Download or read book Antimicrobial Photodynamic Therapy what We Know and what We Don t written by Fabian Alfred Aloi Cieplik and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Considering increasing number of pathogens resistant towards commonly used antibiotics as well as antiseptics, there is a pressing need for antimicrobial approaches that are capable of inactivating pathogens efficiently without the risk of inducing resistances. In this regard, an alternative approach is the antimicrobial photodynamic therapy (aPDT). The antimicrobial effect of aPDT is based on the principle that visible light activates a per se non-toxic molecule, the so-called photosensitizer (PS), resulting in generation of reactive oxygen species that kill bacteria unselectively via an oxidative burst. During the last 10-20 years, there has been extensive in vitro research on novel PS as well as light sources, which is now to be translated into clinics. In this review, we aim to provide an overview about the history of aPDT, its fundamental photochemical and photophysical mechanisms as well as photosensitizers and light sources that are currently applied for aPDT in vitro. Furthermore, the potential of resistances towards aPDT is extensively discussed and implications for proper comparison of in vitro studies regarding aPDT as well as for potential application fields in clinical practice are given. Overall, this review shall provide an outlook on future research directions needed for successful translation of promising in vitro results in aPDT towards clinical practice

Download or read book Antimicrobial Photodynamic Therapy written by Siddhardha Busi and published by CRC Press. This book was released on 2023-08-22 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial Photodynamic Therapy: Concepts and Applications explores the novel antimicrobial therapeutic technique. As the world searches for new, efficient modalities for fighting microorganisms, this book offers a complete understanding of the concept, and knowledge about the emerging technique ‘antimicrobial photodynamic therapy’ (aPDT) for the scientific communities and budding researchers. The book aligns concepts, significance, and applications of the technique systematically. Chapters in the book cover microorganisms, pathogenesis, conventional treatment methods, and significance of new treatment approaches to the concept of antimicrobial photodynamic therapy. The authors describe the mechanism behind it, with applications and examples from research studies. The book discusses photosensitisers in detail, with one chapter emphasising natural photosensitisers. Use of nanostructures in the antimicrobial photodynamic therapy is elaborated on, and we conclude with a well-explored application of the therapeutic technique in dentistry. Features: Efficiently covers the topic in detail with scientifically proven examples. Applications of the therapeutic approach are well discussed, and readers can learn about the research gaps, challenges, and future of the technique. Starts from basics, enabling readers to understand why the approach is relevant and important for study. Simplistic elucidated concepts and applications make it accessible at all levels.

Download or read book Photodynamic Inactivation of Microbial Pathogens written by Michael R Hamblin and published by Royal Society of Chemistry. This book was released on 2011-06-06 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) was discovered over one hundred years ago after observing the death of microorganisms upon exposure to dyes and light. It is the combination of non-toxic dyes and harmless visible light that, in the presence of oxygen, produce highly toxic reactive species. The principal medical application during the last century was in cancer therapy but, in these days of rising antibiotic resistance, PDT shows increasing promise as an alternative approach to treating infections. PDT has also been used in blood product sterilization, peridontology, acne reduction, and the treatment of viral lesions such as those caused by human papilloma virus. It may also have potential as an environmentally friendly pesticide. This is the first and only book to comprehensively cover the use of light and photosensitising agents for controlling microbial pathogens. It provides a comprehensive and up-to-date coverage of an emerging field. There are several chapters on the design of antimicrobial photosensitizers, their use to kill pathogenic organisms and their success in treating infections in animal models. It has long been known that gram-positive bacteria are highly susceptible to photoinactivation but the book also discusses means of widening the range of microorganisms that can be tackled by PDT. Edited by two pioneers in the application of PDT to medical and environmental issues, this book covers the basic science, translational research in animals, and the clinical applications in various medical specialities. It represents an indispensable resource for microbiologists and infectious disease doctors as well as dentists, dermatologists, gastroenterologists and transfusion specialists.

