Download or read book Approaches Towards the Total Synthesis of the Bryostatins written by Matthew O'Brien and published by . This book was released on 2002 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaches Towards the Total Synthesis of the 20 deoxy Bryostatins written by Simon Hardy and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaches Towards the Total Synthesis of the 20 deoxy Bryostatins written by Simon Hardy and published by . This book was released on 2009 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of Bryostatins written by Peter Green and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of Bryostatins written by Peter Green and published by . This book was released on 2010 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaches Towards the Total Synthesis of the 20 deoxybryostatins written by Matthew Ball and published by . This book was released on 2004 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Efficient Access to Bryostatin and Functional Bryostatin Analogs written by Adam James Schrier and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The bryostatins are a family of structurally complex natural products isolated from the marine bryozoan Bugula neritina. Bryostatin 1 is currently being investigated for cancer, Alzheimer's and HIV/AIDS indications. Despite these remarkable activities, research on the bryostatins is hampered by their low natural abundance. Efficient access by total chemical synthesis has been in large part precluded by the bryostatins' structural complexity. This dissertation describes the design, synthesis, and preliminary biological evaluation of functional bryostatin analogs that possess biological activities comparable or superior to the natural product. These fully synthetic analogs were convergently assembled in a uniquely step-economical manner using novel macrocyclization strategies, including macroacetalization and Prins-driven macrocyclization approaches. Bryostatin analogs were identified that possess unique affinities (subnanomolar) and selectivities for protein kinase C (PKC). Synthetic bryostatin analogs also exhibit subnanomolar antileukemic activity in in vitro assays. The convergent total synthesis of bryostatin 9, a highly potent congener of the natural product family, is also described.
Download or read book Studies Directed Towards the Total Synthesis of Bryostatin written by Erick Moran Carreira and published by . This book was released on 1990 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Total Synthesis of Bryostatin 1 written by Seyed Hassan Seradj and published by . This book was released on 2009 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of the Bryostatins written by Percy Hudson Carter and published by . This book was released on 1998 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Directed Towards the Total Synthesis of Bryostatins written by David Milburn Robinson and published by . This book was released on 1990 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Efforts Toward the Total Synthesis of Bryostatin 1 Emphasis on the C17 C27 Fragment written by Victoria Lynn Wilde and published by . This book was released on 2008 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis of Bryostatin 7 written by John Charles Roberts and published by . This book was released on 1991 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Total Synthesis of Bryostatin 1 written by David Curtis Whritenour and published by . This book was released on 1988 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis and Biological Evaluation of Bryostatin 1 and Its Analogues written by Yam Bahadur Poudel and published by . This book was released on 2011 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Download or read book Approaches to the Total Synthesis of Cyathin B3 written by Karl Robert Dahnke and published by . This book was released on 1993 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
