Download or read book Predictive Approaches in Drug Discovery and Development written by J. Andrew Williams and published by John Wiley & Sons. This book was released on 2012-04-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Download or read book The Expression of Possession written by William McGregor and published by Walter de Gruyter. This book was released on 2009 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of nine original articles deals with the expression of possession at various levels of grammar, morphological, phrasal, and syntactic, and from a typologically diverse range of languages (including Germanic, Oceanic, Meso-American, and Australian Aboriginal). There are two main aims. The first is to reveal something of the range of constructions employed cross-linguistically in the expression of possession, and second, to present an understanding of the possessive relation itself as a cognitive and linguistic phenomenon. A guiding principle in the selection of contributors has.
Download or read book Building and Interpreting Possession Sentences written by Neil Myler and published by MIT Press. This book was released on 2024-02-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide-ranging generative analysis of the typology of possession sentences, solving long-standing puzzles in their syntax and semantics. A major question for linguistic theory concerns how the structure of sentences relates to their meaning. There is broad agreement in the field that there is some regularity in the way that lexical semantics and syntax are related, so that thematic roles (the different participant roles in an event: agent, theme, goal, etc.) are predictably associated with particular syntactic positions. In this book, Neil Myler examines the syntax and semantics of possession sentences, which are infamous for appearing to diverge dramatically from this broadly regular pattern. On the one hand, Myler points out, possession sentences have too many meanings; in any given language, the construction used to express archetypal possessive meanings (such as personal ownership) is also often used to express other apparently unrelated notions (body parts, kinship relations, and many others). On the other hand, possession sentences have too many surface structures; languages differ markedly in the argument structures used to convey the same possessive meanings. Myler argues that recent work on the syntax-semantics interface in the generative tradition has developed the tools needed to solve these puzzles. Examining and synthesizing ideas from the literature and drawing on data from many languages (including some understudied Quechua dialects), Myler presents a novel way to understand the apparent irregularity of possession sentences while preserving explanations of general cross-linguistic regularities, offering a unified approach to the syntax and semantics of possession sentences that can also be integrated into a general theory of argument structure.
Download or read book Quantitative Approaches to Plant Breeding Concepts Strategies and Practical Applications written by Suchismita Mondal and published by Frontiers Media SA. This book was released on 2022-08-31 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Predicting movie ratings and recommender systems written by Arkadiusz Paterek and published by Arkadiusz Paterek. This book was released on 2012-06-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 195-page monograph by a top-1% Netflix Prize contestant. Learn about the famous machine learning competition. Improve your machine learning skills. Learn how to build recommender systems. What's inside:introduction to predictive modeling,a comprehensive summary of the Netflix Prize, the most known machine learning competition, with a $1M prize,detailed description of a top-50 Netflix Prize solution predicting movie ratings,summary of the most important methods published - RMSE's from different papers listed and grouped in one place,detailed analysis of matrix factorizations / regularized SVD,how to interpret the factorization results - new, most informative movie genres,how to adapt the algorithms developed for the Netflix Prize to calculate good quality personalized recommendations,dealing with the cold-start: simple content-based augmentation,description of two rating-based recommender systems,commentary on everything: novel and unique insights, know-how from over 9 years of practicing and analysing predictive modeling.
Download or read book New Approaches of Protein Function Prediction from Protein Interaction Networks written by Jingyu Hou and published by Academic Press. This book was released on 2017-01-13 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction. Provides innovative approaches and new developments targeting key issues in protein function prediction Presents heuristic ideas for further research in this challenging area
Download or read book Report of the Workshop Predictive Theoretical Computational and Experimental Approaches for Additive Manufacturing WAM 2016 written by Xu Guo and published by Springer. This book was released on 2017-10-23 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume focuses on theoretical and computational approaches and involves areas such as simulation-based engineering and science, integrated computational materials engineering, mechanics, material science, manufacturing processes, and other specialized areas. Most importantly, the state-of-the-art progress in developing predictive theoretical, computational and experimental approaches for additive manufacturing is summarized.
