Download or read book Autophagy in Endocrine metabolic Diseases Associated with Aging written by Maria Ines Vaccaro and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Autophagy in Health and Disease written by Roberta A. Gottlieb and published by Academic Press. This book was released on 2012-12-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables
Download or read book Carotid Artery written by Rita Rezzani and published by BoD – Books on Demand. This book was released on 2019-09-18 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects recent experimental and clinical studies on gender influence in carotid artery compliance in health and pathological states, discussing also the usefulness and appropriateness of specific and personal medical therapy. Additionally, it provides an overview of the growing importance of ongoing studies on the benefit and risk of gender-specific therapy.
Download or read book Age Later written by Nir Barzilai, M.D. and published by St. Martin's Press. This book was released on 2020-06-16 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.
Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Download or read book Functional Foods for Chronic Diseases Volume 3 written by Danik M. Martirosyan and published by D&A Inc.. This book was released on 2008-02-10 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of this book serves two great purposes. First, it spreads the word about new functional food products for chronic diseases such as hypertension, diabetes, and obesity to the general public. It not only introduces new functional foods, but also shows the investigations and research that led to their creation. Second, the book preserves the numerous ideas and contributions made in the field. This shows the progress and evolution of this thriving field, with the power to change the lives of millions of people. The forever growing field of functional foods brings together research scientists, food manufacturers and consumers who are committed to this issue through modern achievements of surgical approaches and potential of drug therapy, where particular emphasis is placed on the unresolved problems of pharmaceutical side effects.
Download or read book Longevity Genes written by Gil Atzmon, PhD and published by Springer. This book was released on 2015-04-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
Download or read book Geriatric Gastroenterology written by C. S. Pitchumoni and published by Springer Science & Business Media. This book was released on 2012-07-26 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Download or read book Autophagy and Cardiometabolic Diseases written by Jun Ren and published by Academic Press. This book was released on 2018-04-12 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations
Download or read book Lysosomes written by Pooja Dhiman and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers current advances in disorders associated with lysosomal function along with techniques to study its function. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on lysosomal diseases and opens new possible research paths.
Download or read book Autophagy in Current Trends in Cellular Physiology and Pathology written by Nikolai Gorbunov and published by BoD – Books on Demand. This book was released on 2016-11-10 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.
Download or read book Principles and Practice of Geriatric Surgery written by Ronnie Ann Rosenthal and published by Springer Science & Business Media. This book was released on 2011-07-12 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In the preface to this impressive and well-produced book, the editors state that their aim is not to describe a new surgical specialty, since most surgeons will soon need to be "geriatric surgeons," but to assemble a comprehensive account that will allow "all providers of healthcare to the elderly to understand the issues involved in choosing surgery as a treatment option for their patients." This is a useful book that deserves to do well. I hope that the editors and their publisher will have the stamina to make this the first of several editions, as it is clear that updated information about surgery in the elderly will be required to keep pace with this important field." NEJM Book Review
Download or read book The Cancer Degradome written by Dylan Edwards and published by Springer Science & Business Media. This book was released on 2008-09-16 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.
Download or read book Protein Metabolism and Homeostasis in Aging written by Nektarios Tavernarakis and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.
Download or read book Endocrine Frailty in the Elderly written by Sandro La Vignera and published by Frontiers Media SA. This book was released on 2019-12-04 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolic Autophagy written by Siim Land and published by Metabolic Autophagy Diet. This book was released on 2019-02-09 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermittent Fasting for Longevity and Performance Your cells are constantly monitoring the nutrient status of the cells to determine whether or not to conserve energy or to promote growth. **One of the few known ways of increasing lifespan in almost all species is caloric restriction and energy deprivation.** This triggers many metabolic pathways and processes that make the organism more adaptable to environmental stressors and thus live longer. **The metabolism has two sub-categories or sub-processes called anabolism and catabolism. ** * Anabolism, meaning 'upward' in Greek, describes the synthesis of biological molecules to build up new physical matter in the body. * Catabolism, meaning 'downward' in Greek, describes the breaking down of biological molecules to release energy. This can apply to the breakdown of bodily tissue as well as the digestion of food that then gets assimilated into the body through anabolic processes. In addition to 'Metabolic', you can also find another word in the title - 'Autophagy', which translates from Ancient Greek into 'self-devouring' or 'eating of self'. This is central to the main practice of this book. By maintaining a balance between anabolism and catabolism, you can effectively extend your lifespan. The process of autophagy entails your healthy cells devouring the old, worn-out, weak ones and converting them back into energy. It's literally your body eating itself and using that to maintain homeostasis. There are many longevity-boosting benefits to this as illustrated in virtually all other species. This book is a collection of guidelines about the principles of the anabolic-catabolic cycles in regards to nutrition and exercise. It's definitely not a panacea - a solution or remedy for all conditions and circumstances. Instead, it's a very specific protocol that's not supposed to apply for all situations. **Metabolic Autophagy will teach you:** * What increases lifespan in humans and other species * Why there's so much disease and obesity in society * How to promote health and longevity with intermittent fasting * What is Autophagy and how it works * How to age slower and be vigorous throughout your life * Which foods make you live longer and build muscle * How the nutrient regulators of mTOR, AMPK, sirtuins, FOXO proteins, hormesis and others affect longevity * What are circadian rhythms and how they affect your health * Metabolic Autophagy Foods list and their anabolic-catabolic score * Supplements that support muscle growth and longevity * Many extras and bonuses in regards to food and exerciseSiim Land is a best-selling author, anthropologist, entrepreneur, high-performance coach and a biohacker who writes about optimizing health and human performance.This book incorporates daily lifestyle and dietary practices that help to cross the chasm between longevity and high performance.
