Download or read book Biological Response Modifiers and Cancer Therapy written by J. W. Chiao and published by Marcel Dekker. This book was released on 1988 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Response Modifiers written by Biological Response Modifier Program (U.S.). Subcommittee on Biological Response Modifiers and published by . This book was released on 1983 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Combination Therapies written by E. Garaci and published by Springer. This book was released on 2012-10-21 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.
Download or read book Combination Therapies 2 written by E. Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd International Symposium on Combination Therapies brought together several hundred of the leading researchers, scientists and clinicians in this area to discuss new and emerging uses for biological response modifiers (BRM's) in the treatment of cancer and infectious diseases. The meeting was held during May 1-3, 1992 in Acireale, Sicily (Italy). It was hosted by Professor G. Nicoletti CU. of Catania) and organized by the Institute for Advanced Studies in Immunology and Aging (Washington, D. C. ) in collaboration with the University of Rome "Tor Vergata," the University of Catania and The George Washington University Medical Center. The synergy exhibited between BRM's and conventional therapies including bone marrow and other lymphoid cell transplants is a rapidly expanding area with significant promise for the treatment of human diseases. Advances in this area of biomedicine are leading to the rapid development of new therapeutic approaches that are being applied clinically as both primary and adjuvant therapy to enhance the effectiveness of conventional treatments. The 2nd International Symposium on Combination Therapy provided a setting for the exchange of new scientific information regarding the emerging uses for BRM's alone or in combination with conventional therapies. The 1st International Symposium on Combination Therapies was held in 1991 in Washington, D. C.
Download or read book Rationale of Biological Response Modifiers in Cancer Treatment written by Eiro Tsubura and published by . This book was released on 1985 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Response Modifiers in Human Oncology and Immunology written by Andor Szentivanyi and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of biological response modifiers has attracted the attention of many biomedical investigators, including immunologists, oncologists, pharmacologists, microbiologists, and biochemists, as well as clinical practitioners of medicine. This has occurred mainly because of the realization that the complex system of cellular and humoral interactions culminating in a productive immune response is under exquisite regulatory control for normal immune responses and that loss of control may markedly influence the capability of a host to respond in a productive manner to the numerous immunologic "insults" encountered in the environment. Furthermore, biological response modification is considered by many to be a natural offshoot of the relatively new application of "immunotherapy" to cancer. It is widely recognized that "immunotherapy" was practiced at the end of the last century and the beginning of this century when it was recognized that microbial infections were caused by distinct species of bacteria and that passive administration of serum con taining antibody to these microbes or their products could, in many cases, favorably influence the outcome of an infectious process.
Download or read book Screening for Biological Response Modifiers Methods and Rationale written by James E. Talmadge and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for "screening" drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).
Download or read book Biological Response Modifiers Interferons Double Stranded RNA and 2 5 Oligoadenylates written by W.E.G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
Download or read book Cancer Management in Man written by Paul V. Woolley and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the last in this series on cancer growth and Moreover, the current status of plant-derived vinca alka progression, is a companion volume to Volume IX and loids and non-alkaloid natural products is summarized. further explores established and novel approaches for the Advances in hyperthermia and additional approaches for therapy of patients with malignant neoplasms. The stra the therapy of malignancies are also presented. tegies reflected in these volumes are direct extrapolations The volume continues with chapters on bone marrow from the basic science of cancer biology, growth and pro transplantation as well as hematologic and nutritional sup gression described in earlier volumes of this series. Some port for the cancer patient. Blood pressure in the cancer approaches are directed towards the eradication or modifi patient, therapy for nausea and vomiting as well as pain are cation of the properties of heterogeneous malignant tumor discussed. The last chapter is devoted to the problems of the cells at various stages of tumor progression, while other terminally ill, including evaluations of the burden relatives approaches are directed towards modification of the host and friends of the cancer patient have to bear. antitumor defense systems, e. g. , enhancement of host anti It is clear that important advances in the basic science of tumor immune reactivity.
Download or read book Cancer Chemotherapy and Biological Response Modifiers Annual written by Herbert Michael Pinedo and published by . This book was released on 1987 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its ninth year the Cancer Chemotherapy Annual series has been renamed, reformatted and expanded to include a section on biological response modifiers. It is, and will remain, the only medium for oncologists to keep pace with the many thousands of articles published in their field. The international board of some seventy contributors now also includes experts in biological therapeutics, who have evaluated their segment of the international medical literature. The editors, H.M. Pinedo and B.A. Chabner, have secured the assistance of D.L. Longo, who qualifies as the director of the Biological Response Modifiers Program of the National Cancer Institute in Frederick, MD, USA.
