Download or read book Genome Wide Association Studies written by Tatsuhiko Tsunoda and published by Springer Nature. This book was released on 2019-10-31 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.
Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Download or read book Direct to Consumer Genetic Testing written by National Research Council and published by National Academies Press. This book was released on 2011-01-16 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, scores of companies, primarily in the United States and Europe, are offering whole genome scanning services directly to the public. The proliferation of these companies and the services they offer demonstrate a public appetite for this information and where the future of genetics may be headed; they also demonstrate the need for serious discussion about the regulatory environment, patient privacy, and other policy implications of direct-to-consumer (DTC) genetic testing. Rapid advances in genetic research already have begun to transform clinical practice and our understanding of disease progression. Existing research has revealed a genetic basis or component for numerous diseases, including Parkinson's disease, Alzheimer's disease, diabetes, heart disease, and several forms of cancer. The availability of the human genome sequence and the HapMap, plummeting costs of high-throughput screening, and increasingly sophisticated computational analyses have led to an explosion of discoveries of linkages between patterns of genetic variation and disease susceptibility. While this research is by no means a straight path toward better public health, improved knowledge of the genetic linkages has the potential to change fundamentally the way health professionals and public health practitioners approach the prevention and treatment of disease. Realizing this potential will require greater sophistication in the interpretation of genetic tests, new training for physicians and other diagnosticians, and new approaches to communicating findings to the public. As this rapidly growing field matures, all of these questions require attention from a variety of perspectives. To discuss some of the foregoing issues, several units of the National Academies held a workshop on August 31 and September 1, 2009, to bring together a still-developing community of professionals from a variety of relevant disciplines, to educate the public and policy-makers about this emerging field, and to identify issues for future study. The meeting featured several invited presentations and discussions on the many technical, legal, policy, and ethical questions that such DTC testing raises, including: (1) overview of the current state of knowledge and the future research trajectory; (2) shared genes and emerging issues in privacy; (3) the regulatory framework; and (4) education of the public and the medical community.
Download or read book Empirical Inference written by Bernhard Schölkopf and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book honours the outstanding contributions of Vladimir Vapnik, a rare example of a scientist for whom the following statements hold true simultaneously: his work led to the inception of a new field of research, the theory of statistical learning and empirical inference; he has lived to see the field blossom; and he is still as active as ever. He started analyzing learning algorithms in the 1960s and he invented the first version of the generalized portrait algorithm. He later developed one of the most successful methods in machine learning, the support vector machine (SVM) – more than just an algorithm, this was a new approach to learning problems, pioneering the use of functional analysis and convex optimization in machine learning. Part I of this book contains three chapters describing and witnessing some of Vladimir Vapnik's contributions to science. In the first chapter, Léon Bottou discusses the seminal paper published in 1968 by Vapnik and Chervonenkis that lay the foundations of statistical learning theory, and the second chapter is an English-language translation of that original paper. In the third chapter, Alexey Chervonenkis presents a first-hand account of the early history of SVMs and valuable insights into the first steps in the development of the SVM in the framework of the generalised portrait method. The remaining chapters, by leading scientists in domains such as statistics, theoretical computer science, and mathematics, address substantial topics in the theory and practice of statistical learning theory, including SVMs and other kernel-based methods, boosting, PAC-Bayesian theory, online and transductive learning, loss functions, learnable function classes, notions of complexity for function classes, multitask learning, and hypothesis selection. These contributions include historical and context notes, short surveys, and comments on future research directions. This book will be of interest to researchers, engineers, and graduate students engaged with all aspects of statistical learning.
Download or read book The Maize Genome written by Jeffrey Bennetzen and published by Springer. This book was released on 2018-11-24 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses advances in our understanding of the structure and function of the maize genome since publication of the original B73 reference genome in 2009, and the progress in translating this knowledge into basic biology and trait improvement. Maize is an extremely important crop, providing a large proportion of the world’s human caloric intake and animal feed, and serving as a model species for basic and applied research. The exceptionally high level of genetic diversity within maize presents opportunities and challenges in all aspects of maize genetics, from sequencing and genotyping to linking genotypes to phenotypes. Topics covered in this timely book range from (i) genome sequencing and genotyping techniques, (ii) genome features such as centromeres and epigenetic regulation, (iii) tools and resources available for trait genomics, to (iv) applications of allele mining and genomics-assisted breeding. This book is a valuable resource for researchers and students interested in maize genetics and genomics.
