Download or read book Applications and Methods in Genomic Networks written by Kimberly Glass and published by Frontiers Media SA. This book was released on 2022-07-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Weighted Network Analysis written by Steve Horvath and published by Springer Science & Business Media. This book was released on 2011-04-30 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.
Download or read book Handbook of Machine Learning Applications for Genomics written by Sanjiban Sekhar Roy and published by Springer Nature. This book was released on 2022-06-23 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, machine learning is playing a pivotal role in the progress of genomics. The applications of machine learning are helping all to understand the emerging trends and the future scope of genomics. This book provides comprehensive coverage of machine learning applications such as DNN, CNN, and RNN, for predicting the sequence of DNA and RNA binding proteins, expression of the gene, and splicing control. In addition, the book addresses the effect of multiomics data analysis of cancers using tensor decomposition, machine learning techniques for protein engineering, CNN applications on genomics, challenges of long noncoding RNAs in human disease diagnosis, and how machine learning can be used as a tool to shape the future of medicine. More importantly, it gives a comparative analysis and validates the outcomes of machine learning methods on genomic data to the functional laboratory tests or by formal clinical assessment. The topics of this book will cater interest to academicians, practitioners working in the field of functional genomics, and machine learning. Also, this book shall guide comprehensively the graduate, postgraduates, and Ph.D. scholars working in these fields.
Download or read book Networks in Systems Biology written by Fabricio Alves Barbosa da Silva and published by Springer Nature. This book was released on 2020-10-03 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.
Download or read book Computational and Statistical Approaches to Genomics written by Wei Zhang and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book adds eight new contributors to reflect a modern cutting edge approach to genomics. It contains the newest research results on genomic analysis and modeling using state-of-the-art methods from engineering, statistics, and genomics. These tools and models are then applied to real biological and clinical problems. The book’s original seventeen chapters are also updated to provide new initiatives and directions.
Download or read book Gene Regulatory Networks written by Guido Sanguinetti and published by Humana. This book was released on 2018-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores recent techniques for the computational inference of gene regulatory networks (GRNs). The chapters in this book cover topics such as methods to infer GRNs from time-varying data; the extraction of causal information from biological data; GRN inference from multiple heterogeneous data sets; non-parametric and hybrid statistical methods; the joint inference of differential networks; and mechanistic models of gene regulation dynamics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, descriptions of recently developed methods for GRN inference, applications of these methods on real and/ or simulated biological data, and step-by-step tutorials on the usage of associated software tools. Cutting-edge and thorough, Gene Regulatory Networks: Methods and Protocols is an essential tool for evaluating the current research needed to further address the common challenges faced by specialists in this field.
Download or read book Systems Biology written by Isidore Rigoutsos and published by Oxford University Press. This book was released on 2006-09-14 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes.Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
Download or read book Probabilistic Boolean Networks written by Ilya Shmulevich and published by SIAM. This book was released on 2010-01-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive treatment of probabilistic Boolean networks (PBNs), an important model class for studying genetic regulatory networks. This book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes." "Researchers in mathematics, computer science, and engineering are exposed to important applications in systems biology and presented with ample opportunities for developing new approaches and methods. The book is also appropriate for advanced undergraduates, graduate students, and scientists working in the fields of computational biology, genomic signal processing, control and systems theory, and computer science.
