Download or read book Applied Imaging in Systems Pharmacology written by Freedman and published by . This book was released on 2019-08-20 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Imaging in CNS Drug Discovery and Development written by David Borsook and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Download or read book Pharmacology and Drug Administration for Imaging Technologists E Book written by Steven C. Jensen and published by Elsevier Health Sciences. This book was released on 2013-08-07 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a complete resource for all the imaging technologies, not just plain film radiography. It provides introductory material on pharmacological nomenclature, drug classifications, pharmacokinetics, and drugs used in imaging. It also offers comprehensive coverage of diagnostic contrast agents, along with drug administration procedures, emergency responses to drug reactions, and legal and ethical aspects of medication administration. Objectives and Key Terms open each chapter. Learning exercises include true/false, fill-in-the-blank, multiple-choice, and short-answer questions at the end of each chapter, with answers at the end of the book. Did You Know? boxes offer interesting tidbits of historical or current pharmacology information, connecting the book's drug content to everyday situations. Clinical Alert icons point out possible adverse reactions and toxic effects. Discussion of pharmacodynamics and drug classifications focuses on radiopaque contrast media used in imaging procedures, using clearly written text and useful tables. Pharmacokinetics coverage describes how drugs are absorbed, metabolized, distributed, and eliminated. Complete coverage of emergency procedures in response to adverse reactions to contrast media includes crash cart procedures and drugs used to treat cardiac and/or respiratory arrest and how to administer them appropriately. Updates on all contrast agents. New information on the use of contrast agents in ultrasound. New Drug Classifications chapter. New chapter on drug-related emergencies includes case studies. Evolve Resources for instructors include a 220-question test bank and an electronic image collection.
Download or read book Pharmacology In Vivo Imaging written by Felix Jackson and published by American Medical Publishers. This book was released on 2021-11-16 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology is a branch of medicine which is associated with the study of drug action. A drug can be characterized as any man-made, natural, or endogenous molecule. These drugs can have a biochemical or physiological effect over the cell, tissue, organ, or organism. In vivo imaging or preclinical imaging refers to the visualization of living animals for research purposes, such as drug development and cancer research. Imaging modalities are used in identifying changes, either at the organ, tissue, cell, or molecular level. The imaging systems can be characterized into morphological/anatomical and molecular imaging techniques. The aim of this book is to present researches that have transformed this discipline and aided its advancement. It contains some path-breaking studies in the field of pharmacology and in vivo imaging. The book is appropriate for students seeking detailed information in this area as well as for the experts.
Download or read book Systems Pharmacology and Pharmacodynamics written by Donald E. Mager and published by Springer. This book was released on 2016-11-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Download or read book Imaging in Drug Discovery and Early Clinical Trials written by Markus Rudin and published by Birkhäuser. This book was released on 2009-09-03 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.
Download or read book Advances in Medical Imaging Detection and Diagnosis written by Raj Bawa and published by CRC Press. This book was released on 2023-10-18 with total page 1426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical care is the most critical issue of our time and will be so for the foreseeable future. In this regard, the pace and sophistication of advances in medicine in the past two decades have been truly breathtaking. This has necessitated a growing need for comprehensive reference resources that highlight current issues in specific sectors of medicine. Keeping this in mind, each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various important topics in a focused area of medicine—all accomplished in a user-friendly yet interconnected format. This volume addresses advances in medical imaging, detection, and diagnostic technologies. Technological innovations in these sectors of medicine continue to provide for safer, more accurate, and faster diagnosis for patients. This translates into superior prognosis and better patient compliance, while reducing morbidity and mortality. Hence, it is imperative that practitioners stay current with these latest advances to provide the best care for nursing and clinical practices. While recognizing how expansive and multifaceted these areas of medicine are, Advances in Medical Imaging, Detection, and Diagnosis addresses crucial recent progress, integrating the knowledge and experience of experts from academia and the clinic. The multidisciplinary approach reflected makes this volume a valuable reference resource for medical practitioners, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, venture capitalists, policymakers, and biomedical researchers. A wide audience will benefit from having this volume on their bookshelf: health care systems, the pharmaceutical industry, academia, and government.
Download or read book Applying Systems Pharmacology to the Treatment of Chronic Illness Using Novel Scoring and Translational Methods written by Spencer Richman and published by . This book was released on 2020 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Chronic illnesses are poorly understood diseases that are often highly resistant to treatment. The prevalence and severity of these illnesses necessitates new methods for treatment development that diverge from the paradigm of one drug, one illness. Instead, multidrug interventions that utilize repurposable, previously approved drugs could be far more advantageous. In order to support this, a novel scoring framework and accompanying set of tools, collectively termed DrugAble, have been developed. DrugAble scores proposed, model-based treatment target solutions by analyzing drug-target interaction data and addressing the network complexity of these solutions. Actionability scores that summarize the likelihood of a proposed target set constituting a pharmacologically accessible path to remission are generated. Additionally, DrugAble proposes combinations of repurposable drugs that can potentially be used in tandem to achieve remission. Here, DrugAble is demonstrated on molecular target solutions supporting an escape from Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, a debilitating illness that affects up to 2.5 million Americans alone. DrugAble effectively discriminates between theoretical target sets and those that are clinically actionable using available drugs while simultaneously accounting for drug-target interactions and off-target effects of these drugs. This framework constitutes the necessary first steps to designing more effective treatments for chronic illnesses, with the ultimate goal of reducing the failure rate of clinical trials and the financial burden on both drug developers and patients. Most importantly, it opens new and more immediately accessible paths toward achieving remission and full recovery for those suffering from chronic illnesses."--Abstract.
