Download or read book Biological aspects of targeted drug discovery Development of novel targets and or chemotherapies and drug repurposing written by Sandeep Singh and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Targeted Drugs for the Treatment of Lymphoma written by Owen A. O'Connor and published by Humana Press. This book was released on 2014-03-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, there has been an explosion in the number of new drugs being developed for the treatment of cancer. This has become particularly true in the case of lymphoma. However, what frequently remains unclear to many is that this increase in new agents, and the often novel targets they affect, is a direct product of our never ending quest to understand the fundamentals of cancer cell biology. Targeting these unique pathogenetic mechanisms is the most attractive strategy for altering the natural history of any malignancy, and the pace at which we are clarifying this biology is truly daunting. One of the primary goals of Novel Targeted Drugs for the Treatment of Lymphoma is to emphasize this new biology, allowing it it become the cornerstone for understanding how and why these novel agents are moving rapidly into the mainstream of patient care. Each section starts with a comprehensive chapter on the important aspects of the relevant biology, written by an authority in that field. Subsequent chapters focus on discrete agents, and how they establish the 'proof of principle'. Every effort is made to present a fair and unbiased account of those agents, with particular attention being paid to those compounds that appear the most differentiated. Well organized and easy to read, this book is a valuable resource for all practitioners in the field.
Download or read book Drug Repurposing written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2020-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.
Download or read book Introduction to Biological and Small Molecule Drug Research and Development written by C. Robin Ganellin and published by Academic Press. This book was released on 2013-05-07 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. - For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level - Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs - Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development
Download or read book Drug Repurposing written by Mithun Rudrapal and published by BoD – Books on Demand. This book was released on 2023-06-07 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repurposing (or drug repositioning) is defined as the process of identifying new pharmacological indications of old, existing, investigational, or FDA-approved drugs for use in the treatment of diseases other than the drugs’ original intended therapeutic use. Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery delivers up-to-date information on the identification of newer uses, molecular mechanisms, and novel targets of existing drug candidates through the application of various experimental, biophysical, and computational approaches and techniques. Chapters discuss recent advances in drug repurposing strategies that are currently being used in the discovery and development of drugs against difficult-to-treat, rare, and life-threatening diseases, including microbial infections, COVID-19, parasitic diseases, cardiovascular diseases, neurological disorders, and cancer. The book also discusses the modern experimental assays (HTS) and computational techniques including informatics and databases, molecular docking and dynamics, artificial intelligence and machine learning, virtual screening and pharmacophore modeling, proteomics and metabolomics, and network pharmacology and systems biology approaches. Some of the key features of the book are: • Presents the strategies available for the development of drugs by drug repurposing approaches through various experimental and computational techniques for the treatment of difficult-to-treat, rare, and deadly diseases • Summarizes the latest advances in the application of drug repurposing strategies, techniques, and approaches in the discovery and development of drugs • Depicts drug development approaches from existing drug candidates and/or lead molecules through modern experimental assays, biophysical tools, and computational techniques Written by a global team of experts, this book is useful for drug discovery scientists, drug developers, medicinal chemists, phytochemists, pharmacologists, clinicians, biochemists, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.
Download or read book Human Drug Targets written by Edward D. Zanders and published by Wiley-Blackwell. This book was released on 2015-10-19 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Target Validation in Drug Discovery written by Brian W. Metcalf and published by Elsevier. This book was released on 2011-04-28 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
Download or read book Unique Aspects of Anti cancer Drug Development written by Jolanta Natalia Latosińska and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evidence of cancer in humans, animals and plant species suggests that it is as old as multicellular life on Earth. Why is it so difficult to understand and fight? Because cancer begins from the organism's own mutated single cell focused on its own survival. It would be naive to expect that cancer could be ever entirely eliminated, but there is still hope for finding effective treatments. The book is to give a view of selected aspects of cancer like its spread in nature, novel anticancer drugs based on Chinese herbs or birch bark, novel promising targets of annexins and kinases and progress in immunotherapy. It is our hope that you will find in this book interesting, inspiring and stimulating information concerning cancer research.
