Download or read book Between Bench and Bedside written by Ilana Löwy and published by Harvard University Press. This book was released on 1996 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.

Download or read book Empathy written by Jean Decety and published by MIT Press. This book was released on 2014-01-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent work on empathy theory, research, and applications, by scholars from disciplines ranging from neuroscience to psychoanalysis. There are many reasons for scholars to investigate empathy. Empathy plays a crucial role in human social interaction at all stages of life; it is thought to help motivate positive social behavior, inhibit aggression, and provide the affective and motivational bases for moral development; it is a necessary component of psychotherapy and patient-physician interactions. This volume covers a wide range of topics in empathy theory, research, and applications, helping to integrate perspectives as varied as anthropology and neuroscience. The contributors discuss the evolution of empathy within the mammalian brain and the development of empathy in infants and children; the relationships among empathy, social behavior, compassion, and altruism; the neural underpinnings of empathy; cognitive versus emotional empathy in clinical practice; and the cost of empathy. Taken together, the contributions significantly broaden the interdisciplinary scope of empathy studies, reporting on current knowledge of the evolutionary, social, developmental, cognitive, and neurobiological aspects of empathy and linking this capacity to human communication, including in clinical practice and medical education.

Download or read book Principles of Translational Science in Medicine written by Martin Wehling and published by Academic Press. This book was released on 2015-04-02 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Download or read book Covid 19 written by Taylor & Francis Group and published by CRC Press. This book was released on 2021-10-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic has affected the entire world in an unprecedented way and this book provides an overview of the historical facts as well as ongoing approaches to tackle the COVID-19 pandemic. Experts of the respective domains provide details on anti-SARS-COV-2 drug strategies, including repurposing drugs used for other indications and development of novel drugs looking at different approaches to target virus entry and replication. COVID-19 vaccine development based on inactivated and attenuated live virus, protein subunit and peptide-based vaccines and utilization of vaccine candidates based on viral vectors, DNA and RNA are presented for both preclinical studies and clinical trials. Key Features - Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with pandemics. - Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engaged in its management. - Features the patent aspects of COVID-19.

Download or read book Placebo and Pain written by Luana Colloca and published by Academic Press. This book was released on 2013-08-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain: “This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School Contains historical aspects of the placebo effect Discusses biological and psychological mechanisms of placebo analgesic responses Reviews implications of the placebo effect for clinical research and pain management Includes methodological and ethical aspects of the placebo effect

Download or read book Inflammatory Bowel Disease written by Stephan R. Targan and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 891 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders is explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.

Download or read book Biomedical Product Development Bench to Bedside written by Babak Arjmand and published by Springer Nature. This book was released on 2020-02-05 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook covers all the steps in manufacturing a biomedical product from bench to bedside. It specifically focuses on quality assurance and management and explains the different good practice principles in the various phases of product development as well as how to fulfill them: Good laboratory practice, good manufacturing practice and good clinical practice. It provides readers with the know-how to design biomedical experiments to ensure quality and integrity, to plan and conduct standard preclinical studies and to assure the quality of the final manufactured biomedical products. Importantly, it also addresses ethical concerns and considerations. The book discusses the guidelines and ethical considerations for preclinical and clinical studies, to allow readers to identify safety concerns regarding biomedical products and to improve pre-clinical studies for the development of better products. This textbook is a valuable guide for biomedical students (B.Sc., M.S., and Ph.D. students) in the field of molecular medicine, medical biotechnology, stem cell research and related areas, as well as for professionals such as quality control staff, tissue bankers, policy-makers and health professionals.

Download or read book Bone Cancer written by Dominique Heymann and published by Academic Press. This book was released on 2021-09-23 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Download or read book Alcohol Research from Bench to Bedside written by Boris Tabakoff and published by Psychology Press. This book was released on 1989 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable book serves as a forum for the communication of ideas between all segments of the research and treatment communities. Scientists and clinicians examine the exciting endeavors in science that have produced medical knowledge applicable to a wide spectrum of treatment and prevention efforts. The topics--from studies on the molecular actions of alcohol to clinical studies with human subjects--underscore the complexity of alcoholism and focus on both the biological and environmental determinants contributing to the etiology of the disorder. Contributors from the fields of biology, chemistry, neurology, child health, gastroenterology, genetics, psychiatry, and numerous other specialties describe the fascinating collaborative ventures that have enhanced the opportunities to apply the latest technology and medical knowledge to studies of alcohol's actions and alcoholism. This need to understand alcoholism at all levels of biologic and social complexity is highlighted throughout this scholarly volume. Alcohol Research From Bench to Bedside contains the published proceedings of a symposium sponsored by the National Institute on Alcohol Abuse and Alcoholism in 1987, as part of the 100th anniversary celebration of the National Institutes of Health.

