Download or read book Antigen Studies in Transplantation Immunology written by Felix T. Rapaport and published by . This book was released on 1967 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transplantation Immunology written by Philip Hornick and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.
Download or read book Transplant Immunology written by Xian C. Li and published by John Wiley & Sons. This book was released on 2015-11-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.
Download or read book Transplantation Immunology Research Trends written by Oliver N. Ulricker and published by Nova Publishers. This book was released on 2007 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. Included within the scope are T cell immunity; Antigen presentation; Alloreactivity; Pancreas and islet cell transplantation; Allogeneic bone marrow transplantation Models of tolerance induction; Xenotransplantation and The swine leukocyte antigen (SLA) complex. This book gathers the latest research in the exciting new field of transplantation immunology.
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Immunobiology of Organ Transplantation written by David S. Wilkes and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.
Download or read book Transplantation Immunology written by Fritz H. Bach and published by Wiley-Liss. This book was released on 1995-08-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided into four sections: Major and Minor Histocompatibility Antigens, Immunobiology of Graft Rejection, Clinical Transplantation, and Frontiers in Transplantation. The first two sections cover present-day understanding of the genetic controls of immunity as well as the two basic concerns of transplantation immunology, namely donor tissue antigens and the host cellular response. The third section deals with clinical aspects of transplantation, while the fourth looks toward future efforts of scientific research in this field—including advances in tolerance and xenotransplantation. A detailed appendix entitled "Molecular Biology for the Clinician" is included to help make the material accessible to readers of all backgrounds. Authored by a wide range of experts in both clinical and research fields, individual chapters cover such topics as: T cell immunity Antigen presentation Alloreactivity Pancreas and islet cell transplantation Allogeneic bone marrow transplantation Models of tolerance induction Xenotransplantation The swine leukocyte antigen (SLA) complex Transplantation Immunology is an ideal teaching text for the fundamental concepts, latest findings, and future directions in this increasingly important field. This volume will appeal to a wide range of clinicians including surgeons and primary-care physicians, as well as scientists in molecular biology and immunology.
Download or read book The HLA System in Clinical Transplantation written by Bjarte G. Solheim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this book we· want to address young graduate students, clini cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.
Download or read book Transplantation Antigens written by Barry D. Kahan and published by . This book was released on 1972 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunological Aspects of Transplantation Surgery written by R.Y. Carne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: R. Y.Calne Surgeons are transplanting kidneys in ever increasing numbers-more than 10000 renal allografts have now been reported to the Transplant Registry. With related donors 75% of grafted kidneys continued to function after 2 years, compared with 50% when the donors were unrelated. The therapeutic value is obvious, but the management is largely empirical and results have improved little in the past 5 years. The basic sciences related to tissue transplantation have advanced rapidly. New serological and tissue culture techniques and chemical analysis of antigens and anti bodies have produced complicated data that is almost incomprehensible to the non specialist. Mathematical treatment of genetic probabilities and of immunological kinetics are similarly difficult to follow for those not especially trained. There has always been a gulf between the practical clinician whose patients do not behave like inbred rodents and the biologist who likes carefully controlled experiments with easily observed results. Both realize, however, that predictable and safe control of rejection must involve close collaboration and co-operation between the laboratory and the clinic. Unfortwlately, the different nature of the work and the workers has widened the gap between them. The clinicians tend to improve their techniques and patient care, whilst the biologists seek clearer and more precisely deflned experi ments which lead them to use increasingly artiflcial experimental models.
