Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.

Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by . This book was released on 2014-01-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioactive Microbial Metabolites written by Vaibhav Mishra and published by Elsevier. This book was released on 2024-06-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation and purification of bioactive metabolites, the book also provides an understanding of the metabolic pathways for bioactive metabolites production that play an important role in modern healthcare as frontline treatments for many diseases. This is a valuable reference for research students, academicians and scientists in environmental microbiology and biotechnology, and for industry personnel related to microbiology/ biotechnology. The science discussed herein plays an important role in expanding the market of antibiotics, food and agriculture but also offers eco-friendly, safer and profitable solutions to respective industries. Focuses on the identification and structure elucidation of novel microbial metabolites Uncovers extended functions of microbial metabolites Provides understanding of metabolic pathways for bioactive metabolites production by using several illustrations, figures and tables so that the readers can easily grasp key concepts

Download or read book Pharmaceuticals from Microbes written by Divya Arora and published by Springer. This book was released on 2019-02-12 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance of probiotics and their specialized molecules in human health and disease as well as their role in dietary intervention for reducing the risk of non-alcoholic fatty liver disease. This work also serves as excellent reference material for researchers, students and academicians in the field of natural product chemistry, pharmacology and applied microbiology.

Download or read book Bioactive Metabolites from Microorganisms written by M. E. Bushell and published by Elsevier Publishing Company. This book was released on 1989 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.

Download or read book Volatiles and Metabolites of Microbes written by Ajay Kumar and published by Academic Press. This book was released on 2021-06-22 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues Provides a broad aspect about volatiles, bioactive compounds, and secondary metabolites of microbes compiled in one cover Gives the latest research and advancement in the field of volatiles, secondary metabolites, and bioactive compounds synthesized from the different microbial strains Responds to new developments in the detection of the complex compound structures of volatiles Offers insight to a very broad audience in Biotechnology, Applied Microbiology, Agronomy, and Pathology

Download or read book Microbial Secondary Metabolites and Biotechnology written by and published by . This book was released on 2022-03-02 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isolation Structure Synthesis and Biosynthesis of Selected Bioactive Microbial Metabolites written by Andrew Lawrence Staley and published by . This book was released on 1990 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biosynthetic origin of the $meta$-C$\sb7$N unit of the naphthoquinoid chromophore of the streptovaricins was shown to be 3-amino-5-hydroxybenzoic acid (AHBA) through carbon-14 and carbon-13 labeling studies. ($Carboxy$-$\sp{14}$C) AHBA was incorporated at a rate of 0.1% into streptovaricin C, and ($carboxy$-$\sp{13}$C) AHBA gave an enrichment factor of 21 for the resonance corresponding to the C-21 carbonyl in the $\sp{13}$C NMR spectrum of labeled streptovaricin C. The optimization of incorporation of labeled glucose and the production of mutants of Streptomyces spectabilis are also discussed. A detailed analysis of the $\sp1$H and $\sp{13}$C NMR spectra of streptovaricin C is described. Two new series of metabolic products were isolated from modified culture broths of S. spectabilis. The first series of compounds were members of the aureolic acid class of antibiotics and were trivially named the spectomycins. The compounds were isolated as monomeric and dimeric forms of the same chromophore structure. The second series of compounds proved to be cyclic depsipeptides that were closely related to the monamycins, but differed from the latter by one oxygen atom. The new compounds were trivially named the deoxymonamycins. The synthesis of the iron-chelating siderophore pyochelin, isolated from Pseudomonas aeruginosa, was reinvestigated, and a significant improvement in the overall yield of four of the eight possible diastereomers of the compound was realized. The relative and absolute stereochemistry of the four diastereomers was assigned through a combination of spectroscopic, crystallographic, and chemical analyses.

Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Omura and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.