Download or read book New Frontiers in Chemical Biology written by Mark E. Bunnage and published by Royal Society of Chemistry. This book was released on 2011 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.
Download or read book DEVELOPMENT OF NOVEL COMPUTATIONAL METHODS FOR DRUG DISCOVERY AND REPURPOSING IN ONCOLOGIC DISEASES AND OTHER ILLNESSES written by Naiem Tony Issa and published by . This book was released on 2015 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting disease-related proteins is important for drug discovery, yet target-based method have not been fruitful. Bottlenecks involve: (1) establishing biologically valid drug- protein target associations, and (2) assessing the physiologic effects of those interactions at the systems level. Here we develop novel computational methods for overcoming these challenges. For the accurate prediction of drug-target interactions, we investigate the ability of two independent proteochemometric methods entitled R-TMFS and ES-Screen to prioritize known drug binders over decoys for diverse sets of protein targets. R-TMFS is a docking-based method that incorporates molecule shape and physicochemical properties, whereas ES-Screen is an electrostatics-driven method that accentuates the role of electrostatics in biomolecular recognition and binding kinetics. R-TMFS and ES-Screen are also used to predict previously un-reported kinase targets for the anti-hookworm medication mebendazole. Follow-up in vitro binding assays confirm mebendazole inhibition of multiple kinases such as ABL1, JAK2, JNK3, and RAF1, attesting to the repurposing potential of mebendazole for various cancers. For higher-order physiologic contextualization of drug-target signatures, we devised a computational platform named NET-TMFS that annotates drugs with biological endpoint effects including protein-protein interactions, signaling pathways, molecular functions, and disease effects. NET-TMFS recapitulated over 50 drug-disease, 100 drug-pathway, and drug-PPI associations established in the literature. NET-TMFS also predicted potential carcinogenic effects of the cholesterol-lowering drug ezetimibe, a phenomenon documented in clinical trials. In summary, we have developed novel computational methods for addressing major bottlenecks in the drug discovery process. We hope our methods will aid in finding effective therapeutics for many diseases with greater efficiency and lower costs.
Download or read book Drug Repurposing written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2022-06-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.
Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Download or read book Genome Based Therapeutics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-11-21 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many suspected causes for this trend, including increases in regulatory barriers, the rising costs of scientific inquiry, a decrease in research and development efficiency, the downstream effects of patient expirations on investment, and the lack of production models that have successfully incorporated new technology. Regardless, this trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development, whether with other industrial firms, academia, or government. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to reverse the trends highlighted above, while producing more effective drugs in the process. Genome-Based Therapeutics explains that new technologies have the potential to open up avenues of development and to identify new drug targets to pursue. Specifically, improved validation of gene-disease associations through genomics research has the potential to revolutionize drug production and lower development costs. Genetic information has helped developers by increasing their understanding of the mechanisms of disease as well as individual patients' reactions to their medications. There is a need to identify the success factors for the various models that are being developed, whether they are industry-led, academia-led, or collaborations between the two. Genome-Based Therapeutics summarizes a workshop that was held on March 21, 2012, titled New Paradigms in Drug Discovery: How Genomic Data Are Being Used to Revolutionize the Drug Discovery and Development Process. At this workshop the goal was to examine the general approaches being used to apply successes achieved so far, and the challenges ahead.
Download or read book Natural Products and Cancer Drug Discovery written by Frank E. Koehn and published by Springer Science & Business Media. This book was released on 2012-11-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.
Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Download or read book Drug Discovery and Development written by Raymond G Hill and published by Elsevier Health Sciences. This book was released on 2021-05-16 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry. Key stages of drug discovery and development Chapters outline the contribution of individual disciplines to the overall process Supplemented by specific chapters on different modalities Includes coverage of Oligonucleotide therapies; cell and gene therapy Now comes with online access on StudentConsult
Download or read book Designing Multi target Drugs written by J. Richard Morphy and published by Royal Society of Chemistry. This book was released on 2012 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements, and the challenges of the field and lessons learned by researchers.
