Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Download or read book Spinal Muscular Atrophy written by Charlotte J Sumner and published by Academic Press. This book was released on 2016-10-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. - Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development - Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA - Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Download or read book China s Communist Party written by David L Shambaugh and published by Univ of California Press. This book was released on 2008-04-02 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few issues affect the future of China--and hence all the nations that interact with China--more than the nature of its ruling party and government. In this timely study, David Shambaugh assesses the strengths and weaknesses, durability, adaptability, and potential longevity of China's Communist Party (CCP). He argues that although the CCP has been in a protracted state of atrophy, it has undertaken a number of adaptive measures aimed at reinventing itself and strengthening its rule. Shambaugh's investigation draws on a unique set of inner-Party documents and interviews, and he finds that China's Communist Party is resilient and will continue to retain its grip on power. Copub: Woodrow Wilson Center Press

Download or read book Multiple System Atrophy written by Gregor K. Wenning and published by Springer Science & Business Media. This book was released on 2013-09-14 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C).The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.

Download or read book Lectures on Nutrition Hypertrophy and Atrophy written by Sir James Paget and published by . This book was released on 1847 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Slice Harvester written by Colin Atrophy Hagendorf and published by Simon and Schuster. This book was released on 2016-11-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the course of two years, a twenty-something punk rocker eats a cheese slice from every pizzeria in New York City, gets sober, falls in love, and starts a blog that captures headlines around the world--he is the Slice Harvester, and this is his story. Since its arrival on US shores in 1905, pizza has risen from an obscure ethnic food to an iconic symbol of American culture. It has visited us in our dorm rooms and apartments, sometimes before we'd even unpacked or painted. It has nourished us during our jobs, consoled us during break-ups, and celebrated our triumphs right alongside us. In August 2009, Colin Hagendorf set out to review every regular slice of pizza in Manhattan, and his blog, Slice Harvester, was born. Two years and nearly 400 slices later, he'd been featured in The Wall Street Journal, the Daily News (New York), and on radio shows all over the country. Suddenly, this self-proclaimed punk who was barely making a living doing burrito delivery and selling handmade zines had a following. But at the same time Colin was stepping up his game for the masses (grabbing slices with Phoebe Cates and her teenage daughter, reviewing kosher pizza so you don't have to), his personal life was falling apart. A problem drinker and chronic bad boyfriend, he started out using the blog as a way to escape--the hangovers, the midnight arguments, the hangovers again--until finally realizing that by taking steps to reach a goal day by day, he'd actually put himself in a place to finally take control of his life for good"--

Download or read book Genetic Neuromuscular Disorders written by Corrado Angelini and published by Springer. This book was released on 2017-10-05 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated and expanded new edition of a successful book describes genetic diagnostic entities of neuromuscular disorders. Neuromuscular syndromes are presented clinically either as a case study or as an overview from the literature, accompanied by text presenting molecular defects, and differential diagnosis. This collection of neuromuscular disorders features the differential clinical phenotypes related to each genotype and are representative of the whole spectrum of a genetic muscle disorder, helping the clinician and neuromuscular physician to make a diagnosis. Key points for each genetic disease are identified to suggest treatment, when available, or the main clinical exams useful in follow-up of patients. Genetic Neuromuscular Disorders: A Case-Based Approach is aimed at neuromuscular physicians and neurology residents.

Download or read book Musculoskeletal Diseases 2021 2024 written by Juerg Hodler and published by Springer Nature. This book was released on 2021 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.

Download or read book Neuropathologic and Neuroradiologic Correlations written by Murat Gokden and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: While neuropathologists and neuroradiologists are increasingly required to work together to diagnose nervous system diseases, many remain unfamiliar with the other's disciplines. Featuring over 900 images, this practical textbook and atlas combines both specialities, providing an extensive understanding of the disease process. It offers a comprehensive review of the nervous system and diseases of the eye, skeletal muscle, and bone and soft tissue. Topics are covered in chapters arranged by region, allowing for quick reference of conditions such as brain tumors, spinal cord diseases, or congenital malformations. Introductory chapters on pathologic and radiologic techniques are also featured, enabling specialists of both areas to familiarise themselves with the other's subject. Packaged with a password to give the user online access to all the text and images, this is a must-have resource for comprehensive and accurate diagnosis.

Download or read book Macular Dystrophies written by Giuseppe Querques and published by Springer. This book was released on 2016-02-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.