Download or read book Computational Methods for Integrative Inference of Genome scale Gene Regulatory Networks written by Alireza Fotuhi Siahpirani and published by . This book was released on 2019 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inference of transcriptional regulatory networks is an important filed of research in systems biology, and many computational methods have been developed to infer regulatory networks from different types of genomic data. One of the most popular classes of computational network inference methods is expression based network inference. Given the mRNA levels of genes, these methods reconstruct a network between regulatory genes (called transcription factors) and potential target genes that best explains the input data. However, it has been shown that the networks that are inferred only using expression, have low agreement with experimentally validated physical regulatory interactions. In recent years, many methods have been developed to improve the accuracy of these computational methods by incorporating additional data types. In this dissertation, we describe our contributions towards advancing the state of the art in this field. Our first contribution, is developing a prior-based network inference method, MERLIN-P. MERLIN-P uses both expression of genes, and prior knowledge of interactions between regulatory genes and their potential targets, and infers a network that is supported by both expression and prior knowledge. Using a logistic function, MERLIN-P could incorporate and combine multiple sources of prior knowledge. The inferred networks in yeast, outperform state of the art expression based network inference methods, and perform better or at a par with prior based state of the art method. Our second contribution, is developing a method to estimate transcription factor activity from a noisy prior network, NCA+LASSO. Network Component Analysis (NCA), is a computational method that given expression of target genes and a (potentially incomplete and noisy) network structure that describes the connection of regulatory genes to these target genes, estimates unobserved activity of the regulators (transcription factor activities, TFA). It has been shown that using TFA can improve the quality of inferred networks. However, our prior knowledge in new contexts could be incomplete and noisy, and we do not know to what extent presence of noise in input network affects the quality of estimated TFA. We first show how presence of noise in the input prior network can decrease the quality of estimated TFA, and then show that by adding a regularization term, we can improve the quality of the estimated TFA. We show that using estimated TFA instead of just expression of TFs in network inference, improves the agreement of inferred networks to experimentally validated physical interactions, for all state of the art methods, including MERLIN-P. Our final contribution, is developing a multi-task inference method, Dynamic Regulatory Module Network (DRMN), that simultaneously infers regulatory networks for related cell lines, while taking into account the expected similarity of the cell lines. Many biological contexts are hierarchically related, and leveraging the similarity of these contexts could help us infer more accurate regulatory programs in each context. However, the small number of measurements in each context makes the inference of regulatory networks challenging. By inferring regulatory programs at module level (groups of co-expressed genes), DRMN is able to handle the small number of measurements, while the use of multi-task learning allows for incorporation of hierarchical relationship of contexts. DRMN first infers modules of co-expressed genes in each cell line, then infers a regulatory network for each module, and iteratively updates the inferred modules to reflect both co-expression and co-regulation, and updates the inferred networks to reflect the updated modules. We assess the accuracy of the inferred networks by predicting the expression on hold out genes, and show that the resulting modules and networks, provide insight into the process of differentiation between these related cell lines. For all the developed methods, we validate our results by comparing to known experimentally validated networks, and show that our results provide useful insight into the biological processes under consideration. Specifically, in chapter 2, we evaluated our inferred networks based on both network structure and predictive power, identified TFs that all tested methods fail to recover their target sets, and explored potential reasons that can explain this failure. Additionally, we used our method to infer stress specific networks, and evaluated predictions using stress specific knock-down experiments. In chapter 3, we evaluated our inferred networks based on both network structure and predictive power, and furthermore used our inferred networks to identify potential regulators that could be important for pluripotency state in mESC. We tested the effect of these regulators using shRNA experiments, and experimentally validated some of their predicted targets. Finally, in chapter 4, we evaluated our inferred models based on their predictive power and ability to predict gene expression in hold out data.
Download or read book Introduction to Biological Networks written by Alpan Raval and published by CRC Press. This book was released on 2013-04-24 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network biology for physical scientists and biologists involved in interdisciplinary research. The book focuses on the concept of molecular and genetic interaction networks as a paradigm for interpreting the complexity of molecular biology at a genomic scale. The authors describe the experimental methods used to discover and test networks of interaction among biological molecules. They also present computational methods for predicting the interaction networks, discuss general mechanisms of network formation and evolution, and explore the application of network approaches to important problems in biology and medicine. With many examples throughout and clear explanations of key concepts, this book is the first to offer a broad treatment of genomics-inspired network biology with sufficient mathematical and biological rigor. It gives readers a conceptual understanding of this burgeoning scientific field.
