Download or read book Biochemical and Immuno Histochemical Analysis of APP Processing and Amyloid Pathology in Single and Multiple Transgenic Mice as Models for Alzheimer s Disease written by Tom V. Dooren and published by Leuven University Press. This book was released on 2006-09 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Contractility and Ca2 Handling in Mouse Models of Type II Diabetes written by An Van Den Bergh and published by Leuven University Press. This book was released on 2006-12 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vitro and in Vivo Analysis of the Role of PEX 19 P Farnesylation and PEX 14P Phosphorylation in Peroxisome Biogenesis written by Ilse Vastiau and published by Leuven University Press. This book was released on 2006-12 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Expression and Function of a Serotoninergic System in the Rat Anterior Pituitary written by Anna-Pia Papageorgiou and published by Leuven University Press. This book was released on 2006-12 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrical Brain Stimulation in Psychiatric Disorders Contributions from Research in Animal Models written by Kris Van Kuyck and published by Leuven University Press. This book was released on 2006 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Il 6 Il 8 on Respiratory Peripheral Skeletal Muscle Function written by Sofie Janssen and published by Leuven University Press. This book was released on 2006-12-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Axon Growth Injury and Regeneration in the Fly Brain written by Maarten Leyssen and published by Leuven University Press. This book was released on 2006 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitric Oxide and Cytochrome P450 Signaling in Experimental Pulmonary Hypertension written by Peter Pokreisz and published by Leuven University Press. This book was released on 2006 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantification of Regional Myocardial Deformation Normal Characteristics and Clinical Use in Ischaemic Heart Disease written by Lieven Herbots and published by Leuven University Press. This book was released on 2006 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Evaluation of the Host Immune Response to Xenogenic Bio derived Collagen Grafts in Rodent Models written by Fang Zheng and published by Leuven University Press. This book was released on 2006-09 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Repopulation of Bioprosthetic Heart Valves written by Jessa Yperman and published by Leuven University Press. This book was released on 2006 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amyloid Proteins written by Einar M. Sigurdsson and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Download or read book The Biology of Alzheimer Disease written by Dennis J. Selkoe and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.
Download or read book Molecular Pathology of Alzheimer s Disease written by Rudy Castellani and published by Biota Publishing. This book was released on 2013-10-01 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Download or read book Encyclopedia of Psychopharmacology written by Ian Stolerman and published by Springer Science & Business Media. This book was released on 2010-07-31 with total page 1433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Download or read book Cyclin Dependent Kinase 5 Cdk5 written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Download or read book Statistical Analysis of Behavioural Data written by Patsy Haccou and published by Oxford University Press, USA. This book was released on 1994 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a how-and-why-to-do-it book for students and scientists in all the behavioral sciences. It presents sophisticated statistical methods for analyzing continuous-time records of behavior, and integrates many recent developments in ethology, mathematical modeling, statistics, and technology. These new methods are explicitly designed to handle sequential or simultaneous acts where neither the duration nor the sequence of the acts is predetermined, which is often the case if the time scale on which behavior is studied is relatively short. The authors show how to analyze behavioral data starting with a basic model, the continuous time Markov chain. They then indicate how and when this model can be generalized and demonstrate the suitability of their approach for detecting, for example, the effects of different experimental treatments or of gradual changes in the social or physical environment. Competitive interactions such as predator-prey or host-parasite are also good subjects for this type of analysis. There are eight chapters and many worked examples, leading the reader through the mathematical processes and their applications. Students and researchers in all fields of behavioral science will find this book incomparably useful for planning and performing data analysis.
