Download or read book Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3 D Molecular Breast Imaging written by and published by . This book was released on 2007 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall objective of this proposal is to fully automate and optimize the performance of a 3-D dedicated emission mammotomography system for enhanced semi-automated clinical testing. A retrospective study of 103 clinical MRI uncompressed breast scans was conducted to create surface renderings of the uncompressed breasts and analyze how to adapt existing acquisition orbits for varying breast shapes. Laser ribbon ranging sensors and associated hardware to fully automate the radius of rotation were acquired and tested. An observer based 3D contrast-detail study was performed in an effort to evaluate the limits of object detectability for the dedicated CZT-based SPECT mammotomography imaging system under various imaging conditions. Other aspects of the training program were also initiated including clinical shadowing in the mammography, nuclear medicine, and breast oncology divisions at Duke University.
Download or read book Design Implementation and Characterization of a Dedicated Breast Computed MammoTomography System for Enhanced Lesion Imaging written by and published by . This book was released on 2008 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of this work was to design, implement, and characterize a novel dedicated mammotomography system for enhanced lesion detection. This novel system allows fully 3-D imaging of a pendant, uncompressed breast using novel 3-D complex orbit capabilities. A prototype system has been designed, developed, and extensively characterized with a number of figures of merit including SNR, dose efficiency, and contrast sensitivity. Results indicate the potential for sub dual-view dose uncompressed breast imaging. Observer studies have been performed to determine the lower limits of detectibility. Patient bed optimization has also been performed as well as system/bed positioning and tilt angles for optimal chest wall imaging and patient comfort. The outcome of this project is a fully functioning 3D dedicated breast imaging system ready for initial patient studies. In addition, the training provided by this grant has allowed the PI to continue on with further research and development of this system through SBIR and North Carolina state funding with the goal of commercialization.
Download or read book Development and Characterization of Novel Olumetric Acquisition Orbits With an Application Specific Emission Tomograph for Improved Breast Cancer Detection written by and published by . This book was released on 2004 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear medicine based molecular imaging techniques can be used as an adjunct tool in the diagnosis of breast cancer, particularly for women with dense breast tissue. The dedicated emission mammotomograph is now fully functional; the tomographic gantry was enhanced by including an automated radius-of-rotation capability, to allow for fully 3D imaging of a pendant, uncompressed breast. As a result, novel 3D acquisition orbits have been developed to contour various sized breasts. Initial phantom measurements with a l6x20 sq cm field-of-view cadmium zinc telluride detector show the capability of the system to acquire data about concentric hemispheres of the breast, minimizing distance-dependent spatial resolution effects, maximizing the viewable breast volume while more-nearly- completely sampling the breast, and minimizing background contamination from the heart and liver. Results indicate 3D mamnotomography, incorporating a compact CZT detector and unique 3D camera trajectories, is a promising dedicated breast imaging technique for visualization of tumors less than 1cm in diameter. Future work includes evaluation of: patient bed shielding, sampling schemes for various shaped breasts, and axillary imaging.
Download or read book Optimizing and Evaluating an Integrated SPECT CmT System Dedicated to Improved 3 D Breast Cancer Imaging written by and published by . This book was released on 2009 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall objective of this research is to optimize the development of a combined dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the earlier detection and staging of breast cancer, improving surgical biopsy guidance, and the monitoring of patient therapy response. It is believed that co-registered acquisition of emission (nuclear) and transmission (x-ray) data using both 3D imaging modalities in a common field of view may aid to accurately localize the radioactive uptake of a tumor in the emission image by using anatomical structure from the transmission image. In this second year, the radiation dose absorbed by the uncompressed breast during a regular tomographic scan using is extensively quantified using the developed tomographic system. New concept designs for the next generation 3D breast CmT system are also developed, in addition to new tomographic trajectories designed to overcome limitations in the ability of the developed CmT system to view the chest wall of the prone patient. In addition to the technical work, other aspects of the training program were also completed, including site visits to a major medical imaging company, the presentation of the research at scientific conferences, and the ongoing submission of a manuscript to a major peer reviewed journal. Finally, the doctoral thesis arising from this research was written and successfully defended by the author.
