Download or read book Apoptosis Genes written by James W. Wilson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful work presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, this one deals specifically with its regulation.
Download or read book Genetics of Apoptosis written by Stefan Grimm and published by Garland Science. This book was released on 2003-12-16 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.
Download or read book Apoptosis written by C. S. Potten and published by Cambridge University Press. This book was released on 2004-08-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.
Download or read book Apoptosis and Cancer written by Seamus J. Martin and published by S. Karger AG (Switzerland). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Download or read book Apoptosis Methods and Protocols written by Hugh J. M. Brady and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most fundamental question facing each and every cell within an org- ism is to survive or to die. Cell death is required for normal function; some estimates suggest that as many as one million cells undergo cell death every second in the adult human body. Almost all cells undergoing physiological, or programmed, cell death, independent of cell type, manifest a stereotypic p- tern of morphological changes termed apoptosis. Typically, apoptotic cells d- play shrinkage, membrane blebbing, chromatin condensation, and nuclear fragmentation. The integrity of the cell membrane is not lost during apoptosis and so avoids eliciting the inflammatory response that would have been caused by the spillage of the cell’s contents. This is quite in contrast to the loss of cell contents typical of necrosis. The caspases, the family of intracellular cysteine proteases associated with apoptosis, are responsible for the stereotypical m- phological changes. Caspases cleave various substrate proteins that act on DNA fragmentation, nuclear envelope integrity, the cytoskeleton, and cell volume regulation. Apoptotic cells are cleared in vivo by the process of phagocytosis, in which specific “phagocytes” move to the site of apoptosis, engulf the dying cells and digest them. Apoptosis has a central role in many physiological processes, for example, in the immune system. Autoreactive cells are deleted via apoptosis to prevent autoimmunity. At the end of an immune response, activated lymphocytes are removed to maintain homeostasis within the immune system.
Download or read book Apoptosis written by Douglas R. Green and published by Cambridge University Press. This book was released on 2011-08-22 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Download or read book Apoptosis in Toxicology written by R. J. Roberts and published by CRC Press. This book was released on 1999-12-02 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiato
Download or read book Perspectives on Mammalian Cell Death written by C. S. Potten and published by Oxford University Press, USA. This book was released on 1987 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the wide range of approaches to and definitions of cell death as explored by scientists in different disciplines. There is no single definition of cell death that can be accepted and used by all biologists, yet it is clear that understanding how and why cells die is crucial to understanding many biological and pathological processes. The thirteen chapters, written by scientists involved in various disciplines, bring together the experimental approaches and most up-to-date concepts important to different biological disciplines, providing an insight into the common ground and fundamental principles.
Download or read book The Molecular Basis of Apoptosis written by Patrick Kimuyu and published by GRIN Verlag. This book was released on 2018-01-31 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research Paper (postgraduate) from the year 2018 in the subject Medicine - Anatomy, Physiology, Cytology, grade: 1, Egerton University, language: English, abstract: Apoptosis refers to a programmed cell death; a biological process in which the body of an organism destroys its cells for different reasons. In reality, apoptosis and necrosis involve different mechanisms, and this implies they are different. In addition, the changes that occur in the process of cell death are differing in terms of morphology and chemical composition. Evidence indicates that there are various factors that make cells commit suicide. In most cases, cells commit suicide due to imbalances between positive and negative signals that determine cell survival. Cells can consider committing suicide upon the recipient of negative signals. This research will provide a comprehensive overview of apoptosis. It will discuss mechanisms of apoptosis and the factors involved in the process. It will also explain the association between apoptosis.
Download or read book Mitochondrial Pathogenesis written by Hong Kyu Lee and published by Springer. This book was released on 2014-01-10 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Surface GRP78 a New Paradigm in Signal Transduction Biology written by Salvatore V. Pizzo and published by Academic Press. This book was released on 2018-03-20 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apoptosis in Normal Development and Cancer written by M Sluyser and published by CRC Press. This book was released on 2014-04-21 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the
Download or read book Apoptosis Genomic Integrity and Cancer written by Julien L. Van Lancker and published by Jones & Bartlett Learning. This book was released on 2006 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the molecules involved in apoptosis and genomal integrity and considers the gain or loss of the functions that lead to cancer.
Download or read book Apoptosis Biology and Mechanisms written by Sharad Kumar and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is currently one of the fastest moving fields in biology with spectacular progress made over the past few years in delineating the molecular It is now indisputable that apoptosis mechanisms which underlie this process. plays an essential role in normal cell physiology and that aberrant apoptosis can manifest itself in a variety of human disorders. Published in two parts (Volumes 23 and 24 of the series entitled Results and Problems in Cell Differen tiation), this is an attempt to bring together many different aspects of apoptosis. Given that this is such a vast and rapidly expanding field, it is almost impossible to cover everything that is now known about apoptosis in two short books, but 1 hope these volumes prove to be a guidepost, providing basic essential information on the biology and molecular mechanisms of apoptosis and its implications in some human diseases. As a significant am o unt of new information on apoptosis is emerging every week, it is unrealistic to expect that by the time these two books are published, all the articles will deliver up-to-date information. Nevertheless, 1 believe that the fundamentals of the apoptotic phenomenon are now firmly in place and are discussed at length in various chapters. Readers may find a small degree of overlap between some chapters. This was unavoidable since closely related areas of apoptosis research have been covered by more than one author.
Download or read book Regulated Cell Death Part A written by Avi Ashkenazi and published by Elsevier. This book was released on 2014-06-25 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches
Download or read book Apoptosis in Neurobiology written by Yusuf A. Hannun and published by CRC Press. This book was released on 1998-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical access to the study of apoptosis, with special consideration to the nervous system. The first section concentrates on conceptual approaches to the study of apoptosis in neurobiology and its significance to the nervous system. The second section provides a user-friendly approach to methods and techniques in the study of apoptosis as applied to neurobiology.