Download or read book Quantitative Systems Pharmacology written by Davide Manca and published by Elsevier. This book was released on 2018-07-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation
Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Download or read book Systems Pharmacology and Traditional Chinese Medicine written by Aiping Lu and published by Frontiers Media SA. This book was released on 2021-06-23 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Imaging in Movement Disorders Imaging in Movement Disorder Dementias and Rapid Eye Movement Sleep Behavior Disorder written by and published by Academic Press. This book was released on 2019-01-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging in Movement Disorders: Imaging in Movement Disorder Dementias and Rapid Eye Movement Sleep Behavior Disorder, Volume 144 provides an up-to-date textbook on the use of imaging modalities across the spectrum of movement disorders and dementias. The book brings together lessons learned from neuroimaging tools in the content of movement disorders, including chapters on Molecular Imaging of Dementia with Lewy Bodies, Structural and Functional Magnetic Resonance Imaging of Dementia with Lewy Bodies, Network Imaging in Parkinsonian and Other Movement Disorders: Network Dysfunction and Clinical Correlates, Neuroimaging of Rapid Eye Movement Sleep Behavior Disorder, Hybrid PET-MRI Applications in Movement Disorders, and more. Covers the role of neuroimaging research in movement disorder dementias Presents the importance of imaging techniques as biomarkers of disease progression and treatment response in therapeutic trials
Download or read book Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Chemical Optical and Bioorthogonal Methods written by and published by Academic Press. This book was released on 2020-07-24 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods, Volume 641 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include caged cyclopropanes with improved tetrazine ligation kinetics, an analysis of metabolically labeled inositol phosphate messengers by NMR, cell-permeant caged inositol pyrophosphates for probing ß-cells, imaging phospholipase D activity with clickable alcohols via transphosphatidylation, fluorescent biorthogonal labeling of class B GPCRs in live cells, near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Download or read book Computational Systems Pharmacology and Toxicology written by Rudy J Richardson and published by Royal Society of Chemistry. This book was released on 2017-03-03 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.
Download or read book Comparative Diagnostic Pharmacology written by C.P. Coyne and published by John Wiley & Sons. This book was released on 2008-01-09 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comparative Diagnostic Pharmacology: Clinical and Research Applications in Living-System Models is the first evidence-based reference text devoted exclusively to the subject of applying pharmaceutical and biopharmaceutical agents as diagnostic probes in clinical medicine and investigative research.This unique and groundbreaking book is a versatile guide for clinicians and researchers interested in using pharmacologic agents to: Diagnose disease Assess physiological processes Identify the appropriateness of a therapeutic agent Determine appropriate dosing for therapeutic use. Extensively referenced and organized by major body systems, individual topics are listed in an evidence-based format according to specific disease processes or physiological processes of interest. Each entry also includes information on the mechanism of action, administration, and diagnostic interpretation. Descriptions have been provided for the application of diagnostic pharmaceuticals to assess a wide spectrum of diseases and physiological processes relevant to the fields of veterinary and human medicine. Comparative Diagnostic Pharmacology is useful not merely for pharmaceutical-oriented research investigations, but it will also prove invaluable for the monitoring and evaluation of physiological responses and disease processes in animal models.
Download or read book Pharmacology for Chemists written by Raymond Hill and published by Royal Society of Chemistry. This book was released on 2017-10-30 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook explains the key issues in pharmacology to chemists interested in or planning to work in drug discovery.
Download or read book Intelligent Healthcare Systems written by Vania V. Estrela and published by CRC Press. This book was released on 2023-08-04 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book sheds light on medical cyber-physical systems while addressing image processing, microscopy, security, biomedical imaging, automation, robotics, network layers’ issues, software design, and biometrics, among other areas. Hence, solving the dimensionality conundrum caused by the necessity to balance data acquisition, image modalities, different resolutions, dissimilar picture representations, subspace decompositions, compressed sensing, and communications constraints. Lighter computational implementations can circumvent the heavy computational burden of healthcare processing applications. Soft computing, metaheuristic, and deep learning ascend as potential solutions to efficient super-resolution deployment. The amount of multi-resolution and multi-modal images has been augmenting the need for more efficient and intelligent analyses, e.g., computer-aided diagnosis via computational intelligence techniques. This book consolidates the work on artificial intelligence methods and clever design paradigms for healthcare to foster research and implementations in many domains. It will serve researchers, technology professionals, academia, and students working in the area of the latest advances and upcoming technologies employing smart systems’ design practices and computational intelligence tactics for medical usage. The book explores deep learning practices within particularly difficult computational types of health problems. It aspires to provide an assortment of novel research works that focuses on the broad challenges of designing better healthcare services.
