Download or read book ApoB in Clinical Care written by Jacqueline de Graaf and published by Springer. This book was released on 2015-11-10 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now, based on the apoB algorithm, that is outlined and illustrated in this book, family physicians as well as cardiologists, endocrinologists and internists will be able to easily and accurately identify and treat these disorders. The apoB dyslipoproteinemias are major common causes of vascular disease. But until now, accurate diagnosis has not been possible. With just total cholesterol, triglycerides and apoB, all the apoB dyslipoproteinemias, with the exception of elevated Lp(a), can be identified using the apoB algorithm. The apoB app, which incorporates this algorithm, is available from both Apple and Android and is free.

Download or read book Clinical Lipidology written by Christie M. Ballantyne and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Lipidology, a companion to Braunwald's Heart Disease, is designed to guide you through the ever-changing therapeutic management of patients with high cholesterol levels. From basic science to pathogenesis of atherothrombotic disease, to risk assessment and the latest therapy options, this medical reference book offers unparalleled coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style. Get authoritative guidance from some of the foremost experts in the field. Easily access key content with help from treatment algorithms. Access options and evidence-based solutions for every type of patient scenario, as well as the latest clinical guidelines and clinically relevant evidence on risk assessment, special patient populations, and therapy, including recently approved and experimental therapies. Remain at the forefront of the cardiology field with up-to-date chapters on treatment guidelines; diet, exercise, and weight loss; pharmacologic therapies such as statins, omega-3 fatty acids, and combination therapy; evolving targets of therapy such as PCSK9 inhibition, CETP inhibition, and inflammation Prepare for special patient populations such as children and adolescents; women and the elderly; transplant recipients; HIV patients; and those with chronic renal disease, familial hypercholesterolemia, other severe hypercholesterolemias, diabetes, or other metabolic syndromes. Take advantage of a format that follows that of the well-known and internationally recognized Braunwald's Heart Disease. Expert Consult eBook version included with purchase.

Download or read book Biological Variation written by Callum G. Fraser and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2001 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lipids and Renal Disease written by William F. Keane and published by . This book was released on 1991 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent experimental and clinical data pertaining to the role of abnormal lipid metabolism in patients with hypertension and renal disease. Amongst the areas covered are hypercholesterolemia, hyperglycemia and hypertension and lipid abnormalities after renal transplantation.

Download or read book What Is the Apolipoprotein B 100 An Overview written by Dr. H. K. Saboowala. and published by Dr.Hakim Saboowala. This book was released on 2024-06-05 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is the Apolipoprotein B-100? An Overview. Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the: · Very-low-density lipoprotein (VLDL), · Intermediate-density lipoprotein (IDL), and · Low-density lipoprotein (LDL). Each of these lipoprotein particles carries one apoB molecule; as a result, the total serum apoB level corresponds to the total number of VLDL, IDL, and LDL particles. · Because VLDL, IDL, and LDL are considered atherogenic, the apoB level should reflect the atherogenic potential of these lipoproteins. Cardiovascular risk is associated more with the number and size of circulating atherogenic particles. ApoB is not equivalent to non-LDL-C, because the latter reflects the cholesterol content of all atherogenic lipoproteins rather than the total number of circulating atherogenic particles. ApoB plays a central role in carrying cholesterol and triglycerides from the liver and gut to utilization and storage sites. Because VLDL, IDL, and LDL are considered atherogenic, it is strived in this E-Booklet to describe Causes, Function, Molecular level, Clinical significance etc. for the enthusiastic medicos. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Download or read book Biochemistry of Lipids Lipoproteins and Membranes written by Neale Ridgway and published by Elsevier. This book was released on 2015-07-24 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Download or read book Handbook of Pharmacogenomics and Stratified Medicine written by Sandosh Padmanabhan and published by Academic Press. This book was released on 2014-04-28 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Download or read book Regulation of Apolipoprotein B Metabolism by Cholesterol and written by John Robert Burnett and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1998 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a series of in vivo tracer kinetic studies in miniature pigs we have examined the role of cholesterol and/or cholesteryl esters in the regulation of apolipoprotein (apo)B secretion. The experiments demonstrate that inhibition of cholesterol biosynthesis by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors decreases hepatic apoB secretion into plasma. The results are consistent with the hypothesis that the extent and/or duration of the HMG-CoA reductase inhibition determines the magnitude of reduction in hepatic apoB secretion. Consistent with in vitro findings, HMG-CoA reductase inhibition had no effect on intestinal apoB assembly and secretion, however, the plasma clearance of triglyceride rich lipoproteins was increased, perhaps related to decreased competition for removal processes by hepatic VLDL. We also showed that inhibition of cholesterol esterification by acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitors decreases hepatic apoB secretion into plasma and speculate that a specific endoplasmic reticulum ACAT pool regulates apoB secretion and that the extent and/or duration of ACAT inibition determines the magnitude of reduction in hepatic apoB secretion. We postulate that HMG-CoA reductase and ACAT inhibition reduces cholesteryl ester synthesis below a critical level required for apoB translocation, and lipoprotein assembly and secretion, thereby stimulating the rate of apoB degradation. In conclusion, the in vivo experiments presented clearly demonstrate the regulatory role of cholesterol and/or cholesteryl esters on hepatic apoB secretion. These studies add further support to the concept that a reduction in the assembly and secretion of apoB is an important mechanism whereby HMG-CoA reductase inhibitors and ACAT inhibitors lower the plasma concentration of apoB containing lipoproteins. The effects of markedly decreasing plasma apoB levels may significantly impact on the atherogenic process.