Download or read book Social Structure Space and Possession in Tongan Culture and Language written by Svenja Völkel and published by John Benjamins Publishing. This book was released on 2010 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This interdisciplinary study investigates the relationship between culture, language and cognition based on the aspects of social structure, space and possession in Tonga, Polynesia. Grounded on extensive field research, Volkel explores the subject from an anthropological as well as from a linguistic perspective. The book provides new insights into the language of respect, an honorific system which is deeply anchored in the societal hierarchy, spatial descriptions that are determined by socio-cultural and geocentric parameters, kinship terminology and possessive categories that perfectly express the system of social status inequalities among relatives. These examples impressively show that language is deeply anchored in its cultural context. Moreover, the linguistic structures reflect the underlying cognitive frame of its speakers. Just as several cultural practices (sitting order, access to land and gift exchange processes) the linguistic means are not only expressions of stratified social networks but also tools to maintain or negotiate the underlying socio-cultural system."
Download or read book Critical Approaches to Science and Philosophy written by Mario Bunge and published by Routledge. This book was released on 2018-10-08 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays, written on four continents by scientists, philosophers and humanists, was initially presented to Karl R. Popper on his sixtieth birthday as a token of critical admiration and in recognition of his work. But the volume also stands on its own as a remarkable series of statements utilizing Popper's critical vision in the study of philosophy proper, logic, mathematics, science as method and theory, and finally to the study of society and history. What is remarkable is that Popper worked in all of these areas, not in a cursory or discursive way, but with the utmost clarity and rigor. . The core position of this volume and its contributors is that the progress of knowledge is not a linear accumulation of definitive acquisitions but a zigzagging process in which counterexamples and unfavorable evidence ruin generalizations and prompt the invention of more comprehensive and sometimes deeper generalizations, to be criticized in their turn. A critical approach to problems, procedures, and results in every field of inquiry is therefore a necessary condition for the continuance of progress. The title of this volume then is, in a sense, an homage to Popper's critical rationalism and critical empiricism. The essays are a tribute to his unceasing and uncompromising quest, not for final certainty, but for closer truth and increased clarity. Among the contributors are outstanding figures in philosophy and the exact sciences in their own right, including Herbert Feigl, R. M. Hare, J.O. Wisdom, Nicholas Rescher, David Bohm, Paul K. Feyerabend, F. A. Hayek, and Adolf Grunbaum. Social science contributions include Hans Albert on social science and moral philosophy, W. B. Gallie, on the critical philosophy of history, Pieter Geyl on The Open Society and its Enemies, and George H. Nadel on the philosophy of History.
Download or read book Pragmatic Idealism and Scientific Prediction written by Amanda Guillán and published by Springer. This book was released on 2017-08-30 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph analyzes Nicholas Rescher’s system of pragmatic idealism. It also looks at his approach to prediction in science. Coverage highlights a prominent contribution to a central topic in the philosophy and methodology of science. The author offers a full characterization of Rescher’s system of philosophy. She presents readers with a comprehensive philosophico-methodological analysis of this important work. Her research takes into account different thematic realms: semantic, logical, epistemological, methodological, ontological, axiological, and ethical. The book features three, thematic-parts: I) General Coordinates, Semantic Features and Logical Components of Scientific Prediction; II) Predictive Knowledge and Predictive Processes in Rescher’s Methodological Pragmatism; and III) From Reality to Values: Ontological Features, Axiological Elements, and Ethical Aspects of Scientific Prediction. This insightful analysis offers a critical reconstruction of Rescher’s philosophy. The system he created is often characterized as pragmatic idealism that is open to some realist elements. He is a prominent representative of contemporary pragmatism who has made a great deal of contributions to the study of this topic. This area is crucial for science and it has been little considered in the philosophy of science.
