Download or read book Computational Analysis of the Mammalian Cis regulatory Landscape written by Cory Yuen Fu McLean and published by Stanford University. This book was released on 2011 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improvements in DNA sequencing technologies have made it possible to determine the genetic makeup of many organisms. Computational analyses of the massive amounts of sequence data available have produced many insights into evolutionary and developmental biology. For example, comparison of the full genome sequences of human and mouse discovered that the majority of functional sequence in the human genome does not code for protein. Much of this functional non-coding sequence appears to act in a regulatory role, dictating the precise tissues and developmental time points in which each protein should be produced. This dissertation describes three major contributions to the computational analysis of regulatory elements. First, I describe the Genomic Regions Enrichment of Annotations Tool (GREAT), a novel statistical method and associated web-based tool developed to infer the biological functions of regulatory elements based on the functions of their putative target genes. I demonstrate its marked improvement over current methods at interpreting functional enrichment signals for a variety of regulatory element types. Next, I discuss a computational methodology developed to identify medium- to large-scale (10-100,000 nucleotide) genomic deletions from whole genome sequences of multiple mammals. Using this methodology, I quantify the dispensability of highly conserved non-coding elements (CNEs) as their likelihood to be deleted in a subset of species. Despite their genomic prevalence and apparent redundancy in function, CNEs are very rarely lost in extant species. Even more surprisingly, there is a very weak relationship between dispensability and nucleotide conservation level. Sequences under purifying selection at moderate levels of nucleotide conservation are lost at a rate similar to those at perfect sequence conservation. Instead, evolutionary resistance to loss is more strongly correlated with depth of sequence homology, as ancient enhancers are more resistant to deletion than ones that arose more recently in evolution. Finally, I present the discovery and analysis of human-specific genomic deletions. By comparing the genome sequences of five species including human and our nearest ape relative, the chimpanzee, I identified 583 regions present in non-human species that contain highly-conserved sequence but are surprisingly deleted in humans. Statistical analyses indicate that these deletions occur preferentially near steroid hormone receptor genes and brain-expressed genes that are known to inhibit proliferation. Experimental results provide particular examples that may have contributed to unique human traits: the loss of an AR enhancer is correlated with the human loss of penile spines and sensory vibrissae, and the loss of a GADD45G enhancer is correlated with the human expansion of the cerebral cortex.

Download or read book The Book of Even More Awesome written by Neil Pasricha and published by Penguin. This book was released on 2011-04-28 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the bestselling author of The Book of Awesome, You Are Awesome, and the award-winning, multimillion-hit blog 1000 Awesome Things comes even more of the little things that make us smile every day! Neil Pasricha is back with a collection of hundreds more awesome things from the website, as well as never-before-seen extraordinary moments that deserve celebration: • Letting go of the gas pump perfectly so you end on a round number • When a baby falls asleep on you • When your pet notices you’re in a bad mood and comes to see you • Pulling a weed and getting all the roots with it • When your windshield wipers match the beat of the song you’re listening to • When the hiccups stop • The smooth feeling on your teeth when you get your braces off • Driving from a rough road onto a smooth one • When the person you’re meeting is even later than you are • That guy who helps you parallel park There’s even space for you to write your very own Awesome Things in the back. Because couldn’t we all use (even more) awesome?

Download or read book Focus On 100 Most Popular American Agnostics written by Wikipedia contributors and published by e-artnow sro. This book was released on with total page 1652 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Ken Fisher Classics Collection written by Kenneth L. Fisher and published by John Wiley & Sons. This book was released on 2012-08-23 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three of Ken Fisher's bestselling books in one handy e-book When it comes to finance and investing, there may be no name as big as Ken Fisher's. A long-time columnist at Forbes magazine and CEO of Fisher Investments, every one of his books has appeared on both the Wall Street Journal and New York Times bestseller lists. In this new e-book bundle, you'll get the best of Fisher with three of his most acclaimed titles in one convenient package. In The Only Three Questions That Count, Fisher shows investors how to improve their investing success by answering three simple questions In Debunkery, Fisher helps investors how to avoid the costly mistakes that happen when people rely on "common sense" and standard investing cliches In Markets Never Forget (But People Do), Fisher explains why investors' memories so often fail them and how to use the history of markets to avoid repeating the same investing mistakes For investors, fans of Fisher, and anyone who cares about their money, the Ken Fisher Classics Collection offers three volumes of proven advice from an investing legend.