Download or read book Genome Wide Association Studies and Genomic Prediction written by Cedric Gondro and published by Humana Press. This book was released on 2013-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.
Download or read book Mapping Humanity written by Joshua Z. Rappoport and published by BenBella Books. This book was released on 2020-07-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A good companion for those with a science background interested in learning more about human genetics." —Booklist Thanks to the popularity of personal genetic testing services, it's now easier than ever to get information about our own unique DNA—but who does this information really benefit? And, as genome editing and gene therapy transform the healthcare landscape, what do we gain—and what might we give up in return? Inside each of your cells is the nucleus, a small structure that contains all of the genetic information encoded by the DNA inside, your genome. Not long ago, the first human genome was sequenced at a cost of nearly $3 billion; now, this same test can be done for about $1,000. This new accessibility of genome sequence information creates huge potential for advances in how we understand and treat disease, among other things. It also raises significant concerns regarding ethics and personal privacy. In Mapping Humanity: How Modern Genetics Is Changing Criminal Justice, Personalized Medicine, and Our Identities, cellular biology expert Joshua Z. Rappoport provides a detailed look at how the explosion in genetic information as a result of cutting-edge technologies is changing our lives and our world. Inside, discover: • An in-depth look at how your personal genome creates the unique individual that you are • How doctors are using DNA sequencing to identify the underlying genetic causes of disease • Why the field of gene therapy offers amazing potential for medical breakthroughs—and why it's taking so long • The fantastic potential—and troubling concerns—surrounding genome editing • The real impact—and validity—of popular personal genetic testing products, such as 23andMe • Details of how molecular biology and DNA are changing the criminal justice system • Facts you should know about Genetically Modified Organisms (GMOs) Throughout, in compelling, accessible prose, Rappoport explores the societal, ethical, and economic impacts of this new era. Offering a framework for balancing the potential risks and benefits of genetic information technologies and genetic engineering, Mapping Humanity is an indispensable guide to navigating the possibilities and perils of our gene-centric future.
Download or read book Blueprint written by Robert Plomin and published by MIT Press. This book was released on 2019-07-16 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: A top behavioral geneticist argues DNA inherited from our parents at conception can predict our psychological strengths and weaknesses. This “modern classic” on genetics and nature vs. nurture is “one of the most direct and unapologetic takes on the topic ever written” (Boston Review). In Blueprint, behavioral geneticist Robert Plomin describes how the DNA revolution has made DNA personal by giving us the power to predict our psychological strengths and weaknesses from birth. A century of genetic research shows that DNA differences inherited from our parents are the consistent lifelong sources of our psychological individuality—the blueprint that makes us who we are. Plomin reports that genetics explains more about the psychological differences among people than all other factors combined. Nature, not nurture, is what makes us who we are. Plomin explores the implications of these findings, drawing some provocative conclusions—among them that parenting styles don't really affect children's outcomes once genetics is taken into effect. This book offers readers a unique insider’s view of the exciting synergies that came from combining genetics and psychology.
Download or read book Maize Kernel Development written by Brian A Larkins and published by CABI. This book was released on 2017-11-21 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an authoritative book that acts as a guide to understanding maize kernel development. Written by a team of experts, it covers topics spanning pre- and post-fertilization events, embryo and endosperm development, grain filling and maturation, and factors influencing crop yield. It explores the significance of maize and other cereal grains, existing hypotheses and research, and important gaps in our knowledge and how we might fill them. This is a valuable resource for researchers of maize and other cereals, and anyone working on basic or applied science in the fields of seed development, plant genetics, and crop physiology.
Download or read book Gene Environment Interaction Analysis written by Sumiko Anno and published by CRC Press. This book was released on 2016-03-30 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene-environment (GE) interaction analysis is a statistical method for clarifying GE interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of GE interaction analysis. It compiles and details cutting-edge research in bioinformatics
Download or read book Plant Resistance to Viruses written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern about the environmental consequences of the widespread use of pesticides has increased, and evidence of pesticide-resistant virus vectors have continued to emerge. This volume presents a timely survey of the mechanisms of plant resistance and examines current developments in breeding for resistance, with particular emphasis on advances in genetic engineering which allow for the incorporation of viral genetic material into plants. Discusses the mechanisms of innate resistance in strains of tobacco, tomato, and cowpea; various aspects of induced resistance, including the characterization and roles of the pathogenesis-related proteins; antiviral substances and their comparison with interferon; and cross-protection between plant virus strains. Also presents several papers which evaluate the status of genetic engineering as it relates to breeding resistant plants. Among these are discussions of the potential use of plant viruses as gene vectors, gene coding for viral coat protein, satellite RNA, and antisense RNA, and practical issues such as the durability of resistant crop plants in the field.