Download or read book Computational Methods in Inferring Cancer Tissue of Origin and Cancer Molecular Classification Volume I written by Min Tang and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Research Methods and Applications in Experimental Economics written by Arthur Schram and published by Edward Elgar Publishing. This book was released on 2019 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive review of experimental methods in economics. Its 21 chapters cover theoretical and practical issues such as incentives, theory and policy development, data analysis, recruitment, software and laboratory organization. The Handbook includes separate parts on procedures, field experiments and neuroeconomics, and provides the first methodological overview of replication studies and a novel set-valued equilibrium concept. As a whole, the combination of basic methods and current developments will aid both beginners and advanced experimental economists.
Download or read book Bayesian Economics Through Numerical Methods written by Jeffrey H. Dorfman and published by Springer Science & Business Media. This book was released on 2006-03-31 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing researchers in economics, finance, and statistics with an up-to-date introduction to applying Bayesian techniques to empirical studies, this book covers the full range of the new numerical techniques which have been developed over the last thirty years. Notably, these are: Monte Carlo sampling, antithetic replication, importance sampling, and Gibbs sampling. The author covers both advances in theory and modern approaches to numerical and applied problems, and includes applications drawn from a variety of different fields within economics, while also providing a quick overview of the underlying statistical ideas of Bayesian thought. The result is a book which presents a roadmap of applied economic questions that can now be addressed empirically with Bayesian methods. Consequently, many researchers will find this a readily readable survey of this growing topic.
Download or read book Annual Reports in Medicinal Chemistry written by and published by Elsevier. This book was released on 2011-08-09 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. * Critical reviews of the previous year’s literature in many topics of interest to medicinal chemists * Highlights major developments in medicinal chemistry * Includes a comprehensive set of cumulative indexes to easily locate topics in all published volumes
Download or read book The Mind Possessed written by Emma Cohen and published by Oxford University Press. This book was released on 2007-08-09 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cognitive science of religion has made a persuasive case for the view that a number of different psychological systems are involved in the construction and transmission of notions of extranatural agency such as deities and spirits. Until now this work has been based largely on findings in experimental psychology, illustrated mainly with hypothetical or anecdotal examples. In The Mind Possessed, Emma Cohen considers how the psychological systems undergirding spirit concepts are activated in real-world settings. Spirit possession practices have long had a magnetizing effect on academic researchers but there have been few, if any, satisfactory theoretical treatments of spirit possession that attempt to account for its emergence and spread globally. Drawing on ethnographic data collected during eighteen months of fieldwork in Bel?m, northern Brazil, Cohen combines fine-grained descriptions and analyses of mediumistic activities in an Afro-Brazilian cult house with a scientifically-grounded explanation for the emergence and spread of ideas about spirits, possession and healing. Cohen shows why spirit possession and its associated activities are inherently attention-grabbing. Making a radical departure from traditional anthropological, medicalist and sociological analyses, she argues that a cognitive approach offers more precise and testable hypotheses concerning the spread and appeal of spirit concepts and possession activities. This timely book presents new lines of enquiry for the cognitive science of religion (a rapidly growing field of interdisciplinary scholarship) and challenges the theoretical frameworks within which spirit possession practices have traditionally been understood.
Download or read book Non Verbal Predication written by Kees Hengeveld and published by Walter de Gruyter. This book was released on 2011-05-02 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-Verbal Predication : Theory, Typology, Diachrony.
Download or read book Criminological Theory a Life Course Approach written by Matt DeLisi and published by Jones & Bartlett Publishers. This book was released on 2010-03 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to understand the perpetuance of crime, multiple influences in offenders' lives must be considered. Criminological Theory: A Life-Course Approach explores criminal and anti-social behavior by examining important factors occurring at each stage of life. This collection of cutting-edge scholarship comprehensively covers life-course antisocial behavior ranging from prenatal factors, to childhood examples of disruptive behavior, delinquency, and adult crime. Diverse research from internationally recognized experts on criminal behavior brings readers towards a sharpened understanding of crime and the prevailing life-course approach.