Download or read book Great Jobs for Everyone 50 written by Kerry E. Hannon and published by John Wiley & Sons. This book was released on 2012-08-30 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The how-to guide to finding profitable, fulfilling work after 50 Aimed at workers aged 50+ looking for a new job—whether they have been laid off or taken early retirement, need supplemental income, or want to pursue an encore career—Great Jobs for Everyone 50+ is the definitive guide to finding lasting financial security and personal and professional fulfillment. Opportunities abound—the trick is knowing where to look and what to expect. Whether readers are interested in trying jobs they've long dreamed of doing, or just want something with flexible hours that brings in a little extra income, this book covers all the options. As Americans live longer and healthier lives, the desire to work longer—for the income, the mental engagement, or the chance to give back—has grown. But there is little guidance for the 50+ crowd looking for work and few role models who've blazed a path. In Great Jobs for Everyone 50+, author and personal finance, retirement, and career transitions expert Kerry Hannon shows the way, with compelling stories from people who've been there. Presenting the nitty-gritty details of available job opportunities, wages to expect, typical hours, and the qualifications and savvy needed to get hired, the book is loaded with practical advice on how to prepare both professionally and financially to start out on a new adventure. Shows where the best opportunities for new employment lie Helps readers find profitable and rewarding jobs to save for retirement Understands that different workers want different things from their jobs and shows how to cast a wide net to find an opportunity that fits Provides incredible insights into working after 50 from Kerry Hannon, a nationally renowned expert in personal finance, retirement, and career transitions Motivational, inspirational, and thoroughly practical, Great Jobs for Everyone 50+ explains how to find part-time, temporary, work-at-home, or seasonal employment in profitable, rewarding jobs.

Download or read book Amazing Beauty written by Su Proctor and published by WestBow Press. This book was released on 2014-09-22 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amazing Beauty details the chronological account of one woman's messiness in losing five different babies to miscarriages and a tubal pregnancy. Over a span of five years, from almost dying to being on the brink of divorce, to seriously contemplating death, and through it all, the Lord gently led, healed and mended one woman's heart, soul, mind and body. This book goes deep underground and honestly portrays one woman's struggle with infertility and loss. Even in today's sensational culture, miscarriage is still a topic of taboo and one that is quickly hushed. Amazing Beauty shows how through our darkest hours, the only spark of light to be illuminated is by the hand of God. The finished work of Jesus Christ on the cross displays the most divine amazing beauty through love, hurt, forgiveness, and suffering. Women, and their men, will be able to label their confusion and ultimately, start the process of healing and letting go, by letting God.

Download or read book e Pedia Captain America Civil War written by Contributors, Wikipedia and published by e-artnow. This book was released on 2017-02-11 with total page 6089 pages. Available in PDF, EPUB and Kindle. Book excerpt: This carefully crafted ebook is formatted for your eReader with a functional and detailed table of contents. Captain America: Civil War is a 2016 American superhero film based on the Marvel Comics character Captain America, produced by Marvel Studios and distributed by Walt Disney Studios Motion Pictures. It is the sequel to 2011's Captain America: The First Avenger and 2014's Captain America: The Winter Soldier, and the thirteenth film of the Marvel Cinematic Universe (MCU). The film is directed by Anthony and Joe Russo, with a screenplay by Christopher Markus & Stephen McFeely, and features an ensemble cast, including Chris Evans, Robert Downey Jr., Scarlett Johansson, Sebastian Stan, Anthony Mackie, Don Cheadle, Jeremy Renner, Chadwick Boseman, Paul Bettany, Elizabeth Olsen, Paul Rudd, Emily VanCamp, Tom Holland, Frank Grillo, William Hurt, and Daniel Brühl. In Captain America: Civil War, disagreement over international oversight of the Avengers fractures them into opposing factions—one led by Steve Rogers and the other by Tony Stark. This book has been derived from Wikipedia: it contains the entire text of the title Wikipedia article + the entire text of all the 634 related (linked) Wikipedia articles to the title article. This book does not contain illustrations.

