Download or read book Biological Prototypes and Synthetic Systems written by E. E. Bernard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the present symposium was first conceived, it was decided that more emphasis be given to contributions from biological laboratories than has typically appeared in previous bionics meetings. Accordingly, most of the invited speakers are biologists, in the broad sense of representing some area of the life sciences. Likewise, many of the submitted papers eventually chosen by the technical com mittee were from the life sCiences, rather than the physical sciences or mathe matics. In this way, it was hoped that a greater direct interest in the technological problems of bionics might be stimulated among biologists, upon whose work much of the success of bionics necessarily lies. Because of the wide interdisciplinary span of the papers, it was necessary to impose some artificial organization upon them, specifically for continuity in the transactions. We elected to put the biological papers first, followed by those which deal with reasonably specific models, and reserveto the last those papers reporting models which are more general in nature. The editorial function was kept to a minimum, with no major alterations of content and few of style being exercised. Several of the papers delivered at the symposium required a longer format for clarity and are included here in ex panded versions. Assitance in the preparation of this volume was received from the National Institute of Neurologic Diseases and Blindness, Grant number B-3896.
Download or read book Biological Prototypes and Synthetic Systems written by Eugene E. Bernard and published by . This book was released on 1962 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Prototypes and Synthetic Systems written by Eugene E. Bernard and published by . This book was released on 1962 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Download or read book Biological Prototypes and Synthetic Systems written by Eugene E. Bernard and published by . This book was released on 1962 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Biology engineering complexity and refactoring cell capabilities written by Pablo Carbonell and published by Frontiers Media SA. This book was released on 2015-10-26 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rules of how complex behaviors arise, however, are not yet well understood. For instance, instead of considering cells as inert chassis in which synthetic devices could be easily operated to impart new functions, the presence of these systems may impact cell physiology with reported effects on transcription, translation, metabolic fitness and optimal resource allocation. The result of these changes in the chassis may be failure of the synthetic device, unexpected or reduced device behavior, or perhaps a more permissive environment in which the synthetic device is allowed to function. While new efforts have already been made to increase standardization and characterization of biological components in order to have well known parts as building blocks for the construction of more complex devices, also new strategies are emerging to better understand the biological dynamics underlying the phenomena we observe. For example, it has been shown that the features of single biological components [i.e. promoter strength, ribosome binding affinity, etc] change depending on the context where the sequences are allocated. Thus, new technical approaches have been adopted to preserve single components activity, as genomic insulation or the utilization of prediction algorithms able to take biological context into account. There have been noteworthy advances for synthetic biology in clinical technologies, biofuel production, and pharmaceuticals production; also, metabolic engineering combined with microbial selection/adaptation and fermentation processes allowed to make remarkable progress towards bio-products formation such as bioethanol, succinate, malate and, more interestingly, heterologous products or even non-natural metabolites. However, despite the many progresses, it is still clear that ad hoc trial and error predominates over purely bottom-up, rational design approaches in the synthetic biology community. In this scenario, modelling approaches are often used as a descriptive tool rather than for the prediction of complex behaviors. The initial confidence on a pure reductionist approach to the biological world has left space to a new and deeper investigation of the complexity of biological processes to gain new insights and broaden the categories of synthetic biology. In this Research Topic we host contributions that explore and address two areas of Synthetic Biology at the intersection between rational design and natural complexity: (1) the impact of synthetic devices on the host cell, or "chassis" and (2) the impact of context on the synthetic devices. Particular attention will be given to the application of these principles to the rewiring of cell metabolism in a bottom-up fashion to produce non-natural metabolites or chemicals that should eventually serve as a substitute for petrol-derived chemicals, and, on a long-term view, to provide economical, ecological and ethical solutions to today’s energetic and societal challenges.
Download or read book Systems Theory and Biology written by Mihajlo D. Mesarovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: By J OHN A. HRONES Provost, Case Institute 0/ Technology SYSTEMS have been the subject of man's study for many hundreds of years. Thus, the solar system has been the concern of the astronomer. The study of the allocation of material and human resources within the boundaries of an industrial firm or a government has been the concern of the economist. The subject of such studies have been widely known as economic systems. Medieal men have worked with the human body. Thus, man has attempted to deal with a complicated array of interconnected elements since the very earliest of recorded time. In his attcmpt to improve his understanding of physieal systems the need to concentrate on a specific kind of system, e.g., the solar system. the human body, became more imperative. However in recent years there has begun to grow and develop an increasing number of people who are working on thc development of general systems theory and analysis. Such a development is based upon the belief that certain view points, certain kinds of mathematics and technologieal procedures can be applied to a wide variety of important systems with considerable profit. The pres sures for the development of such a body of knowledge grew with the de velopment of a technologieal socicty.
Download or read book Progress in Theoretical Biology written by Fred M. Snell and published by Elsevier. This book was released on 2013-09-03 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Theoretical Biology, Volume 1 brings together the significant and timely theoretical developments in particular areas of biology. Topics range from chemical evolution and biological self-replicating systems to quantitative aspects of goal-seeking self-organizing systems. An essay on Erwin Schrödinger (1887-1961) and his work on genetics and quantum mechanics, as well as its influence on molecular biology, is also included. Comprised of five chapters, this volume first discusses chemical evolution in terms of organic geochemistry and prebiotic chemistry. Dehydration condensation reactions as well as the generation of order and new information are also considered. The next chapter deals with biological self-replicating systems and focuses on such topics as the minimum system capable of self-replication; the minimum system capable of self-replication in terms of the generalizations of terrestrial biology; and which biological systems most nearly approach this limiting behavior. A series of definitions that provide a framework for examining minimal reproducing systems are also presented. The final three chapters explore the quantitative aspects of goal-seeking self-organizing systems; statistical thermodynamics of polymerization and polymorphism of proteins; and the importance of models in theoretical biology. This book is intended for both biological and physical scientists.
