Download or read book Molecular and Cellular Aspects of Basement Membranes written by David H Rohrbach and published by Academic Press. This book was released on 2012-12-02 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Aspects of Basement Membranes reviews the knowledge about the molecular and cellular aspects of basement membranes. This book focuses on the composition of basement membranes and their organization in extracellular matrices and presents a structural analysis of the various components of the basement membrane. The importance of basement membranes with respect to cell-matrix interactions, differentiation, and pathology is also considered. This text is organized into three sections and is comprised of 20 chapters. It begins with historical perspectives and an overview of the extracellular matrix in general and the basement membrane in particular. The discussion then turns to the organization of basement membrane components into a three-dimensional and functional matrix, along with the unique characteristics of basement membranes in skin, nerve, and kidney. The reader is also introduced to the specificity of particular basement membranes in particular histological sites; the molecular characteristics of basement membrane collagens, laminins, and proteoglycans; and the interaction of specific peptide domains of basement membrane components with cell surface receptors. Finally, the book explains how subtle changes in basement membrane composition or protein structure can cause dramatic pathology. This book will be of value to cell biologists, molecular biologists, biochemists, and pathologists.
Download or read book Basement Membranes Cell and Molecular Biology written by Nicholas Kefalides and published by Gulf Professional Publishing. This book was released on 2005-10-24 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basement Membranes: Cell and Molecular Biology brings together the most important research developments of the past 45 years that have enriched our knowledge and contributed to a better understanding of the biochemistry and cell and molecular biology of basement membranes. It describes the studies that shed light on the ultrastructural organization, the biosynthesis of the macromolecular components, their functions in embryonic development and differentiation, and in the mature state. A major portion of the book is devoted to the description of the genes that regulate the expression of the various structural macromolecules. Reviews the early years of research and the discovery of type IV collagen Presents the diversity of basement membrane morphology Discusses gene structure
Download or read book Basement Membranes written by and published by Academic Press. This book was released on 2015-11-24 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basement Membranes focuses on specialized extracellular matrices that provide the scaffolds used and required by cells to organize themselves into tissues and organs. As basement membranes have been shown to be defective in numerous genetic and acquired diseases and to contribute to the microenvironment of both tumor cells and stem cells, this book presents a view of specific basement membrane components and their roles in development and disease, all written and commented on in chapters written by leaders in the basement membrane field. Written by leading experts in the basement membrane field Contains original material, both textual and illustrative, that should become a very relevant reference material Presents material in a very comprehensive manner Ideal for both researchers in the field and general readers who will find relevant and up-to-date information
Download or read book Biology and Chemistry of Basement Membranes written by Nicholas A. Kefalides and published by . This book was released on 1978 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Basement Membranes and Cell Movement written by Ruth Porter and published by John Wiley & Sons. This book was released on 2009-09-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book Functional Ultrastructure written by Margit Pavelka and published by Springer Science & Business Media. This book was released on 2010-07-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.
Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Download or read book Epidermolysis Bullosa written by Andrew N. Lin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because skin blisters are the initial manifestation of epidermolysis bullosa (EB), patients invariably present to the dermatologist for diagnosis and treatment. However, EB is a systemic disease whose management requires input from clinicians in virtually all fields of medicine, including pediatri cians, surgeons, dentists, gastroenterologists, hematologists, otorhinolaryn gologists, dietitians, and physical therapists, to name a few. Because EB is a rare disease, few clinicians are familiar with it, and many recoil at the pros pect of caring for individuals covered with blisters caused by a disease they know little about. For patients, insult is thus added to injury and they feel abandoned, neglected, and frustrated. One way to remedy this deplorable situation is to provide clinicians with a compact source of information de tailing the principles of EB diagnosis and treatment. This text seeks to fulfill this role. From 1986-1991, The Rockefeller University Hospital has been the co ordinating center of the National EB Registry. Supported by The National Institutes of Health, this Registry consists of four university centers* commit ted to collecting clinical data concerning diagnosis, treatment, and epidemio logy on all American EB patients. As of April 1992, nearly 1,799 EB patients have enrolled nationwide. The Registry is now in its second five-year phase of operation.
