Download or read book Asymmetric Synthesis Mediated by Chiral Lithium Amides written by Johan Granander and published by . This book was released on 2005 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Lithium Amides in Asymmetric Synthesis written by Jane M. Paul and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Asymmetric Synthesis written by Alfred Hassner and published by Elsevier. This book was released on 1999-02-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enantioselective synthetic methods are not only in the forefront of chemical and pharmaceutical research but activity in this area is constantly increasing. It is stimulated by the urgency to obtain drugs or compounds of medicinal interest as single anantiomers, and the keeness to synthesize natural products in nonracemic form. This volume presents seven chapters from pioneers and authorities in this rapidly expanding field.
Download or read book Advanced Asymmetric Synthesis written by G.R. Stephenson and published by Boom Koninklijke Uitgevers. This book was released on 1996-06-30 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design of asymmetric synthesis. Nonlinear effects in enantioselective synthesis - asymmetric amplification. Chiral enolates. Optically active B-ketosulfoxides in asymmetric synthesis. Chiral aminals in asymmetric synthesis. Asymmetric deprotonation reactions using enantiopure lithium amide bases. Asymmetric Diels-Alder reactions. Asymmetric oxidiation. Transition metal catalysts for asymmetric reduction. Asymmetric hydroboration. Asymmetric hydrosilylation and hydroformylation. Asymmetric conjugate addition reactions. Stereoselective transformations mediated by chiral titanium complexes. Asymmetric synthesis using enzymes and whole cells. Asymmetric palladium catalysed coupling reactions. Palladium allyl pi-complexes in asymmetric synthesis. Worked examples in asymmetric synthesis design. Stoichiometric electrophilic pi-complexes in asymmetric synthesis.
Download or read book Asymmetric Butylation of Aldehydes Mediated by Chiral Lithium Amides and Investigations of Lithium Amide Aggregates in Solution written by Jia Liu and published by . This book was released on 2007 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis of Piperidines Using the Chiral Lithium Amide Base Approach written by Nicholas J. Goldspink and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Lithium Amides in Asymmetric Synthesis written by Per I. Arvidsson and published by . This book was released on 1999 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis and NMR Studies of Chiral Lithium N P amide Complexes written by Petra Rönnholm and published by . This book was released on 2010 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis V3 written by James Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis, Volume 3: Stereodifferentiating Addition Reactions, Part B presents intensive investigations in leading academic and industrial laboratories on stereodifferentiating addition reactions. This book is divided into eight chapters and begins with a comprehensive review of the formation of chiral metal enolates and their stereoselective alkylation reactions. These topics are followed by discussions on chiral Aldol addition reactions and the many variations of asymmetric synthesis that may be carried out using chiral oxazolines. A chapter describes the alkylation of chiral hydrazones, a process that yields chiral-substituted aldehydes and ketones. Other chapters explore a variety of cyclization processes that form carbon-carbon and carbon-heteroatom bonds. The last chapters deal with the asymmetric cycloadditions and sigma-tropic rearrangements. Synthetic chemists and researchers will find this book invaluable.
Download or read book Chiral Lithium Amides written by Mark Robert Prestly and published by . This book was released on 2013 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chiral Base mediated Asymmetric Synthesis of Tricarbonyl written by David A. Price and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Development and Application of Magnesium Amide Bases in Asymmetric Synthesis written by Linsey S. Bennie and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A range of bridged bicyclic ketones were then prepared in order to probe their application in magnesium amide-mediated asymmetric deprotonation reactions. Initial studies were performed using a simple oxabicyclic substrate and our C2-symmetric bisamide. Pleasingly, after a short period of optimisation, the enantioenriched silyl enol ether was obtained in unprecedented yield and enantioselectivity. Attention was then turned to the analogous thiabicyclic ketone substrate. When performing the asymmetric deprotonation of this novel substrate under the previously optimised conditions at -78 oC, an outstanding level of enantioselection was observed (99:1 er), and the silyl enol ether product was obtained in good yield. Having achieved such impressive results at -78 oC, the efficiency of the transformation at room temperature was probed. Pleasingly, the enantioenriched silyl enol ether was obtained in excellent enantioselectivity (94:6 er) and yield, without the requirement for subambient temperatures. This is in marked contrast to the results achieved using the corresponding lithium amide, which delivered the silyl enol ether with a lower level of enantioselectivity (93:7) at -78 oC. Impressive results could also be achieved when the analogous alkylmagnesium amide was applied to the desymmetrisation of the thiabicyclic substrate. Studies within the area of magnesium base chemistry have been extended to the enantioselective total synthesis of the bicyclic eicosanoid, (-)-mucosin. The synthetic strategy which has been devised involves a magnesium base-mediated enantioselective deprotonation as the key transformation. As such, the required meso-ketone substrate has been prepared efficiently using a series of simple synthetic transformations. With the mesoketone in hand, conversion to the racemic enol silane has been achieved by utilising carboncentred magnesium base chemistry. In addition, preparation of the required allylic bromide electrophile has been completed in a short number of synthetic steps using readily available starting materials, and the racemic enol silane and allylic bromide coupling partners were reacted to give the required -substituted ketone in moderate yield. Efforts were then focused on the development of an asymmetric method for the preparation of the enol silane intermediate, delivering the optically-enriched enol silane in high enantioselectivity using our C2-symmetric magnesium bisamide (93:7 er) or the C2-symmetric lithium amide (94:6 er) at - 78 oC.
Download or read book Asymmetric Synthesis V4 written by James Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almost 1,300 structures and the use of chiral building blocks to prepare alkaloids, arachidonic acid metabolites, compounds with chemotherapeutic and pharmacological activity, insect pheromones, sugars, vitamins, terpenoids, and miscellaneous compounds are also included in this text. The remaining chapters provide a similar overview of the chemistry of compounds chiral at sulfur, phosphorus, nitrogen, and silicon. Synthetic chemists and researchers, especially those engaged in pharmaceutical research and specialty chemicals production, will find this book invaluable.
Download or read book Chiral Lithium Amides in Enantioselective Deprotonations written by Daniel Pettersen and published by . This book was released on 2005 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis written by Tamio Hayashi and published by CRC Press. This book was released on 1998-06-09 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of the rapidly developing field of asymmetric synthesis. Using easy to understand graphical abstracts it presents 348 important catalytic and stoichiometric reactions leading to the synthesis of optically active chiral compounds. The first part of the book covers reactions related to reductions, oxidations, carbon-carbon bond formation and carbon-heteroatom bond formation. Each graphical abstract is accompanied by a list of important keywords and references to assist the reader. The second part concentrates on experimental aspects, describing synthetic procedures for selected chiral reagents and chiral auxiliaries, and provides an invaluable reference tool for laboratory work. Written with both the graduate student and professional organic chemist in mind, this book will serve as an important resource for the synthetic organic chemist.
Download or read book Synthesis and applications of chiral lithium amides written by Michiel Barend Eleveld and published by . This book was released on 1984 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis written by James D. Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume have been written by some of the foremost practictioners in the field and should be of interest to both mechanistic and synthetic chemists.