Download or read book Design Implementation and Characterization of a Dedicated Breast Computed MammoTomography System for Enhanced Lesion Imaging written by and published by . This book was released on 2008 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of this work was to design, implement, and characterize a novel dedicated mammotomography system for enhanced lesion detection. This novel system allows fully 3-D imaging of a pendant, uncompressed breast using novel 3-D complex orbit capabilities. A prototype system has been designed, developed, and extensively characterized with a number of figures of merit including SNR, dose efficiency, and contrast sensitivity. Results indicate the potential for sub dual-view dose uncompressed breast imaging. Observer studies have been performed to determine the lower limits of detectibility. Patient bed optimization has also been performed as well as system/bed positioning and tilt angles for optimal chest wall imaging and patient comfort. The outcome of this project is a fully functioning 3D dedicated breast imaging system ready for initial patient studies. In addition, the training provided by this grant has allowed the PI to continue on with further research and development of this system through SBIR and North Carolina state funding with the goal of commercialization.
Download or read book Development and Evaluation of a Dedicated Emission Mammotomography System written by Caryl N. Brzymialkiewicz and published by . This book was released on 2005 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Digital Mammography written by Elizabeth Krupinski and published by Springer Science & Business Media. This book was released on 2008-07-01 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume (5116) of Springer’s Lecture Notes in Computer Science contains the th proceedings of the 9 International Workshop on Digital Mammography (IWDM) which was held July 20 – 23, 2008 in Tucson, AZ in the USA. The IWDM meetings traditionally bring together a diverse set of researchers (physicists, mathematicians, computer scientists, engineers), clinicians (radiologists, surgeons) and representatives of industry, who are jointly committed to developing technologies to support clinicians in the early detection and subsequent patient management of breast cancer. The IWDM conference series was initiated at a 1993 meeting of the SPIE Medical Imaging Symposium in San Jose, CA, with subsequent meetings hosted every two years at sites around the world. Previous meetings were held in York, England; Chicago, IL USA; Nijmegen, Netherlands; Toronto, Canada; Bremen, Germany; Durham, NC USA and Manchester, UK. th The 9 IWDM meeting was attended by a very international group of participants, and during the two and one-half days of scientific sessions there were 70 oral presentations, 34 posters and 3 keynote addresses. The three keynote speakers discussed some of the “hot” topics in breast imaging today. Karen Lindfors spoke on “Dedicated Breast CT: Initial Clinical Experiences. ” Elizabeth Rafferty asked the question is “Breast Tomosynthesis: Ready for Prime Time?” Finally, Martin Tornai discussed “3D Multi-Modality Molecular Breast Imaging.
Download or read book Alternative Breast Imaging written by Keith D. Paulsen and published by Springer Science & Business Media. This book was released on 2006-01-11 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical imaging has been transformed over the past 30 years by the advent of computerized tomography (CT), magnetic resonance imaging (MRI), and various advances in x-ray and ultrasonic techniques. An enabling force behind this progress has been the (so far) exponentially increasing power of computers, which has made it practical to explore fundamentally new approaches. In particular, what our group terms "model-based" modalities-which produce tissue property images from data using nonlinear, iterative numerical modeling techniques-have become increasingly feasible. Alternative Breast Imaging: Four Model-Based Approaches explores our research on four such modalities, particularly with regard to imaging of the breast: (1) MR elastography (MRE), (2) electrical impedance spectroscopy (EIS), (3) microwave imaging spectroscopy (MIS), and (4) near infrared spectroscopic imaging (NIS). Chapter 1 introduces the present state of breast imaging and discusses how our alternative modalities can contribute to the field. Chapter 2 looks at the computational common ground shared by all four modalities. Chapters 2 through 10 are devoted to the four modalities, with each modality being discussed first in a theory chapter and then in an implementation-and-results chapter. The eleventh and final chapter discusses statistical methods for image analysis in the context of these four alternative imaging modalities. Imaging for the detection of breast cancer is a particularly interesting and relevant application of the four imaging modalities discussed in this book. Breast cancer is an extremely common health problem for women; the National Cancer Institute estimates that one in eight US women will develop breast cancer at least once in her lifetime. Yet the efficacy of the standard (and notoriously uncomfortable) early-detection test, the x-ray mammogram, has been disputed of late, especially for younger women. Conditions are thus ripe for the development of affordable techniques that replace or complement mammography. The breast is both anatomically accessible and small enough that the computing power required to model it, is affordable.
Download or read book Development and Characterization of Novel Volumetric Acquisition Orbits with an Application Specific Emission Tomograph for Improved Breast Cancer Detection written by and published by . This book was released on 2007 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of this work was to develop, implement, and evaluate novel three-dimensional acquisition orbits for a dedicated emission mammotomography system. The system can revolve around a pendant, uncompressed breast with fully three dimensional orbital trajectories, which allow for chest wall and axillary imaging. Further optimization and characterization of the system's flexible trajectories and resulting reconstructed images continues. Upon the recommendations from this and prior work, one patient study has been completed.
