Download or read book Persister Cells and Infectious Disease written by Kim Lewis and published by Springer Nature. This book was released on 2019-11-13 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.
Download or read book Bacterial Persistence written by Jan Michiels and published by Humana. This book was released on 2015-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli cultures, protocols for the determination of the persister subpopulation in Candida albicans, quantitative measurements of Type I and Type II persisters using ScanLag, to in vitro and in vivo models for the study of the intracellular activity of antibiotics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols brings together the most respected researchers in bacterial persistence whose studies will remain vital to understanding this field for many years to come.
Download or read book Bacterial Persistence written by Natalie Verstraeten and published by . This book was released on 2021 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a collection of methods that have contributed to the current understanding of bacterial persisters. Chapters in the book detail general guidelines for measuring persister levels in bacterial cultures, strategies to enrich and resuscitate persister subpopulations, single-cell approaches for visualizing and characterizing persisters, omics techniques and cellular and animal models for studying persistence. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols, Second Edition aims to be a useful practical guide to researchers to help further their study in this field.
Download or read book Persistent Bacterial Infections written by James P. Nataro and published by . This book was released on 2000 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of persistent bacterial infections in the light of ecological and evolutionary principles. - Focuses on the principles of parasitism and commensalism and our ability to distinguish the two states. - Explores the ways in which persistent infections differ from acute, self-limiting bacterial infections and how both differ from the nonpathogenic commensal state. - Addresses coevolution, host adaptation, natural selection, and other fundamental biological principles. - Serves as a resource for investigators and advanced students in the field of bacterial pathogenesis.
Download or read book Drug Discovery and Development written by Omboon Vallisuta and published by BoD – Books on Demand. This book was released on 2015-06-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
Download or read book Persistent Viral Infections written by R. Ahmed and published by Wiley-Blackwell. This book was released on 1999 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
Download or read book Control of Salmonella and Other Bacterial Pathogens in Low Moisture Foods written by Richard Podolak and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first and only comprehensive reference/solutions manual for managing food safety in low-moisture foods The first book devoted to an increasingly critical public health issue, Control of Salmonella and Other Bacterial Pathogens in Low-Moisture Foods reviews the current state of the science on the prevalence and persistence of bacterial pathogens in low-moisture foods and describes proven techniques for preventing food contamination for manufacturers who produce those foods. Many pathogens, such as Salmonella, due to their enhanced thermal resistance in dry environments, can survive the drying process and may persist for prolonged periods in low-moisture foods, especially when stored in refrigerated environments. Bacterial contamination of low-moisture foods, such as peanut butter, present a vexing challenge to food safety, and especially now, in the wake of widely publicized food safety related events, food processors urgently need up-to-date, practical information on proven measures for containing the risk of contamination. While much has been written on the subject, until now it was scattered throughout the world literature in scientific and industry journals. The need for a comprehensive treatment of the subject has never been greater, and now this book satisfies that need. Discusses a wide variety of foods and evaluates multiple processing platforms from the standpoint of process validation of all food safety objectives for finished food products Takes a practical approach integrating the latest scientific and technological advances in a handy working resource Presents all known sources and risk factors for pathogenic bacteria of concern in the manufacturing environment for low-moisture/water activity products Characterizes the persistence and thermal resistance of bacterial pathogens in both the environment and most low-moisture food products Control of Salmonella and Other Bacterial Pathogens in Low-Moisture Foods is a much-needed resource for food microbiologists and food industry scientists, as well as managers and executives in companies that produce and use low-moisture foods. It also belongs on the reference shelves of food safety regulatory agencies worldwide.
Download or read book Horizontal Gene Pool written by Christopher M. Thomas and published by CRC Press. This book was released on 2003-09-02 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteria are the most ubiquitous of all organisms. Responsible for a number of diseases and for many of the chemical cycles on which life depends, they are genetically adaptable. Vital to this adaptability is the existence of autonomous genetic elements-plasmids-which promote genetic exchange and recombination. The genes carried by any particular plasmid may be found in only a few individuals of any species but can also be shared with other species and thus constitute a horizontal gene pool. This book explains the various contributions that plasmids make to this pool: the replication, stable inheritance and transfer modules, the phenotypic markers they carry, the way they evolve, the ways they contribute to their host population and the approaches that we use to study and classify them. It also looks at what we know about their activity in natural communities and the way that they interact with other mobile elements to promote bacterial evolution.