Download or read book The Need to Use Microorganisms and Their Biosynthesized Bioactive Metabolites for Biological and Medical Activities written by Zeinab Amanzadeh and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some microorganisms (MOs) such as bacteria, fungi and aquatic creatures synthesize bioactive secondary metabolites synthesis that known as natural products. A series of landmark metabolomics studies by using mass spectrometry (MS) or nuclear magnetic resonance (NMR) analysis to identify potentially important microbial metabolites that derive from the intestine microbes. Vital roles for numerous microbial metabolic pathways in host physiology had been long established, such as in the synthesis of vitamin K and the synthesis of water-soluble B vitamins including biotin, folates, nicotinic acid, pyridoxine, riboflavin, cobalamin and panthotenic acid, the degradation of nutritional oxalates, and amendment of bile salts. These metabolites have biological and medical activities. The medical activities including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory, antibiotic, antitumor, antioxidant activities, etc. Also biological activities derive from metabolites microbial transformation have effects on physiological processes such as gut and immune homeostasis, energy metabolism, vascular function, and neurological behavior such as short-chain fatty acids, trimethylamine N-oxide, tryptophan and tyrosine derivatives, and oxidized fatty acids. Using recombinant DNA technology synthesize a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical. Such interventions will require modulating either bacterial species or the bacterial biosynthetic enzymes required to synthesis these metabolites.

Download or read book Actinobacteria Prolific Producers of Bioactive Metabolites written by Learn-Han Lee and published by Frontiers Media SA. This book was released on 2020-12-09 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book New Approaches to the Detection of Bioactive Microbial Metabolites written by Society for Industrial Microbiology (U.S.) and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Microbial Secondary Metabolites Recent Developments and Technological Challenges written by Bhim Pratap Singh and published by Frontiers Media SA. This book was released on 2019-08-02 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on microbes plays an essential role in the improvement of biotechnological and biomedical areas. It has turned into a subject of expanding significance as new organisms and their related biomolecules are being characterized for several applications in health and agriculture. Microbial biomolecules confer the ability of microbes to cope with a range of adverse conditions. However, these biomolecules have several advantages over the plant origin, which makes them a suitable target in drug discovery and development. The reasons could be that microbial sources can be genetically engineered to enhance the production of desired natural production by large-scale fermentation. The interaction between microbes and their biotic and abiotic environment is fundamental to numerous processes taking place in the biosphere. The natural environments and hosts of these microorganisms are extremely diverse being reflected by the fact that microbes are widespread and occur in nearly every biological community on Earth. This metabolic versatility makes microbes interesting objects for a range of economically important biotechnological applications. Most of the biotechniques are established but inefficient genetic engineering strategies are still a bottleneck for selected microbe producing industrial scale biomolecules. Therefore, untapped microbial biodiversity and related metablomics, give a noteworthy wellspring of biologicals for the advancement of meds, immunizations, enhanced plants and for other natural applications. The present eBook volume contains articles on microbial secondary metabolites, microbial biosynthetic potential including biosynthetic gene expression, and metagenomics obtained from microorganism isolated unique from habitats like marine sources, endophytes, thermal springs, deserts, etc.

Download or read book Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Microbial Sources written by Kate J. Graham and published by . This book was released on 1994 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial organisms often produce biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay- guided fractionations were employed on a variety of natural products sources. Active compounds were characterized by spectroscopic analysis and X-ray diffraction methods. As a result of these studies, six projects were completed, resulting in the purification of a diverse range of compounds containing activity in a variety of assays. A coumarin and parahydroxyphenylethanol were determined to possess phytotoxic activity from fungal pathogens. Two novel C-glycosidic compounds from a bacterial plant pathogen were found to be the first low molecular weight elicitors of the hypersensitive response in plants. A verticillin of the epi-polythiodiketopiperazine class isolated from a soil fungus was discovered to be responsible for inhibition of ras farnesylation transferase. Leafcutter ants were found to be deterred by the presence of a novel sesqualterpenoid in epiphylls. Finally, inhibitors of the PDGF receptor were isolated and characterized from a lichen.

Download or read book Extremophilic Microbes and Metabolites written by Afef Najjari and published by BoD – Books on Demand. This book was released on 2021-02-24 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the diversity and biotechnological applications of metabolites produced by extremophilic microbes thriving in different ecological niches citing the low troposphere, the gastrointestinal tract of ruminants, tropical dry forest, and saline ecosystems. These studies were based on metabolomics and molecular approaches like metagenomics and single-cell genomic analyses. Various implications of Electro-Rheological Fluid are also discussed. The editor embarked on this writing project entitled “Extremophilic Microbes and Metabolites - Diversity, Bioprospecting, and Biotechnological Applications” to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will benefit from the chapters of this book.

Download or read book Biotechnology of Bioactive Compounds written by Vijai Kumar Gupta and published by John Wiley & Sons. This book was released on 2015-04-20 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career