Download or read book Management of Dyslipidemia written by Wilbert S. Aronow and published by BoD – Books on Demand. This book was released on 2021-07-21 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dyslipidemia is a major risk factor for cardiovascular events, cardiovascular mortality, and all-cause mortality. The earlier in life dyslipidemia is treated, the better the prognosis. The current book is an excellent one on dyslipidemia written by experts on this topic. This book includes 12 chapters including 5 on lipids, 4 on hypercholesterolemia in children, and 3 on the treatment of dyslipidemia. This book should be read by all health care professionals taking care of patients, including pediatricians since atherosclerotic cardiovascular disease begins in childhood.

Download or read book Handbook of Lipoprotein Testing written by Nader Rifai and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2000 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Apolipoproteins in Lipid Disorders written by Maryvonne Rosseneu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is increasing evidence for the clinicial value of the apo lipoprotein measurements. Besides cholesterol in plasma and li poprotein fractions, which is currently used as an indicator of cardiovascular risk, the measurement of the AI and B apolipopro teins can provide additional information about the patients' clinical status. Several studies show that apo B is higher and apo AI is lower in patients with angiographically documented coronary heart dis ease than in symptomatic patients without coronary heart disease. Moreover, discriminant analysis indicated that the concentration of Apo AI and B in plasma are better discriminators than lipo protein cholesterol for identifying patients with coronary heart disease. In some studies the apo Bjapo AI ratio appears to be a more powerful predictor than individual lipoproteins. In a recent study carried out in men, apolipoproteins AI and B were better correlated with the severity of cardiovascular disease than HDL and LDL cholesterol. The predictive power of apolipoproteins could however not be demonstrated in all studies and the value of apolipoprotein measurements in the field of clinical chemistry is still controversial. This is probably due to discrepancies between the results of various studies, arising from differences in the type of immunoassays, the lack of universal reference materials, differ ences between study protocols, variations in the selection of patients and in the grading and interpretation of coronary lesions.

Download or read book Neurodegeneration and Alzheimer s Disease written by Ralph N. Martins and published by John Wiley & Sons. This book was released on 2019-07-10 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Download or read book Vascular Endothelium written by John D. Catravas and published by Springer. This book was released on 1996 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The June 1994 proceedings consisting of 15 papers reviewing the research in the field of vascular endothelium. The presentations discuss various aspects of transplantation and tissue damage, resenosis, inflammation, angiongenesis, vasculogenesis, and pulmonary hypertension. Accompanying abstracts o

Download or read book Plasma Lipoproteins written by Antonio M. Gotto and published by Elsevier Publishing Company. This book was released on 1987 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this rapidly evolving field of research, an enormous amount of new knowledge of lipoprotein structure, function and metabolism has emerged. The 1985 Nobel Prize-winning pioneering work of Brown and Goldstein on the LDL receptor has had a profound impact on developments in the field. This work is one of the many subjects reviewed in detail in this book. The volume begins with chapters on structure, then proceeds to analysis of lipid and lipoprotein dynamics, metabolism, function, genetics, and molecular biology. Lipoprotein genetics in molecular biology, the role of lipoprotein receptors, and Lp(a) - a topic underrepresented in volumes on lipoproteins, are another three such topics in an impressive volume. This work will mainly be of interest to researchers interested in lipid and lipoprotein structure and metabolism, but will also be of great value to clinical medicine and biology in general.

Download or read book Assembly and Secretion of Apolipoprotein B 100 Containing Lipoproteins written by Margit Wettesten and published by . This book was released on 1990 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Lipid Research Clinics Population Studies Data Book The prevalence study aggregate distribution of lipids lipoproteins and selected variables in 11 North American populations written by and published by . This book was released on 1980 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Physiology of the Gastrointestinal Tract Two Volume Set written by Hamid M. Said and published by Academic Press. This book was released on 2012-07-04 with total page 2250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn’s disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. 2013 Highly Commended BMA Medical Book Award for Internal Medicine Discusses the multiple processes governing gastrointestinal function Each section edited by preeminent scientist in the field Updated, four-color illustrations