Download or read book Human Brain Proteome written by and published by Elsevier. This book was released on 2004-12-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer's disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.* Describes the latest databases and techniques for analyzing the data generated by proteomics* Outlines the latest developments in proteomic methods* Provides numerous color illustrations highlighting the application of proteomics to the identification of novel drug targets and biomarkers
Download or read book The Neurobiology of Schizophrenia written by Ted Abel and published by Academic Press. This book was released on 2016-07-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. - Provides a comprehensive overview of neurobiological aspects of schizophrenia - Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels - Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance - Elucidates connections between the various systems depicted, when possible
Download or read book Progress and Challenges in Precision Medicine written by Mukesh Verma and published by Academic Press. This book was released on 2016-12-22 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. - Provides an overview of the growing field of precision medicine - Contains chapters from geographically diverse experts in their field - Explores important aspects of precision medicine, including applications, ethics, and development
Download or read book Association Mapping in Plants written by Nnadozie C. Oraguzie and published by Springer Science & Business Media. This book was released on 2007 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the past decade, there has been success in using conventional map-based strategies in identification and cloning of quantitative trait loci (QTL) in model plant species including tomato and Arabidopsis. These quantitative traits are generally the products of many loci with varying degrees of effect upon the observed phenotypes. Recently, a new approach to genetic mapping has emerged called association mapping. This new technique takes into account the thousands of genes to evaluate for QTL effect and is a more efficient approach that does not require generation of segregating populations/large numbers of progeny. As it can utilize all of the historic recombination events in a diverse population of individuals it can generate higher resolution genetic maps and, is needed to complement current map based cloning methods. Association Mapping in Plants provides both basic and advanced understanding of association mapping and an awareness of population genomics tools to facilitate mapping and identification of the underlying causes of quantitative trait variation in plants. It acts as a useful review of the marker technology, the statistical methodology, and the progress to date. It also offers guides to the use of single nucleotide polymorphisms (SNPs) in association studies. This book will appeal to all those with an interest in plant genetics, plant breeding, and plant genomics. About the Editors: Dr. Nnadozie C. Oraguzie is a Senior Scientist in Genetics at the Horticulture and Food Research Institute of New Zealand Ltd (HortResearch). Dr. Erik H. A. Rikkerink is a Science Leader at HortResearch, New Zealand. Dr. Susan E. Gardiner is a Principal Scientist and leader of the Gene Mapping research team at HortResearch, New Zealand. Dr. H. Nihal De Silva/STRONG is a Senior Scientist of Biometrics at HortResearch, New Zealand.
Download or read book The Soybean Genome written by Henry T. Nguyen and published by Springer. This book was released on 2017-09-20 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the application of soybean genome sequences to comparative, structural, and functional genomics. Since the availability of the soybean genome sequence has revolutionized molecular research on this important crop species, the book also describes how the genome sequence has shaped research on transposon biology and applications for gene identification, tilling and positional gene cloning. Further, the book shows how the genome sequence influences research in the areas of genetic mapping, marker development, and genome-wide association mapping for identifying important trait genes and soybean breeding. In closing, the economic and botanical aspects of the soybean are also addressed.
Download or read book Precision Public Health written by Tarun Weeramanthri and published by Frontiers Media SA. This book was released on 2018-06-25 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, data linkage, epidemiology, health informatics, big data, predictive analytics and communications. The hope is that these new technologies will strengthen preventive health, improve access to health care, and reach disadvantaged populations in all areas of the world. But what are the downsides and what are the risks, and how can we ensure the benefits flow to those population groups most in need, rather than simply to those individuals who can afford to pay? This is the first collection of theoretical frameworks, analyses of empirical data, and case studies to be assembled on this topic, published to stimulate debate and promote collaborative work.