Download or read book Mechanisms of Persistence Survival and Transmission of Bacterial Foodborne Pathogens in Production Animals written by Christina L. Swaggerty and published by Frontiers Media SA. This book was released on 2018-08-31 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foodborne illness resulting from food production animals is a global health concern, and the Centers for Disease Control estimate that one in six Americans will become sick with a foodborne illness each year. Of course there are numerous causes for these outbreaks, but contamination from a food production animal is certainly one source. Understanding the host-pathogen interaction and how foodborne bacterial pathogens establish a persistent infection and evade host immune responses will be pivotal in reducing the instance of foodborne illness traced back to a food production animal source. In this volume, we bring together original research and review articles covering some of the key issues surrounding the mechanisms of persistence, survival, and transmission of bacterial foodborne pathogens in production animals. The research focused on poultry and specifically addressed antibiotic resistance, Salmonella colonization, pathogen reduction strategies using pre- or probiotics, pathogen evasion, and post-harvest intervention and pathogen testing. The following 11 articles are fine examples of the multidisciplinary approaches that will be required to address and understand the complex interplay between food safety and animal production.
Download or read book Bacterial Infections written by M. Finland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bacterial pathogens in the non clinical environment written by Sebastien P. Faucher and published by Frontiers Media SA. This book was released on 2015-06-18 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transmission route used by many bacterial pathogens of clinical importance includes a step outside the host; thereafter refer to as the non-clinical environment (NCE). Obvious examples include foodborne and waterborne pathogens and also pathogens that are transmitted by hands or aerosols. In the NCE, pathogens have to cope with the presence of toxic compounds, sub-optimal temperature, starvation, presence of competitors and predators. Adaptation of bacterial pathogens to such stresses affects their interaction with the host. This Research Topic presents important concept to understand the life of bacterial pathogens in the NCE and provides the reader with an overview of the strategies used by bacterial pathogens to survive and replicate outside the host.
Download or read book Bacterial Resistance to Antibiotics written by Boyan B. Bonev and published by John Wiley & Sons. This book was released on 2019-03-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Download or read book Prokaryotic Toxin Antitoxins written by Kenn Gerdes and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic Toxins – Antitoxins gives the first overview of an exciting and rapidly expanding research field. Toxin – antitoxin (TA) genes were discovered on plasmids 30 years ago. Since then it has become evident that TA genes are highly abundant in bacterial and archaeal chromosomes. TA genes code for an antitoxin that combine with and neutralize a cognate toxin. When activated, the toxins inhibit protein synthesis and cell growth and thereby induce dormancy and multidrug tolerance (persistence). Remarkably, in some species, the TA gene families have undergone dramatic expansions. For example, the highly persistent major human pathogen Mycobacterium tuberculosis has »100 TA loci. The large expansion of TA genes by some organisms is a biological mystery. However, recent observations indicate that TA genes contribute cumulatively to the persistence of bacteria. This medically important phenomenon may thus for the first time become experimentally tractable at the molecular level.
Download or read book Urinary Tract Infections written by Peter Tenke and published by BoD – Books on Demand. This book was released on 2011-10-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, and they are also the leading cause of hospital-acquired infections. Therefore, the appropriate management of UTIs is a major medical and financial issue. This book covers different clinical manifestations of UTI, with special emphasis on some hard-to-treat diseases, and special conditions in respect of treatment; antibiotic resistance and the available alternative strategies for the prevention and treatment of UTIs and it deals with urinary tract infections in children. The aim of this book is to give a summary about the different aspects of the diagnosis, management and prevention of urinary tract infections for all medical disciplines.
