Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases written by Patrick C. Even and published by Frontiers Media SA. This book was released on 2018-02-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
Download or read book Are Rodent Models Fit for Investigation of Human Obesity and Related Diseases written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
Download or read book Eat Like a Pig Run Like a Horse written by Anastacia Marx de Salcedo and published by Simon and Schuster. This book was released on 2022-07-05 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no magic pill. There is no perfect diet. Could it be that our underlying assumption—that what we’re eating is making us fat and sick—is just plain wrong? To address the rapid rise of “lifestyle diseases” like diabetes and heart disease, scientists have conducted a whopping 500,000 studies of diet and another 300,000 of obesity. Journalists have written close to 250 million news articles combined about these topics. Yet nothing seems to halt the epidemic. Anastacia Marx de Salcedo’s Eat Like a Pig, Run Like a Horse looks not just to data-driven science, but to animals and the natural world around us for a new approach. What she finds will transform the national debate about the root causes of our most pervasive diseases and offer hope of dramatically reducing the number who suffer—no matter what they eat. It all began with her own medical miracle—she has multiple sclerosis but has discovered that daily exercise was key to keeping it from progressing. And now, new research backs up her own experience. This revelation prompted Marx de Salcedo to ask what would happen if people with lifestyle illnesses put physical activity front and center in their daily lives? Eat Like a Pig, Run Like a Horse takes us on a fascinating journey that weaves together true confessions, mad(ish) scientists, and beguiling animal stories. Marx de Salcedo shows that we need to move beyond our current diet-focused model to a new, dynamic concept of metabolism as regulated by exercise. Suddenly the answer to good health is almost embarrassingly simple. Don’t worry about what you eat. Worry about how much you move. In a few years’ time, adhering to a finicky Keto, Paleo, low-carb, or any other special diet to stay healthy will be as antiquated as using Daffy’s Elixir or Dr. Bonker’s Celebrated Egyptian Oil—popular “medicines” from the 1800s—to cure disease. And just as the 19th-century health revolution was based on a new understanding that the true cause of malaria, tuberculosis, and cholera was microorganisms, so the coming 21st-century one will be based on our new understanding that exercise is the only way to metabolic health. Fascinating and brilliant, Eat Like a Pig, Run Like a Horse is primed to usher in that new era.
Download or read book Neural Control of Energy Homeostasis and Energy Homeostasis Regulation of Brain Function written by Lionel Carneiro and published by Frontiers Media SA. This book was released on 2022-04-26 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Download or read book Clinical Guidelines on the Identification Evaluation and Treatment of Overweight and Obesity in Adults written by Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (U.S.) and published by . This book was released on 1998 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of evidence-based recommendations -- Introduction -- Overweight and obesity: background -- Examination of randomized controlled trial evidence -- Treatment guidelines -- Summary of recommendations -- Future research.
Download or read book The Nature of Nutrition written by Stephen J. Simpson and published by Princeton University Press. This book was released on 2012-07-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition has long been considered more the domain of medicine and agriculture than of the biological sciences, yet it touches and shapes all aspects of the natural world. The need for nutrients determines whether wild animals thrive, how populations evolve and decline, and how ecological communities are structured. 'The Nature of Nutrition' addresses nutrition's enormously complex role in biology, both at the level of individual organisms and in their broader ecological interactions.
Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
Download or read book Animal Models for the Study of Human Disease written by Heather A. Lawson and published by Elsevier Inc. Chapters. This book was released on 2013-05-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic syndrome (MetS) is a clustering of metabolic complications representing a pre-morbid condition that is a substantial public health burden. Animal models provide an opportunity to examine correlations among different metabolic parameters to understand why metabolic complications sometimes cluster and sometimes do not. This chapter provides an overview of animal models of MetS that are used to understand etiology and pathophysiology, with a focus on methods of identifying and testing candidate genes with the aim of translating results to human studies. Genetic, epigenetic, environmental, and gene by environmental methods and results are discussed along with important lessons learned. Rodent models are the most frequently used, however other animal models including dogs, pigs, sheep, and non-human primates have contributed to our understanding of MetS and each are discussed. Additionally, animal models used to test physiological hypotheses are reviewed along with their potential to illuminate DNA sequence–metabolic function relationships to inform therapies.
Download or read book Cells and Materials for Disease Modeling and Regenerative Medicine written by Ander Abarrategi and published by MDPI. This book was released on 2021-05-05 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.
Download or read book Animal Models for the Study of Human Disease written by P. Michael Conn and published by Academic Press. This book was released on 2017-06-20 with total page 1198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases
Download or read book Departments of Labor Health and Human Services and Education and Related Agencies Appropriations for Fiscal Year 2002 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2002 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2002 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2001 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Laboratory Mouse written by Peggy J. Danneman and published by CRC Press. This book was released on 2012-09-25 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a
Download or read book Genetics of Fitness and Physical Performance written by Claude Bouchard and published by Human Kinetics. This book was released on 1997 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Fitness and Physical Performance is the first comprehensive reference on the role of the genes in influencing individual variation in fitness and performance. This essential compendium reviews the past 25 years of accumulated evidence on the genetic basis of health- and performance-related fitness phenotypes. Focusing on the interests of sport scientists, the authors provide insight into the significance of this research on nearly every aspect of the study of human physical activity. The book presents the biological basis of heredity and explains the concepts and methods of genetic epidemiology and molecular biology that are necessary to understand this specialized field. With the rapid advances in molecular biology and the paradigms of human genetics, exercise scientists face a dynamic and vibrant new field. This book offers readers new opportunities to better understand atherosclerosis, noninsulin dependent diabetes, obesity, and hypertension by searching for single gene effects and identifying susceptibility genes. The authors review the evidence on the role of the genes for human traits as it pertains to the exercise science field. And they explore the scientific, practical, and ethical issues that confront exercise scientists as progress is made in this field. Genetics of Fitness and Physical Performance is vital reading for scholars in the field of exercise and sport science to understand how recent discoveries in genetics might shape their future research.
Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
Download or read book Why We Age written by Steven N. Austad and published by Wiley. This book was released on 1999-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why has the life span of the average American increased from 48 to 75 years in this century alone? . . . If the body is a machine that simply wears out, why do some cells seem immortal? . . . Is there an aging gene? And can we control it? . . . Can antioxidants and hormone therapy actually slow the aging process and extend life? Steven Austad s compelling book investigates the history, the theories, and the personalities behind the quest to understand the nature of aging. Here is hard evidence from the front lines of research that science is finally closing in on the fundamental processes of human biology and life. "Austad s book can be read with pleasure and profit by any intelligent person with a smattering of biological knowledge." Science "In this clear, engrossing overview, Austad takes the sting out of a subject that will ultimately capture us all." Publishers Weekly "Why We Age is remarkably rigorous in its analysis and thorough scope. . . . A comprehensive examination of its topic." Science Editors, Amazon.com "The problem with long life is that one keeps getting older; here s an able and clearly written summary of the latest theories on why we age and what might be done to ameliorate the process." Kirkus Reviews