Download or read book Photodynamic Therapy written by Natalia Mayumi Inada and published by BoD – Books on Demand. This book was released on 2021-05-05 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, in the face of resistant microorganisms, aggressive cancers unresponsive to conventional treatments, and the COVID-19 pandemic, the need for advanced and innovative protocols for combating and treating disease is paramount. This book presents basic concepts of photodynamic therapy along with data from clinical research on its use in treating oncologic and other diseases. It also presents innovative strategies in photodynamic therapy, including information on polymer nanoparticles. This book was prepared with great care and by many valuable hands so that we can expand the dissemination of Photodynamic Therapy, as well as motivate for new research.

Download or read book Nanostructures for Antimicrobial Therapy written by Anton Ficai and published by Elsevier. This book was released on 2017-05-29 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Download or read book Photodynamic Medicine written by Herwig Kostron and published by Royal Society of Chemistry. This book was released on 2016 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Series in Photochemical and Photobiological Sciences. Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of disease. This book reviews the current state of development of PDT, and also presents the foreseeable advancements of the field in the next decade. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find this book an invaluable source of information. Chapters are drawn from research discusses at the 10th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice in Brixen and are written and edited by leaders in the field. Mirroring the philosophy of that meeting, this book contains an informative balance of the basic sciences and clinical applications of PDT. Following an introduction to PDT, its history, and how techniques have developed, chapter serve as a practical guide for practitioners, covering topics such as sensitizer dosage and light dosage, and examples of relevant studies. The text goes further tp explore areas outside the medical field, such as the impact of PDT on society and the environment, and the economics of therapies. This book is dedicated to the memory of Professor Giulio Jori, and expert in this field, who sadly passed away on the 23rd December 2014.

Download or read book Singlet Oxygen written by Santi Nonell and published by Royal Society of Chemistry. This book was released on 2016-01-27 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meeting the desire for a comprehensive book that collects and curates the vast amount of knowledge gained in the field of singlet oxygen, this title covers the physical, chemical and biological properties of this reactive oxygen species and also its increasingly important applications across chemical, environmental and biomedical areas.The editors have a long and distinguished background in the field of singlet oxygen chemistry and biomedical applications, giving them a unique insight and ensuring the contributions attain the highest scientific level.The book provides an up to date reference resource for both the beginner and experienced researcher and crucially for those working across disciplines such as photochemistry, photobiology and photomedicine.

Download or read book Applications of Porphyrinoids as Functional Materials written by Heinrich Lang and published by Royal Society of Chemistry. This book was released on 2021-08-18 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of the applications and potential applications of porphyrins and related macrocycles as smart or functional materials.

Download or read book Nanomaterials for Photodynamic Therapy written by Prashant Kesharwani and published by Woodhead Publishing. This book was released on 2023-01-14 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Photodynamic Therapy takes a unique approach to this area, with a key focus on the use of nanomaterials and nanocarriers for photodynamic therapy (PDT). The book introduces the history and mechanism of action behind PDT, covering the variety of sensitizers currently available. Subsequent chapters review existing and emerging nanomaterials for PDT, including hydrogel nanocomposites, fullerenes, quantum dots, polymeric micelles, and more. Challenges and translational aspects of PDT are also discussed, touching on the issues and hindrances of drug resistant cancers.The book bridges the gap between the physics and clinical aspects of PDT, offering a unique nanomaterials-focused perspective. This book will prove useful for materials scientists, biomedical engineers, electrical and optical engineers, and pharmaceutical scientists interested in cancer treatment. Reviews a broad range of nanomaterials for PDT, such as graphene oxide, dendrimers, solid lipid nanoparticles, and more Provides a helpful introduction to the history and mechanism of action behind PDT Discusses challenges in clinical translational, particularly in drug-resistant cancers