Download or read book Advancing Gene Targeted Therapies for Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-12-01 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Download or read book Gene Therapy of the Central Nervous System From Bench to Bedside written by Michael G. Kaplitt and published by Gulf Professional Publishing. This book was released on 2006 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.

Download or read book Cardio Oncology From Bench to Bedside written by Jun-ichi Abe and published by Frontiers Media SA. This book was released on 2019-05-17 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardio-oncology is a medical subspecialty concerned with the diagnosis and treatment of cardiovascular disease (CVD) and organ failure mediated by micro- to macro-circulation defects in cancer patients and survivors. The risk of CVD in cancer survivors is eight times higher than the general population, and the relative risk of coronary artery disease and heart failure (HF) is 10 times and 15 times higher, respectively, compared to their siblings without cancer. It is important to note that cancer treatments including chemotherapy and radiation can lead to both short- (< 1 year) and long-term (> 5 years) cardiovascular complications. Previously, Dr. Edward T.H. Yeh initiated the MD Anderson Practice (MAP) project, and published 16 MAPs to provide the current best practice we considered at UT MD Anderson. As shown in these MAPs, one of the key issues of cardio-oncology practice and science is how we can allow cancer patients to receive maximum and uninterrupted treatments for cancer while protecting them from cancer therapy-mediated cardiovascular complications. Therefore, it is crucial to understand not only pathophysiology of CVD, but also mechanistic insights of how each cancer treatment can control cancer growth and metastasis. Without having the profound knowledge in the pathophysiological, clinical and epidemiologic aspects of cardiovascular complications of existing cancer therapy, it is impossible to establish the strong evidence-based strategies and approaches for both short- and long-term cardiovascular complications after cancer treatment. In addition, we believe that cardio-oncology science should not be restricted to deal with the side effects of each specific cancer drug, because many common cardiovascular phenotypes among the different cancer treatments are also observed. This Research Topic provides a comprehensive overview from both of the current research and practice, and a platform for obtaining the logical and up-to-date treatment and prevention of CVD in cancer patients and survivors.

Download or read book Septic Cardiomyopathy From Bench to Bedside written by Vasilios E. Papaioannou and published by Bentham Science Publishers. This book was released on 2015-07-15 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Myocardia is an eBook series which compiles information about the structure and function of myocardial (the heart muscles) and includes updated reviews on the recent developments in the treatment of associated diseases such as angina, cardiac arrhythmias and myocardial infarction. Advances in research on clinical sepsis in the last few decades have lead to the use of new concepts and treatment paradigms that have been tested and implemented in the clinical setting of Intensive Care Units around the world. An integrative approach towards understanding the pathophysiology of cardiac dysfunction in septic patients can, therefore, lead to better patient outcomes. The first volume of this series, Septic Cardiomyopathy: from bench-to-bedside, integrates new and old information about the molecular mechanisms, histopathological and electrophysiological alterations with novel findings for diagnosing treating septic cardiomyopathy. This eBook attempts to bridge the gap between basic and clinical scientists and presents new data on different aspects of cardiac physiology during critical illness in a single volume. Chapters in this volume also cover cardiovascular changes that occur as a consequence of sepsis including metabolic, mitochondrial arrhythmic changes. This eBook will add significant value to medical students, cardiac physicians and medical scientists engaged in the field of critical care medicine.

Download or read book Predictive Preventive and Personalised Medicine From Bench to Bedside written by Halina Podbielska and published by Springer Nature. This book was released on 2023-12-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

Download or read book Human Papillomavirus written by M.K. Ramírez-Fort and published by Karger Medical and Scientific Publishers. This book was released on 2014-03-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted. Finally, Dr. Neil Christensen discusses viral immunology, and the difficulties and successes in the development of an HPV vaccine. Bringing together basic science and clinical information on HPV, this book is an excellent resource and reference for all researchers and clinicians who encounter human papillomavirus-related disease.

Download or read book HLA from Benchtop to Bedside written by A. Bradley Eisenbrey and published by Academic Press. This book was released on 2021-01-05 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: HLA from Benchtop to Bedside provides the reader with a comprehensive, concise and thoroughly up-to-date book on all aspects of the HLA system, including new techniques and methodologies. Each chapter begins with bullet point lists of principle learning points, including comprehensive references and validated links to international resources. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this book is ideal for organ and stem cell transplant professionals, histocompatibility laboratory professionals and staff, medical residents and fellows on transplant services, medical students, and students in clinical laboratory science. The book's author, Dr. Arthur Bradley Eisenbrey, is an experienced transplant pathologist who has held significant academic and leadership positions in the field. Reviews current knowledge surrounding the HLA system Covers current methodologies and utilization of histocompatibility testing Authored by a leader in the field of histocompatibility and transfusion medicine

Download or read book LED Based Photoacoustic Imaging written by Mithun Kuniyil Ajith Singh and published by Springer Nature. This book was released on 2020-04-07 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.