Download or read book The Switch written by Chris Goodall and published by Profile Books. This book was released on 2016-07-07 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: How will the world be powered in ten years' time? Not by fossil fuels. Energy experts are all saying the same thing: solar photovoltaics (PV) is our future. Reports from universities, investment banks, international institutions and large investors agree. It's not about whether the switch from fossil fuels to solar power will happen, but when. Solar panels are being made that will last longer than ever hoped; investors are seeing the benefits of the long-term rewards provided by investing in solar; in the Middle East, a contractor can now offer solar-powered electricity far cheaper than that of a coal-fired power station. The Switch tracks the transition away from coal, oil and gas to a world in which the limitless energy of the sun provides much of the energy the 10 billion people of this planet will need. It examines both the solar future and how we will get there, and the ways in which we will provide stored power when the sun isn't shining. We learn about artificial photosynthesis from a start-up in the US that is making petrol from just CO2 and sunlight; ideas on energy storage are drawn from a company in Germany that makes batteries for homes; in the UK, a small company in Swindon has the story of wind turbines; and in Switzerland, a developer shows how we can use hydrogen to make 'renewable' natural gas for heating. Told through the stories of entrepreneurs, inventors and scientists from around the world, and using the latest research and studies, The Switch provides a positive solution to the climate change crisis, and looks to a brighter future ahead.

Download or read book Focus On 100 Most Popular 2010s Fantasy Films written by Wikipedia contributors and published by e-artnow sro. This book was released on with total page 1343 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Managing Healthy Organizations written by Mikael Holmqvist and published by Routledge. This book was released on 2010-10-04 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book studies worksite health promotion as a way of managing organizations. It examines the character of corporate health experts’ work, the social contexts of their profession, their striving for influence, the way they try to affect people’s thinking and behaviour, and the organizational ethic and culture that they contribute to construct.

Download or read book Sonic the Hedgehog 218 written by Ian Flynn and published by Archie Comic Publications. This book was released on with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Thicker than Water - Part Two": It's Sonic versus Bunnie in a no-holds-barred battle! The prize: the sprawling Oil Ocean Refinery! Two factions stand poised to attack as hero turns on hero - but is everything as it seems? There will be as many revelations as explosions!

Download or read book How to Fix Copyright written by William Patry and published by Oxford University Press. This book was released on 2012-01-02 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do copyright laws directly cause people to create works they otherwise wouldn't create? Do those laws directly put substantial amounts of money into authors' pockets? Does culture depend on copyright? Are copyright laws a key driver of competitiveness and of the knowledge economy? These are the key questions William Patry addresses in How to Fix Copyright. We all share the goals of increasing creative works, ensuring authors can make a decent living, furthering culture and competitiveness and ensuring that knowledge is widely shared, but what role does copyright law actually play in making these things come true in the real world? Simply believing in lofty goals isn't enough. If we want our goals to come true, we must go beyond believing in them; we must ensure they come true, through empirical testing and adjustment. Patry argues that laws must be consistent with prevailing markets and technologies because technologies play a large (although not exclusive) role in creating consumer demand; markets then satisfy that demand. Patry discusses how copyright laws arose out of eighteenth-century markets and technology, the most important characteristic of which was artificial scarcity. Artificial scarcity was created by the existence of a small number gatekeepers, by relatively high barriers to entry, and by analog limitations on copying. Markets and technologies change, in a symbiotic way, Patry asserts. New technologies create new demand, requiring new business models. The new markets created by the Internet and digital tools are the greatest ever: Barriers to entry are low, costs of production and distribution are low, the reach is global, and large sums of money can be made off of a multitude of small transactions. Along with these new technologies and markets comes the democratization of creation; digital abundance is replacing analog artificial scarcity. The task of policymakers is to remake our copyright laws to fit our times: our copyright laws, based on the eighteenth century concept of physical copies, gatekeepers, and artificial scarcity, must be replaced with laws based on access not ownership of physical goods, creation by the masses and not by the few, and global rather than regional markets. Patry's view is that of a traditionalist who believes in the goals of copyright but insists that laws must match the times rather than fight against the present and the future.