Download or read book Bibliographia Biotheoretica written by Cornelis Jakob Van Der Klaauw and published by BRILL. This book was released on 2023-07-24 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Computers written by and published by Academic Press. This book was released on 1964-01-01 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: The survey articles included in Volume 5 have been selected with two aims in mind: to arrive at a balanced sampling of the computer field, and to emphasize the subjects of most active current interest. Articles cover topics such as the role of computers in delivering election results; the state of computer development in the Soviet Union and its neighbors; artificial intelligence; and applications of computers to the design of optical instruments, to nuclear reactor design, and to the determination of the structure of crystals or molecules from X-ray diffraction patterns.
Download or read book Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability written by Lucien Marie Le Cam and published by Univ of California Press. This book was released on 1967 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1965 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Intelligence written by Nazmul Siddique and published by John Wiley & Sons. This book was released on 2013-05-06 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Intelligence: Synergies of Fuzzy Logic, Neural Networks and Evolutionary Computing presents an introduction to some of the cutting edge technological paradigms under the umbrella of computational intelligence. Computational intelligence schemes are investigated with the development of a suitable framework for fuzzy logic, neural networks and evolutionary computing, neuro-fuzzy systems, evolutionary-fuzzy systems and evolutionary neural systems. Applications to linear and non-linear systems are discussed with examples. Key features: Covers all the aspects of fuzzy, neural and evolutionary approaches with worked out examples, MATLAB® exercises and applications in each chapter Presents the synergies of technologies of computational intelligence such as evolutionary fuzzy neural fuzzy and evolutionary neural systems Considers real world problems in the domain of systems modelling, control and optimization Contains a foreword written by Lotfi Zadeh Computational Intelligence: Synergies of Fuzzy Logic, Neural Networks and Evolutionary Computing is an ideal text for final year undergraduate, postgraduate and research students in electrical, control, computer, industrial and manufacturing engineering.
Download or read book System Theories and A Priori Aspects of Perception written by J.S. Jordan and published by Elsevier. This book was released on 1998-04-21 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book takes as a starting point, John Dewey's article, The Reflex Arc Concept in Psychology, in which Dewey was calling for, in short, the utilisation of systems theories within psychology, theories of behaviour that capture its nature as a vastly-complex dynamic coordination of nested coordinations. This line of research was neglected as American psychology migrated towards behaviourism, where perception came to be thought of as being both a neural response to an external stimulus and a mediating neural stimulus leading to, or causing a muscular response. As such, perception becomes a question of how it is the perceiver creates neural representations of the physical world. Gestalt psychology, on the other hand, focused on perception itself, utilising the term Phenomenological Field; a term that elegantly nests perception and the organism within their respective, as well as relative, levels of organisation. With the development of servo-mechanisms during the second world war, systems theory began to take on momentum within psychology, and then in the 1970s William T Powers brought the notion of servo-control to perception in his book, Behavior: The Control of Perception. Since then, scientists have come to see nature not as linear chain of contingent cause-effect relationships, but rather, as a non linear, unpredictable nesting of self referential, emergent coordinations, best described as Chaos theory. The implications for perception are astounding, while maintaining the double-aspect nature of perception espoused by the Gestalt psychologists. In short, system theories model perception within the context of a functioning organism, so that objects of experience come to be seen as scale-dependent, psychophysically-neutral, phenomenological transformations of energy structures, the dynamics of which are the result of evolution, and therefore, a priori to the individual case. This a priori, homological unity among brain perception and world is revealed through the use of systems theories and represents the thrust of this book. All the authors are applying some sort of systems theory to the psychology of perception. However, unlike Dewey we have close to a century of technology we can bring to bear upon the issue. This book should be seen as a collection of such efforts.
Download or read book Current Research and Development in Scientific Documentation written by and published by . This book was released on 1964 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Research and Development in Scientific Documentation written by National Science Foundation (U.S.). Office of Scientific Information and published by . This book was released on with total page 942 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Automata A Discrete Universe written by Andrew Ilachinski and published by World Scientific Publishing Company. This book was released on 2001-07-03 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular automata are a class of spatially and temporally discrete mathematical systems characterized by local interaction and synchronous dynamical evolution. Introduced by the mathematician John von Neumann in the 1950s as simple models of biological self-reproduction, they are prototypical models for complex systems and processes consisting of a large number of simple, homogeneous, locally interacting components. Cellular automata have been the focus of great attention over the years because of their ability to generate a rich spectrum of very complex patterns of behavior out of sets of relatively simple underlying rules. Moreover, they appear to capture many essential features of complex self-organizing cooperative behavior observed in real systems.This book provides a summary of the basic properties of cellular automata, and explores in depth many important cellular-automata-related research areas, including artificial life, chaos, emergence, fractals, nonlinear dynamics, and self-organization. It also presents a broad review of the speculative proposition that cellular automata may eventually prove to be theoretical harbingers of a fundamentally new information-based, discrete physics. Designed to be accessible at the junior/senior undergraduate level and above, the book will be of interest to all students, researchers, and professionals wanting to learn about order, chaos, and the emergence of complexity. It contains an extensive bibliography and provides a listing of cellular automata resources available on the World Wide Web.
