Download or read book Role of Nutraceuticals in Cancer Chemosensitization written by and published by Academic Press. This book was released on 2017-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. - Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field - Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients - Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations

Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Download or read book Handbook of Arsenic Toxicology written by Swaran Jeet Singh Flora and published by Academic Press. This book was released on 2014-12-26 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasure

Download or read book Biological Chemistry of Arsenic Antimony and Bismuth written by Hongzhe Sun and published by John Wiley & Sons. This book was released on 2010-12-10 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.

Download or read book Arsenic written by Assembly of Life Sciences (U.S.). Committee on Medical and Biologic Effects of Environmental Pollutants and published by National Academies Press. This book was released on 1977-01-01 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth review of arsenic and its affect on the environment and to man.

Download or read book Arsenic in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2001-12-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Having safe drinking water is important to all Americans. The Environmental Protection Agency's decision in the summer of 2001 to delay implementing a new, more stringent standard for the maximum allowable level for arsenic in drinking water generated a great deal of criticism and controversy. Ultimately at issue were newer data on arsenic beyond those that had been examined in a 1999 National Research Council report. EPA asked the National Research Council for an evaluation of the new data available. The committee's analyses and conclusions are presented in Arsenic in Drinking Water: 2001 Update. New epidemiological studies are critically evaluated, as are new experimental data that provide information on how and at what level arsenic in drinking water can lead to cancer. The report's findings are consistent with those of the 1999 report that found high risks of cancer at the previous federal standard of 50 parts per billion. In fact, the new report concludes that men and women who consume water containing 3 parts per billion of arsenic daily have about a 1 in 1,000 increased risk of developing bladder or lung cancer during their lifetime.

Download or read book Medicinal Organometallic Chemistry written by Gérard Jaouen and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Download or read book Poison Panic written by Helen Barrell and published by Pen and Sword. This book was released on 2016-08-31 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: True crime that “will appeal to readers interested in gaining an insight into the lives of women accused of murder in the mid 19th century” (Essex Family Historian). For a few years in the 1840s, Essex was notorious in the minds of Victorians as a place where women stalked the winding country lanes looking for their next victim to poison with arsenic. Though that terrible image may not have much basis in truth, it was a symptom of an anxiety-filled time . . . The 1840s were also known as the “hungry ’40s,” when crop failures pushed up food prices and there was popular unrest across Europe. The decade culminated in a cholera epidemic in which tens of thousands of people in the British Isles died. It is perhaps no surprise that people living through that troubled decade were captivated by the stories of the “poisoners”: that death was down to “white powder” and the evil intentions of the human heart. Sarah Chesham, Mary May, and Hannah Southgate are the protagonists of this tale of how rural Essex, in a country saturated with arsenic, was touched by the tumultuous 1840s. “Barrell’s meticulous research and eye for detail recreate lurking threats, and these scandalous true stories are as compelling as any crime fiction.” —History of War “An intriguing read that brings a forgotten history to light and reveals past attitudes to women—and a national fear that gripped Victorian Britain.” —Family Tree Magazine “This book will fascinate not only historians of true crime and those with an interest in genealogy but any reader seeking a story that would make Agatha Christie proud.” —All About History

Download or read book Chemotherapy for Leukemia written by Takanori Ueda and published by Springer. This book was released on 2018-09-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the latest progress in chemotherapy for leukemia and related diseases, including still-ongoing but promising studies. The effectiveness of treatment for chronic myeloid leukemia and acute promyelocytic leukemia has been dramatically improved in recent years. This improvement has been made possible with the development of molecular targeted agents such as bcr-abl tyrosine kinase inhibitors and all-trans retinoic acid. The antibody for the unique target of chemokine receptor 4 for adult T-cell leukemia/lymphoma, or FLT3 inhibitors (signaling inhibitors) has been applied to other leukemias. Also, chemotherapeutic agents including antimetabolite analogues such as clofarabine, and azacitidine (an epigenetic regulator) have undergone progressive development. Meanwhile, the novel concept of therapy targeting leukemic stem cells has been developed. The contributors discuss prospective results of basic and preclinical studies and clinical possibilities based on the effects for leukemic stem cells. This work facilitates a comprehensive understanding of modern treatment methodology for leukemia. The volume therefore will greatly benefit not only hematologists but also oncologists, all physicians who specialize in blood cancer, and pharmacologists who are involved in the development of therapeutic agents for leukemia.

Download or read book The Arsenic Eaters written by Rob van Hoesel and published by . This book was released on 2018-07-24 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the widespread historical belief that the consumption of arsenic, generally known to be a deadly poison, is beneficial to one's health. Accordingly, many "poison eaters" were found among the Austrian rural population in the nineteenth century. What they were ingesting was white (arsenic trioxide) or yellow arsenic (arsenic trisulfide). It was produced by roasting arsenic-containing minerals. Arsenic eaters were robust persons, and usually of the lower class of society, wood cutters, charcoal burners, stablemen, foresters, etc. They ingested arsenic to be 'strong and healthy': to look rosy, to resist fatigue or to strengthen their physique: "See how strong and fresh I am, and what an advantage I have over you all! In times of epidemic fever or cholera, what a fright you are in, while I feel sure of never taking infection." Though being a popular custom among hard working people, arsenic eaters were very anxious to conceal the fact, particularly from medical men and priests. It was also believed that once a person became an arsenic eater, he can never stop the habit. To do so would bring rapid decline in health, leading inevitably to death.