Download or read book Biological Approaches to Cancer Treatment written by Malcolm S. Mitchell and published by McGraw-Hill Professional Publishing. This book was released on 1993 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique monograph reviews the biological principles of cancer immunotherapy & focuses specifically on biomodulation-the use of any substance to augment the host's antitumor response. Coverage begins with a detailed overview of the immunological basis on which biological therapy is grounded. Here, interactions among elements of the immune response are stressed throughout. Next, the text focuses on treatment including various forms of immunotherapy & future directions of cancer therapy in this rapidly expanding area.
Download or read book Principles of Cancer Biotherapy written by Robert K. Oldham and published by Springer Science & Business Media. This book was released on 2003 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes an evolving science and a rapidly changing medical practice. In this new millennium, it now becomes possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for patients. Some forms of cancer biotherapy use the strategy of tumour stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fourth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients, for researchers and clinicians to explore and apply these new opportunities in cancer biotherapy.
Download or read book Cancer Chemotherapy and Biological Response Modifiers written by H. M. Pinedo and published by Elsevier Science & Technology. This book was released on 1994-01-01 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is part of a series of annuals that present critical reviews of the recent developments in the pharmacology of anti-cancer agents, the area of biologicals and the clinical management of the cancer patient.
Download or read book Biological Response Modifiers written by Paul Torrence and published by Elsevier. This book was released on 2012-12-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Response Modifiers: New Approaches to Disease Intervention focuses on biological response modifiers (BRMs) and the ways they provide novel approaches to disease control. It examines how BRMs act through an organism's own biological response mechanisms and how their mechanisms of action can be utilized to develop new modalities of chemotherapy. Organized into 15 chapters, this volume begins with an overview of specific agents and approaches to biological therapy, the basic concepts of immunity, and BRM screening. It then discusses interferons and their immunoregulatory functions; mechanism of interferon action; how nucleic acids and polynucleotides regulate the immune system; clinical applications of thymosins and other thymic hormones; the antibacterial and antineoplastic properties of tuftsin; and production and characterization of tumor necrosis factor. The reader is also introduced to detection and activity of colony-stimulating factor; the role of neuroendocrine hormones in the immune system; chalones and other endogenous inhibitors of cell proliferation; biochemistry of lymphotoxins; muramyl peptides as immunopharmacological response modifiers; biological activities of transfer factor in leukocyte dialysates; and requirements for activation and growth of human lymphocytes. This book is a valuable resource for immunologists, clinicians, biochemists, and organic/medicinal chemists.
Download or read book Biological and Hormonal Therapies of Cancer written by Kenneth A. Foon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Biological and Hormonal Therapies of Cancer, which is part of the series Cancer Treatment and Research, presents selected new information concerning biologic and hormonal therapy of cancer. We have attempted to provide the reader with topics of major interest in a timely fashion. There is renewed interest in biologic therapy of cancer. Two chapters review the role of interferon in the hematologic malignancies and in solid tumors. Vaccine therapies have come to the forefront of cancer therapy re cently, and two chapters approach different strategies of vaccine therapies; one reviews the cellular vaccine therapies and another the anti-idiotype ap proach. The hormonal therapy chapters focus on current uses of endocrine therapy in endometrial, breast, and prostate cancer. In addition, hormonal strategies for the prevention of breast cancer and endometrial cancer, including excit ing information relating to phytochemicals, are presented. The effects of tamoxifen on endometrium is a topic of major interest and is discussed in detail. Finally, there is a chapter on estrogen receptor expression and regula tion in human breast cancer. These chapters are all written by experts in the field and contain timely and relevant information of interest to laboratory and clinical scientists and practitioners alike. Biologic and endocrine therapies represent major areas of cancer research interest. The advent of newer biologic therapies, including new antibody targeted treatments, and the use of biologics as tumor modulators to enhance the effects of other treatment regimens is an exploding avenue of research.
Download or read book Cancer Chemotherapy Immunotherapy and Biotherapy written by Bruce A. Chabner and published by Lippincott Williams & Wilkins. This book was released on 2018-09-06 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly revised and reformatted, the sixth edition of Cancer Chemotherapy, Immunotherapy and Biotherapy reflects recent significant changes in cancer treatment. This newly streamlined edition contains full-color illustrations, more tables for quick reference, and new immunotherapy and molecular targeted therapy content that brings you fully up to date with the state of the art in all current cancer therapies.
Download or read book Cancer Chemotherapy and Biological Response Modifiers written by Guiseppe Giaccone and published by Elsevier. This book was released on 2001 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Chemotherapy & Biological Response Modifiers Annual 19 provides its readers with a timely overview of therapeutic approaches in the areas of drugs and biologics and highlights important recent advances in the management of common cancers.Annual 19 reflects progress in the identification of new biological targets, the pre-clinical and early clinical development of target-directed therapies, and summarises the impact of these strategies on improving the outcomes of patients with cancer. The authors are internationally renowned experts who are active investigators in rapidly advancing areas of research. The contents of this new volume will ensure that its readers are kept up-to-date with the latest information relating to their fields of interest.