Download or read book Vascular Endothelium written by J. Catravas and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988.
Download or read book The Extracellular Matrix an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Download or read book Extracellular Matrix and Egg Coats written by and published by Academic Press. This book was released on 2018-05-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix and Egg Coats, Volume 130, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on The Human Egg’s Zona Pellucida, the Structure of Zona Pellucida Module Proteins, The Fish Egg’s Zona Pellucidam The Chicken Egg’s Zona Pellucidam The Marsupial Egg’s Zona Pellucida, the Evolution of Zona Pellucida Proteins, The Mouse Egg’s Zona Pellucida, Aspects of ECM, ECM and Morphogenesis, Collagen fibril assembly and function, The Ear's Tectorial Membrane, ECM and Cell Fate, and the Aspects of ECM. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on the Extracellular Matrix in Development
Download or read book A Clinician s Guide to Pemphigus Vulgaris written by Pooya Khan Mohammad Beigi and published by Springer. This book was released on 2017-11-24 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giving dermatologists, dermatology residents, and primary care physicians a deeper insight into pemphigus vulgaris, a rare autoimmune disease characterized by blisters and lesions on the skin and mucous membranes, this book provides insight and treatment options alongside dozens of high quality photographs, pathology slides, illustrations, algorithms, figures and clinical tables detailing the disease at all stages. Providing more than 20 clinical case photos of patients exhibiting symptoms, A Clinician’s Guide to Pemphigus Vulgaris summarizes much of what is known about this disease, including categories of the disorder, clinical symptoms, diagnosis and treatment, and recent clinical research photos about the disease.
Download or read book Extracellular Matrix Assembly and Structure written by Peter D. Yurchenco and published by Academic Press. This book was released on 1994-03-30 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Key Features * Addresses assembly of most of the known classes of extracellular matrix macromolecules * Discusses higher order structures produced by ECM * Gives important concepts in: * ECM and cell-matrix interactions * Protein structure and protein-protein interactions * Development and tissue remodeling
Download or read book Histology and Cell Biology An Introduction to Pathology E Book written by Abraham L Kierszenbaum and published by Elsevier Health Sciences. This book was released on 2011-04-12 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histology and Cell Biology: An Introduction to Pathology uses a wealth of vivid, full-color images to help you master histology and cell biology. Dr. Abraham L. Kierszenbaum presents an integrated approach that correlates normal histology with cellular and molecular biology, pathology, and clinical medicine throughout the text. A unique pictorial approach—through illustrative diagrams, photomicrographs, and pathology photographs—paired with bolded words, key clinical terms in red, and clinical boxes and "Essential Concepts" boxes that summarize important facts give you everything you need to prepare for your course exams as well as the USMLE Step 1. Access to studentconsult.com, with USMLE-style multiple-choice review questions, downloadable images, and online only references. Easily find and cross-reference information through a detailed table of contents that highlights clinical examples in red. Review material quickly using pedagogical features, such as Essential Concept boxes, bolded words, and key clinical terms marked in red, that emphasize key details and reinforce your learning. Integrate cell biology and histology with pathology thanks to vivid descriptive illustrations that compare micrographs with diagrams and pathological images. Apply the latest developments in pathology through updated text and new illustrations that emphasize appropriate correlations. Expand your understanding of clinical applications with additional clinical case boxes that focus on applying cell and molecular biology to clinical conditions. Effectively review concepts and reinforce your learning using new Concept Map flow charts that provide a framework to illustrate the integration of cell-tissue-structure-function within a clinical-pathology context.
Download or read book Extracellular Matrix in the Kidney written by Hikaru Koide and published by . This book was released on 1994 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Capillary Fluid Exchange written by Joshua Scallan and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
Download or read book Amniotic Membrane written by Ana Catarina Mamede and published by Springer. This book was released on 2015-07-14 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the human amniotic membrane from its origin, characterization and medical applications, summarizing all the latest developments and findings related to this tissue with contributions from some of the leading researchers in the field. The book addresses issues for its preservation, separation and identification of amniotic membrane-derived cells, as well as the potential ethical issues involved in their use. The topic of this book is particularly pertinent for clinicians and researchers involved in the research and use of this tissue.