Download or read book Emergency Response Guidebook written by U.S. Department of Transportation and published by Simon and Schuster. This book was released on 2013-06-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.

Download or read book Toxicological Risks of Selected Flame Retardant Chemicals written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Download or read book Is Arsenic an Aphrodisiac written by William R Cullen and published by Royal Society of Chemistry. This book was released on 2008-04-22 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex, drugs, rocks, gold, murder, war, mass poisonings, the deaths of Napoleon, Tchaikovsky, Mozart, and others are all linked by one element - arsenic! Arsenic has been around since the beginning of time and the word has become a metaphor for poison with associated shock value. The general public are fearful of any possible exposure to it and yet it holds a certain dark and eerie fascination! The average person has only one idea about arsenic - it is poison - and this reputation has a sound base. Some arsenic compounds are very toxic and have been used with criminal intent from the time of the ancient Romans to the present day. Up until now, there has been no book that covers arsenic with such breadth. This book is a general appreciation of how much the element, arsenic, has become part of our lives in an entertaining style covering the years 1000 BC to the present day. The coverage of the chemistry, toxicology, and medicinal aspects is deliberately kept at a level for the general reader to understand. It covers the way in which this ubiquitous element and its compounds have influenced the lives of the people of the world. The author's objective in writing this book was not to elaborate on the vast chemistry of the element, but to try to reveal to the general reader how the element and its compounds have become embedded in our social fabric, for good and for ill. No other element comes close in this regard and he uses the word sociochemistry to describe this interface between society and chemistry. The book covers a broad range of topics including the use of arsenic in human medicine in many cultures from Chinese medicine to the beginning of chemotherapy. This peaked in the western world in the early 20th century, with Ehrlich's discovery of salvarsan, an arsenic-based cure for syphilis that gave rise to the field of chemotherapy. Salvarsan and related compounds were eventually displaced by antibiotics such as penicillin. Arsenic trioxide has staged a comeback, however, and is being used as a successful treatment for a form of leukemia. Other chapters cover arsenic compounds which were widely used in agriculture and wood preservation during the 20th century and their associated myths as well as arsenic compounds as chemical warfare agents and the resulting stockpile. The topic of arsenic in the environment is discussed in depth - arsenic is all around us - in our soil, our water, and our food, and our bodies have adapted to its presence and it does not usually pose a problem. However, the natural presence of high concentrations of arsenic in drinking water currently threatens the lives of millions of people in India, Bangladesh, Mexico and elsewhere. It also covers mining and pesticide manufacturing which can lead to high local arsenic concentrations in soils, slag heaps and mine tailings which, when located close to human activities, can produce human health risks. Other chapters cover a variety of topics including: " A proposed connection between arsenic and Cot Death (SIDS) which caused panic " The high concentration of arsenic in kelp products-is this harmful? " What about the 237,000 tonnes of arsenic trioxide stored in a mine in Canada? " How toxic is arsenic anyway, and how do you assess the risks of exposure? " How did Napoleon die? These and many other topics are addressed at a level that will result in understanding without delving into too much technical detail or requiring a degree in chemistry. Essential reading for everyone with a general interest in science, this illuminating text covers a broad range of topics.

Download or read book Biochemistry of the Essential Ultratrace Elements written by Earl Frieden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable development of molecular biology has had its counterpart in an impressive growth of a segment of biology that might be described as atomic biology. The past several decades have witnessed an explosive growth in our knowledge of the many elements that are essential for life and maintenance of plants and animals. These essential elements include the bulk elements (hydro gen, carbon, nitrogen, oxygen, and sulfur), the macrominerals (sodium, potas sium, calcium, magnesium, chloride, and phosphorus), and the trace elements. This last group includes the ultra trace elements and iron, zinc, and copper. Only the ultratrace elements are featured in this book. Iron has attracted so much research that two volumes are devoted to this metal-The Biochemistry of Non-Heme Iron by A. Bezkoravainy, Plenum Press, 1980, and The Biochemistry of Heme Iron (in preparation). Copper and zinc are also represented by a separate volume in this series. The present volume begins with a discussion of essentiality as applied to the elements and a survey of the entire spectrum of possible required elements.

Download or read book Report written by Queensland. Department of Public Lands and published by . This book was released on 1911 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Arsenic written by Assembly of Life Sciences (U.S.). Committee on Medical and Biologic Effects of Environmental Pollutants and published by National Academies Press. This book was released on 1977-01-01 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth review of arsenic and its affect on the environment and to man.