Download or read book Optimization of Molecular Breast Imaging with Dedicated Gamma Camera Systems written by Carrie Beth Hruska and published by . This book was released on 2007 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small Animal SPECT Imaging written by Matthew A. Kupinski and published by Springer Science & Business Media. This book was released on 2007-05-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small-Animal SPECT Imaging is an edited work derived from the first workshop on Small-Animal SPECT Imaging held January 14-16, 2004 at the University of Arizona, Tucson, AZ, USA. The overall goal of the meeting and therefore this volume is to promote information exchange and collaboration between the research groups developing systems for small-animal applications. Topics include the biomedical significance of small-animal imaging, an overview of detector technologies including scintillation cameras and semi-conductor arrays, imager design and data acquisition systems, animal handling and anesthesia issues, objective assessment of image quality, and system modeling and reconstruction algorithms.
Download or read book Physics in Nuclear Medicine written by Simon R. Cherry and published by . This book was released on 2003 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work, the authors provide up-to-date, comprehensive information on the physics underlying modern nuclear medicine and imaging using radioactively labelled tracers. Examples are presented with solutions worked out in step-by-step detail, illustrating important concepts and calculations.
Download or read book Fundamentals of Nuclear Medicine written by Naomi P. Alazraki and published by . This book was released on 1988 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Imaging Physics written by Ehsan Samei and published by John Wiley & Sons. This book was released on 2020-06-30 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Medical Imaging Physics: Current and Emerging Practice is the first text of its kind—a comprehensive reference work covering all imaging modalities in use in clinical medicine today. Destined to become a classic in the field, this book provides state-of-practice descriptions for each imaging modality, followed by special sections on new and emerging applications, technologies, and practices. Authored by luminaries in the field of medical physics, this resource is a sophisticated, one-volume handbook to a fast-advancing field that is becoming ever more central to contemporary clinical medicine. Summarizes the current state of clinical medical imaging physics in one volume, with a focus on emerging technologies and applications Provides comprehensive coverage of all key clinical imaging modalities, taking into account the new realities in healthcare practice Features a strong focus on clinical application of principles and technology, now and in the future Contains authoritative text compiled by world-renowned editors and contributors responsible for guiding the development of the field Practicing radiologists and medical physicists will appreciate Clinical Medical Imaging Physics as a peerless everyday reference work. Additionally, graduate students and residents in medical physics and radiology will find this book essential as they study for their board exams.
Download or read book Experimental Techniques in Nuclear and Particle Physics written by Stefaan Tavernier and published by Springer Science & Business Media. This book was released on 2010-02-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been teaching courses on experimental techniques in nuclear and particle physics to master students in physics and in engineering for many years. This book grew out of the lecture notes I made for these students. The physics and engineering students have rather different expectations of what such a course should be like. I hope that I have nevertheless managed to write a book that can satisfy the needs of these different target audiences. The lectures themselves, of course, need to be adapted to the needs of each group of students. An engineering student will not qu- tion a statement like “the velocity of the electrons in atoms is ?1% of the velocity of light”, a physics student will. Regarding units, I have written factors h and c explicitly in all equations throughout the book. For physics students it would be preferable to use the convention that is common in physics and omit these constants in the equations, but that would probably be confusing for the engineering students. Physics students tend to be more interested in theoretical physics courses. However, physics is an experimental science and physics students should und- stand how experiments work, and be able to make experiments work. This is an open access book.
Download or read book Clinical 3D Dosimetry in Modern Radiation Therapy written by Ben Mijnheer and published by CRC Press. This book was released on 2017-10-31 with total page 845 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a first comprehensive summary of the basic principles, instrumentation, methods, and clinical applications of three-dimensional dosimetry in modern radiation therapy treatment. The presentation reflects the major growth in the field as a result of the widespread use of more sophisticated radiotherapy approaches such as intensity-modulated radiation therapy and proton therapy, which require new 3D dosimetric techniques to determine very accurately the dose distribution. It is intended as an essential guide for those involved in the design and implementation of new treatment technology and its application in advanced radiation therapy, and will enable these readers to select the most suitable equipment and methods for their application. Chapters include numerical data, examples, and case studies.
Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-07-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