Download or read book Nanophototherapy written by Panchanathan Manivasagan and published by Elsevier. This book was released on 2024-08-23 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanophototherapy: Preparations and Applications provides a comprehensive overview of the various multifunctional nanoparticles used for phototherapy, with an emphasis on fundamental nanotechnology and the latest research of photothermal therapy (PTT) and photodynamic therapy (PDT). The different types of phototherapeutic nanomaterials are thoroughly described, along with their structural features and synthesis. This is the first book to cover nanomaterial-based phototherapy for both cancer and bacterial infections. It is an essential resource for researchers, academics, and professionals interested in the potential of multifunctional nanomaterials for therapeutic applications. Overviews the types, structural features, design, and fabrication of advanced nanomaterial-based phototherapy of cancer and microbial infections Provides fundamentals and reviews the latest research on nanomaterial-based phototherapy for the treatment of cancer and bacterial infections Features definitions, synthesis, and characterization of various nanomaterials, such as NIR-based metals, photosensitizer-loaded nanomaterials, polymer nanoparticles, and more

Download or read book Chemical Aspects of Photodynamic Therapy written by Raymond Bonnett and published by CRC Press. This book was released on 2000-08-07 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) is a ground breaking medical technique which uses lasers to activate light-sensitive chemicals to treat cancer and other diseases without resorting to surgery. For the first time, Chemical Aspects of Photodynamic Therapy introduces in an accessible way the physics, chemistry and biology behind the technique. This highly a

Download or read book Infection Prevention written by Gonzalo Bearman and published by Springer. This book was released on 2017-09-07 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews evolving areas in infection prevention on topics including contact precautions, technology implementation, specific infections, and care in various settings. The book summarizes the current data oninfection prevention, presents controversies on the various topics, and includes recommendations for patient safety. Addressing hot topics such as MRSA, C. difficile vaccination, mandatory flu vaccines, and CLABSI, this is the only text to include prevention and control overviews across a range of infection issues. Written by experts in thefield, this book contains 32 chapters that educates and presents the most cutting-edge models of care on emerging and evolving topics in infectious diseases. Infection Prevention: New Perspectives and Controversies is a valuable resource for infection prevention professionals, healthcare quality and safety professionals, caring for patients in in- and outpatient settings.

Download or read book Lasers in Dentistry written by Patricia M. Freitas and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lasers have become an increasingly useful tool in conventional dental practice. Their precision and less invasive quality make them an attractive technology in esthetic and pediatric dentistry, oral medicine, and a range of other dental procedures. Lasers in Dentistry: Guide for Clinical Practice is a comprehensive, yet concise and easy-to-use guide to integrating lasers into conventional clinical practice. The book begins by providing the reader a thorough understanding of how lasers work and their varied effects on oral tissues. Subsequent chapters are organized by procedure type, illustrating common clinical techniques with step-by-step illustrations and case examples. In addition, each chapter provides an overview of the latest research for use in clinical practice. More comprehensive than at atlas yet practical and clinically oriented in its approach, Lasers in Dentistry is an essential tool for practitioners and students looking to broader their skill set in laser dentistry.

Download or read book Antimicrobial Materials for Biomedical Applications written by Abraham J Domb and published by Royal Society of Chemistry. This book was released on 2019-07-31 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry. Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored. Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.

Download or read book Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications written by Krishnan Anand and published by Elsevier. This book was released on 2021-03-19 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics

Download or read book Redox Active Therapeutics written by Ines Batinić-Haberle and published by Springer. This book was released on 2016-10-13 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.

Download or read book Oral Biofilms written by S. Eick and published by Karger Medical and Scientific Publishers. This book was released on 2020-12-21 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book covers all aspects of oral biofilms, including models used in the laboratory, biofilms in dental water unit lines, periodontal and peri-implant biofilms, caries-related biofilms, halitosis, endodontic biofilms, and Candida infections, as well as biofilms on dental materials and on orthodontic appliances. Several chapters deal with anti-biofilm therapy, from the efficacy of mechanical methods and the use of antimicrobials, to alternative concepts. This publication is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on biofilms.