their role in transformation from healthy to neoplastic B cells, we use the observation of a novel chromosome translocation, t(X;14)(q28;q32), to evaluate a role for the MTCP1 gene in the development and progression of CLL, and lastly we identify aberrant PRMT5 expression as a mechanism promoting the rapid evolution from CLL to Richter’s Transformation. Using rationale from genetic aberrations in CLL patients at The Ohio State University to establish these models, we provide evidence to support aberrations in XPO1, MTCP1, and PRMT5 as major contributing factors in advanced CLL. Importantly, these new models are ideally suited for further characterization of CLL disease biology and for pre-clinical evaluation of novel therapeutic strategies for high risk CLL patients.

Download or read book Adult Acute Lymphocytic Leukemia written by Anjali S. Advani and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.

Download or read book Fast Facts Chronic Lymphocytic Leukemia written by Toby A Eyre and published by Karger Medical and Scientific Publishers. This book was released on 2022-02-11 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic lymphocytic leukemia (CLL) is the most diagnosed leukemia in the Western world, accounting for approximately 25% of all new leukemia diagnoses. In recent years, remarkable progress has been made in our understanding of both the pathophysiology and genetics of CLL. While the disease generally affects older adults and initially follows an indolent course, cytogenetic and molecular profiling have helped to predict clinical outcomes. Greater prognostication, alongside the development of an increasing armamentarium of novel targeted therapies, has enabled us to provide more personalized management options for patients. 'Fast Facts: Chronic Lymphocytic Leukemia' covers the epidemiology, etiology, diagnosis and staging of the disease, and the molecular and genetic aspects that underpin treatment and prognosis. It provides a concise overview of treatment options, in both the front-line and relapsed/refractory settings, with particular focus on the novel targeted agents that have overcome many adverse prognostic factors, improving overall survival. Table of Contents: • Epidemiology and etiology • Molecular biology and genetics • Diagnosis, staging and prognosis • Management • Research directions

Download or read book Chronic Lymphoid Leukemias Second Edition written by Bruce D. Cheson and published by CRC Press. This book was released on 2001-04-25 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters! Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago. Chronicling the complete history and variations of CLL-type leukemia, the Second Edition reviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias analyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL examines recent research on the role cytokines and regulatory molecules may play in cross-cell communication profiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production utilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations explores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications identifies how to manage infectious and psychiatric complications in patients with CLL and much more! Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine! Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.

Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Download or read book Blood and Marrow Transplant Handbook written by Richard T. Maziarz and published by Springer. This book was released on 2015-04-20 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees.

Download or read book Chronic Leukemias and Lymphomas written by Gary J. Schiller and published by Springer Science & Business Media. This book was released on 2002-10-16 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Chronic Leukemias and Lymphomas: Clinical Management, a panel of recognized experts in hematological oncology describe the unique biological features of indolent hematologic neoplasms, providing powerful insight into their clinical manifestation, highlighting potential targets for novel therapies, and distinguishing these disorders from aggressive lymphoma and Hodgkin's disease. In their integrated surveys of these chronic myeloproliferative and lymphoproliferative disorders, the authors emphasize such unique entities as prolymphocytic leukemias and cutaneous lymphomas. Special emphasis is given to the mechanisms of disease progression with authoritative insights into the promising new era of antineoplastic pharmacology.

Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Download or read book Chronic Lymphocytic Leukemia written by Inès B. Moreau and published by Nova Publishers. This book was released on 2008 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent and important research on Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, which is a type of leukemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age; over 75% of new cases are diagnosed in patients over age 50.

Download or read book Chronic Lymphocytic Leukemia written by and published by . This book was released on 2015 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Inflammation and Cognitive Function in Chronic Lymphocytic Leukemia Survivors written by AnnaLynn M. Williams and published by . This book was released on 2019 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer-related cognitive impairment (CRCI) may occur through pro-inflammatory pathways, but the role of inflammation is not fully understood and the relative contribution of cancer-related pathology and cancer treatment to CRCI is unknown. We used chronic lymphocytic leukemia (CLL), an indolent cancer of the immune system, as a novel model in which to study differential roles of disease, treatment, and inflammation in CRCI. We recruited 100 treatment nav̐e and 50 chemotherapy treated CLL patients. To examine effects of disease biology, 84 patients were categorized as high risk of progression/recurrence and 66 as low risk based on validated biomarkers. Participants self-reported level of cognitive impairment and completed objective neuropsychological tests to assess global cognition, processing speed, attention, and executive function. Serum pro-inflammatory markers, including cytokines previously implicated in CRCI, were measured using Luminex multiplex assays. Multivariable linear regression models examined cognitive outcomes in relation to patient groups (i.e. treatment and risk status) and pro-inflammatory markers, while adjusting for age, gender, race, and education. Treated participants, on average, self-reported significantly greater cognitive difficulties (? = ?6.1, 95% CI ?10.1, ?2.2) than treatment naive participants, even after adjustment for anxiety, depression, and fatigue. High-risk participants, on average, recalled almost two fewer words on a test of memory (? = ?1.79, 95% CI = ?3.4, ?0.4) and took 15 seconds longer to complete a task of executive function (? = 15.4, 95% CI = 3.1, 27.7) than low-risk participants, independent of treatment status. Contrary to expectation, increasing levels of interleukin-6 and interferon-? were associated with better global cognition (? = 1.94, 95% CI 0.59, 3.30 and ? = 1.64, 95% CI 0.46, 2.82 respectively). Increasing levels of CRP were associated with higher self-reported cognitive difficulties (? = ?2.51, 95% CI ?4.26, ?0.75). Overall, we conclude that high-risk patients may experience more impairments in executive function and memory, suggesting that disease biology may play a role in CRCI, independent of treatment. Treated patients only displayed significant self-reported cognitive difficulties that were not observed on our neuropsychological assessments. Future, larger, longitudinal studies of treatment nav̐e patients are warranted to confirm a high-risk association and define the trajectory and mechanisms of CRCI through disease progression and treatment.

Download or read book Advances in Chronic Lymphocytic Leukemia written by Sami Malek and published by . This book was released on 2013-09-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer and Aging written by M. Extermann and published by Karger Medical and Scientific Publishers. This book was released on 2013-01-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Download or read book Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues written by World Health Organization and published by IARC. This book was released on 2001 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third volume in the new World Health Organization series on histological and genetic typing of tumours. Tumours of the haematopoietic and lymphoid tissues are covered. This was a collaborative project of the European Association for Haematolpathology and the Society for Haematopathology and others. The WHO classification is based on the principles defined in the Revised European-American Classification of Lymphoid Neoplasms (REAL) classification. Over 50 pathologists from around the world were involved in the project and proponents of all major lymphoma and leukaemia classifications have agreed to accept the WHO as the standard classification of haematological malignancies. So this classification represents the first true world wide concensus of haematologic malignancies. Colour photographs, magnetic resonance and ultrasound images and CT scans are included.