Download or read book Genomic Signal Processing and Statistics written by Edward R. Dougherty and published by Hindawi Publishing Corporation. This book was released on 2005 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Processing the vast genomic data, especially the recent large-scale microarray gene expression data, to reveal the complex biological functionality, represents enormous challenges to signal processing and statistics. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and in industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference book. The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The first part of this book provides a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives, so that readers can easily follow the material presented in the rest of the book. In what follows, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, classification, and clustering of microarray data. We then discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. Visualization and compression of gene data, and supercomputer implementation of genomic signal processing systems are also treated. Finally, we discuss systems biology and medical applications of genomic research as well as the future trends in genomic signal processing and statistics research.
Download or read book Evolutionary Computation in Gene Regulatory Network Research written by Hitoshi Iba and published by John Wiley & Sons. This book was released on 2016-02-23 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.
Download or read book An Integrated Experimental computational Approach to Infer Gene Regulatory Networks written by David Ronald Lorenz and published by . This book was released on 2009 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Elucidating the structure and function of biological interaction networks is a major challenge of the post-genomic era; the development of methods to infer these networks has thus been an active area of research. In this work, I describe an integrated experimental/computational strategy for reverse-engineering gene regulatory networks called NIR (Network Inference by multiple Regression), derived from a branch of engineering known as system identification. This method uses mRNA expression changes in response to network gene perturbations to formulate a first-order model of functional interactions between genes in the chosen network, providing a quantitative, directed and unsupervised description of transcriptional regulatory interactions. This approach was first applied to nine genes from the SOS pathway in the model prokaryote Escherichia coli, where it correctly identified RecA and LexA as key transcriptional regulators responding to DNA damage. Further, the quantitative network model was used to distinguish the transcriptional targets of pharmacological compounds, an important consideration in drug development and discovery. In the model eukaryote Saccharomyces cerevisiae, I applied the NIR method to ten genes from the glucose-responsive Snf 1 pathway. The network model inferred from this analysis correctly identified the major transcriptional regulators, and revealed a greater degree of complexity for this pathway than previously known. The majority of putative novel interactions were subsequently verified using gene deletions and chromatin immunoprecipitation experiments. This new, validated network architecture was then used to identify and experimentally confirm combinatorial transcriptional regulation of yeast aging, a mechanism not likely to be identified in the absence of knowledge of the network structure. Overall, these results demonstrate the utility of our inference approach to characterize smaller gene regulatory networks at a higher level of detail, and to successfully use the network model to gain new insights into complex biological processes.
Download or read book Summarizing Biological Networks written by Sourav S. Bhowmick and published by Springer. This book was released on 2017-04-17 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the data mining, systems biology, and bioinformatics computational methods that can be used to summarize biological networks. Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network. The authors also examine crucial open research problems in this arena. Academics, researchers, and advanced-level students will find this book to be a comprehensive and exceptional resource for understanding computational techniques and their applications for a summary of biological networks.
Download or read book Computational Systems Bioinformatics written by Xiaobo Zhou and published by World Scientific. This book was released on 2008 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.
Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain. Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context. By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.
Download or read book Computational Methods in Genome Research written by Sándor Suhai and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of computational methods to solve scientific and pratical problems in genome research created a new interdisciplinary area that transcends boundaries traditionally separating genetics, biology, mathematics, physics, and computer science. Computers have been, of course, intensively used for many year~ in the field of life sciences, even before genome research started, to store and analyze DNA or proteins sequences, to explore and model the three-dimensional structure, the dynamics and the function of biopolymers, to compute genetic linkage or evolutionary processes etc. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function of genomes of higher organisms, has generated, however, not only a huge and burgeoning body of data but also a new class of scientific questions. The nature and complexity of these questions will require, beyond establishing a new kind of alliance between experimental and theoretical disciplines, also the development of new generations both in computer software and hardware technologies, respectively. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can ·attack with success. Many of us still feel that computational models rationalizing experimental findings in genome research fulfil their promises more slowly than desired. There also is an uncertainity concerning the real position of a 'theoretical genome research' in the network of established disciplines integrating their efforts in this field.