Download or read book Atlas of Inherited Retinal Diseases written by Stephen H. Tsang and published by Springer. This book was released on 2018-12-21 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas of Inherited Retinal Disorders provides a thorough overview of various inherited retinal dystrophies with emphasis on phenotype characteristics and how they relate to the most frequently encountered genes. It also meets the previously unmet needs of PhD students who will benefit from seeing the phenotypes of genes they work on and study. Further, because genetic-testing costs are quite high and spiraling higher, this Atlas will help geneticists familiarize themselves with the candidate gene approach to test patients’ genomes, enabling more cost-efficient testing. This invaluable atlas is organized into eight sections starting with an introduction to the basic knowledge on retinal imaging, followed by diseases listed according to inheritance pattern and disorders with extraocular manifestations grouped by defining features. This structure will be intuitive to clinicians and students studying inherited retinal disorders.

Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Download or read book Neurology in Clinical Practice written by Walter George Bradley and published by . This book was released on 2004 with total page 1672 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Download or read book Atlas of Skin Disorders written by Wen-Yuan Zhu and published by Springer. This book was released on 2018-07-31 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written to assist the dermatologists and practitioners in the management of rare and challenging skin disorders. It is the most valuable collection of such skin disorders from more than 274 outstanding contributors over 4 decades in China. In this book, a comprehensive coverage of about 387 conditions are illustrated by 1215 superb images, and each is introduced with an initial summary of clinical characters. This atlas incorporates a wide range of skin disorders from the mildest and common conditions to the most severe conditions. The objective of this book is to provide readers with a clinical reference, which can be easily approachable and possesses the necessary expertise to sharpen a dermatologist’s diagnostic and clinical acumen.

Download or read book Fecal Incontinence written by Carlo Ratto and published by Springer Science & Business Media. This book was released on 2007-06-08 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fecal incontinence is a common and embarrassing condition with a devastating impact on patients’ lives. Since it may result from a variety of pathophysiological situations, an accurate diagnostic work-up is crucial. A range of therapies is available, but choosing the correct option is pivotal to successful management. This book reviews the latest advances in the epidemiologic, socio-economic, psychological, diagnostic, and therapeutic aspects of fecal incontinence, helping to establish effective treatment guidelines.

Download or read book Atrophic Rhinitis written by Stefano Di Girolamo and published by Springer Nature. This book was released on 2020-08-25 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art in atrophic rhinitis and analyses its specific characteristics in non-allergic rhinitis. Little has been written on this condition, which represents a topical issue in modern clinical practice, and as such many clinicians tend to underestimate its impact on patients’ quality of life. This book covers the definition, aetiology, clinical presentation, diagnosis and management, providing specialists with a better understanding of this condition and of the treatment options. It describes in detail the latest diagnostic tools, such as the innovative computational fluid-dynamics studies, nasal cytology, trigeminal stimulation tests, olfactometry, subjective questionnaires, with a focus on the psychological aspects, which have not yet been systematically investigated. Further, it discusses therapeutic strategies, both medical and surgical, reviewing the literature, from the first historical procedures to recent conservative techniques, such as lateral nasal wall reconstruction with various materials, and septal perforation repair. Illustrating all the options currently available, the book is an invaluable resource, not only for otolaryngologists, but also for plastic surgeons, clinical allergists and rheumatologists.

Download or read book Atrophy written by Jackson Burgess and published by SCB Distributors. This book was released on 2018-09-21 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dive bars, gas stations, bedrooms, and snowfields comprise the setting as the speaker asks: What do we feel? What should we feel? Who gets to feel what? In his moving debut collection, Jackson Burgess examines heartbreak, depression, and empathy through a lens of rigorous introspection. Atrophy’s poems vary in location, mostly between Los Angeles and Iowa City, with reoccurring characters serving as touchstones, forming the book’s narrative. Much of the collection is about or directly addresses an ex-lover, Lily. In the wake of that failed relationship, Atrophy wrestles with loneliness, substance abuse, and dissociation, utilizing lists, letters, prose poems, and free verse. These poems celebrate the past while mourning it, armed with the advantage of retrospect. Prescription drugs, dog fights, dance parties, love letters, and ghosts—the world depicted is at times dark, at times humorous, but always human. Atrophy is vulnerable and cinematic, a series of manic meditations exploring what it means to love and be loved, to hurt and be hurt.