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Download or read book Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation written by Narinder K. Mehra and published by Frontiers Media SA. This book was released on 2017-07-25 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, in addition to serving as excellent tools for initiating pre-transplant desensitization and post- transplant antibody monitoring. Consensus is evolving on the optimal routine employment of these methods in donor selection strategies along with an understanding of the clinical relevance of antibodies detected by each of them. The immunoassays based on the Luminex platform and flow cytometric beads are however unable to discriminate complement fixing from non-complement fixing HLA antibodies. This is important because the former are considered clinically more pertinent in the peri-transplant period. The C1q assay which is a modification of the solid phase assay based on Luminex single antigen beads, which can be used effectively to monitor high dose IVIG desensitization is essentially a surrogate complement fixing assay, retaining the exquisite sensitivity and specificity of the Luminex platform. Currently, information obtained from these assays is preliminary and much needs to be done to standardize technologies and set a consensus ‘MFI cut off’ for antibody positivity. Besides the overriding influence of anti-HLA antibodies on overall solid organ graft survival, immune response to non-HLA antigens has become a topic of substantial interest in recent years. An ever expanding list of non-HLA antigens has been implicated in graft rejection for various organs, of which the most noted are the Major Histocompatibility Complex class I chain-related molecule A (MICA), Vimentin, Myosin, Angiotensin II type 1 receptor (AT1R), Tubulin and Collagen. MICA is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in renal transplantation. Although there are clear indications of MICA antibodies being associated with adverse graft outcome, to date a definitive consensus on this relationship has not been agreed. Because MICA molecules are not expressed constitutively on immunocompetent cells such as T and B lymphocytes, it is of utmost importance to address the impact of MICA donor specific antibodies (DSA) as compared to those that are non- donor specific (NDSA) on graft outcome. The soluble isoform of MICA molecule (sMICA) that is derived from the proteolytic shedding of membrane bound molecules has the potential to engage the NK-cell activating receptor NKG2D and down-regulate its expression. Consequent to the interaction of NKG2D by sMICA, the receptor ligand complex is endocytosed and degraded and thus suppresses NKG2D mediated lysis of the target by NK cells. Thus interaction between NKG2D and sMICA leads to expansion of immunosuppressive/anergic T cells thereby resulting in suppression of NKG2D mediated host innate immunity. These concept support the possible involvement of an immunosuppressive role for sMICA during allotransplantation as shown recently for heart transplantation. This research topic focusses on the clinical utility of investigating the complete antibody repertoire in solid organ transplantation.
Download or read book Transplantation Antigens written by Barry Kahan and published by Elsevier. This book was released on 2012-12-02 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation Antigens: Markers of Biological Individuality investigates transplantation antigens and their function as markers of biological individuality. Topics covered include transplantation antigens of the human fetus, trophoblast, and spermatozoa; tissue distribution and cellular location of transplantation antigens; and serologic identification of human transplantation antigens. The biological significance of cross-reactions between histocompatibility antigens and antigens of bacterial and/or heterologous mammalian origin is also examined. This book is comprised of 25 chapters and begins with an introduction to the phylogeny of transplantation reactivity, followed by a discussion on the appearance of transplantation antigens in the embryo and fetus and the ways in which these antigens interact with or are masked from the immunocytes of the pregnant female. The next chapter analyzes the data on the detection of transplantation antigens on human fetal cells, cells of trophoblastic origin, and spermatozoa. The intracellular distribution of transplantation antigens is also considered, along with the extraction of membranous transplantation antigens by pressure homogenization; the molecular nature of HL-A antigens; and solubilization of histocompatibility antigens with detergents. This monograph will appeal to biologists, physiologists, immunologists, and clinicians.
Download or read book Transplant Rejection and Tolerance Advancing the Field through Integration of Computational and Experimental Investigations written by Giorgio Raimondi and published by Frontiers Media SA. This book was released on 2017-12-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
Download or read book Tumor Specific Transplantation Antigen written by Pavel Koldovský and published by Butterworth-Heinemann. This book was released on 2013-09-24 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on the tumor antigen responsible for transplantation resistance. The monograph presents discussions on the methods of induction of antitumor immunity; methods of detection of antitumor immunity; virus-induced tumors; the characteristics of TSTA; tumor growth and development of immunity; and the theoretical and practical possibilities of the presence of transplantation immunity against tumors in man. Oncologists, cell biologists, immunobiologists, and medical researchers will find the book invaluable.
Download or read book A History of Transplantation Immunology written by Leslie Brent and published by Academic Press. This book was released on 1996-11-18 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen
Download or read book Transplantation Immunology written by Roy Yorke Calne and published by Oxford University Press, USA. This book was released on 1984 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a team of clinicians and immunologists who have pioneered many renowned transplantation procedures, this in-depth study explores clinical and experimental aspects of transplantation and details the immensely complex immunological processes involved. The scope of this work reflects the knowledge and experience the contributors bring to their discussion of organ preservation, advances in tissue-typing, rejection of implanted tissue, patient survival, and immunosuppression with drugs such as cyclosporin B.