Download or read book People Environment Studies Promoting Sustainable Places and Behaviors written by Giuseppe Carrus and published by Frontiers Media SA. This book was released on 2022-09-26 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Soil Constraints and Productivity written by Nanthi Bolan and published by CRC Press. This book was released on 2023-05-29 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identifying, interpreting, and managing soil constraints are major challenges, especially when multiple constraints occur in the same soil at various depth zones. Although amelioration tools and strategies are available to manage some of these constraints, field adoption of these technologies is a major challenge to the farming community. Soil Constraints and Productivity helps in identifying and understanding soil constraints, focusing on management practices to alleviate problems associated with these restrictions, and their impacts on crop productivity. Soil Constraints and Productivity aims to: Describe various strategies suitable for mitigating soil constraints Provide data on cost-benefit analysis of managing soil constraints Provide case studies of managing soil constraints to increase productivity Soil is essential for the doubling of major grain production proposed to be necessary to avoid major food security collapses in the future. This book will be a key resource for soil and environmental scientists, farmers, students majoring in agricultural and environmental sciences, and crop consultants.

Download or read book Regain Be Gone written by Sameera Khan and published by Morgan James Publishing. This book was released on 2019-12-03 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: An experienced dietician shows how to keep the weight off after bariatric surgery. With twenty years of training in the field of bariatrics, trusted dietitian Sameera Khan shares strategies toward a balanced, stress-free weight-loss journey so that readers can feel confident, powerful, and successful. Weight regain is a manageable setback that can be reversed with a little effort and guidance. The longer one ignores it, the harder it is to regain lost ground, so act now. Regain Be Gone is the only resource people need to help them keep weight regain at bay after bariatric surgery. Praise for Regain Be Gone “A great book and really good, comprehensive companion for both patients and practitioners.” —William S. Richardson, MD, FACS, FAMBS; Professor, University of Queensland; Section Head General Surgery, Ochsner Clinic, New Orleans, LA “Sameera Khan is an incredibly knowledgeable guide on your weight loss journey following bariatric surgery. With decades of experience as a dietitian and physical assistant working with weight loss surgery patients, she is an invaluable resource.” —Allison M. Barrett, MD. FACS, FASMBS; Director of Bariatric Surgery at Penn State St. Joseph Medical Center, Reading, PA; Clinical Assistant Professor of Surgery at Penn State University

Download or read book How Will You Measure Your Life Harvard Business Review Classics written by Clayton M. Christensen and published by Harvard Business Review Press. This book was released on 2017-01-17 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the spring of 2010, Harvard Business School’s graduating class asked HBS professor Clay Christensen to address them—but not on how to apply his principles and thinking to their post-HBS careers. The students wanted to know how to apply his wisdom to their personal lives. He shared with them a set of guidelines that have helped him find meaning in his own life, which led to this now-classic article. Although Christensen’s thinking is rooted in his deep religious faith, these are strategies anyone can use. Since 1922, Harvard Business Review has been a leading source of breakthrough ideas in management practice. The Harvard Business Review Classics series now offers you the opportunity to make these seminal pieces a part of your permanent management library. Each highly readable volume contains a groundbreaking idea that continues to shape best practices and inspire countless managers around the world.

Download or read book The End of Cool Japan written by Mark McLelland and published by Routledge. This book was released on 2016-07-22 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today’s convergent media environment offers unprecedented opportunities for sourcing and disseminating previously obscure popular culture material from Japan. However, this presents concerns regarding copyright, ratings and exposure to potentially illegal content which are serious problems for those teaching and researching about Japan. Despite young people’s enthusiasm for Japanese popular culture, these concerns spark debate about whether it can be judged harmful for youth audiences and could therefore herald the end of ‘cool Japan’. This collection brings together Japan specialists in order to identify key challenges in using Japanese popular culture materials in research and teaching. It addresses issues such as the availability of unofficially translated and distributed Japanese material; the emphasis on adult-themes, violence, sexual scenes and under-age characters; and the discrepancies in legislation and ratings systems across the world. Considering how these issues affect researchers, teachers, students and fans in the US, Canada, Australia, China, Japan and elsewhere in Asia, the contributors discuss the different ways in which academic and fan practices are challenged by local regulations. Illustrating from personal experience the sometimes fraught nature of teaching about ‘cool Japan’, they suggest ways in which Japanese Studies as a discipline needs to develop clearer guidelines for teaching and research, especially for new scholars entering the field. As the first collection to identify some of the real problems faced by teachers and researchers of Japanese popular culture as well as the students over whom they have a duty of care, this book will be of great interest to students and scholars of Japanese Studies and Cultural Studies.